| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert L Copeland, Yaminah A Leggett, Yasmine M Kanaan, Robert E Taylor, Yousef Tizab. Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371323. |
in this study we sought to determine whether salsolinol-induced cytotoxicity in sh-sy5y human neuroblastoma cells, a cloned cell line which expresses dopaminergic activity, could also be prevented by nicotine pretreatment, and if so, which nicotinic receptors may mediate the actions of nicotine. |
2006-04-27 |
2023-08-12 |
human |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
thus, the changes occurring in the sensitivity of d2-like dopamine receptors probably play a minor role in regulating the dopaminergic transmission during long-term nicotine administration. |
2006-04-18 |
2023-08-12 |
mouse |
| Sarah E McCallum, Neeraja Parameswaran, Tanuja Bordia, Hong Fan, Rachel F Tyndale, J William Langston, J Michael McIntosh, Maryka Qui. Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412091. |
these divergent actions of chronic nicotine treatment on alpha4* versus alpha6* nachrs, as well as effects on dopamine uptake, allow for a complex control of striatal activity to maintain dopaminergic function. |
2006-04-06 |
2023-08-12 |
Not clear |
| Boris S Gutkin, Stanislas Dehaene, Jean-Pierre Changeu. A neurocomputational hypothesis for nicotine addiction. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 4. 2006-03-17. PMID:16415156. |
we propose that combining changes in the nicotinic receptor response, expressed by mesolimbic dopaminergic neurons, with dopamine-gated learning in action-selection circuits, suffices to capture the acquisition of nicotine addiction. |
2006-03-17 |
2023-08-12 |
Not clear |
| Mariko Saito, Danielle O'Brien, Krisztina M Kovacs, Ray Wang, Jiri Zavadil, Csaba Vadas. Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression. Neurochemical research. vol 30. issue 8. 2006-01-24. PMID:16258852. |
down-regulation of gaba-a receptors induced by repeated nicotine exposure may facilitate dopaminergic neuronal transmission and may contribute to increased locomotor activity. |
2006-01-24 |
2023-08-12 |
mouse |
| Hongwen Zhu, MoonSook Lee, Fangxia Guan, Soh Agatsuma, Daniel Scott, Kevin Fabrizio, Allen A Fienberg, Noboru Hiro. DARPP-32 phosphorylation opposes the behavioral effects of nicotine. Biological psychiatry. vol 58. issue 12. 2006-01-20. PMID:16084497. |
the addictive properties of nicotine are mediated via dopaminergic pathways and their post-synaptic neurons in the striatum. |
2006-01-20 |
2023-08-12 |
Not clear |
| M Picciolo, D Gigante, A Nunziat. [Nicotine addiction and current therapy of smoking cessation]. La Clinica terapeutica. vol 156. issue 4. 2006-01-04. PMID:16342517. |
nicotine is defined as substance which provokes addiction because it creates both physiological and biochemical modifications in the nervous system stimulating the activity of dopaminergic neurons releasing dopamine in the areas of the brain that control pleasure. |
2006-01-04 |
2023-08-12 |
Not clear |
| Mohammad Tariq, Haseeb Ahmad Khan, Ibrahim Elfaki, Saleh Al Deeb, Khalaf Al Moutaer. Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain research bulletin. vol 67. issue 1-2. 2005-12-13. PMID:16140176. |
preservation of striatal dopaminergic neurons by nicotine was also confirmed by immunohistochemical studies. |
2005-12-13 |
2023-08-12 |
rat |
| C L Parish, J Nunan, D I Finkelstein, F N McNamara, J Y Wong, J L Waddington, R M Brown, A J Lawrence, M K Horne, J Drag. Mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16077034. |
given the known effects of nachrs on dopaminergic neurotransmission, we assessed the ability of the alpha4 nachr subunit to regulate arbor size of dopaminergic neurons by comparing responses of wild-type and alpha4 nachr subunit knockout [alpha4(-/-)] mice to long-term exposure to cocaine, amphetamine, nicotine, and haloperidol, and after substantia nigra neurotoxic lesioning. |
2005-11-28 |
2023-08-12 |
mouse |
| Hao Chen, Steven L Parker, Shannon G Matta, Burt M Shar. Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045491. |
gestational nicotine exposure reduces nicotinic cholinergic receptor (nachr) expression in dopaminergic brain regions of adolescent rats. |
2005-09-23 |
2023-08-12 |
human |
| Jennie Z Ma, Joke Beuten, Thomas J Payne, Randolph T Dupont, Robert C Elston, Ming D L. Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Human molecular genetics. vol 14. issue 12. 2005-09-13. PMID:15879433. |
because the mesolimbic dopaminergic system is implicated in the reinforcing effects of many drugs, including nicotine, the ddc gene is considered a plausible candidate for involvement in the development of vulnerability to nicotine dependence (nd). |
2005-09-13 |
2023-08-12 |
Not clear |
| Caroline Cohen, Ercem Kodas, Guy Griebe. CB1 receptor antagonists for the treatment of nicotine addiction. Pharmacology, biochemistry, and behavior. vol 81. issue 2. 2005-09-08. PMID:15935455. |
rimonabant appears to reduce nicotine addiction by attenuating the hyperactivation of the endocannabinoid system and the mesolimbic dopaminergic neuronal pathway. |
2005-09-08 |
2023-08-12 |
mouse |
| Sanna Janhunen, Raimo K Tuominen, Liisa Ahte. Comparison of the effects of nicotine and epibatidine given in combination with nomifensine on rotational behaviour in rats. Neuroscience letters. vol 381. issue 3. 2005-07-26. PMID:15896491. |
however, when given repeatedly once a day for five days, nicotine (0.5 mg/kg) and epibatidine (0.6 microg/kg but not 3.0 microg/kg) induced ipsilateral rotations indicating sensitization of the nigrostriatal dopaminergic system to activation by repeated treatment with nicotinic agonists. |
2005-07-26 |
2023-08-12 |
rat |
| Sanna Janhunen, Raimo K Tuominen, Liisa Ahte. Comparison of the effects of nicotine and epibatidine given in combination with nomifensine on rotational behaviour in rats. Neuroscience letters. vol 381. issue 3. 2005-07-26. PMID:15896491. |
the sensitization of the nigrostriatal dopaminergic pathway might be involved in the beneficial effects of nicotine in parkinson's disease by allowing the remaining dopaminergic synapses to compensate for the functional deficiency of nigrostriatal pathway. |
2005-07-26 |
2023-08-12 |
rat |
| Massimo Grilli, Monica Parodi, Maurizio Raiteri, Mario March. Chronic nicotine differentially affects the function of nicotinic receptor subtypes regulating neurotransmitter release. Journal of neurochemistry. vol 93. issue 5. 2005-06-24. PMID:15934954. |
it is known that nicotine can activate several subtypes of release-regulating presynaptic nicotinic receptors (nachrs) including those situated on central noradrenergic, dopaminergic, cholinergic and glutamatergic axon terminals. |
2005-06-24 |
2023-08-12 |
rat |
| Hiroaki Matsubayashi, Atsuko Inoue, Taku Amano, Takahiro Seki, Yoshihiro Nakata, Masashi Sasa, Norio Saka. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469877. |
these results suggest that nicotine directly acts on postsynaptic alpha7- and alpha4beta2-type nicotinic acetylcholine receptors and induces inward current, which result in the excitation of dopaminergic neurons in the substantia nigra. |
2005-04-19 |
2023-08-12 |
Not clear |
| Layla Azam, J Michael McIntos. Effect of novel alpha-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes. The Journal of pharmacology and experimental therapeutics. vol 312. issue 1. 2005-04-13. PMID:15316087. |
nicotine's action on the midbrain dopaminergic neurons is mediated by nicotinic acetylcholine receptors (nachrs) that are present on the cell bodies and the terminals of these neurons. |
2005-04-13 |
2023-08-12 |
rat |
| Stephanie L Collins, Dean Wade, Jennifer Ledon, Sari Izenwasse. Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats. European journal of pharmacology. vol 502. issue 1-2. 2005-04-08. PMID:15464092. |
in the current study, the effects of a 7-day treatment with nicotine on nicotinic, dopaminergic, and serotonergic neurochemistry were examined in the caudate putamen and nucleus accumbens in periadolescent vs. adult male rats. |
2005-04-08 |
2023-08-12 |
rat |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type b receptor expression of the rat prefrontal cortex. |
2005-03-07 |
2023-08-12 |
rat |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the psychopharmacologic effects of nicotine depend to a great extent on activation of nicotinic receptors within the mesolimbocortical dopaminergic projection. |
2005-03-07 |
2023-08-12 |
rat |