| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Muneoka, T Nakatsu, J Fuji, T Ogawa, M Takigaw. Prenatal administration of nicotine results in dopaminergic alterations in the neocortex. Neurotoxicology and teratology. vol 21. issue 5. 1999-10-22. PMID:10492395. |
this study examined the effect of two high doses (3 or 6 mg/kg/day) of nicotine administrations via injections to pregnant rats on the dopaminergic, serotonergic, and noradrenergic systems in six brain regions in young adult male rats. |
1999-10-22 |
2023-08-12 |
rat |
| K Muneoka, T Nakatsu, J Fuji, T Ogawa, M Takigaw. Prenatal administration of nicotine results in dopaminergic alterations in the neocortex. Neurotoxicology and teratology. vol 21. issue 5. 1999-10-22. PMID:10492395. |
these data demonstrated that prenatal nicotine induced disturbances in the dopaminergic system in the young adult period. |
1999-10-22 |
2023-08-12 |
rat |
| K Muneoka, T Nakatsu, J Fuji, T Ogawa, M Takigaw. Prenatal administration of nicotine results in dopaminergic alterations in the neocortex. Neurotoxicology and teratology. vol 21. issue 5. 1999-10-22. PMID:10492395. |
furthermore, the region-specific reductions in the dopac content suggests that the exposure to a high dose of nicotine in utero might cause a predisposition to diseases related to a dopaminergic dysfunction in the frontal cortex. |
1999-10-22 |
2023-08-12 |
rat |
| Z J Yang, V Blaha, M M Meguid, A Oler, G Miyat. Infusion of nicotine into the LHA enhances dopamine and 5-HT release and suppresses food intake. Pharmacology, biochemistry, and behavior. vol 64. issue 1. 1999-10-21. PMID:10495010. |
these findings indicate that nicotine enhances dopaminergic and serotonergic activity in the lha, and that the enhanced lha-5-ht activity may contribute to nicotine-induced hypophagia. |
1999-10-21 |
2023-08-12 |
rat |
| H S Kim, K S Kim, K W O. Ginseng total saponin inhibits nicotine-induced hyperactivity and conditioned place preference in mice. Journal of ethnopharmacology. vol 66. issue 1. 1999-10-20. PMID:10432212. |
these results suggest that inhibition by gts of the nicotine-induced hyperactivity and cpp may be closely related with the inhibition of dopaminergic activation induced by nicotine and that the development of nicotine-induced cpp may be associated with the enhanced da receptor supersensitivity. |
1999-10-20 |
2023-08-12 |
mouse |
| H S Kim, K S Ki. Inhibitory effects of ginseng total saponin on nicotine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity. Behavioural brain research. vol 103. issue 1. 1999-10-19. PMID:10475164. |
these results suggest that inhibition by gts of nicotine-induced hyperactivity and reverse tolerance may be closely related with the inhibition of the dopaminergic activation induced by nicotine and that the development of nicotine-induced reverse tolerance may be associated with enhanced da receptor sensitivity. |
1999-10-19 |
2023-08-12 |
mouse |
| C Léna, J P Changeu. The role of beta 2-subunit-containing nicotinic acetylcholine receptors in the brain explored with a mutant mouse. Annals of the New York Academy of Sciences. vol 868. 1999-08-12. PMID:10414341. |
submicromolar doses of nicotine, corresponding to the concentrations of nicotine in vivo in self-administration paradigms, increased the firing rate of dopaminergic neurons in vitro in normal mice but not in mice lacking the beta 2 subunit. |
1999-08-12 |
2023-08-12 |
mouse |
| I M Maisonneuve, S D Glic. (+/-)Cyclazocine blocks the dopamine response to nicotine. Neuroreport. vol 10. issue 4. 1999-06-29. PMID:10208532. |
the aim of the present study was to determine whether (+/-)cyclazocine would alter the dopaminergic effects of nicotine that are thought to mediate its rewarding effects. |
1999-06-29 |
2023-08-12 |
rat |
| T P George, C D Verrico, R H Rot. Effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729261. |
effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress. |
1999-05-12 |
2023-08-12 |
rat |
| T P George, C D Verrico, R H Rot. Effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729261. |
the effects of acute and repeated nicotine administration on the stress response of rat mesoprefrontal dopaminergic pathways were examined. |
1999-05-12 |
2023-08-12 |
rat |
| M R Zarrindast, F Sedaghati, F Borzouye. Nicotine-induced grooming: a possible dopaminergic and/or cholinergic mechanism. Journal of psychopharmacology (Oxford, England). vol 12. issue 4. 1999-04-23. PMID:10065912. |
it is concluded that nicotine elicits grooming indirectly through a possible d1 dopaminergic mechanism. |
1999-04-23 |
2023-08-12 |
rat |
| M Gasior, M Shoaib, S Yasar, M Jaszyna, S R Goldber. Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027843. |
in conclusion, chronic caffeine exposure (average, 135 mg/kg/day) did not affect the rate of acquisition of the nicotine discrimination, but it did reduce the dopaminergic component of the nicotine-discriminative cue. |
1999-04-01 |
2023-08-12 |
rat |
| M Gasior, M Shoaib, S Yasar, M Jaszyna, S R Goldber. Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027843. |
the reduction of the dopaminergic component of the nicotine cue was permanent, as this effect was still evident after the caffeine solution was replaced with water in caffeine-drinking rats. |
1999-04-01 |
2023-08-12 |
rat |
| M Gasior, M Shoaib, S Yasar, M Jaszyna, S R Goldber. Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027843. |
that nicotine could reliably serve as a discriminative stimulus in the absence of the dopaminergic component of its discriminative cue may differentiate nicotine from "classical dopaminergic" drugs of abuse such as cocaine and amphetamine. |
1999-04-01 |
2023-08-12 |
rat |
| M Louis, P B Clark. Effect of ventral tegmental 6-hydroxydopamine lesions on the locomotor stimulant action of nicotine in rats. Neuropharmacology. vol 37. issue 12. 1999-03-23. PMID:9886673. |
convergent evidence suggests that the locomotor stimulant effect of nicotine is mediated by nicotinic receptors located on mesolimbic dopaminergic neurons. |
1999-03-23 |
2023-08-12 |
rat |
| W Kostowski, P Bieńkowsk. Discriminative stimulus effects of ethanol: neuropharmacological characterization. Alcohol (Fayetteville, N.Y.). vol 17. issue 1. 1999-03-23. PMID:9895039. |
the ethanol stimulus effect may be increased (i.e., stronger recognition) by n-cholinergic drugs (nicotine), dopaminergic drugs (apomorphine), and 5-ht3 receptor agonists (m-chlorophenylbiguanide). |
1999-03-23 |
2023-08-12 |
Not clear |
| R S Mansbach, C C Rovetti, C S Freedlan. The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug and alcohol dependence. vol 52. issue 2. 1999-02-04. PMID:9800142. |
in particular, compounds with dopaminergic activity have been reported to modify both the reinforcing and discriminative stimulus properties of nicotine. |
1999-02-04 |
2023-08-12 |
rat |
| R S Mansbach, C C Rovetti, C S Freedlan. The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug and alcohol dependence. vol 52. issue 2. 1999-02-04. PMID:9800142. |
the present study examined a number of dopaminergic, noradrenergic and serotonergic compounds for their effectiveness in reproducing or modifying the stimulus properties of nicotine in rats. |
1999-02-04 |
2023-08-12 |
rat |
| R S Mansbach, C C Rovetti, C S Freedlan. The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug and alcohol dependence. vol 52. issue 2. 1999-02-04. PMID:9800142. |
the selective d1 agonist skf 81,297 produced partial substitution for nicotine (45% maximum), but further experiments with the d1 antagonist sch 23,390 and with rats trained in a three-way discrimination procedure failed to support a primary role for this receptor in the substitution of dopaminergic drugs for nicotine. |
1999-02-04 |
2023-08-12 |
rat |
| D Y Kuo, C N Liu, J C Tsay, C L Chang, J T Chen. Effects of nicotine on spontaneous and amphetamine-induced motor behaviors: the differences between nicotine tolerant and nontolerant rats. The Chinese journal of physiology. vol 41. issue 2. 1999-01-19. PMID:9801839. |
in other words, acute tolerance modified the effect of nicotine on locomotion-related dopaminergic system, and it affected the stereotypy-related dopaminergic system only in the spontaneous one but not in the amp-induced one. |
1999-01-19 |
2023-08-12 |
rat |