| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
nicotine prevents alpha-synuclein accumulation in mouse and human ipsc-derived dopaminergic neurons through activation of the dopamine d3- acetylcholine nicotinic receptor heteromer. |
2020-03-24 |
2023-08-13 |
mouse |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
we recently found that in mouse dopaminergic neurons, the heteromer formed by the dopamine d3 receptor (d3r) and the β2 subunit of acetylcholine nicotinic receptor (nachr) exerts neurotrophic effects when activated by nicotine, leading to neurons with enlarged cell bodies and increased dendrite arborization. |
2020-03-24 |
2023-08-13 |
mouse |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
beside this action, we now show that nicotine, by activating the d3r-nachr heteromer, protects dopaminergic neurons against neuronal injury. |
2020-03-24 |
2023-08-13 |
mouse |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
in primary cultures of mouse dopaminergic neurons, in fact, the ability of nicotine to inhibit both the pathological accumulation of alpha-synuclein induced by glucose deprivation and the consequent morphological defects were strongly prevented by disrupting the d3r-nachr heteromer with specific interfering tat-peptides; the relevance of the phosphoinositide 3-kinase (pi3k) intracellular signaling in mediating nicotine prevention of alpha-synuclein aggregation has been also demonstrated. |
2020-03-24 |
2023-08-13 |
mouse |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
in this human cell model, nicotine exerts neuroprotective effects specifically acting through the d3r-nachr complex thus indicating that this heteromer is a relevant molecular effector involved in the protection of human dopaminergic neurons. |
2020-03-24 |
2023-08-13 |
mouse |
| Chaoran Ma, Yesong Liu, Samantha Neumann, Xiang Ga. Nicotine from cigarette smoking and diet and Parkinson disease: a review. Translational neurodegeneration. vol 6. 2020-02-08. PMID:28680589. |
as a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against pd risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system. |
2020-02-08 |
2023-08-13 |
Not clear |
| Edward D Levin, Corinne Wells, Leah Yao, Wendi Guo, Anica Nangia, Sarah Howard, Erica Pippen, Andrew B Hawkey, Jed E Rose, Amir H Rezvan. Chronic memantine decreases nicotine self-administration in rats. European journal of pharmacology. vol 861. 2020-02-06. PMID:31421087. |
neurobehavioral bases of tobacco addiction and nicotine reinforcement are complex, involving more than only nicotinic cholinergic or dopaminergic systems. |
2020-02-06 |
2023-08-13 |
rat |
| Michelle Ren, Shahrdad Lotfipou. Nicotine Gateway Effects on Adolescent Substance Use. The western journal of emergency medicine. vol 20. issue 5. 2019-12-30. PMID:31539325. |
in this review, we emphasize that the effects of nicotine are highly dependent on timing of exposure, with a dynamic interaction of nachrs with dopaminergic, endocannabinoid, and opioidergic systems to enhance general drug reward and reinforcement. |
2019-12-30 |
2023-08-13 |
Not clear |
| Bruk Getachew, Antonei B Csoka, Michael Aschner, Yousef Tizab. Nicotine protects against manganese and iron-induced toxicity in SH-SY5Y cells: Implication for Parkinson's disease. Neurochemistry international. vol 124. 2019-12-24. PMID:30557592. |
nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopaminergic cells. |
2019-12-24 |
2023-08-13 |
Not clear |
| Carlo Matera, Federica Bono, Silvia Pelucchi, Ginetta Collo, Leonardo Bontempi, Cecilia Gotti, Michele Zoli, Marco De Amici, Cristina Missale, Chiara Fiorentini, Clelia Dallanoc. The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons. Biochemical pharmacology. vol 163. 2019-12-18. PMID:30772268. |
in this paper, we designed, synthesized and tested a small set of three new derivatives potentially targeting the d3r-nachr heteromer, a receptor complex recently identified and characterized as the molecular entity that, in dopaminergic neurons, mediates the neurotrophic effects of nicotine. |
2019-12-18 |
2023-08-13 |
mouse |
| Katja Baur, Arian Hach, Rick E Bernardi, Rainer Spanagel, Hilmar Bading, C Peter Bengtso. c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo. The Journal of comparative neurology. vol 526. issue 13. 2019-12-16. PMID:29888787. |
complex circuitry interconnecting dopaminergic and cholinergic regions of the midbrain and mesopontine tegmentum are critical for nicotine associated reward. |
2019-12-16 |
2023-08-13 |
mouse |
| Katja Baur, Arian Hach, Rick E Bernardi, Rainer Spanagel, Hilmar Bading, C Peter Bengtso. c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo. The Journal of comparative neurology. vol 526. issue 13. 2019-12-16. PMID:29888787. |
we performed double immunohistochemistry for the immediate early gene and surrogate activity sensor, c-fos, and markers for either cholinergic, dopaminergic or gabaergic cell types in mice treated with nicotine. |
2019-12-16 |
2023-08-13 |
mouse |
| Katja Baur, Arian Hach, Rick E Bernardi, Rainer Spanagel, Hilmar Bading, C Peter Bengtso. c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo. The Journal of comparative neurology. vol 526. issue 13. 2019-12-16. PMID:29888787. |
acute but not chronic nicotine also activated small percentages of dopaminergic and other neurons in the ventral tegmental area (vta) as well as noncholinergic neurons in the pedunculotegmental and laterodorsal tegmental nuclei (ptg/ldtg). |
2019-12-16 |
2023-08-13 |
mouse |
| Katja Baur, Arian Hach, Rick E Bernardi, Rainer Spanagel, Hilmar Bading, C Peter Bengtso. c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo. The Journal of comparative neurology. vol 526. issue 13. 2019-12-16. PMID:29888787. |
in comparison to nicotine, a single dose of cocaine caused a similar activation in the ptg/ldtg but not the vta where gabaergic cells were strongly activated but dopaminergic neurons were not affected. |
2019-12-16 |
2023-08-13 |
mouse |
| S.L. Peters, M.H. Josep. Haloperidol potentiation of latent inhibition in rats: evidence for a critical role at conditioning rather than pre-exposure. Behavioural pharmacology. vol 4. issue 2. 2019-11-20. PMID:11224185. |
this supports our earlier results with nicotine, pointing to conditioning as the critical time for the action of dopaminergic manipulations on li. |
2019-11-20 |
2023-08-12 |
rat |
| Marcus Munafò, Elaine Johnstone, Michael Murphy, Robert Walto. New directions in the genetic mechanisms underlying nicotine addiction. Addiction biology. vol 6. issue 2. 2019-11-20. PMID:11341850. |
studies of the personality correlates of smoking behaviour suggest that these factors mediate the association between genetics and smoking initiation, while learning models of nicotine addiction suggest a role for dopaminergic genes in facilitating neuroadaptations associated with smoking persistence and development of nicotine dependence. |
2019-11-20 |
2023-08-12 |
Not clear |
| M.J. Tsai, H.L. Wang, E.H.Y. Le. Interactive Effects of Nicotine and MPTP on Striatal Tetrahydrobiopterin in Mice. Journal of biomedical science. vol 3. issue 1. 2019-11-20. PMID:11725082. |
these results suggest that nicotine interacts with the dopaminergic system probably at the level of da biosynthesis through activating toh and its coenzyme tetrahydrobiopterin. |
2019-11-20 |
2023-08-12 |
mouse |
| Jed E Rose, Ozra Dehkordi, Kebreten F Manaye, Richard M Millis, Salman Ameri Cianaki, Annapurni Jayam-Trout. The Sensory Impact of Nicotine on Noradrenergic and Dopaminergic Neurons of the Nicotine Reward - Addiction Neurocircuitry. Journal of addiction research & therapy. vol 7. issue 2. 2019-11-20. PMID:27347434. |
the sensory impact of nicotine on noradrenergic and dopaminergic neurons of the nicotine reward - addiction neurocircuitry. |
2019-11-20 |
2023-08-13 |
mouse |
| Jed E Rose, Ozra Dehkordi, Kebreten F Manaye, Richard M Millis, Salman Ameri Cianaki, Annapurni Jayam-Trout. The Sensory Impact of Nicotine on Noradrenergic and Dopaminergic Neurons of the Nicotine Reward - Addiction Neurocircuitry. Journal of addiction research & therapy. vol 7. issue 2. 2019-11-20. PMID:27347434. |
sequential double-labelling was then performed to determine whether noradrenergic and dopaminergic neurons of the nicotine reward-addiction circuitry were primary targets of nic and nic-pm. |
2019-11-20 |
2023-08-13 |
mouse |
| Renee F Keller, Andrei Dragomir, Fan Yantao, Yasemin M Akay, Metin Aka. Investigating the genetic profile of dopaminergic neurons in the VTA in response to perinatal nicotine exposure using mRNA-miRNA analyses. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30213973. |
investigating the genetic profile of dopaminergic neurons in the vta in response to perinatal nicotine exposure using mrna-mirna analyses. |
2019-10-31 |
2023-08-13 |
rat |