| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology. vol 58. issue 5-6. 2013-12-10. PMID:23466634. |
our results demonstrated that isoproterenol significantly increased the expression of hypertrophic marker, atrial natriuretic peptide (anp) and brain natriuretic peptide (bnp), parallel to a significant increase in cell surface area. |
2013-12-10 |
2023-08-12 |
rat |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology. vol 58. issue 5-6. 2013-12-10. PMID:23466634. |
interestingly, 20-hydroxyeicosatetraenoic acid (20-hete) treatment caused similar effects to that of isoproterenol treatment and induced cellular hypertrophy in h9c2 cells. |
2013-12-10 |
2023-08-12 |
rat |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology. vol 58. issue 5-6. 2013-12-10. PMID:23466634. |
in conclusion, isoproterenol induces cellular hypertrophy and modulates the expression of cyps and ephx2 in h9c2 cells. |
2013-12-10 |
2023-08-12 |
rat |
| Liang Yang, Xiangyu Cai, Jie Liu, Zhe Jia, Jinjin Jiao, Jincai Zhang, Changlin Li, Jing Li, Xiang D Tan. CpG-ODN attenuates pathological cardiac hypertrophy and heart failure by activation of PI3Kα-Akt signaling. PloS one. vol 8. issue 4. 2013-11-26. PMID:23638055. |
in vitro studies indicated that c274 could blunt reactivation of fetal cardiac genes and cell enlargement induced by a hypertrophic agent, isoproterenol. |
2013-11-26 |
2023-08-12 |
mouse |
| Jørgen Gravning, M Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal, Håvard Attramada. Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes. Molecular pharmacology. vol 84. issue 3. 2013-11-26. PMID:23778361. |
finally, tg-ctgf mice subjected to chronic exposure (14 days) to isoproterenol revealed blunted myocardial hypertrophy and preserved cardiac function versus nlc mice. |
2013-11-26 |
2023-08-12 |
mouse |
| Shouting Liu, Canguo Zhao, Changshan Yang, Xiaofen Li, Hongbiao Huang, Ningning Liu, Shujue Li, Xuejun Wang, Jinbao Li. Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. American journal of cardiovascular disease. vol 3. issue 4. 2013-11-13. PMID:24224134. |
in the present study, we examined the effect of ga on pressure overload or isoproterenol infusion induced cardiac hypertrophy and fibrosis, and changes in myocardial nf-κb signaling. |
2013-11-13 |
2023-08-12 |
human |
| Shouting Liu, Canguo Zhao, Changshan Yang, Xiaofen Li, Hongbiao Huang, Ningning Liu, Shujue Li, Xuejun Wang, Jinbao Li. Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. American journal of cardiovascular disease. vol 3. issue 4. 2013-11-13. PMID:24224134. |
in conclusion, ga treatment can suppress cardiac hypertrophy and fibrosis induced by pressure overload or isoproterenol possibly through the inhibition of the proteasome and the nf-κb pathway, suggesting that ga treatment may provide a new strategy to treat cardiac hypertrophy. |
2013-11-13 |
2023-08-12 |
human |
| Weiping Wang, Man Zhang, Pingping Li, Hui Yuan, Nan Feng, Ying Peng, Ling Wang, Xiaoliang Wan. An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. Journal of cardiovascular pharmacology. vol 61. issue 4. 2013-11-11. PMID:23232841. |
to elucidate the expression and identify the functional changes of 2 pore domain potassium channel trek-1 during cardiac hypertrophy in rats, left ventricular hypertrophy was induced by subcutaneous injection with isoproterenol. |
2013-11-11 |
2023-08-12 |
rat |
| Haneen A Al-Mazroua, Nawal M Al-Rasheed, Hesham M Korash. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. Journal of cardiovascular pharmacology. vol 61. issue 4. 2013-11-11. PMID:23288202. |
therefore, healthy and isoproterenol (iso)-induced hypertrophy adult male wistar albino rats were treated with either val or spl for 14 days. |
2013-11-11 |
2023-08-12 |
rat |
| Shinichi Mitsuyama, Daisuke Takeshita, Koji Obata, Guo-Xing Zhang, Miyako Takak. Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats. Journal of molecular and cellular cardiology. vol 59. 2013-10-29. PMID:23458361. |
to investigate whether it would be beneficial in a cardiac failure model with down-regulated serca2a levels, we made a cardiac hypertrophy model using isoproterenol infusion (1.2mgkg(-1)day(-1) for 1 or 4weeks; tg-iso1w and tg-iso4w, respectively) in serca2a transgenic (tg) rats and compared these rats with littermate wt rats that underwent the same treatments (wt-iso1w and wt-iso4w). |
2013-10-29 |
2023-08-12 |
rat |
| Fabio D'Amico, Evangelia Skarmoutsou, Katia Mangano, Grazia Malaponte, Maria Clorinda Mazzarin. Isoproterenol modulates matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor-2 (TIMP-2) in rat parotid gland. Archives of oral biology. vol 58. issue 4. 2013-09-03. PMID:22947212. |
chronic isoproterenol treatment causes hypertrophy and hyperplasia of rodent salivary glands. |
2013-09-03 |
2023-08-12 |
rat |
| Subhro Jyoti Roy, P Stanely Mainzen Princ. Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. European journal of pharmacology. vol 699. issue 1-3. 2013-09-02. PMID:23178800. |
pre- and co-treatment with sinapic acid ameliorated cardiac hypertrophy, dyslipidemia and elevated st-segments in isoproterenol induced myocardial infarcted rats. |
2013-09-02 |
2023-08-12 |
rat |
| Ruotian Li, Guijun Yan, Qun Zhang, Yue Jiang, Haixiang Sun, Yali Hu, Jianxin Sun, Biao X. miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS letters. vol 587. issue 12. 2013-08-14. PMID:23624080. |
here, we report mir-145 regulates both expression and localization of gata6, thereby protecting the heart against cardiomyocyte hypertrophy induced by isoproterenol (iso). |
2013-08-14 |
2023-08-12 |
mouse |
| Jing Lu, Zhou-Yan Bian, Ran Zhang, Yan Zhang, Chen Liu, Ling Yan, Shu-Min Zhang, Ding-Sheng Jiang, Xiang Wei, Xue Hai Zhu, Manyin Chen, Ai-Bing Wang, Yingjie Chen, Qinglin Yang, Peter P Liu, Hongliang L. Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Basic research in cardiology. vol 108. issue 2. 2013-07-18. PMID:23307144. |
herein, we employed an irf3-deficient mouse model, cardiac-specific irf3-overexpression mouse model and isolated cardiomyocytes to investigate the role of irf3 in cardiac hypertrophy induced by aortic banding (ab) or isoproterenol (iso). |
2013-07-18 |
2023-08-12 |
mouse |
| Andrei Molojavyi, Antje Lindecke, Annika Raupach, Sarah Moellendorf, Karl Köhrer, Axel Gödeck. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiological genomics. vol 41. issue 2. 2013-07-15. PMID:20145201. |
to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild-type (wt) controls. |
2013-07-15 |
2023-08-12 |
mouse |
| Andrei Molojavyi, Antje Lindecke, Annika Raupach, Sarah Moellendorf, Karl Köhrer, Axel Gödeck. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiological genomics. vol 41. issue 2. 2013-07-15. PMID:20145201. |
after 14 days of isoproterenol infusion cardiac hypertrophy in wt and myo-/- mice reached a similar level. |
2013-07-15 |
2023-08-12 |
mouse |
| Ana Paula Nadu, Anderson J Ferreira, Timothy L Reudelhuber, Michael Bader, Robson A S Santo. Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats. Journal of the American Society of Hypertension : JASH. vol 2. issue 5. 2013-07-04. PMID:20409916. |
we investigated the expression of specific extracellular matrix (ecm) proteins in cardiac hypertrophy induced by isoproterenol in tgr(a1-7)3292 rats. |
2013-07-04 |
2023-08-12 |
rat |
| Rogerio Faustino Ribeiro, Felipe F Potratz, Brunella M M Pavan, Ludimila Forechi, Filipe Lugon Moulin Lima, Jonaina Fiorim, Aurelia Araujo Fernandes, Dalton Valentim Vassallo, Ivanita Stefano. Carvedilol prevents ovariectomy-induced myocardial contractile dysfunction in female rat. PloS one. vol 8. issue 1. 2013-07-01. PMID:23308166. |
carvedilol treatment in the ovx animals: prevented weight gain and slight hypertrophy, restored the reduced positive inotropic responses to ca(2+) and isoproterenol, prevented the reduction in serca2a expression, abolished the increase in superoxide anion production, normalized the increase in p22(phox) expression, and decreased serum angiotensin converting enzyme (ace) activity. |
2013-07-01 |
2023-08-12 |
rat |
| Isil Ozakca, Ebru Arioglu-Inan, Hrag Esfahani, V Melih Altan, Jean-Luc Balligand, Gizem Kayki-Mutlu, A Tanju Ozcelika. Nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage. American journal of physiology. Heart and circulatory physiology. vol 304. issue 9. 2013-06-28. PMID:23457011. |
nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage. |
2013-06-28 |
2023-08-12 |
rat |
| Vandana Sankar, Balasubramaniam Pangayarselvi, Ayyappan Prathapan, Kozhiparambil Gopalan Ragh. Desmodium gangeticum (Linn.) DC. exhibits antihypertrophic effect in isoproterenol-induced cardiomyoblasts via amelioration of oxidative stress and mitochondrial alterations. Journal of cardiovascular pharmacology. vol 61. issue 1. 2013-06-12. PMID:23052030. |
hypertrophy was induced by exposing h9c2 cell line to β-adrenergic receptor agonist, isoproterenol (iso), for 96 hours. |
2013-06-12 |
2023-08-12 |
Not clear |