| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Yu, H Matsubayashi, T Amano, J Cai, M Sas. Activation by nicotine of striatal neurons receiving excitatory input from the substantia nigra via dopamine release. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924698. |
these findings suggested that nicotine enhances dopamine release from the sn-derived dopaminergic nerve terminals by activating the neurons via d2 receptors. |
2000-09-20 |
2023-08-12 |
rat |
| H Tsuneki, R Klink, C Léna, H Korn, J P Changeu. Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947823. |
these results demonstrate that in nigral dopaminergic neurons, nicotine can elicit ca2+ mobilization via activation of two distinct nachr subtypes: that of beta2-subunit-containing nachr followed by activation of na+ channel and t-type ca2+ channels, and/or activation of alpha7-subunit-containing nachr. |
2000-09-19 |
2023-08-12 |
mouse |
| H Tsuneki, R Klink, C Léna, H Korn, J P Changeu. Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947823. |
this ca2+ mobilization may possibly contribute to the long-term effects of nicotine on the dopaminergic system. |
2000-09-19 |
2023-08-12 |
mouse |
| G Kameda, M Dadmarz, W H Voge. Influence of various drugs on the voluntary intake of nicotine by rats. Neuropsychobiology. vol 41. issue 4. 2000-09-06. PMID:10828730. |
the effects of the dopaminergic agonists (l-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of the animals. |
2000-09-06 |
2023-08-12 |
rat |
| G Kameda, M Dadmarz, W H Voge. Influence of various drugs on the voluntary intake of nicotine by rats. Neuropsychobiology. vol 41. issue 4. 2000-09-06. PMID:10828730. |
these results indicate that blockade of nicotinic and dopaminergic d4 receptors partially reduce the desired effect of nicotine by forcing the animals to consume more of this substance. |
2000-09-06 |
2023-08-12 |
rat |
| M Quik, G Jeyarasasinga. Nicotinic receptors and Parkinson's disease. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771017. |
as an approach to evaluate neuroprotective effects of nicotine against nigral neuron damage, we used mesencephalic neurons in culture, treated with a selective dopaminergic neurotoxin. |
2000-08-11 |
2023-08-12 |
monkey |
| M Quik, G Jeyarasasinga. Nicotinic receptors and Parkinson's disease. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771017. |
the results show that nicotine pretreatment protected against dopaminergic nigral neural degeneration. |
2000-08-11 |
2023-08-12 |
monkey |
| T P George, C D Verrico, L Xu, R H Rot. Effects of repeated nicotine administration and footshock stress on rat mesoprefrontal dopamine systems: Evidence for opioid mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 1. 2000-07-17. PMID:10869888. |
these results suggest that eops may be involved in mediating repeated nicotine administration effects on mesoprefrontal dopaminergic and immobility responses to acute footshock stress. |
2000-07-17 |
2023-08-12 |
rat |
| G Tanda, S R Goldber. Alteration of the behavioral effects of nicotine by chronic caffeine exposure. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837843. |
in particular, recent experiments are reviewed in which chronic exposure to caffeine in the drinking water of rats facilitated acquisition of self-adminstration behavior, enhanced nicotine-induced increases in dopamine levels in the shell of the nucleus accumbens and altered the dopaminergic component of a nicotine discrimination. |
2000-07-06 |
2023-08-12 |
rat |
| W K Schiffer, M R Gerasimov, R A Bermel, J D Brodie, S L Dewe. Stereoselective inhibition of dopaminergic activity by gamma vinyl-GABA following a nicotine or cocaine challenge: a PET/microdialysis study. Life sciences. vol 66. issue 13. 2000-04-11. PMID:10737423. |
stereoselective inhibition of dopaminergic activity by gamma vinyl-gaba following a nicotine or cocaine challenge: a pet/microdialysis study. |
2000-04-11 |
2023-08-12 |
Not clear |
| R Pawlak, Y Takada, H Takahashi, T Urano, H Ihara, N Nagai, A Takad. Differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus. European journal of pharmacology. vol 387. issue 2. 2000-03-28. PMID:10650157. |
differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus. |
2000-03-28 |
2023-08-12 |
rat |
| R Pawlak, Y Takada, H Takahashi, T Urano, H Ihara, N Nagai, A Takad. Differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus. European journal of pharmacology. vol 387. issue 2. 2000-03-28. PMID:10650157. |
since it is well known that nicotine or stress alter the dopaminergic system, we examined the effect of chronic nicotine administration on the dopamine level and its metabolism in the striatum and the hippocampus during stressful conditions in rats. |
2000-03-28 |
2023-08-12 |
rat |
| E S Vizi, B Lendva. Modulatory role of presynaptic nicotinic receptors in synaptic and non-synaptic chemical communication in the central nervous system. Brain research. Brain research reviews. vol 30. issue 3. 2000-01-05. PMID:10567725. |
since the varicose noradrenergic, dopaminergic, serotonergic, glutamatergic and cholinergic axon terminals mainly do not make synaptic contact, but their varicosities are equipped with nachrs and these non-synaptically localized receptors are of high affinity, it is suggested that nicotine inhaled during smoking might exert its behavioral, psychological, neurological and neuroendocrinological effects via these receptors. |
2000-01-05 |
2023-08-12 |
mouse |
| G Panagis, B E Hildebrand, T H Svensson, G G Nomiko. Selective c-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Synapse (New York, N.Y.). vol 35. issue 1. 2000-01-05. PMID:10579804. |
in the present study the neuronal expression of fos, the protein product of c-fos, was used to study changes in neuronal activity in nerve terminal regions of the ascending dopaminergic system during nicotine withdrawal. |
2000-01-05 |
2023-08-12 |
rat |
| G Panagis, B E Hildebrand, T H Svensson, G G Nomiko. Selective c-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Synapse (New York, N.Y.). vol 35. issue 1. 2000-01-05. PMID:10579804. |
since there are indications of involvement of amygdaloid dopaminergic neurotransmission in anxiety-a core symptom of withdrawal from dependence-producing drugs-in a second experiment utilizing microdialysis we examined whether nicotine withdrawal affects dopaminergic neurotransmission in the cna. |
2000-01-05 |
2023-08-12 |
rat |
| N le Novère, M Zoli, C Léna, R Ferrari, M R Picciotto, E Merlo-Pich, J P Changeu. Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. Neuroreport. vol 10. issue 12. 1999-12-21. PMID:10574359. |
enhanced locomotion in a habituated environment is a well documented effect of nicotine mediated by the mesotelencephalic dopaminergic system. |
1999-12-21 |
2023-08-12 |
Not clear |
| N le Novère, M Zoli, C Léna, R Ferrari, M R Picciotto, E Merlo-Pich, J P Changeu. Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. Neuroreport. vol 10. issue 12. 1999-12-21. PMID:10574359. |
these data support the notion that the effects of nicotine on the dopaminergic system involve alpha6 subunit containing nachrs. |
1999-12-21 |
2023-08-12 |
Not clear |
| L H Ferr. Non-nicotine pharmacotherapy for smoking cessation. Primary care. vol 26. issue 3. 1999-11-30. PMID:10436292. |
the only non-nicotine, fda-approved medication is bupropion, an amino-ketone agent that is believed to work on the dopaminergic and noradrenergic neurotransmitters involved in perpetuating nicotine dependence. |
1999-11-30 |
2023-08-12 |
Not clear |
| D Y Kuo, T B Lin, C C Huang, S L Duh, J M Liao, J T Chen. Nicotine-induced hyperlocomotion is not modified by the estrous cycle, ovariectomy and estradiol replacement at physiological level. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513603. |
the observed data provided behavioral evidence to suggest that the effect of nicotine on locomotion-related dopaminergic neurons might not be modified by the physiological action of estrogen. |
1999-11-02 |
2023-08-12 |
rat |
| K Muneoka, T Nakatsu, J Fuji, T Ogawa, M Takigaw. Prenatal administration of nicotine results in dopaminergic alterations in the neocortex. Neurotoxicology and teratology. vol 21. issue 5. 1999-10-22. PMID:10492395. |
prenatal administration of nicotine results in dopaminergic alterations in the neocortex. |
1999-10-22 |
2023-08-12 |
rat |