| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nii A Add. An ongoing saga of nicotine complexity and dopamine heterogeneity: Nicotine activation and inhibition mediating reward and anxiety. Neuron. vol 109. issue 16. 2021-08-25. PMID:34411537. |
their findings provide new understanding of the functional role of ventral tegmental area (vta) dopamine neurons and reveal topographically distinct, pathway-specific, and opposite dopaminergic responses to nicotine that likely mediate reward and anxiety, respectively. |
2021-08-25 |
2023-08-13 |
Not clear |
| Yuka Kasahara, Daiki Masukawa, Yoshie Nakamura, Koshi Murata, Tatsuo Hashimoto, Kohtaro Takizawa, Motokazu Koga, Fumio Nakamura, Yugo Fukazawa, Kengo Funakoshi, Yoshio Goshim. Distribution of mRNA for GPR143, a receptor of 3,4-L-dihydroxyphenylalanine, and of immunoreactivities for nicotinic acetylcholine receptors in the nigrostriatal and mesolimbic regions. Neuroscience research. vol 170. 2021-08-04. PMID:32896531. |
these findings suggest that dopa-gpr143 signaling may be involved in the nicotine action in the nigrostriatal and mesolimbic dopaminergic systems. |
2021-08-04 |
2023-08-13 |
Not clear |
| Bonn Lee, Seon Mi Park, SunHwa Jeong, KangMin Kim, Eui-Bae Jeun. Combined Exposure to Diazinon and Nicotine Exerts a Synergistic Adverse Effect In Vitro and Disrupts Brain Development and Behaviors In Vivo. International journal of molecular sciences. vol 22. issue 14. 2021-08-04. PMID:34299375. |
moreover, 0.18 mg/kg diazinon and 2 mg/kg nicotine co-exposure resulted in an increase in tyrosine hydroxylase (th)-positive dopaminergic neurons. |
2021-08-04 |
2023-08-13 |
mouse |
| Angela M Lee, Mohammad Shahid Mansuri, Rashaun S Wilson, TuKiet T Lam, Angus C Nairn, Marina R Picciott. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers in molecular neuroscience. vol 14. 2021-08-03. PMID:34335180. |
sub-chronic nicotine exposure in female mice increased proteins related to dopaminergic signaling in the nac shell but decreased them in the vta, whereas the opposite pattern was observed in male mice. |
2021-08-03 |
2023-08-13 |
mouse |
| Angela M Lee, Mohammad Shahid Mansuri, Rashaun S Wilson, TuKiet T Lam, Angus C Nairn, Marina R Picciott. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers in molecular neuroscience. vol 14. 2021-08-03. PMID:34335180. |
in contrast, dopaminergic signaling pathways were similarly upregulated in both male and female vta after chronic nicotine and withdrawal. |
2021-08-03 |
2023-08-13 |
mouse |
| Umair Ali Khan Saddozai, Fengling Wang, Muhammad Usman Akbar, Lu Zhang, Yang An, Wan Zhu, Longxiang Xie, Yongqiang Li, Xinying Ji, Xiangqian Gu. Identification of Clinical Relevant Molecular Subtypes of Pheochromocytoma. Frontiers in endocrinology. vol 12. 2021-07-27. PMID:34234737. |
genes enriched in subtype i pccs were involved in the dopaminergic synapse, nicotine addiction, and long-term depression pathways, while genes enriched in subtype ii pccs were involved in protein digestion and absorption, vascular smooth muscle contraction, and ecm receptor interaction pathways. |
2021-07-27 |
2023-08-13 |
Not clear |
| Roberto Ciccocioppo, Giordano de Guglielmo, Hongwu Li, Miriam Melis, Lucia Caffino, Quienwei Shen, Ana Domi, Fabio Fumagalli, Gregory A Demopulos, George A Gaitanari. Selective inhibition of phosphodiesterase 7 enzymes reduces motivation for nicotine use through modulation of mesolimbic dopaminergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021-07-15. PMID:34083258. |
selective inhibition of phosphodiesterase 7 enzymes reduces motivation for nicotine use through modulation of mesolimbic dopaminergic transmission. |
2021-07-15 |
2023-08-13 |
Not clear |
| Marcin Delijewski, Khaled Radad, Christopher Krewenka, Barbara Kranner, Rudolf Moldzi. The Reassessed Impact of Nicotine against Neurotoxicity in Mesencephalic Dopaminergic Cell Cultures and Neuroblastoma N18TG2 Cells. Planta medica. 2021-07-06. PMID:34229355. |
the reassessed impact of nicotine against neurotoxicity in mesencephalic dopaminergic cell cultures and neuroblastoma n18tg2 cells. |
2021-07-06 |
2023-08-13 |
Not clear |
| Marcin Delijewski, Khaled Radad, Christopher Krewenka, Barbara Kranner, Rudolf Moldzi. The Reassessed Impact of Nicotine against Neurotoxicity in Mesencephalic Dopaminergic Cell Cultures and Neuroblastoma N18TG2 Cells. Planta medica. 2021-07-06. PMID:34229355. |
in our present study, we used primary dopaminergic cell cultures and n18tg2 neuroblastoma cells to investigate the effect of nicotine and its neuroprotective potential against rotenone toxicity. |
2021-07-06 |
2023-08-13 |
Not clear |
| Marcin Delijewski, Khaled Radad, Christopher Krewenka, Barbara Kranner, Rudolf Moldzi. The Reassessed Impact of Nicotine against Neurotoxicity in Mesencephalic Dopaminergic Cell Cultures and Neuroblastoma N18TG2 Cells. Planta medica. 2021-07-06. PMID:34229355. |
nicotine protected dopaminergic (tyrosine hydroxylase immunoreactive) neurons against rotenone. |
2021-07-06 |
2023-08-13 |
Not clear |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. |
2021-06-24 |
2023-08-13 |
rat |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nicotine is transferred through milk and alters the dopaminergic reward system of adult male rats, reducing dopamine action in the nucleus accumbens (nac) and hypothalamic arcuate nucleus. |
2021-06-24 |
2023-08-13 |
rat |
| Sanaa A M Elgayar, Ola A Hussein, Heba A Mubarak, Amany M Ismaiel, Asmaa M S Goma. Nicotine impact on rat substantia nigra compacta. Anatomy & cell biology. vol 54. issue 1. 2021-04-09. PMID:33782217. |
nicotine administered subcutaneously in a small dose may have a deleterious effect on snc, mainly involving dopaminergic neurons and blood capillaries. |
2021-04-09 |
2023-08-13 |
rat |
| b' Sergej Nadalin, Veljko Flego, Sanja Devi\\xc4\\x87 Pavli\\xc4\\x87, Darian Volari\\xc4\\x87, An\\xc4\\x91elka Radoj\\xc4\\x8di\\xc4\\x87 Badovinac, Miljenko Kapovi\\xc4\\x87, Smiljana Risti\\xc4\\x8. Association between the ACE-I/D polymorphism and nicotine dependence amongst patients with lung cancer. Biomedical reports. vol 13. issue 6. 2021-01-10. PMID:33123372.' |
ras may be important in the etiology of nicotine dependence by influencing dopaminergic signaling. |
2021-01-10 |
2023-08-13 |
Not clear |
| Tina Kazemi, Shuyan Huang, Naze G Avci, Charlotte Mae K Waits, Yasemin M Akay, Metin Aka. Investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the VTA using miRNA-mRNA analysis. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32929144. |
investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the vta using mirna-mrna analysis. |
2020-12-08 |
2023-08-13 |
rat |
| Tina Kazemi, Shuyan Huang, Naze G Avci, Charlotte Mae K Waits, Yasemin M Akay, Metin Aka. Investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the VTA using miRNA-mRNA analysis. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32929144. |
using a well-established rat model for both nicotine and alcohol perinatal exposure, we investigated mirna and mrna expression of dopaminergic (da) neurons of the vta in rat pups following perinatal alcohol and joint nicotine-alcohol exposure. |
2020-12-08 |
2023-08-13 |
rat |
| Funda Akkus, Sylvia Terbeck, Connor J Haggarty, Valerie Treyer, Janan J Dietrich, Stefanie Hornschuh, Gregor Hasle. The role of the metabotropic glutamate receptor 5 in nicotine addiction. CNS spectrums. 2020-10-07. PMID:32713396. |
previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has provided strong evidence for the involvement of dopaminergic neuronal circuitry in nicotine addiction. |
2020-10-07 |
2023-08-13 |
human |
| Aditya N Bade, Howard E Gendelman, Michael D Boska, Yutong Li. MEMRI is a biomarker defining nicotine-specific neuronal responses in subregions of the rodent brain. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337287. |
nicotine dependence is defined by dopaminergic neuronal activation within the nucleus accumbens (acb) and by affected neural projections from nicotine-stimulated neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ozra Dehkordi, Jed E Rose, Richard M Millis, Maryam Mehdipour Dalivand, Shereé M Johnso. GABAergic Neurons as Putative Neurochemical Substrate Mediating Aversive Effects of Nicotine. Journal of alcoholism and drug dependence. vol 6. issue 2. 2020-10-01. PMID:30009210. |
double labeling of gad67-gfp positive cells with th ir cells showed that the gabaergic neurons that were activated by high-dose nicotine were located in close proximity to the dopaminergic neurons of substantia nigra compact part and vta. |
2020-10-01 |
2023-08-13 |
mouse |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. |
2020-10-01 |
2023-08-13 |
Not clear |