| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiomara A Perez, Tanuja Bordia, J Michael McIntosh, Sharon R Grady, Maryka Qui. Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. Molecular pharmacology. vol 74. issue 3. 2008-09-18. PMID:18583454. |
nicotine treatment has long been associated with alterations in alpha4beta2(*) nicotinic acetylcholine receptor (nachr) expression that modify dopaminergic function. |
2008-09-18 |
2023-08-12 |
mouse |
| Xiomara A Perez, Tanuja Bordia, J Michael McIntosh, Sharon R Grady, Maryka Qui. Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. Molecular pharmacology. vol 74. issue 3. 2008-09-18. PMID:18583454. |
however, the influence of long-term nicotine treatment on the alpha6beta2(*) nachr, a subtype specifically localized on dopaminergic neurons, is less clear. |
2008-09-18 |
2023-08-12 |
mouse |
| Taku Nagai, Kiyofumi Yamad. [Role of tissue plasminogen activator in the rewarding effect of nicotine]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 43. issue 3. 2008-09-03. PMID:18646640. |
drugs of abuse including nicotine acutely modulate the activity of mesolimbic dopaminergic neurons, projecting from the ventral tegmental area of the midbrain to the nucleus accumbens (nac). |
2008-09-03 |
2023-08-12 |
mouse |
| Stefania Preda, Stefano Govoni, Cristina Lanni, Marco Racchi, Elisa Mura, Massimo Grilli, Mario March. Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 5. 2008-08-01. PMID:17581530. |
also the nicotinic agonists epibatidine and nicotine evoked a dopaminergic outflow in nucleus accumbens, which, however, was lower. |
2008-08-01 |
2023-08-12 |
Not clear |
| Heather Walsh, Anitha P Govind, Ryan Mastro, J C Hoda, Daniel Bertrand, Yolanda Vallejo, William N Gree. Up-regulation of nicotinic receptors by nicotine varies with receptor subtype. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18174175. |
recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. |
2008-05-30 |
2023-08-12 |
Not clear |
| Bombi Lee, Chae Ha Yang, Dae-Hyun Hahm, Hye-Jung Lee, Eun Sang Choe, Kwang-Ho Pyun, Insop Shi. Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat. The Journal of pharmacy and pharmacology. vol 59. issue 12. 2008-05-27. PMID:18053328. |
repeated injections of nicotine can produce an increase in locomotor activity and the expression of immediate-early gene, c-fos, in the central dopaminergic areas. |
2008-05-27 |
2023-08-12 |
rat |
| Bombi Lee, Chae Ha Yang, Dae-Hyun Hahm, Hye-Jung Lee, Eun Sang Choe, Kwang-Ho Pyun, Insop Shi. Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat. The Journal of pharmacy and pharmacology. vol 59. issue 12. 2008-05-27. PMID:18053328. |
these results suggest that cr and ber may produce inhibitory effects of nicotine on behavioural sensitization by possibly reducing postsynaptic neuronal activation in the central dopaminergic systems. |
2008-05-27 |
2023-08-12 |
rat |
| Leszek Bidza. [A review of the effects of nicotine on schizophrenia]. Psychiatria polska. vol 41. issue 5. 2008-05-20. PMID:18421928. |
nicotine treatment modulates both dopaminergic and glutamatergic neurotransmission, and these effects are specific both to brain region and functional system. |
2008-05-20 |
2023-08-12 |
Not clear |
| U Masko. The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology. British journal of pharmacology. vol 153 Suppl 1. 2008-04-28. PMID:18223661. |
the anatomy, physiology, functional and pathological implications of these interactions with the nicotinic subtype of acetylcholine receptors (nachrs) are discussed with a view of the important role of the mpt as a master regulator of nicotinic dopaminergic signalling in the brain, including for nicotine addiction. |
2008-04-28 |
2023-08-12 |
Not clear |
| Anthony S Rauhut, Isaac J Zentner, Stacey K Mardekian, Jason B Tanenbau. Wistar Kyoto and Wistar rats differ in the affective and locomotor effects of nicotine. Physiology & behavior. vol 93. issue 1-2. 2008-04-22. PMID:17889041. |
anhedonia is a characteristic of clinical depression and has been associated with dysfunction of the mesolimbic dopaminergic system, a system also involved in mediating nicotine reward. |
2008-04-22 |
2023-08-12 |
rat |
| Weihua Huang, Jennie Z Ma, Thomas J Payne, Joke Beuten, Randolph T Dupont, Ming D L. Significant association of DRD1 with nicotine dependence. Human genetics. vol 123. issue 2. 2008-04-22. PMID:18092181. |
genes in the dopaminergic system, which mediates the reinforcing and dependence-producing properties of nicotine, are plausible candidates for roles in nicotine dependence (nd). |
2008-04-22 |
2023-08-12 |
human |
| Yann S Mineur, Marina R Picciott. Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochemical pharmacology. vol 75. issue 1. 2008-02-26. PMID:17632086. |
genetic engineering studies in mice have identified a number of subunits that are critical for the ability of nicotine to activate the reward system in the brain, consisting of the dopaminergic cell bodies in the ventral tegmental area and their terminals in the nucleus accumbens and other portions of the mesolimbic system. |
2008-02-26 |
2023-08-12 |
mouse |
| T Flatscher-Bader, N Zuvela, N Landis, P A Wilc. Smoking and alcoholism target genes associated with plasticity and glutamate transmission in the human ventral tegmental area. Human molecular genetics. vol 17. issue 1. 2008-02-11. PMID:17928304. |
drugs of abuse including nicotine and alcohol elicit their effect by stimulating the mesocorticolimbic dopaminergic system. |
2008-02-11 |
2023-08-12 |
human |
| Toshihisa Tajima, Kentaro Hatano, Mitsuru Suzuki, Mikako Ogawa, Yojiro Sakiyama, Takashi Kato, Hidetoshi Endo, Hisayuki Miura, Michitaka Matsubara, Kengo It. Increased binding potential of [(11)C]raclopride during unilateral continuous microinjection of nicotine in rat striatum observed by positron emission tomography. Synapse (New York, N.Y.). vol 61. issue 12. 2008-01-24. PMID:17787002. |
in animal studies, nicotine improves the performance of various memory-related tasks, an effect that is thought to be mediated by the neuronal dopaminergic system as systemic administration of nicotine decreased [(11)c]raclopride binding in the anesthetized state. |
2008-01-24 |
2023-08-12 |
rat |
| Maryka Quik, Heather Cox, Neeraja Parameswaran, Kathryn O'Leary, J William Langston, Donato Di Mont. Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys. Annals of neurology. vol 62. issue 6. 2008-01-22. PMID:17960553. |
however, the cholinergic system has received little attention despite an extensive overlap between dopaminergic terminals and cholinergic interneurons in the striatum and the well-known ability of nicotine to stimulate striatal dopamine release. |
2008-01-22 |
2023-08-12 |
monkey |
| Ryan M Drenan, Raad Nashmi, Princess Imoukhuede, Herwig Just, Sheri McKinney, Henry A Leste. Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits. Molecular pharmacology. vol 73. issue 1. 2008-01-16. PMID:17932221. |
nicotinic receptors containing alpha4, alpha6, beta2, and beta3 subunits are expressed in midbrain dopaminergic neurons, and they are implicated in the response to smoked nicotine. |
2008-01-16 |
2023-08-12 |
Not clear |
| Jeffrey G Edwards, Ann Greig, Yoko Sakata, Dimitry Elkin, William C Miche. Cholinergic innervation of the zebrafish olfactory bulb. The Journal of comparative neurology. vol 504. issue 6. 2008-01-04. PMID:17722029. |
nicotine (50 microm) significantly increased the activity-dependent labeling of mitral cells and juxtaglomerular cells but not of tyrosine hydroxlase-positive dopaminergic neurons (th(+) cells) compared to control preparations. |
2008-01-04 |
2023-08-12 |
zebrafish |
| Hyun Jung Park, Phil Hyu Lee, Young Whan Ahn, Yun Jung Choi, Gwang Lee, Da-Yong Lee, Eun S Chung, Byung Kwan Ji. Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action. The European journal of neuroscience. vol 26. issue 1. 2007-09-19. PMID:17581257. |
neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action. |
2007-09-19 |
2023-08-12 |
rat |
| Hyun Jung Park, Phil Hyu Lee, Young Whan Ahn, Yun Jung Choi, Gwang Lee, Da-Yong Lee, Eun S Chung, Byung Kwan Ji. Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action. The European journal of neuroscience. vol 26. issue 1. 2007-09-19. PMID:17581257. |
in the present study, we used lipopolysaccharide (lps)-induced in vitro and in vivo inflammation models to investigate whether nicotine has a protective effect on the dopaminergic system through an anti-inflammatory mechanism. |
2007-09-19 |
2023-08-12 |
rat |
| Hyun Jung Park, Phil Hyu Lee, Young Whan Ahn, Yun Jung Choi, Gwang Lee, Da-Yong Lee, Eun S Chung, Byung Kwan Ji. Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action. The European journal of neuroscience. vol 26. issue 1. 2007-09-19. PMID:17581257. |
the present study demonstrated that nicotine has a neuroprotective effect on dopaminergic neurons via an anti-inflammatory mechanism mediated by the modulation of microglial activation. |
2007-09-19 |
2023-08-12 |
rat |