| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren M Reynolds, Aylin Gulmez, Sophie L Fayad, Renan Costa Campos, Daiana Rigoni, Claire Nguyen, Tinaïg Le Borgne, Thomas Topilko, Domitille Rajot, Clara Franco, Sebastian P Fernandez, Fabio Marti, Nicolas Heck, Alexandre Mourot, Nicolas Renier, Jacques Barik, Philippe Faur. Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state. Nature communications. vol 15. issue 1. 2024-10-18. PMID:39424848. |
we found transient nicotine exposure in early adolescent (pnd 21-28) male mice was sufficient to produce a marked vulnerability to nicotine in adulthood (pnd 60 + ), associated with disrupted functional connectivity in dopaminergic circuits. |
2024-10-18 |
2024-10-21 |
mouse |
| Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. |
the association of genetic polymorphisms within the dopaminergic system with nicotine dependence: a narrative review. |
2024-07-18 |
2024-07-20 |
Not clear |
| Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. |
numerous studies have identified genetic polymorphisms of dopaminergic pathways which may influence susceptibility to nicotine addiction. |
2024-07-18 |
2024-07-20 |
Not clear |
| Giulia Sbrini, Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Cristina Missale, Chiara Fiorentin. 17-β-estradiol potentiates the neurotrophic and neuroprotective effects mediated by the dopamine D3/acetylcholine nicotinic receptor heteromer in dopaminergic neurons. European journal of pharmacology. 2024-05-31. PMID:38821163. |
dopaminergic neurons express an heteromer composed of the dopamine d3 receptor and the α4-β2 nicotinic acetylcholine receptor, the d3r-nachr heteromer, activated by both nicotine and dopamine d2 and d3 receptors agonists, such as quinpirole, and crucial for dopaminergic neuron homeostasis. |
2024-05-31 |
2024-06-02 |
mouse |
| Giulia Sbrini, Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Cristina Missale, Chiara Fiorentin. 17-β-estradiol potentiates the neurotrophic and neuroprotective effects mediated by the dopamine D3/acetylcholine nicotinic receptor heteromer in dopaminergic neurons. European journal of pharmacology. 2024-05-31. PMID:38821163. |
in mouse dopaminergic neurons, in fact, 17-β-estradiol significantly increased the ability of nicotine and quinpirole in promoting neuron dendritic remodeling and in protecting neurons against the accumulation of α-synuclein induced by deprivation of glucose, with a mechanism that does not involve the classical estrogen receptors. |
2024-05-31 |
2024-06-02 |
mouse |
| Inam Ullah, Shahab Uddin, Longhe Zhao, Xin Wang, Hongyu L. Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease. Experimental brain research. 2024-03-02. PMID:38430248. |
according to numerous studies, nicotine enhances synaptic plasticity and dopaminergic neuronal survival. |
2024-03-02 |
2024-03-04 |
caenorhabditis_elegans |
| Sheketha R Hauser, Robert A Waeiss, Gerald A Deehan, Eric A Engleman, Richard L Bell, Zachary A Rod. Adolescent alcohol and nicotine exposure alters the adult response to alcohol use. Advances in drug and alcohol research. vol 3. 2024-02-23. PMID:38389816. |
this review will focus on studies that have examined the effects of adolescent alcohol and nicotine exposure on adult alcohol consumption, the hypersensitivity of the mesolimbic dopaminergic system, and enhanced responses not only to alcohol but also to nicotine during adulthood. |
2024-02-23 |
2024-02-25 |
human |
| Danyang Chen, Liang Shen, Yu-Zhuo Zhang, Bu-Fan Kan, Qian-Qian Lou, Dan-Dan Long, Ji-Ye Huang, Zhi Zhang, Shan-Shan Hu, Di Wan. Chronic nicotine exposure elicits pain hypersensitivity through activation of dopaminergic projections to anterior cingulate cortex. British journal of anaesthesia. 2024-02-09. PMID:38336518. |
chronic nicotine exposure elicits pain hypersensitivity through activation of dopaminergic projections to anterior cingulate cortex. |
2024-02-09 |
2024-02-12 |
Not clear |
| Wolfgang H Oertel, Hans-Helge Müller, Marcus M Unger, Carmen Schade-Brittinger, Kerstin Balthasar, Konstantin Articus, Marc Brinkman, C S Venuto, Ferenc Tracik, Jamie Eberling, Karla M Eggert, Cornelia Kamp, Karl Kieburtz, James T Boy. Transdermal Nicotine Treatment and Progression of Early Parkinson's Disease. NEJM evidence. vol 2. issue 9. 2024-02-06. PMID:38320207. |
nicotine treatment and parkinson's diseasein this randomized, controlled trial, patients with parkinson's disease not on dopaminergic therapy were randomly assigned to receive transdermal nicotine or placebo. |
2024-02-06 |
2024-02-09 |
Not clear |
| Tomás Mouro Ferraz Lima, João Mauricio Castaldelli-Maia, Gisèle Apter, Kae Leopold. Neurobiological associations between smoking and internalizing disorders. International review of psychiatry (Abingdon, England). vol 35. issue 5-6. 2024-02-01. PMID:38299645. |
nicotine improves dopaminergic signalling and balances glutamatergic and gabaergic pathways, improving symptoms and increasing the risk of nicotine dependence. |
2024-02-01 |
2024-02-03 |
Not clear |
| Yousef Tizabi, Bruk Getachew, Michael Aschne. Butyrate Protects and Synergizes with Nicotine against Iron- and Manganese-induced Toxicities in Cell Culture. Neurotoxicity research. vol 42. issue 1. 2023-12-14. PMID:38095760. |
we have previously reported that damage to neuroblastoma-derived dopaminergic cells (sh-sy5y) by both fe and mn could be prevented by pre-treatment with nicotine. |
2023-12-14 |
2023-12-17 |
Not clear |
| Yousef Tizabi, Bruk Getachew, Michael Aschne. Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases. Research square. 2023-10-27. PMID:37886507. |
we have previously reported that damage to neuroblastoma-derived dopaminergic cells (sh-sy5y) by both fe and mn could be prevented by pre-treatment with nicotine. |
2023-10-27 |
2023-11-08 |
Not clear |
| Seyedeh Leila Mousavi, Ameneh Rezayof, Sakineh Alijanpour, Ladan Delphi, Oveis Hosseinzadeh Sahaf. Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF expression. Pharmacology, biochemistry, and behavior. 2023-10-01. PMID:37778541. |
these findings suggest that the functional interaction between the md dopaminergic d1/d2-like and the vh/pfc glutamatergic nmda receptors may be partially involved in the anxiogenic-like effects of nicotine, likely via the alteration of bdnf levels in the hippocampus and the pfc. |
2023-10-01 |
2023-10-07 |
rat |
| Ranjithkumar Chellian, Azin Behnood-Rod, Ryann Wilson, Karen Lin, Grace Wing-Yan King, Adriaan W Bruijnzee. Dopamine D1-like receptor activation decreases nicotine intake in rats with short or long access to nicotine. Addiction biology. vol 28. issue 8. 2023-07-27. PMID:37500487. |
the dopaminergic system plays a key role in the initiation and maintenance of nicotine intake. |
2023-07-27 |
2023-08-14 |
human |
| Maria Echeveste Sanchez, ManHua Zhu, Sarah Magee, Shyenne Grady, Hayley Guerry, Tara N Guhr-Lee, Charles R Esther, Melissa A Herma. Electronic Vaporization of Nicotine Salt or Freebase produces differential effects on metabolism, neuronal activity and behavior in male and female C57BL/6J mice. Addiction neuroscience. vol 6. 2023-06-09. PMID:37292173. |
in contrast increased activity in the ventral tegmental area (vta) was only observed in female mice exposed to 3% nicotine freebase and specifically in the dopaminergic population. |
2023-06-09 |
2023-08-14 |
mouse |
| Sarah Falk, Jonas Petersen, Charlotte Svendsen, Cesar R Romero-Leguizamón, Søren Heide Jørgensen, Nathalie Krauth, Mette Q Ludwig, Kathrine Lundø, Urmas Roostalu, Grethe Skovbjerg, Duy Anh Gurskov Nielsen, Aske Lykke Ejdrup, Tune H Pers, Oksana Dmytriyeva, Jacob Hecksher-Sørensen, Ulrik Gether, Kristi A Kohlmeier, Christoffer Clemmense. GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity. Cell reports. 2023-05-06. PMID:37148870. |
co-treatment with nicotine and liraglutide gives rise to neuronal activity in multiple brain regions, and we demonstrate that glp-1r agonism increases excitability of hypothalamic proopiomelanocortin (pomc) neurons and dopaminergic neurons in the ventral tegmental area (vta). |
2023-05-06 |
2023-08-14 |
mouse |
| Kechun Yang, Ian McLaughlin, Jessica K Shaw, Natalia Quijano-Cardé, John A Dani, Mariella De Bias. CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal. Neuropharmacology. 2023-04-28. PMID:37116611. |
chrna5 gene variation affects the response of vta dopaminergic neurons during chronic nicotine exposure and withdrawal. |
2023-04-28 |
2023-08-14 |
mouse |
| Alina Lakosa, Anaïs Rahimian, Flavio Tomasi, Fabio Marti, Lauren M Reynolds, Léa Tochon, Vincent David, Anne Danckaert, Candice Canonne, Sylvana Tahraoui, Fabrice de Chaumont, Benoît Forget, Uwe Maskos, Morgane Besso. Impact of the gut microbiome on nicotine's motivational effects and glial cells in the ventral tegmental area in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-03-18. PMID:36932179. |
we further show that gut microbiota depletion enhances the response to nicotine of dopaminergic neurons of the posterior ventral tegmental area (pvta), and alters nicotine's rewarding and aversive effects in an intra-vta self-administration procedure. |
2023-03-18 |
2023-08-14 |
mouse |
| Angel Carvajal-Oliveros, Carmen Dominguez-Baleón, Iván Sánchez-Díaz, Diego Zambrano-Tipan, René Hernández-Vargas, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment. PloS one. vol 18. issue 3. 2023-03-01. PMID:36857384. |
parkinsonian phenotypes induced by synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment. |
2023-03-01 |
2023-08-14 |
human |
| Angel Carvajal-Oliveros, Carmen Dominguez-Baleón, Iván Sánchez-Díaz, Diego Zambrano-Tipan, René Hernández-Vargas, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment. PloS one. vol 18. issue 3. 2023-03-01. PMID:36857384. |
these results indicate that both the serotonergic and dopaminergic systems contribute to different aspects of pd symptomatology and that nicotine has beneficial effects on specific symptoms. |
2023-03-01 |
2023-08-14 |
human |