| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Bo Lu, Hongjuan Yu, Maarten Zwartbol, Willem P Ruifrok, Wiek H van Gilst, Rudolf A de Boer, Herman H W Sillj\\xc3\\xa. Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models. Physiological genomics. vol 44. issue 8. 2012-08-02. PMID:22353257.' |
hypertensive ren2 rats and animals with postmyocardial infarction (post-mi) hf were used as in vivo hf models, and neonatal rat cardiomyocytes treated with hypertrophy inducing hormones phenylephrine, endothelin-1, and isoproterenol were used as in vitro models. |
2012-08-02 |
2023-08-12 |
rat |
| Emanuele Giordano, Rebecca A Hillary, Thomas C Vary, Anthony E Pegg, Andrew D Sumner, Claudio M Caldarera, Xue-Qian Zhang, Jianliang Song, JuFang Wang, Joseph Y Cheung, Lisa M Shant. Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21814794. |
transgenic mice overexpressing odc in the heart (mhc-odc mice) experience a much more dramatic left ventricular hypertrophy in response to β-adrenergic stimulation with isoproterenol (iso) compared to wild-type (wt) controls. |
2012-05-31 |
2023-08-12 |
mouse |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie. vol 67. issue 2. 2012-05-08. PMID:22512090. |
the function of calcineurin and erk1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. |
2012-05-08 |
2023-08-12 |
Not clear |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie. vol 67. issue 2. 2012-05-08. PMID:22512090. |
we determined the effects of trans-(+/-)-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamid methanesulfonate salt (u50,488h), a selective kappa-opioid receptor agonist, on the enhancement of spontaneous ca2+ transients and the induction of hypertrophy by isoprenaline, a beta-adrenoceptor agonist, in cultured neonatal ventricular myocytes. |
2012-05-08 |
2023-08-12 |
Not clear |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie. vol 67. issue 2. 2012-05-08. PMID:22512090. |
isoprenaline (10 micromol x l(-1)) increased all the three indices of hypertrophy, ca2+ transients, calcineurin activity and the level of phospho-erk1/2. |
2012-05-08 |
2023-08-12 |
Not clear |
| Li-Fang Song, Wei Jiang, Yong Qing, Xiao-Hong Hu, Yi Li, Qing-Yi Tong, Xiao-Hua W. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 42. issue 4. 2012-05-03. PMID:21866628. |
[the antagonistic effect of pi3k-gamma inhibitor as605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. |
2012-05-03 |
2023-08-12 |
rat |
| Li-Fang Song, Wei Jiang, Yong Qing, Xiao-Hong Hu, Yi Li, Qing-Yi Tong, Xiao-Hua W. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 42. issue 4. 2012-05-03. PMID:21866628. |
to investigate the therapeutic effect of pi3kgamma inhibitor as605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats. |
2012-05-03 |
2023-08-12 |
rat |
| David R Murray, Srinivas Mummidi, Anthony J Valente, Tadashi Yoshida, Naveen K Somanna, Patrice Delafontaine, Charles A Dinarello, Bysani Chandraseka. β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. Journal of molecular and cellular cardiology. vol 52. issue 1. 2012-04-24. PMID:22004899. |
β2 adrenergic activation induces the expression of il-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. |
2012-04-24 |
2023-08-12 |
mouse |
| Nada Choucair-Jaafar, Nadine Beetz, Ralf Gilsbach, Ipek Yalcin, Elisabeth Waltisperger, Marie-José Freund-Mercier, Laurent Monassier, Lutz Hein, Michel Barro. Cardiovascular effects of chronic treatment with a β2-adrenoceptor agonist relieving neuropathic pain in mice. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21352833. |
our data show that a chronic treatment with the β(2)-ar agonist terbutaline at low antiallodynic dose does not affect cardiovascular parameters, whereas the mixed β(1)/β(2)-ar agonist isoproterenol induces cardiac hypertrophy. |
2012-04-17 |
2023-08-12 |
mouse |
| Ning Liu, Kai-zheng Gong, Yuan-bin Cai, Zijian L. Identification of proteins responding to adrenergic receptor subtype-specific hypertrophy in cardiomyocytes by proteomic approaches. Biochemistry. Biokhimiia. vol 76. issue 10. 2012-03-19. PMID:22098239. |
we present the first proteomics study identifying proteins that are related to ar subtype-specific hypertrophy in cardiomyocytes by comparing the two-dimensional electrophoresis patterns between neonatal rat cardiomyocytes treated by phenylepinephrin (pe) and by isoproterenol (iso). |
2012-03-19 |
2023-08-12 |
rat |
| Sanjeewa A Goonasekera, Karin Hammer, Mannix Auger-Messier, Ilona Bodi, Xiongwen Chen, Hongyu Zhang, Steven Reiken, John W Elrod, Robert N Correll, Allen J York, Michelle A Sargent, Franz Hofmann, Sven Moosmang, Andrew R Marks, Steven R Houser, Donald M Bers, Jeffery D Molkenti. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation. vol 122. issue 1. 2012-03-06. PMID:22133878. |
however, α1c⁻/⁺ mice subjected to pressure overload stimulation, isoproterenol infusion, and swimming showed greater cardiac hypertrophy, greater reductions in ventricular performance, and greater ventricular dilation than α1c⁺/⁺ controls. |
2012-03-06 |
2023-08-12 |
mouse |
| Alex P Carll, Najwa Haykal-Coates, Darrell W Winsett, Mehdi S Hazari, Abraham Nyska, Judy H Richards, Monte S Willis, Daniel L Costa, Aimen K Farra. Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. Toxicologic pathology. vol 39. issue 6. 2012-02-13. PMID:21878552. |
isoproterenol (iso) infusion can accelerate cardiomyopathy in young shhfs, while dietary salt loading in hypertensive rats induces cardiac fibrosis, hypertrophy, and--in a minority-congestive hf. |
2012-02-13 |
2023-08-12 |
rat |
| Changlin Li, Jing Li, Xiangyu Cai, Haili Sun, Jinjin Jiao, Ting Bai, Xing Wang Zhou, Xiongwen Chen, Donald L Gill, Xiang D Tan. Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21971046. |
in both in vitro and in vivo cardiac hypertrophic models, the normally undetectable pkd3 was profoundly up-regulated by isoproterenol followed by overt expression of cardiac tfs including nfatc4, nk family of transcription factor 2.5 (nkx2.5), gata4 and myocyte enhancer factor 2 (mef2). |
2012-01-16 |
2023-08-12 |
Not clear |
| Tzu-Chieh Wei, Hui-Yu Lin, Cheng-Chieh Lu, Chun-Ming Chen, Li-Ru Yo. Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene expression patterns : GEP. vol 11. issue 7. 2011-12-27. PMID:21601656. |
nonetheless, experimental studies revealed that the expression level of crip2 is not altered in the isoproterenol (iso) induced hypertrophic heart. |
2011-12-27 |
2023-08-12 |
mouse |
| John T Liles, Kevin K Ida, Kristin M Joly, Joseph Chapo, Craig F Plat. Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 2. 2011-10-18. PMID:21593430. |
contractile reserve decreases with advancing age and chronic isoproterenol (iso) administration is a well-characterized model of cardiac hypertrophy known to impair cardiovascular function. |
2011-10-18 |
2023-08-12 |
rat |
| FuKun W Hoffmann, Ann S Hashimoto, Byung Cheon Lee, Aaron H Rose, Ralph V Shohet, Peter R Hoffman. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Archives of biochemistry and biophysics. vol 512. issue 1. 2011-09-12. PMID:21621505. |
to determine how the selenoproteome responds to myocardial hypertrophy, two mouse models were employed: triidothyronine (t3)- or isoproterenol (iso)-treatment. |
2011-09-12 |
2023-08-12 |
mouse |
| Lianghui Zhang, Sundeep Malik, Grant G Kelley, Michael S Kapiloff, Alan V Smrck. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21550986. |
nrvms with plcε depletion were stimulated with endothelin (et-1), norepinephrine, insulin-like growth factor-1 (igf-1), or isoproterenol and assessed for development of hypertrophy. |
2011-09-09 |
2023-08-12 |
rat |
| Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie L. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. International journal of biological sciences. vol 7. issue 3. 2011-08-04. PMID:21494433. |
the present study was aimed to investigate whether tanshinone iia prevents cardiac hypertrophy induced by isoproterenol (iso) and to clarify its possible mechanisms. |
2011-08-04 |
2023-08-12 |
Not clear |
| David J Durgan, Ju-Yun Tsai, Maximiliano H Grenett, Betty M Pat, William F Ratcliffe, Carolina Villegas-Montoya, Merissa E Garvey, Jeevan Nagendran, Jason R B Dyck, Molly S Bray, Karen L Gamble, Jeffrey M Gimble, Martin E Youn. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiology international. vol 28. issue 3. 2011-07-19. PMID:21452915. |
wild-type mice exhibit 5-fold greater cardiac hypertrophic growth (and 6-fold greater anf mrna induction) when challenged with the hypertrophic agonist isoproterenol at the active-to-sleep phase transition, relative to isoproterenol administration at the sleep-to-active phase transition. |
2011-07-19 |
2023-08-12 |
mouse |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311678. |
chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac hypertrophy measured by the heart-to-body weight ratio and left ventricular posterior wall thickness. |
2011-07-14 |
2023-08-12 |
mouse |