| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah E McCallum, Matthew A Cowe, Samuel W Lewis, Stanley D Glic. α3β4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo. Neuropharmacology. vol 63. issue 3. 2012-08-27. PMID:22561751. |
α3β4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo. |
2012-08-27 |
2023-08-12 |
rat |
| Eric W Klee, Henning Schneider, Karl J Clark, Margot A Cousin, Jon O Ebbert, W Michael Hooten, Victor M Karpyak, David O Warner, Stephen C Ekke. Zebrafish: a model for the study of addiction genetics. Human genetics. vol 131. issue 6. 2012-07-20. PMID:22207143. |
we present a review of major genes involved in serotonergic, dopaminergic, gabaergic, and adrenoreceptor signaling that are considered to be directly involved in nicotine, opioid, cannabinoid, and ethanol use and dependence. |
2012-07-20 |
2023-08-12 |
zebrafish |
| Ning Guo, Wei Yao, Shi-Rong Wang, Jun Zhu, Dong Huang, Pan-Li Zuo, Xin-Jiang Kang, Chong-Luo Fu, Zhuan Zhou, Bo Zhan. Nicotine dynamically modulates dopamine clearance in rat striatum in vivo. Neurochemistry international. vol 60. issue 4. 2012-07-05. PMID:22310173. |
nicotine binds to nicotinic acetylcholine receptors on dopaminergic terminals to evoke dopamine (da) release. |
2012-07-05 |
2023-08-12 |
rat |
| Liwang Liu, Rubing Zhao-Shea, J Michael McIntosh, Paul D Gardner, Andrew R Tappe. Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22222765. |
nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. |
2012-05-07 |
2023-08-12 |
mouse |
| Liwang Liu, Rubing Zhao-Shea, J Michael McIntosh, Paul D Gardner, Andrew R Tappe. Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22222765. |
nicotine is reinforcing because it activates dopaminergic (daergic) neurons within the ventral tegmental area (vta) of the brain's mesocorticolimbic reward circuitry. |
2012-05-07 |
2023-08-12 |
mouse |
| Taryn E Grieder, Olivier George, Huibing Tan, Susan R George, Bernard Le Foll, Steven R Laviolette, Derek van der Koo. Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 8. 2012-04-12. PMID:22308372. |
selective blockade of phasic da activity prevents the expression of conditioned place aversions to a single injection of nicotine in nondependent mice, but not to withdrawal from chronic nicotine in dependent mice, suggesting a shift from phasic to tonic dopaminergic mediation of the conditioned motivational response in nicotine dependent and withdrawn animals. |
2012-04-12 |
2023-08-12 |
mouse |
| Ting Chen, Die Zhang, Andrei Dragomir, Kunikazu Kobayashi, Yasemin Akay, Metin Aka. Investigating the influence of PFC transection and nicotine on dynamics of AMPA and NMDA receptors of VTA dopaminergic neurons. Journal of neuroengineering and rehabilitation. vol 8. 2012-04-05. PMID:22018308. |
investigating the influence of pfc transection and nicotine on dynamics of ampa and nmda receptors of vta dopaminergic neurons. |
2012-04-05 |
2023-08-12 |
Not clear |
| Yue Li, De-qin Yu, Yan Peng, Yan-hui Feng, Dong-mei Zhang, Jie Zhao, Wan-qin Zhang, Yi-ping Su. [The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 23. issue 4. 2012-03-29. PMID:21180124. |
to investigate the protective effect of nicotine on dopaminergic neurons and its mechanisms in mice with parkinson's disease (pd) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2012-03-29 |
2023-08-12 |
mouse |
| Fabio Marti, Ouafa Arib, Carole Morel, Virginie Dufresne, Uwe Maskos, Pierre-Jean Corringer, Renaud de Beaurepaire, Philippe Faur. Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 11. 2012-03-20. PMID:21716264. |
smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice. |
2012-03-20 |
2023-08-12 |
mouse |
| Fabio Marti, Ouafa Arib, Carole Morel, Virginie Dufresne, Uwe Maskos, Pierre-Jean Corringer, Renaud de Beaurepaire, Philippe Faur. Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 11. 2012-03-20. PMID:21716264. |
in the present study, the electrophysiological effects of tobacco and smoke on ventral tegmental area dopaminergic (da) neurons were examined in vivo in anesthetized wild-type (wt), β2-nicotinic acetylcholine receptor (nachr) knockout (β2-/-), α4-/-, and α6-/- mice and compared with those of nicotine alone. |
2012-03-20 |
2023-08-12 |
mouse |
| J Kleijn, J H A Folgering, M C G van der Hart, H Rollema, T I F H Cremers, B H C Westerin. Direct effect of nicotine on mesolimbic dopamine release in rat nucleus accumbens shell. Neuroscience letters. vol 493. issue 1-2. 2012-02-28. PMID:21352892. |
nicotine on cell firing rate of dopaminergic neurons in the vta was measured. |
2012-02-28 |
2023-08-12 |
rat |
| J Kleijn, J H A Folgering, M C G van der Hart, H Rollema, T I F H Cremers, B H C Westerin. Direct effect of nicotine on mesolimbic dopamine release in rat nucleus accumbens shell. Neuroscience letters. vol 493. issue 1-2. 2012-02-28. PMID:21352892. |
additionally, electrophysiological experiments showed that the dopaminergic firing rate in the vta showed a trend towards an increase after a nicotine dose of 0.1mg/kg i.v. |
2012-02-28 |
2023-08-12 |
rat |
| Stanley D Glick, Elizabeth M Sell, Sarah E McCallum, Isabelle M Maisonneuv. Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration. European journal of pharmacology. vol 669. issue 1-3. 2012-02-08. PMID:21871879. |
these data are consistent with the hypothesis that 18-mc decreases nicotine self-administration by indirectly modulating the dopaminergic mesolimbic pathway via blockade of α3β4 nicotinic receptors in the medial habenula, basolateral amygdala, and dorsolateral tegmentum. |
2012-02-08 |
2023-08-12 |
rat |
| Yu Jin, Kechun Yang, Hong Wang, Jie W. Exposure of nicotine to ventral tegmental area slices induces glutamatergic synaptic plasticity on dopamine neurons. Synapse (New York, N.Y.). vol 65. issue 4. 2011-12-20. PMID:20730803. |
nicotine promotes glutamatergic synaptic plasticity in dopaminergic (da) neurons in the ventral tegmental area (vta), which is thought to be an important mechanism underlying nicotine reward. |
2011-12-20 |
2023-08-12 |
mouse |
| Ronak Azizbeigi, Shamseddin Ahmadi, Vahab Babapour, Ameneh Rezayof, Mohammad Reza Zarrindas. Nicotine restores morphine-induced memory deficit through the D1 and D2 dopamine receptor mechanisms in the nucleus accumbens. Journal of psychopharmacology (Oxford, England). vol 25. issue 8. 2011-12-13. PMID:21616978. |
it can be concluded that the dopaminergic mechanism(s) in the nac is a crosslink for the effect of morphine and nicotine on reinstatement of retrieval of ia memory impaired by post-training administration of morphine. |
2011-12-13 |
2023-08-12 |
rat |
| Yu Ohmura, Emily M Jutkiewicz, Andrew Zhang, Edward F Domin. Dopamine D1/5 and D2/3 agonists differentially attenuate somatic signs of nicotine withdrawal in rats. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21624384. |
there is evidence that dysfunction of brain dopaminergic system might be responsible for some nicotine withdrawal symptoms. |
2011-12-09 |
2023-08-12 |
rat |
| Yu Ohmura, Emily M Jutkiewicz, Andrew Zhang, Edward F Domin. Dopamine D1/5 and D2/3 agonists differentially attenuate somatic signs of nicotine withdrawal in rats. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21624384. |
the hypothesis for the present study was that different dopaminergic agonists would relieve different nicotine withdrawal signs. |
2011-12-09 |
2023-08-12 |
rat |
| Maryka Quik, Xiomara A Perez, Sharon R Grad. Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21684266. |
these latter include the mesolimbic and nigrostriatal dopaminergic systems, which may account for the involvement of α6 containing nachrs in the rewarding properties of nicotine and in movement. |
2011-10-21 |
2023-08-12 |
Not clear |
| Tresa M McGranahan, Natalie E Patzlaff, Sharon R Grady, Stephen F Heinemann, T K Booke. α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795541. |
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. |
2011-10-07 |
2023-08-12 |
mouse |
| Tresa M McGranahan, Natalie E Patzlaff, Sharon R Grady, Stephen F Heinemann, T K Booke. α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795541. |
α4-nachrs specifically on dopaminergic neurons were demonstrated to be necessary for nicotine reward as measured by nicotine place preference, but not for another drug of addiction, cocaine. |
2011-10-07 |
2023-08-12 |
mouse |