| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ranjithkumar Chellian, Azin Behnood-Rod, Ryann Wilson, Karen Lin, Grace Wing-Yan King, Adriaan W Bruijnzee. The D1/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decrease operant responding for nicotine and food and locomotor activity in male and female rats. Journal of psychopharmacology (Oxford, England). 2023-01-21. PMID:36680471. |
dopamine plays a role in the reinforcing properties of nicotine, but little is known about the role of dopamine d2-like receptors in nicotine intake and whether there are sex differences in the effects of dopaminergic drugs on nicotine intake. |
2023-01-21 |
2023-08-14 |
rat |
| Ranjithkumar Chellian, Azin Behnood-Rod, Ryann Wilson, Karen Lin, Grace Wing-Yan King, Marcella Ruppert-Gomez, Alexandria Nicole Teter, Marcelo Febo, Adriaan W Bruijnzee. Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats. Scientific reports. vol 12. issue 1. 2022-08-19. PMID:35986048. |
however, there remains a need for a better understanding of the effects of dopamine d1-like receptor agonists on nicotine intake and the role of sex differences in the effects of dopaminergic drugs on behavior. |
2022-08-19 |
2023-08-14 |
rat |
| Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Higor A Iha, Yukihiro Ohn. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784764. |
since nicotine is known to enhance dopamine release by stimulating α4β2 and/or α6 nach receptors, we examined the effects of various dopamine receptor ligands on nicotine-induced tremor to clarify the role of the dopaminergic system in modulating nicotine tremor. |
2022-07-05 |
2023-08-14 |
Not clear |
| R Goldberg Lisa, J Gould Thoma. "Genetic influences impacting nicotine use and abuse during adolescence: insights from human and rodent studies". Brain research bulletin. 2022-06-23. PMID:35738503. |
human adolescent studies have largely included candidate gene studies for genes identified in adult populations, such as genes involved in nicotine metabolism, nicotinic acetylcholine receptor signaling, dopaminergic signaling, and other neurotransmitter signaling systems. |
2022-06-23 |
2023-08-14 |
human |
| Viktor A Stratilov, Oleg V Vetrovoy, Ekaterina I Tyulkov. Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. Molecular neurobiology. 2022-05-17. PMID:35581520. |
the increased rate of darpp-32 phosphorylation in adult psh rats might result from excessive glutamatergic stimulation of the dopaminergic (da) neurons of the ventral tegmental area (vta) caused by activation of presynaptic nachr by nicotine. |
2022-05-17 |
2023-08-13 |
rat |
| Nancy Y A Sey, Benxia Hu, Marina Iskhakova, Sool Lee, Huaigu Sun, Neda Shokrian, Gabriella Ben Hutta, Jesse A Marks, Bryan C Quach, Eric O Johnson, Dana B Hancock, Schahram Akbarian, Hyejung Wo. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular psychiatry. 2022-04-15. PMID:35422469. |
to investigate the functional impact of common variants associated with cigarette smoking and alcohol use traits, we applied hi-c coupled magma (h-magma) built upon cortical and newly generated midbrain dopaminergic neuronal hi-c datasets to gwas summary statistics of nicotine dependence, cigarettes per day, problematic alcohol use, and drinks per week. |
2022-04-15 |
2023-08-13 |
Not clear |
| Hui Xia, Yasemin M Akay, Metin Aka. Investigating miRNA-mRNA interactions and gene regulatory networks from VTA dopaminergic neurons following perinatal nicotine and alcohol exposure using Bayesian network analysis. IEEE journal of biomedical and health informatics. vol PP. 2022-03-15. PMID:35290190. |
investigating mirna-mrna interactions and gene regulatory networks from vta dopaminergic neurons following perinatal nicotine and alcohol exposure using bayesian network analysis. |
2022-03-15 |
2023-08-13 |
Not clear |
| Priscilla Giner, Liliana Maynez-Anchondo, Anna E Liley, Kevin P Uribe, Gabriel A Frietze, Nicholas W Simon, Ian A Mende. Increased Risky Choice and Reduced International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163155. |
the study also aims to investigate possible long-term effects of nicotine vapor exposure on the expression of genes coding for cholinergic and dopaminergic receptors in brain. |
2022-02-15 |
2023-08-13 |
rat |
| Sabrina Rahman Archie, Sejal Sharma, Elizabeth Burks, Thomas Abbruscat. Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: a pharmacokinetic and pharmacodynamic perspective. Neurotoxicology. 2022-02-12. PMID:35150755. |
accumulating evidence suggests that the detrimental effect of nicotine and tobacco smoke on the central nervous system (cns) is caused by the neurotoxic role of nicotine on blood-brain barrier (bbb) permeability, nicotinic acetylcholine receptor expression, and the dopaminergic system. |
2022-02-12 |
2023-08-13 |
Not clear |
| Veronica Mutti, Federica Bono, Zaira Tomasoni, Leonardo Bontempi, Adele Guglielmi, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentin. Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway. Molecular neurobiology. 2022-01-19. PMID:35044626. |
we have previously shown that the heteromer composed by the dopamine d3 receptor (d3r) and the nicotinic acetylcholine receptor (nachr) (d3r-nachr heteromer) is expressed in dopaminergic neurons, activated by nicotine and represents the molecular unit that, in these neurons, contributes to the modulation of critical events such as structural plasticity and neuroprotection. |
2022-01-19 |
2023-08-13 |
mouse |
| Veronica Mutti, Federica Bono, Zaira Tomasoni, Leonardo Bontempi, Adele Guglielmi, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentin. Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway. Molecular neurobiology. 2022-01-19. PMID:35044626. |
we now extended this study by investigating the d3r-nachr heteromer properties using various cell models such as transfected hek293 cells, primary cultures of mouse dopaminergic neurons and human dopaminergic neurons derived from induced pluripotent stem cells.we found that the d3r-nachr heteromer is the molecular effector that transduces the remodeling properties not only associated with nicotine but also with d3r agonist stimulation: neither nachr nor d3r, in fact, when express as monomers, are able to elicit these effects. |
2022-01-19 |
2023-08-13 |
mouse |
| S A M Elgayar, Ola A Hussein, Heba A Mubarak, Amany M Ismaiel, Asmaa M S Goma. Testing efficacy of the nicotine protection of the substantia nigra pars compacta in a rat Parkinson disease model. Ultrastructure study. Ultrastructural pathology. 2022-01-10. PMID:35001795. |
although nicotine ameliorated the loss of the dopaminergic neurons and motor deficit, it did not show improvement of vascular endothelium. |
2022-01-10 |
2023-08-13 |
rat |
| Joyal Xavier, Sanjiv Singh, Priyanka Kumari, V Ravichandira. Neurological Repercussions of Neonatal Nicotine Exposure: A Review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2021-12-16. PMID:34913189. |
prenatal nicotine intake during the second trimester affects the dopaminergic neurological system, making the fetal brain more susceptible to nicotine and developing adhd symptoms not just in a fetus, but in adolescents also. |
2021-12-16 |
2023-08-13 |
Not clear |
| Tina Kazemi, Shuyan Huang, Naze G Avci, Yasemin M Akay, Metin Aka. Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33888815. |
investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the vta. |
2021-11-12 |
2023-08-13 |
rat |
| Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V Zárate, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953275. |
in this work we evaluate nicotine's protective effect in a drosophila melanogaster model for pd where synphilin-1 (sph-1) is expressed in dopaminergic neurons. |
2021-10-22 |
2023-08-13 |
drosophila_melanogaster |
| Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V Zárate, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953275. |
nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express sph-1. |
2021-10-22 |
2023-08-13 |
drosophila_melanogaster |
| John A Dani, Daniel Jenson, John I Broussard, Mariella De Bias. Neurophysiology of Nicotine Addiction. Journal of addiction research & therapy. vol S1. issue 1. 2021-10-21. PMID:22454789. |
mesocorticolimbic circuitry that includes the dopaminergic pathway originating in the ventral tegmental area and projecting to the nucleus accumbens is recognized as vital for reinforcing behaviors during the initiation of nicotine addiction. |
2021-10-21 |
2023-08-12 |
Not clear |
| Miranda L Fisher, James R Pauly, Brett Froeliger, Jill R Turne. Translational Research in Nicotine Addiction. Cold Spring Harbor perspectives in medicine. vol 11. issue 6. 2021-09-29. PMID:32513669. |
likewise, translational studies investigating single-nucleotide polymorphisms (snps) within the cholinergic, dopaminergic, and opioid systems have found high levels of involvement of these neurotransmitter systems in regulating the reinforcing aspects of nicotine in both humans and mouse models. |
2021-09-29 |
2023-08-13 |
mouse |
| Michael Wolter, Thomas Lapointe, Brett Melanson, Nana Baidoo, Travis Francis, Boyer D Winters, Francesco Ler. Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists. Psychopharmacology. vol 238. issue 9. 2021-09-28. PMID:34175982. |
the present study assessed the effects of blocking noradrenergic and dopaminergic receptors on nicotine and cocaine unconditioned and conditioned memory modulation. |
2021-09-28 |
2023-08-13 |
rat |
| Ahmed El-Boraie, Rachel F Tyndal. The Role of Pharmacogenetics in Smoking. Clinical pharmacology and therapeutics. vol 110. issue 3. 2021-09-14. PMID:34165800. |
candidate gene studies of smoking phenotypes have identified several pharmacogenes implicated in nicotine's pharmacokinetics (cyp2a6, cyp2b6, cyp2a13, fmos, ugts, and oct2), and nicotine's pharmacodynamic response in the central nervous system (nicotinic acetylcholine receptors, as well as through the dopaminergic and serotonergic systems). |
2021-09-14 |
2023-08-13 |
Not clear |