| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Parain, V Marchand, B Dumery, E Hirsc. Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice. Brain research. vol 890. issue 2. 2001-06-07. PMID:11164803. |
nicotine, but not cotinine, partially protects dopaminergic neurons against mptp-induced degeneration in mice. |
2001-06-07 |
2023-08-12 |
mouse |
| K Parain, V Marchand, B Dumery, E Hirsc. Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice. Brain research. vol 890. issue 2. 2001-06-07. PMID:11164803. |
administration of cotinine did not affect mptp toxicity in the nigrostriatal system but chronic nicotine treatment showed a slight protection (15%) of nigrostriatal dopaminergic neurons against mptp. |
2001-06-07 |
2023-08-12 |
mouse |
| T P George, M R Picciotto, C D Verrico, R H Rot. Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects. Biological psychiatry. vol 49. issue 3. 2001-06-07. PMID:11230881. |
effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects. |
2001-06-07 |
2023-08-12 |
rat |
| T P George, M R Picciotto, C D Verrico, R H Rot. Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects. Biological psychiatry. vol 49. issue 3. 2001-06-07. PMID:11230881. |
we have examined the effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in the rat. |
2001-06-07 |
2023-08-12 |
rat |
| J B Becker, C N Rudick, W J Jenkin. The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312308. |
dopamine in dialysate from the nucleus accumbens (nacc) increases during sexual and feeding behavior and after administration of drugs of abuse, even those that do not directly activate dopaminergic systems (e.g., morphine or nicotine). |
2001-06-07 |
2023-08-12 |
rat |
| M Fà, G Carcangiu, N Passino, V Ghiglieri, G L Gessa, G Mere. Cigarette smoke inhalation stimulates dopaminergic neurons in rats. Neuroreport. vol 11. issue 16. 2001-05-31. PMID:11095534. |
the aim of the present study was to clarify whether tobacco smoke inhalation would affect dopaminergic projections differently from the reported activation after the systemic administration of nicotine. |
2001-05-31 |
2023-08-12 |
rat |
| R Walton, E Johnstone, M Munafò, M Neville, S Griffith. Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy. Trends in molecular medicine. vol 7. issue 2. 2001-05-31. PMID:11286758. |
genetically determined variations in dopaminergic neurotransmission predispose to nicotine dependence. |
2001-05-31 |
2023-08-12 |
Not clear |
| J A Trauth, F J Seidler, S F Ali, T A Slotki. Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. Brain research. vol 892. issue 2. 2001-05-17. PMID:11172774. |
adolescent nicotine exposure produces immediate and long-term changes in cns noradrenergic and dopaminergic function. |
2001-05-17 |
2023-08-12 |
rat |
| T Seppä, L Ahte. Comparison of the effects of epibatidine and nicotine on the output of dopamine in the dorsal and ventral striatum of freely-moving rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 4-5. 2001-03-29. PMID:11111841. |
comparison of the effects of epibatidine and nicotine suggests that the responses of the mesolimbic and nigrostriatal dopaminergic systems to the two nicotinic receptor agonists differ. |
2001-03-29 |
2023-08-12 |
rat |
| T Seppä, L Ahte. Comparison of the effects of epibatidine and nicotine on the output of dopamine in the dorsal and ventral striatum of freely-moving rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 4-5. 2001-03-29. PMID:11111841. |
epibatidine, in contrast to nicotine, preferentially stimulates the nigrostriatal vs. the mesolimbic dopaminergic system. |
2001-03-29 |
2023-08-12 |
rat |
| Y Fu, S G Matta, W Gao, B M Shar. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074160. |
in conclusion, the present study demonstrates that different types of nicotinic cholinergic receptors, located in the ventral striatal nucleus accumbens (alpha-bungarotoxin sensitive and mecamylamine insensitive) and the midbrain ventral tegmental area (mecamylamine sensitive), may be required for the full effects of nicotine on the mesostriatal dopaminergic pathway. |
2001-02-01 |
2023-08-12 |
Not clear |
| E F McKinney, R T Walton, P Yudkin, A Fuller, N A Haldar, D Mant, M Murphy, K I Welsh, S E Marshal. Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers. Pharmacogenetics. vol 10. issue 6. 2001-01-25. PMID:10975602. |
central dopaminergic reward pathways give rise to dependence and are activated by nicotine. |
2001-01-25 |
2023-08-12 |
Not clear |
| G G Nomikos, B Schilström, B E Hildebrand, G Panagis, J Grenhoff, T H Svensso. Role of alpha7 nicotinic receptors in nicotine dependence and implications for psychiatric illness. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942036. |
based on the data reviewed in the present study, it is suggested that nicotine by stimulating presynaptic alpha7 nicotinic receptors within the vta, that are probably localized on glutamatergic afferents from the medial prefrontal cortex, produces sequentially an increase in glutamate concentrations, stimulation of nmda receptors found on dopamine (da)-containing neurons in the vta, enhanced firing activity of vta-da neurons, augmented da release in the nerve terminal regions, and enhanced c-fos expression in the dopaminergic projection areas through activation of d1-da receptors. |
2001-01-03 |
2023-08-12 |
Not clear |
| G G Nomikos, B Schilström, B E Hildebrand, G Panagis, J Grenhoff, T H Svensso. Role of alpha7 nicotinic receptors in nicotine dependence and implications for psychiatric illness. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942036. |
these data may be instrumental in understanding how nicotine interacts with the mesolimbocortical dopaminergic system, which is perhaps the most important component of the neural mechanisms underlying nicotine dependence. |
2001-01-03 |
2023-08-12 |
Not clear |
| M R Gerasimov, M Franceschi, N D Volkow, O Rice, W K Schiffer, S L Dewe. Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044890. |
in contrast, nicotine stimulates acetylcholine receptors located presynaptically on dopaminergic projections from the ventral tegmental area (vta) to the nac and increases da transmission. |
2000-12-14 |
2023-08-12 |
Not clear |
| S S Watkins, G F Koob, A Marko. Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 2. issue 1. 2000-11-30. PMID:11072438. |
finally, a theoretical model of the neurobiological mechanisms underlying acute nicotine withdrawal and protracted abstinence involves alterations within dopaminergic, serotonergic, and stress systems that are hypothesized to contribute to the negative affective state associated with nicotine abstinence. |
2000-11-30 |
2023-08-12 |
Not clear |
| M R Zarrindast, G Mohaddess, M Rezvani-Pou. Effect of nicotine on sniffing induced by dopaminergic receptor stimulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 5. 2000-10-30. PMID:10974612. |
effect of nicotine on sniffing induced by dopaminergic receptor stimulation. |
2000-10-30 |
2023-08-12 |
rat |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
the objective of this study was to determine whether nicotine could selectively influence dopamine levels in the prefrontal cortex as compared with other dopaminergic areas of brain. |
2000-09-28 |
2023-08-12 |
rat |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
since low dopaminergic activity in prefrontal cortex is correlated with cognitive deficits in schizophrenia, our findings may help explain why these deficits are improved in schizophrenics by smoking or nicotine administration. |
2000-09-28 |
2023-08-12 |
rat |
| H D Mansvelder, D S McGehe. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. vol 27. issue 2. 2000-09-26. PMID:10985354. |
nicotine reinforces smoking behavior by activating nicotinic acetylcholine receptors (nachrs) in the midbrain dopaminergic (da) reward centers, including the ventral tegmental area (vta). |
2000-09-26 |
2023-08-12 |
Not clear |