| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
upstream of the dopaminergic neurons nicotine induces long-term potentiation of the excitatory input to dopamine cells in the ventral tegmental area, and depresses inhibitory inputs. |
2004-07-22 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
both effects of nicotine were shown to last much longer than the nicotine exposure and together will activate the dopaminergic ventral tegmental area projection toward the nucleus accumbens. |
2004-07-22 |
2023-08-12 |
Not clear |
| Christoph Czermak, Michael Lehofer, Elke M Wagner, Barbara Prietl, Gregor Gorkiewicz, Leonidas Lemonis, Alfred Rohrhofer, Thomas Legl, Konrad Schauenstein, Peter M Liebman. Reduced dopamine D3 receptor expression in blood lymphocytes of smokers is negatively correlated with daily number of smoked cigarettes: a peripheral correlate of dopaminergic alterations in smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 6. issue 1. 2004-07-01. PMID:14982687. |
the mesolimbic dopaminergic system is known to mediate rewarding effects of nicotine administration, and dysfunctions of this system may underlie failure to stop cigarette smoking. |
2004-07-01 |
2023-08-12 |
human |
| Douglas P Dohrman And, Cindy K Reite. Chronic ethanol reduces nicotine-induced dopamine release in PC12 cells. Alcoholism, clinical and experimental research. vol 27. issue 11. 2004-06-29. PMID:14634503. |
one important aspect of nicotine addiction appears to be the activation of nicotinic acetylcholine receptors on dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. |
2004-06-29 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578581. |
nicotine directly acts on postsynaptic alpha4beta2 type nicotinic receptors and induces inward currents, resulting in excitation of dopaminergic neurons in the substantia nigra and subsequent enhancement of dopamine release in the corpus striatum. |
2004-06-18 |
2023-08-12 |
rat |
| Michael C Lewis, Thomas J Goul. Nicotine and ethanol enhancements of acoustic startle reflex are mediated in part by dopamine in C57BL/6J mice. Pharmacology, biochemistry, and behavior. vol 76. issue 1. 2004-05-10. PMID:13679231. |
thus, ethanol or nicotine may enhance the acoustic startle reflex through a common dopaminergic mechanism. |
2004-05-10 |
2023-08-12 |
mouse |
| Volodymyr I Pidoplichko, Jun Noguchi, Oluwasanmi O Areola, Yong Liang, Jayms Peterson, Tianxiang Zhang, John A Dan. Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction. Learning & memory (Cold Spring Harbor, N.Y.). vol 11. issue 1. 2004-04-30. PMID:14747518. |
a component of nicotine's addictive power is attributable to actions on the mesolimbic dopaminergic system, which serves a fundamental role in the acquisition of behaviors that are inappropriately reinforced by addictive drugs. |
2004-04-30 |
2023-08-12 |
Not clear |
| Halina Sienkiewicz-Jarosz, Agnieszka I Członkowska, Małgorzata Lehner, Piotr Maciejak, Marek Siemiatkowski, Janusz Szyndler, Aleksandra Wisłowska, Małgorzata Zienowicz, Andrzej Bidziński, Wojciech Kostowski, Adam Płaźni. Lack of changes in cortical [3H]-muscimol binding in rats sensitized to nicotine-induced enhancement of dopamine metabolism. Polish journal of pharmacology. vol 55. issue 2. 2004-04-07. PMID:12926543. |
it was proposed that chronic nicotine treatment may induce adaptive changes in gabaa receptors, thus leading to the attenuation of a gabaergic inhibition of dopaminergic neurons. |
2004-04-07 |
2023-08-12 |
rat |
| J M Witkin, D Dijkstra, B Levant, H C Akunne, A Zapata, S Peters, H E Shannon, M Gasio. Protection against cocaine toxicity in mice by the dopamine D3/D2 agonist R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907]. The Journal of pharmacology and experimental therapeutics. vol 308. issue 3. 2004-04-06. PMID:14711932. |
the possible selectivity of the effects of (+)-pd 128,907 (3 mg/kg) for these dopaminergic compounds was demonstrated by its general lack of protective efficacy against a host of convulsants acting through other neural mechanisms [pentylenetetrazol, (+)-bicuculline, and picrotoxin, 4-aminopyridine, and t-butylbiclyclophosphoorothionate, n-methyl-d-aspartate, kainate, pilocarpine, nicotine, strychnine, aminophylline, threshold electric shock, and 6-hz electrical stimulation]. |
2004-04-06 |
2023-08-12 |
mouse |
| Diana Amantea, Michela Tessari, Norman G Bower. Reduced G-protein coupling to the GABAB receptor in the nucleus accumbens and the medial prefrontal cortex of the rat after chronic treatment with nicotine. Neuroscience letters. vol 355. issue 3. 2004-03-17. PMID:14732456. |
reduced g-protein coupling to the gabab receptor may result in disinhibition of mesocorticolimbic dopaminergic neurones, which would contribute to the development of sensitised dopaminergic responses to repeated administration of nicotine. |
2004-03-17 |
2023-08-12 |
rat |
| Yasser Khazaal, Sonia Krenz, Daniele Fabio Zullin. Bupropion-induced somnambulism. Addiction biology. vol 8. issue 3. 2004-01-29. PMID:13129839. |
as, on one hand,bupropion is a noradrenergic and dopaminergic drug and nicotine withdrawal, on the other hand, is associated with alterations in monoaminergic functions, an interaction at the level of these neurotransmitters is suggested as the underlying mechanism. |
2004-01-29 |
2023-08-12 |
Not clear |
| Ravi Kumar Kurup, Parameswara Achutha Kuru. A hypothalamic digoxin-mediated model for autism. The International journal of neuroscience. vol 113. issue 11. 2004-01-28. PMID:14585753. |
increased nicotine levels can produce increased dopaminergic transmission in the presence of low dopamine levels. |
2004-01-28 |
2023-08-12 |
Not clear |
| M Reuter, J Henni. Cortisol as an indicator of dopaminergic effects on nicotine craving. Human psychopharmacology. vol 18. issue 6. 2004-01-22. PMID:12923821. |
cortisol as an indicator of dopaminergic effects on nicotine craving. |
2004-01-22 |
2023-08-12 |
human |
| Karine Parain, Céline Hapdey, Estelle Rousselet, Véronique Marchand, Bernard Dumery, Etienne C Hirsc. Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin. Brain research. vol 984. issue 1-2. 2003-12-10. PMID:12932857. |
cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine parkinsonian toxin. |
2003-12-10 |
2023-08-12 |
mouse |
| Karine Parain, Céline Hapdey, Estelle Rousselet, Véronique Marchand, Bernard Dumery, Etienne C Hirsc. Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin. Brain research. vol 984. issue 1-2. 2003-12-10. PMID:12932857. |
the loss of dopaminergic neurons induced by mptp in the substantia nigra was significantly less severe in the chronic nicotine treatment groups (at 0.2 and 2 mg/kg) and the low exposure to cigarette smoke group than in the high exposure to cigarette smoke subgroup and the placebo treated subgroup. |
2003-12-10 |
2023-08-12 |
mouse |
| Karine Parain, Céline Hapdey, Estelle Rousselet, Véronique Marchand, Bernard Dumery, Etienne C Hirsc. Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin. Brain research. vol 984. issue 1-2. 2003-12-10. PMID:12932857. |
this suggests that nicotine and low exposure to cigarette smoke may have a neuroprotective effect on the dopaminergic nigrostriatal system by an as yet unknown mechanism. |
2003-12-10 |
2023-08-12 |
mouse |
| Yael Abreu-Villaça, Frederic J Seidler, Theodore A Slotki. Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. Brain research. vol 988. issue 1-2. 2003-12-10. PMID:14519538. |
ac responses to dopaminergic and noradrenergic stimulants were also enhanced by nicotine exposure. |
2003-12-10 |
2023-08-12 |
rat |
| Kalervo Kiianmaa, Petri Hyytiä, Herman H Samson, Jörgen A Engel, Lennart Svensson, Bo Söderpalm, Anna Larsson, Giancarlo Colombo, Giovanni Vacca, Deborah A Finn, Ryan K Bachtell, Andrey E Ryabini. New neuronal networks involved in ethanol reinforcement. Alcoholism, clinical and experimental research. vol 27. issue 2. 2003-12-02. PMID:12605070. |
the presentations were (1) the role of opioidergic and dopaminergic networks in ethanol-seeking behavior, by kalervo kiianmaa and petri hyytiä; (2) interaction between the dopamine systems in the prefrontal cortex and nucleus accumbens during ethanol self-administration, by herman h. samson; (3) neurochemical and behavioral studies on ethanol and nicotine interactions, by jörgen a. engel, lennart svensson, bo söderpalm, and anna larsson; (4) involvement of the gaba receptor in alcohol reinforcement in sp rats, by giancarlo colombo and giovanni vacca; (5) neuroactive steroids and ethanol reinforcement, by deborah a. finn, and (6) potential contribution of the urocortin system to regulation of alcohol self-administration, by andrey e. ryabinin and ryan k. |
2003-12-02 |
2023-08-12 |
rat |
| Rajeev I Desai, David J Barber, Philip Terr. Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats. Psychopharmacology. vol 167. issue 4. 2003-09-26. PMID:12684733. |
dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats. |
2003-09-26 |
2023-08-12 |
rat |
| Paul Fredrickson, Mona Boules, Sally Yerbury, Elliott Richelso. Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization. Brain research. vol 979. issue 1-2. 2003-09-25. PMID:12850594. |
neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. |
2003-09-25 |
2023-08-12 |
Not clear |