| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Viviana Trezza, Petra J J Baarendse, Louk J M J Vanderschure. Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 12. 2010-01-12. PMID:19657330. |
social play behavior is rewarding, and it is modulated through opioid, cannabinoid and dopaminergic neurotransmission, which are also involved in the reinforcing properties of nicotine and ethanol. |
2010-01-12 |
2023-08-12 |
rat |
| M L Gregório, E C Wietzikoski, M M Ferro, J L M Silveira, M A B F Vital, C Da Cunh. Nicotine induces sensitization of turning behavior in 6-hydroxydopamine lesioned rats. Neurotoxicity research. vol 15. issue 4. 2010-01-11. PMID:19384569. |
in this study, we investigated whether nicotine can sensitize parkinsonian animals to the effect of dopaminergic drugs. |
2010-01-11 |
2023-08-12 |
rat |
| M L Gregório, E C Wietzikoski, M M Ferro, J L M Silveira, M A B F Vital, C Da Cunh. Nicotine induces sensitization of turning behavior in 6-hydroxydopamine lesioned rats. Neurotoxicity research. vol 15. issue 4. 2010-01-11. PMID:19384569. |
however, the expression of such sensitization seems to depend on the activation of dopaminergic receptors, since it was seen when the nicotine-sensitized animals were challenged with apomorphine, but not with a second nicotine challenge. |
2010-01-11 |
2023-08-12 |
rat |
| Cheng Xiao, Raad Nashmi, Sheri McKinney, Haijiang Cai, J Michael McIntosh, Henry A Leste. Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 40. 2009-11-10. PMID:19812319. |
these electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional alpha4beta2* nachrs in the nigrostriatal dopaminergic (da) pathway. |
2009-11-10 |
2023-08-12 |
mouse |
| N Naha, S P Li, B C Yang, T J Park, M O Ki. Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. Synapse (New York, N.Y.). vol 63. issue 10. 2009-10-26. PMID:19562699. |
taken together, the results for the first time suggests the execution of addictive behavior of nicotine through modulation of mesolimbic dopaminergic system targeting subcellular organelle of da d(1) and d(2) rs in the cpu of adult rat brain that may lead to novel therapeutic approaches related to nicotine's neuropsychological disorders including drug addiction. |
2009-10-26 |
2023-08-12 |
rat |
| Marieke Quaak, Constant P van Schayck, Ad M Knaapen, Frederik J van Schoote. Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. Mutation research. vol 667. issue 1-2. 2009-09-25. PMID:19028511. |
furthermore, smokers with reduced dopaminergic and nicotinic receptor activity variants may experience greater benefit from nicotine spray, while smokers with increased activity variants in the opioid receptor may have greater success with transdermal patches. |
2009-09-25 |
2023-08-12 |
Not clear |
| Stéphanie Caillé, Karine Guillem, Martine Cador, Olivier Manzoni, François George. Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 33. 2009-09-11. PMID:19692616. |
voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons. |
2009-09-11 |
2023-08-12 |
rat |
| Isabel R Schlaepfer, Nicole R Hoft, Marissa A Ehringe. The genetic components of alcohol and nicotine co-addiction: from genes to behavior. Current drug abuse reviews. vol 1. issue 2. 2009-08-28. PMID:19492010. |
converging evidence suggests that the dopaminergic system is likely to be important in mediating the pleasurable feelings of reward when activated by nicotine and/or alcohol consumption. |
2009-08-28 |
2023-08-12 |
mouse |
| Isabel R Schlaepfer, Nicole R Hoft, Marissa A Ehringe. The genetic components of alcohol and nicotine co-addiction: from genes to behavior. Current drug abuse reviews. vol 1. issue 2. 2009-08-28. PMID:19492010. |
the nachrs are important components of the dopaminergic reward system because some of the receptors have been shown to activate the release of dopamine, and mice lacking genes for specific nachr gene subunits show altered behavioral responses to nicotine and alcohol. |
2009-08-28 |
2023-08-12 |
mouse |
| M Quaak, C P van Schayck, A M Knaapen, F J van Schoote. Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? The European respiratory journal. vol 33. issue 3. 2009-08-25. PMID:19251795. |
recently, it has been shown that genetic variants in the dopaminergic system, opioid receptors, the bupropion-metabolising enzyme cyp2b6 and the nicotine-metabolising enzyme cyp2a6 may play an important role in predicting smoking cessation responses to nicotine replacement therapy and bupropion treatment. |
2009-08-25 |
2023-08-12 |
Not clear |
| Donnie Eddins, Ann Petro, Paul Williams, Daniel T Cerutti, Edward D Levi. Nicotine effects on learning in zebrafish: the role of dopaminergic systems. Psychopharmacology. vol 202. issue 1-3. 2009-08-05. PMID:18716760. |
nicotine effects on learning in zebrafish: the role of dopaminergic systems. |
2009-08-05 |
2023-08-12 |
mouse |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
nicotine binds to alpha4beta2 and alpha7 nicotinic acetylcholine receptors (nachrs) located on dopaminergic, glutamatergic and gabaergic neurons in the mesolimbic dopamine (da) system, which causes an increase in extracellular da in the nucleus accumbens (nac). |
2009-07-31 |
2023-08-12 |
Not clear |
| Michael Graupner, Boris Gutki. Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498415. |
the first is a large-scale model of nicotine-dependent modulation of dopaminergic signaling that is capable of simulating nicotine self-administration. |
2009-07-31 |
2023-08-12 |
Not clear |
| Michael Graupner, Boris Gutki. Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498415. |
in particular, we show how the model can shed light on the specific mechanisms by which nicotine controls dopaminergic neurotransmission in the vta. |
2009-07-31 |
2023-08-12 |
Not clear |
| Cheng Xiao, Ke-chun Yang, Chun-yi Zhou, Guo-zhang Jin, Jie Wu, Jiang-hong Y. Nicotine modulates GABAergic transmission to dopaminergic neurons in substantia nigra pars compacta. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498424. |
nicotine modulates gabaergic transmission to dopaminergic neurons in substantia nigra pars compacta. |
2009-07-31 |
2023-08-12 |
Not clear |
| Cheng Xiao, Ke-chun Yang, Chun-yi Zhou, Guo-zhang Jin, Jie Wu, Jiang-hong Y. Nicotine modulates GABAergic transmission to dopaminergic neurons in substantia nigra pars compacta. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498424. |
although it is clear that nicotine modulates snc dopaminergic neurons by activating subtypes of somatodendritic nicotinic acetylcholine receptors (nachrs), the detailed mechanisms of this activation remain to be addressed. |
2009-07-31 |
2023-08-12 |
Not clear |
| Y S Mineur, D H Brunzell, S R Grady, J M Lindstrom, J M McIntosh, M J Marks, S L King, M R Picciott. Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19077117. |
high-affinity, beta2-subunit-containing (beta2*) nicotinic acetylcholine receptors (nachrs) are essential for nicotine reinforcement; however, these nachrs are found on both gamma-aminobutyric acid (gaba) and dopaminergic (da) neurons in the ventral tegmental area (vta) and also on terminals of glutamatergic and cholinergic neurons projecting from the pedunculopontine tegmental area and the laterodorsal tegmental nucleus. |
2009-07-14 |
2023-08-12 |
mouse |
| Xun Tang, Song Guo, Hongqiang Sun, Xuemei Song, Zuonin Jiang, Lixiang Sheng, Dongfeng Zhou, Yonghua Hu, Dafang Che. Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. Pharmacogenetics and genomics. vol 19. issue 5. 2009-06-17. PMID:19415821. |
nicotine is the major psychoactive ingredient in tobacco, and is responsible for dependence through the nicotine-stimulated reward pathway mediated by the central dopaminergic system. |
2009-06-17 |
2023-08-12 |
Not clear |
| Luping Z Huang, Neeraja Parameswaran, Tanuja Bordia, J Michael McIntosh, Maryka Qui. Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19250334. |
nicotine reduces dopaminergic deficits in parkinsonian animals when administered before nigrostriatal damage. |
2009-06-09 |
2023-08-12 |
rat |
| Takashi Yanagida, Hiroki Takeuchi, Yoshihisa Kitamura, Kazuyuki Takata, Hideaki Minamino, Tomonori Shibaike, Jun Tsushima, Koji Kishimoto, Hiroyuki Yasui, Takashi Taniguchi, Shun Shimoham. Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model. Neuroscience research. vol 62. issue 4. 2009-04-14. PMID:18845194. |
however, the effects of galantamine and nicotine on dopaminergic neurons remain unclear. |
2009-04-14 |
2023-08-12 |
rat |