| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon J Henderson, Teagan R Wall, Beverley M Henley, Charlene H Kim, Sheri McKinney, Henry A Leste. Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 12. 2018-06-04. PMID:28401925. |
dopaminergic (da) neurons in the ventral tegmental area (vta) mediate the positive reinforcing effects of nicotine. |
2018-06-04 |
2023-08-13 |
mouse |
| Linda Chang, Ahnate Lim, Eric Lau, Daniel Alicat. Chronic Tobacco-Smoking on Psychopathological Symptoms, Impulsivity and Cognitive Deficits in HIV-Infected Individuals. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 3. 2018-05-03. PMID:28303534. |
although greater impulsivity may be premorbid in hiv+ and smokers, the lack of benefits of nicotine in chronic smokers on attention and psychopathology, especially those with hiv-infection, may be due to the negative effects of chronic smoking on dopaminergic and cardio-neurovascular systems. |
2018-05-03 |
2023-08-13 |
human |
| Annabeth P Groenman, Corina U Greven, Marjolein M J van Donkelaar, Arnt Schellekens, Kimm J E van Hulzen, Nanda Rommelse, Catharina A Hartman, Pieter J Hoekstra, Marjolein Luman, Barbara Franke, Stephen V Faraone, Jaap Oosterlaan, Jan K Buitelaa. Dopamine and serotonin genetic risk scores predicting substance and nicotine use in attention deficit/hyperactivity disorder. Addiction biology. vol 21. issue 4. 2018-01-29. PMID:25752199. |
genetic risk scores were created for both serotonergic and dopaminergic risk genes previously shown to be associated with adhd and suds and/or nicotine dependence. |
2018-01-29 |
2023-08-13 |
human |
| Steven J Simmons, Taylor A Gentile, Lili Mo, Fionya H Tran, Sisi Ma, John W Muscham. Nicotinic receptor blockade decreases fos immunoreactivity within orexin/hypocretin-expressing neurons of nicotine-exposed rats. Behavioural brain research. vol 314. 2018-01-18. PMID:27491589. |
nicotine withdrawal is characterized by negative affective and cognitive symptoms that enhance relapse susceptibility, and suppressed dopaminergic transmission from ventral tegmental area (vta) to target structures underlies behavioral symptoms of nicotine withdrawal. |
2018-01-18 |
2023-08-13 |
rat |
| Melissa J Guildford, Anthony V Sacino, Andrew R Tappe. Modulation of ethanol reward sensitivity by nicotinic acetylcholine receptors containing the α6 subunit. Alcohol (Fayetteville, N.Y.). vol 57. 2018-01-03. PMID:27793544. |
nicotine, the addictive component of tobacco, activates nicotinic acetylcholine receptors (nachrs) containing the α6 subunit (α6* nachrs) in dopaminergic (daergic) neurons of the ventral tegmental area (vta), a region known to be crucial for drug reward. |
2018-01-03 |
2023-08-13 |
mouse |
| C D C Neves, A C R Lacerda, L P Lima, V K S Lage, C H Balthazar, H R Leite, V A Mendonç. Different levels of brain-derived neurotrophic factor and cortisol in healthy heavy smokers. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 12. 2017-11-17. PMID:29069228. |
studies suggest that brain-derived neurotrophic factor (bdnf) and the hypothalamic-pituitary-adrenal (hpa) axis modulate dopaminergic activity in response to nicotine and that the concentrations of bdnf and cortisol seem to be dependent on the amount and duration of smoking. |
2017-11-17 |
2023-08-13 |
Not clear |
| Sarah J Cross, Shahrdad Lotfipour, Frances M Lesli. Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. The American journal of drug and alcohol abuse. vol 43. issue 2. 2017-11-13. PMID:27532746. |
nicotine exposure during this time produces a unique and long-lasting vulnerability to subsequent substance use, likely via actions at cholinergic, dopaminergic, and serotonergic systems. |
2017-11-13 |
2023-08-13 |
Not clear |
| Josephine R Tarren, Selena E Bartlet. Alcohol and nicotine interactions: pre-clinical models of dependence. The American journal of drug and alcohol abuse. vol 43. issue 2. 2017-11-13. PMID:27740856. |
while it is agreed that multiple pathways orchestrate the complex reward profile of alcohol and nicotine co-addiction, several lines of evidence suggest the convergent site of action is within the mesolimbic dopaminergic system, at neuronal nicotinic acetylcholine receptors (nachrs). |
2017-11-13 |
2023-08-13 |
Not clear |
| Michelle G Baladi, Shannon M Nielsen, J Michael McIntosh, Glen R Hanson, Annette E Fleckenstei. Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26871405. |
prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. |
2017-11-08 |
2023-08-13 |
rat |
| Michelle G Baladi, Shannon M Nielsen, J Michael McIntosh, Glen R Hanson, Annette E Fleckenstei. Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26871405. |
preclinical studies have demonstrated that oral nicotine exposure attenuates long-term dopaminergic damage induced by toxins, including repeated, high doses of methamphetamine. |
2017-11-08 |
2023-08-13 |
rat |
| Michelle G Baladi, Shannon M Nielsen, J Michael McIntosh, Glen R Hanson, Annette E Fleckenstei. Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26871405. |
the current study extended these findings by investigating whether nicotine self-administration in male, sprague-dawley rats (a) attenuates short-term dopaminergic damage induced by methamphetamine and (b) causes alterations in levels of α4β2* and α6β2* nachr subtypes. |
2017-11-08 |
2023-08-13 |
rat |
| Oguz Gozen, Tanseli Nesil, Lutfiye Kanit, Ersin O Koylu, Sakire Pogu. Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. The American journal of drug and alcohol abuse. vol 42. issue 5. 2017-11-06. PMID:27428758. |
nicotinic cholinergic and dopaminergic receptor mrna expression in male and female rats with high or low preference for nicotine. |
2017-11-06 |
2023-08-13 |
rat |
| Lucia Carboni, Benedetto Romoli, Patrizia Romualdi, Michele Zol. Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway. Drug and alcohol dependence. vol 166. 2017-10-23. PMID:27430399. |
nicotine dependence is maintained by neurobiological adaptations in the dopaminergic brain reward pathway with the contribution of opioidergic circuits. |
2017-10-23 |
2023-08-13 |
Not clear |
| E van de Giessen, J J Weinstein, C M Cassidy, M Haney, Z Dong, R Ghazzaoui, N Ojeil, L S Kegeles, X Xu, N P Vadhan, N D Volkow, M Slifstein, A Abi-Dargha. Deficits in striatal dopamine release in cannabis dependence. Molecular psychiatry. vol 22. issue 1. 2017-09-29. PMID:27001613. |
to test whether cannabis dependence is associated with a similar dopaminergic deficit, we examined striatal and extrastriatal dopamine release in severely cannabis-dependent participants (cd), free of any comorbid conditions, including nicotine use. |
2017-09-29 |
2023-08-13 |
human |
| Yunpeng Zhang, Jing Guo, Aike Guo, Yan L. Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner. Neuroscience. vol 332. 2017-09-05. PMID:27365175. |
suppressing dopaminergic neurons or down-regulating dopamine 1-like receptor (dopr) abolishes this acute nicotine response, but surprisingly, does so only in male flies. |
2017-09-05 |
2023-08-13 |
mouse |
| Yunpeng Zhang, Jing Guo, Aike Guo, Yan L. Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner. Neuroscience. vol 332. 2017-09-05. PMID:27365175. |
furthermore, dopaminergic neurons are widely activated upon nicotine perfusion in both sexes, while the response curve differs significantly between the sexes. |
2017-09-05 |
2023-08-13 |
mouse |
| Yunpeng Zhang, Jing Guo, Aike Guo, Yan L. Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner. Neuroscience. vol 332. 2017-09-05. PMID:27365175. |
moreover, knockdown of the β1 nicotine acetylcholine receptor (nachr) in dopaminergic neurons abolishes the acute nicotine response only in male flies, while panneural knock-down occurs in both sexes. |
2017-09-05 |
2023-08-13 |
mouse |
| Yunpeng Zhang, Jing Guo, Aike Guo, Yan L. Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner. Neuroscience. vol 332. 2017-09-05. PMID:27365175. |
taken together, our results reveal that in fruit flies, dopaminergic neurons mediate nicotine-induced acute locomotor hyperactivity in a sexually dimorphic manner, and drosophila β1 nachr subunit plays a crucial role in this nicotine response. |
2017-09-05 |
2023-08-13 |
mouse |
| Gloria Pérez-Rubio, Alejandra Ramírez-Venegas, Valeri Noé Díaz, Leonor García Gómez, Karina Elvira Fabián, Salvador García Carmona, Luis A López-Flores, Enrique Ambrocio-Ortiz, Rocío Contreras Romero, Noé Alcantar-Ayala, Raúl H Sansores, Ramcés Falfán-Valenci. Polymorphisms in HTR2A and DRD4 Predispose to Smoking and Smoking Quantity. PloS one. vol 12. issue 1. 2017-08-21. PMID:28103253. |
genes encoding the receptors involved in the dopaminergic and serotonergic pathways are potential candidates in the mechanisms of nicotine addiction. |
2017-08-21 |
2023-08-13 |
Not clear |
| Lena Rademacher, Susanne Prinz, Oliver Winz, Karsten Henkel, Claudia A Dietrich, Jörn Schmaljohann, Siamak Mohammadkhani Shali, Ina Schabram, Christian Stoppe, Paul Cumming, Ralf-Dieter Hilgers, Yoshitaka Kumakura, Mark Coburn, Felix M Mottaghy, Gerhard Gründer, Ingo Vernaleke. Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers. Biological psychiatry. vol 80. issue 3. 2017-08-07. PMID:26803340. |
there is evidence of abnormal cerebral dopamine transmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due to acute nicotine abuse or whether they persist with abstinence. |
2017-08-07 |
2023-08-13 |
Not clear |