| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tresa M McGranahan, Natalie E Patzlaff, Sharon R Grady, Stephen F Heinemann, T K Booke. α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795541. |
α4-nachrs are necessary for the anxiolytic effects of nicotine in the elevated plus maze, and elimination of α4β2-nachrs specifically from dopaminergic neurons decreased sensitivity to the anxiolytic effects of nicotine. |
2011-10-07 |
2023-08-12 |
mouse |
| Kenneth Blum, Yijun Liu, Richard Shriner, Mark S Gol. Reward circuitry dopaminergic activation regulates food and drug craving behavior. Current pharmaceutical design. vol 17. issue 12. 2011-08-30. PMID:21492092. |
individuals possessing a paucity of serotonergic and/or dopaminergic receptors and an increased rate of synaptic dopamine catabolism, due to high catabolic genotype of the comt gene, are predisposed to self-medicating any substance or behavior that will activate dopamine release including alcohol, opiates, psychostimulants, nicotine, glucose, gambling, sex, and even excessive internet gaming, among others. |
2011-08-30 |
2023-08-12 |
human |
| Jun Hu, Chenlei Zhu, Yuan Liu, Fang Wang, Zuhu Huang, Weimin Fan, Jie W. Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model. Neuroscience letters. vol 494. issue 3. 2011-08-17. PMID:21406211. |
nicotine, a potent agonist of nicotinic acetylcholine receptors (nachrs), excites midbrain dopaminergic neurons and this may contribute to the anti-parkinsonian effects. |
2011-08-17 |
2023-08-12 |
mouse |
| Rubing Zhao-Shea, Liwang Liu, Lindsey G Soll, Ma Reina Improgo, Erin E Meyers, J Michael McIntosh, Sharon R Grady, Michael J Marks, Paul D Gardner, Andrew R Tappe. Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 5. 2011-07-13. PMID:21289604. |
nicotine activation of nicotinic acetylcholine receptors (nachrs) within the dopaminergic (daergic) neuron-rich ventral tegmental area (vta) is necessary and sufficient for nicotine reinforcement. |
2011-07-13 |
2023-08-12 |
mouse |
| Tanja Kivinummi, Kristiina Kaste, Tomi Rantamäki, Eero Castrén, Liisa Ahte. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21232579. |
alterations in bdnf and phospho-creb levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. |
2011-07-05 |
2023-08-12 |
mouse |
| Tanja Kivinummi, Kristiina Kaste, Tomi Rantamäki, Eero Castrén, Liisa Ahte. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21232579. |
neuronal changes induced by chronic nicotine in the brain dopaminergic circuits are thought to lead to compulsive nicotine use. |
2011-07-05 |
2023-08-12 |
mouse |
| Tanja Kivinummi, Kristiina Kaste, Tomi Rantamäki, Eero Castrén, Liisa Ahte. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21232579. |
here we studied the effects of chronic oral nicotine treatment and nicotine treatment cessation on two well-characterised markers of neuronal plasticity, brain-derived neurotrophic factor (bdnf) and phosphorylated camp-responsive element-binding protein (pcreb), in several dopaminergic brain areas. |
2011-07-05 |
2023-08-12 |
mouse |
| Tanja Kivinummi, Kristiina Kaste, Tomi Rantamäki, Eero Castrén, Liisa Ahte. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21232579. |
these findings suggest that nicotine abstinence promotes long-lasting neuroadaptations in dopaminergic neurocircuits by inducing bdnf production. |
2011-07-05 |
2023-08-12 |
mouse |
| Tanja Kivinummi, Kristiina Kaste, Tomi Rantamäki, Eero Castrén, Liisa Ahte. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21232579. |
these alterations could be compensatory and related to increased dopaminergic signalling during nicotine treatment. |
2011-07-05 |
2023-08-12 |
mouse |
| Teresa Franklin, Ze Wang, Jesse J Suh, Rebecca Hazan, Jeffrey Cruz, Yin Li, Marina Goldman, John A Detre, Charles P O'Brien, Anna Rose Childres. Effects of varenicline on smoking cue–triggered neural and craving responses. Archives of general psychiatry. vol 68. issue 5. 2011-06-30. PMID:21199958. |
it indirectly affects the dopaminergic reward system by reducing withdrawal symptoms during abstinence and by decreasing the reinforcement received from nicotine while smoking. |
2011-06-30 |
2023-08-12 |
Not clear |
| J A Ellis, C A Olsson, E Moore, P Greenwood, M O M Van De Ven, G C Patto. A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 13. issue 2. 2011-06-10. PMID:21127031. |
genetic variants that compromise dopaminergic neurotransmission may motivate exposure to dopamine-stimulating agents, including nicotine. |
2011-06-10 |
2023-08-12 |
Not clear |
| Gabriela Novak, Philip Seeman, Bernard Le Fol. Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity. The International journal of neuroscience. vol 120. issue 11. 2011-05-19. PMID:20942582. |
as nicotine acts through the same mesocortical dopaminergic signaling pathways as other stimulant drugs, which are known to increase the levels of d2(high), we hypothesized that nicotine exposure could produce an increase in d2(high) levels. |
2011-05-19 |
2023-08-12 |
rat |
| Marcelo O Ortells, Hugo R Aria. Neuronal networks of nicotine addiction. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20833261. |
the main effects of nicotine associated with smoking are nicotinic receptor activation, desensitization, and upregulation, with the subsequent modulation of the mesocorticolimbic dopaminergic system. |
2011-04-01 |
2023-08-12 |
Not clear |
| Alexandre Kuryatov, Jon Lindstro. Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Molecular pharmacology. vol 79. issue 1. 2011-01-13. PMID:20923852. |
α6β2β3* acetylcholine receptors (achrs) on dopaminergic neurons are important targets for drugs to treat nicotine addiction and parkinson's disease. |
2011-01-13 |
2023-08-12 |
human |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
through the nachrs in brain reward circuits, nicotine alters dopaminergic (da) neuronal function in the ventral tegmental area (vta) and increases dopamine release from vta to nuclear accumbens (na), which leads to nicotine reward, tolerance and dependence. |
2011-01-04 |
2023-08-12 |
Not clear |
| Kinga Burda, Anna Czubak, Elzbieta Nowakowska, Krzysztof Kus, Jana Metelska, Anna Nowakowsk. Interactions of nicotine and drugs used in the treatment of mental illnesses with respect to cognitive functions. Arzneimittel-Forschung. vol 60. issue 9. 2011-01-03. PMID:21117496. |
the effect of nicotine on other neurotransmission systems--the dopaminergic and glutaminergic systems--seems to be significant for their efficacious cognitive effects in combination with antipsychotic drugs. |
2011-01-03 |
2023-08-12 |
Not clear |
| Yu Liu, Yan-ping Bao, Hong-qiang Sun, Thomas J R Beveridge, Su-xia Li, Xiao-lan Di, Fu-de Yang, Lin L. Long-term treatment with aripiprazole on the waking and postprandial urges to smoke in Chinese heavy smokers. Journal of clinical psychopharmacology. vol 30. issue 4. 2010-11-03. PMID:20631555. |
the central dopaminergic system plays a critical role in the reinforcing effects of nicotine, which are key determinants in the urge to smoke. |
2010-11-03 |
2023-08-12 |
human |
| Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Ennio Esposito, Giuseppe Crescimanno, Giuseppe Di Giovann. Critical role of nitric oxide on nicotine-induced hyperactivation of dopaminergic nigrostriatal system: Electrophysiological and neurochemical evidence in rats. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20345972. |
substantial evidence indicates that the reinforcing properties of drugs of abuse, including nicotine, can be affected by the nitric oxide (no) system, which may act by modulating central dopaminergic function. |
2010-09-22 |
2023-08-12 |
rat |
| Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Ennio Esposito, Giuseppe Crescimanno, Giuseppe Di Giovann. Critical role of nitric oxide on nicotine-induced hyperactivation of dopaminergic nigrostriatal system: Electrophysiological and neurochemical evidence in rats. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20345972. |
these results further support the evidence of an important role played by no on modulation of dopaminergic function and drug addiction, thus revealing new pharmacological possibilities in the treatment of nicotine dependence and other da dysfunctions. |
2010-09-22 |
2023-08-12 |
rat |
| Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg, Bernard Le Fol. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357760. |
these findings suggest that stimulation of noradrenergic alpha(1) receptors is involved in nicotine self-administration and relapse, possibly via facilitation of nicotine-induced activation of the mesolimbic dopaminergic system. |
2010-09-17 |
2023-08-12 |
rat |