| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takashi Yanagida, Hiroki Takeuchi, Yoshihisa Kitamura, Kazuyuki Takata, Hideaki Minamino, Tomonori Shibaike, Jun Tsushima, Koji Kishimoto, Hiroyuki Yasui, Takashi Taniguchi, Shun Shimoham. Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model. Neuroscience research. vol 62. issue 4. 2009-04-14. PMID:18845194. |
although methamphetamine-stimulated rotational behavior and dopaminergic neuronal loss induced by 6-ohda were not inhibited by galantamine alone, those were moderately inhibited by nicotine alone. |
2009-04-14 |
2023-08-12 |
rat |
| Takashi Yanagida, Hiroki Takeuchi, Yoshihisa Kitamura, Kazuyuki Takata, Hideaki Minamino, Tomonori Shibaike, Jun Tsushima, Koji Kishimoto, Hiroyuki Yasui, Takashi Taniguchi, Shun Shimoham. Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model. Neuroscience research. vol 62. issue 4. 2009-04-14. PMID:18845194. |
these results suggest that galantamine synergistically enhances the neuroprotective effect of nicotine against 6-ohda-induced dopaminergic neuronal loss through an allosteric modulation of alpha7 nachr activation. |
2009-04-14 |
2023-08-12 |
rat |
| Janice W Smith, Ian P Stolerma. Recognising nicotine: the neurobiological basis of nicotine discrimination. Handbook of experimental pharmacology. issue 192. 2009-04-07. PMID:19184654. |
the evidence strongly supports central sites as the origins of the nicotine stimulus, and these are likely to be located in the mesocorticolimbic dopaminergic neurons; the medial prefrontal cortex is primarily involved, with the nucleus accumbens and ventral tegmental area of secondary importance, while another element of the complex stimulus may arise in the dorsal hippocampus. |
2009-04-07 |
2023-08-12 |
human |
| Björn Schilström, Nina Rawal, Monica Mameli-Engvall, George G Nomikos, Torgny H Svensso. Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes. The international journal of neuropsychopharmacology. vol 6. issue 1. 2009-04-06. PMID:12899731. |
nicotine has been found to effectively increase burst firing of dopaminergic cells. |
2009-04-06 |
2023-08-12 |
Not clear |
| Björn Schilström, Nina Rawal, Monica Mameli-Engvall, George G Nomikos, Torgny H Svensso. Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes. The international journal of neuropsychopharmacology. vol 6. issue 1. 2009-04-06. PMID:12899731. |
nicotine (0.5 mg/kg s.c.) was found to increase firing rate and burst firing of dopaminergic neurons. |
2009-04-06 |
2023-08-12 |
Not clear |
| Neil E Paterso. Behavioural and pharmacological mechanisms of bupropion's anti-smoking effects: recent preclinical and clinical insights. European journal of pharmacology. vol 603. issue 1-3. 2009-03-18. PMID:19101536. |
third, it is suggested that the unique mixed pharmacological profile of bupropion provides (1) attenuation of the multiple negative consequences of withdrawal via blockade of dopamine and noradrenaline reuptake; (2) replacement of the reward-facilitating and subjective effects of nicotine via blockade of dopaminergic reuptake; (3) attenuation of the rewarding effects of acute nicotine by nicotinic acetylcholine receptor blockade. |
2009-03-18 |
2023-08-12 |
Not clear |
| Kenneth Blum, Amanda Lih Chuan Chen, Thomas J H Chen, Eric R Braverman, Jeffrey Reinking, Seth H Blum, Kimberly Cassel, Bernard W Downs, Roger L Waite, Lonna Williams, Thomas J Prihoda, Mallory M Kerner, Tomas Palomo, David E Comings, Howard Tung, Patrick Rhoades, Marlene Oscar-Berma. Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theoretical biology & medical modelling. vol 5. 2009-03-16. PMID:19014506. |
individuals possessing a paucity of serotonergic and/or dopaminergic receptors, and an increased rate of synaptic da catabolism due to high catabolic genotype of the comt gene, are predisposed to self-medicating any substance or behavior that will activate da release, including alcohol, opiates, psychostimulants, nicotine, gambling, sex, and even excessive internet gaming. |
2009-03-16 |
2023-08-12 |
Not clear |
| Kechun Yang, Jun Hu, Linda Lucero, Qiang Liu, Chao Zheng, Xuechu Zhen, Guozhang Jin, Ronald J Lukas, Jie W. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. The Journal of physiology. vol 587. issue 2. 2009-03-09. PMID:19047205. |
dopaminergic (daergic) neuronal activity in the ventral tegmental area (vta) is thought to contribute generally to pleasure, reward, and drug reinforcement and has been implicated in nicotine dependence. |
2009-03-09 |
2023-08-12 |
rat |
| Weihua Huang, Thomas J Payne, Jennie Z Ma, Joke Beuten, Randolph T Dupont, Naohiro Inohara, Ming D L. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18354387. |
the dopaminergic system in the brain plays a critical role in nicotine addiction. |
2009-02-23 |
2023-08-12 |
human |
| Weihua Huang, Thomas J Payne, Jennie Z Ma, Joke Beuten, Randolph T Dupont, Naohiro Inohara, Ming D L. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18354387. |
genetic variants in the dopaminergic system, including those in dopamine receptor genes, represent plausible candidates for the genetic study of nicotine dependence (nd). |
2009-02-23 |
2023-08-12 |
human |
| Dave J Hayes, Tera M Mosher, Andrew J Greensha. Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behavioural brain research. vol 197. issue 2. 2009-02-23. PMID:18805442. |
nicotine, a potent nicotinic acetylcholine receptor agonist, interacts with the dopaminergic and serotonergic systems and is known to positively affect reward-related behaviours. |
2009-02-23 |
2023-08-12 |
rat |
| Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamad. Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1. Journal of pharmacological sciences. vol 108. issue 4. 2009-02-19. PMID:19098386. |
mesolimbic dopaminergic neurons mediate the rewarding effects of abused drugs, including nicotine. |
2009-02-19 |
2023-08-12 |
mouse |
| Jean-Christian Maillet, Yun Zhang, Xuesheng Li, Xia Zhan. PTEN-5-HT2C coupling: a new target for treating drug addiction. Progress in brain research. vol 172. 2009-01-15. PMID:18772044. |
systemic or intra-amygdaloid application of the interfering peptide tat-3l4f is able to disrupt pten coupling with 5-ht2cr in the rat vta, resulting both in a suppression of the increased firing rate of vta dopaminergic neurons induced by delta 9-tetrahydrocannabinol (thc), the psychoactive ingredient of marijuana, and in a blockade of the conditioned place preference induced by thc and nicotine [ji, s.p. |
2009-01-15 |
2023-08-12 |
rat |
| Tanja Vihavainen, Toni R A Relander, Riikka Leiviskä, Mikko Airavaara, Raimo K Tuominen, Liisa Ahtee, Timo Petteri Pieppone. Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA. Journal of neurochemistry. vol 107. issue 3. 2008-12-16. PMID:18786163. |
previously, we have shown that 7-week oral nicotine treatment enhances morphine-induced behaviors and dopaminergic activity in the mouse brain. |
2008-12-16 |
2023-08-12 |
mouse |
| Tanja Vihavainen, Toni R A Relander, Riikka Leiviskä, Mikko Airavaara, Raimo K Tuominen, Liisa Ahtee, Timo Petteri Pieppone. Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA. Journal of neurochemistry. vol 107. issue 3. 2008-12-16. PMID:18786163. |
thus, our data show that chronic nicotine treatment sensitizes dopaminergic systems to morphine and affects gabaergic systems in the vta/sn. |
2008-12-16 |
2023-08-12 |
mouse |
| Paolo Calabresi, Massimiliano Di Filipp. ACh/dopamine crosstalk in motor control and reward: a crucial role for alpha 6-containing nicotinic receptors? Neuron. vol 60. issue 1. 2008-11-06. PMID:18940582. |
the midbrain dopaminergic system is a key element in the control of motor activity, cognition, and the motivational effects of drugs of abuse, including nicotine. |
2008-11-06 |
2023-08-12 |
Not clear |
| Alexis Evrard, Jean-Pierre Changeu. Abnormal response of dopaminergic neurons to nicotine without perturbation of nicotinic receptors in alphaCGRP knock-out mice. Brain research. vol 1228. 2008-11-03. PMID:18619948. |
abnormal response of dopaminergic neurons to nicotine without perturbation of nicotinic receptors in alphacgrp knock-out mice. |
2008-11-03 |
2023-08-12 |
mouse |
| Laurie H L Sellings, Golriz Baharnouri, Lindsey E McQuade, Paul B S Clark. Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702705. |
dopaminergic denervation in accumbens medial shell was associated with decreased nicotine conditioned place preference. |
2008-10-23 |
2023-08-12 |
rat |
| Laurie H L Sellings, Golriz Baharnouri, Lindsey E McQuade, Paul B S Clark. Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702705. |
in addition, dopaminergic denervation of accumbens core but not medial shell abolished conditioned taste aversion for nicotine. |
2008-10-23 |
2023-08-12 |
rat |
| Laurie H L Sellings, Golriz Baharnouri, Lindsey E McQuade, Paul B S Clark. Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens. The European journal of neuroscience. vol 28. issue 2. 2008-10-23. PMID:18702705. |
we conclude that nucleus accumbens core and medial shell dopaminergic innervation exert segregated effects on rewarding and aversive effects of nicotine. |
2008-10-23 |
2023-08-12 |
rat |