| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
to explore further the relationship between the mesencephalic dopaminergic neurons and pfc gabaergic neurons, we investigated the effects of nicotine and passive exposure to cigarette smoke on the regulation of tyrosine hydroxylase (th) in vta and substantia nigra (snc) and dopamine (da) d1 receptor levels in nucleus accumbens (nac) and caudate-putamen (cpu). |
2005-03-07 |
2023-08-12 |
rat |
| Michael N Smolka, Henning Budde, Anne C Karow, Lutz G Schmid. Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence. Psychopharmacology. vol 175. issue 3. 2005-02-02. PMID:15114432. |
neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence. |
2005-02-02 |
2023-08-12 |
Not clear |
| Michael N Smolka, Henning Budde, Anne C Karow, Lutz G Schmid. Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence. Psychopharmacology. vol 175. issue 3. 2005-02-02. PMID:15114432. |
chronic nicotine exposure leads to changes in these dopaminergic reward circuits. |
2005-02-02 |
2023-08-12 |
Not clear |
| Michael N Smolka, Henning Budde, Anne C Karow, Lutz G Schmid. Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence. Psychopharmacology. vol 175. issue 3. 2005-02-02. PMID:15114432. |
during nicotine withdrawal, an impaired dopaminergic function has been reported. |
2005-02-02 |
2023-08-12 |
Not clear |
| Sarah L King, Barbara J Caldarone, Marina R Picciott. Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464132. |
it has been hypothesized that the initial effect of nicotine on the dopamine system is to activate high affinity nicotinic acetylcholine receptors (nachrs) containing the beta2 subunit, but that these receptors rapidly desensitize and are not critical for ongoing dopaminergic activation. |
2004-12-20 |
2023-08-12 |
mouse |
| Sabine Orb, Johannes Wieacker, Cesar Labarca, Carlos Fonck, Henry A Lester, Johannes Schwar. Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally. Physiological genomics. vol 18. issue 3. 2004-12-13. PMID:15199190. |
recordings from dopaminergic neurons in l9's mice show that 10 microm nicotine depolarizes cells and increases spiking rates in l9's cells but hyperpolarizes and decreases spiking rates in wild-type (wt) cells. |
2004-12-13 |
2023-08-12 |
mouse |
| Sabine Orb, Johannes Wieacker, Cesar Labarca, Carlos Fonck, Henry A Lester, Johannes Schwar. Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally. Physiological genomics. vol 18. issue 3. 2004-12-13. PMID:15199190. |
thus dopaminergic neurons of l9's mice have an excitatory response to nicotine which is qualitatively different from that of wt neurons. |
2004-12-13 |
2023-08-12 |
mouse |
| Maryka Qui. Smoking, nicotine and Parkinson's disease. Trends in neurosciences. vol 27. issue 9. 2004-11-02. PMID:15331239. |
here, a role for nicotine is considered, because this chemical stimulates brain dopaminergic systems and provides some symptomatic benefit in pd. |
2004-11-02 |
2023-08-12 |
Not clear |
| Claire Matson Cannon, Mustafa R Bseikr. Is dopamine required for natural reward? Physiology & behavior. vol 81. issue 5. 2004-10-18. PMID:15234179. |
virtually all drugs of abuse, including heroin and other opiates, alcohol, cocaine, amphetamine and nicotine activate dopaminergic systems. |
2004-10-18 |
2023-08-12 |
mouse |
| Elaine C Johnstone, Patricia L Yudkin, Kate Hey, Sarah J Roberts, Sarah J Welch, Michael F Murphy, Siân E Griffiths, Robert T Walto. Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. Pharmacogenetics. vol 14. issue 2. 2004-09-30. PMID:15077009. |
genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. |
2004-09-30 |
2023-08-12 |
human |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine, acting on nicotinic acetylcholine receptors (nachrs) expressed at pre-synaptic dopaminergic terminals, has been shown to stimulate the release of dopamine in the neostriatum. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine at a low concentration (1 microm) activated dopamine d2 receptor signaling in striatopallidal/indirect pathway neurons, likely by activating alpha4beta2* nachrs at dopaminergic terminals. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine at a high concentration (100 microm) activated dopamine d1 receptor signaling in striatonigral/direct pathway neurons, likely by activating (i) alpha4beta2* nachrs at dopaminergic terminals and (ii) alpha7 nachrs at glutamatergic terminals, which, by stimulating the release of glutamate, activated nmda/ampa receptors at dopaminergic terminals. |
2004-09-30 |
2023-08-12 |
mouse |
| Min-Yau Teo, Michiel van Wyk, John Lin, Janusz Lipsk. Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro. Acta neurobiologiae experimentalis. vol 64. issue 2. 2004-09-30. PMID:15366245. |
differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro. |
2004-09-30 |
2023-08-12 |
rat |
| Min-Yau Teo, Michiel van Wyk, John Lin, Janusz Lipsk. Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro. Acta neurobiologiae experimentalis. vol 64. issue 2. 2004-09-30. PMID:15366245. |
despite resembling each other in many respects, dopaminergic neurons of the substantia nigra pars compacta (snc) and ventral tegmental area (vta) exhibit dissimilar responses to nicotine in vivo. |
2004-09-30 |
2023-08-12 |
rat |
| Min-Yau Teo, Michiel van Wyk, John Lin, Janusz Lipsk. Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro. Acta neurobiologiae experimentalis. vol 64. issue 2. 2004-09-30. PMID:15366245. |
low concentrations of nicotine can thus profoundly modulate the activity of dopaminergic mesencephalic neurons through a local action within the ventral midbrain in vitro, and, similarly to in vivo conditions, evoke stronger effects in the vta. |
2004-09-30 |
2023-08-12 |
rat |
| Kimberly A Badanich, Cheryl L Kirstein. Nicotine administration significantly alters accumbal dopamine in the adult but not in the adolescent rat. Annals of the New York Academy of Sciences. vol 1021. 2004-08-23. PMID:15251919. |
findings suggest that there are significant differences between adolescent and adult animals in their dopaminergic response to nicotine. |
2004-08-23 |
2023-08-12 |
rat |
| Kiyoshi And. [Neuropsychopharmacological profile of nicotine]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 2. 2004-07-30. PMID:15164610. |
the brain mechanism producing the reinforcing effects of nicotine is considered to involve nicotinic receptors at the nucleus accumbens, prefrontal cortex or other regions, as well as the mesolimbic dopaminergic system. |
2004-07-30 |
2023-08-12 |
mouse |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. |
2004-07-22 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
nicotine reinforces smoking behaviour by activating nicotinic acetylcholine receptors in the midbrain dopaminergic reward centres. |
2004-07-22 |
2023-08-12 |
Not clear |