| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shouting Liu, Canguo Zhao, Changshan Yang, Xiaofen Li, Hongbiao Huang, Ningning Liu, Shujue Li, Xuejun Wang, Jinbao Li. Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. American journal of cardiovascular disease. vol 3. issue 4. 2013-11-13. PMID:24224134. |
in conclusion, ga treatment can suppress cardiac hypertrophy and fibrosis induced by pressure overload or isoproterenol possibly through the inhibition of the proteasome and the nf-κb pathway, suggesting that ga treatment may provide a new strategy to treat cardiac hypertrophy. |
2013-11-13 |
2023-08-12 |
human |
| Weiping Wang, Man Zhang, Pingping Li, Hui Yuan, Nan Feng, Ying Peng, Ling Wang, Xiaoliang Wan. An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. Journal of cardiovascular pharmacology. vol 61. issue 4. 2013-11-11. PMID:23232841. |
to elucidate the expression and identify the functional changes of 2 pore domain potassium channel trek-1 during cardiac hypertrophy in rats, left ventricular hypertrophy was induced by subcutaneous injection with isoproterenol. |
2013-11-11 |
2023-08-12 |
rat |
| Haneen A Al-Mazroua, Nawal M Al-Rasheed, Hesham M Korash. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. Journal of cardiovascular pharmacology. vol 61. issue 4. 2013-11-11. PMID:23288202. |
therefore, healthy and isoproterenol (iso)-induced hypertrophy adult male wistar albino rats were treated with either val or spl for 14 days. |
2013-11-11 |
2023-08-12 |
rat |
| Shinichi Mitsuyama, Daisuke Takeshita, Koji Obata, Guo-Xing Zhang, Miyako Takak. Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats. Journal of molecular and cellular cardiology. vol 59. 2013-10-29. PMID:23458361. |
to investigate whether it would be beneficial in a cardiac failure model with down-regulated serca2a levels, we made a cardiac hypertrophy model using isoproterenol infusion (1.2mgkg(-1)day(-1) for 1 or 4weeks; tg-iso1w and tg-iso4w, respectively) in serca2a transgenic (tg) rats and compared these rats with littermate wt rats that underwent the same treatments (wt-iso1w and wt-iso4w). |
2013-10-29 |
2023-08-12 |
rat |
| Fabio D'Amico, Evangelia Skarmoutsou, Katia Mangano, Grazia Malaponte, Maria Clorinda Mazzarin. Isoproterenol modulates matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor-2 (TIMP-2) in rat parotid gland. Archives of oral biology. vol 58. issue 4. 2013-09-03. PMID:22947212. |
chronic isoproterenol treatment causes hypertrophy and hyperplasia of rodent salivary glands. |
2013-09-03 |
2023-08-12 |
rat |
| Subhro Jyoti Roy, P Stanely Mainzen Princ. Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. European journal of pharmacology. vol 699. issue 1-3. 2013-09-02. PMID:23178800. |
pre- and co-treatment with sinapic acid ameliorated cardiac hypertrophy, dyslipidemia and elevated st-segments in isoproterenol induced myocardial infarcted rats. |
2013-09-02 |
2023-08-12 |
rat |
| Ruotian Li, Guijun Yan, Qun Zhang, Yue Jiang, Haixiang Sun, Yali Hu, Jianxin Sun, Biao X. miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS letters. vol 587. issue 12. 2013-08-14. PMID:23624080. |
here, we report mir-145 regulates both expression and localization of gata6, thereby protecting the heart against cardiomyocyte hypertrophy induced by isoproterenol (iso). |
2013-08-14 |
2023-08-12 |
mouse |
| Jing Lu, Zhou-Yan Bian, Ran Zhang, Yan Zhang, Chen Liu, Ling Yan, Shu-Min Zhang, Ding-Sheng Jiang, Xiang Wei, Xue Hai Zhu, Manyin Chen, Ai-Bing Wang, Yingjie Chen, Qinglin Yang, Peter P Liu, Hongliang L. Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Basic research in cardiology. vol 108. issue 2. 2013-07-18. PMID:23307144. |
herein, we employed an irf3-deficient mouse model, cardiac-specific irf3-overexpression mouse model and isolated cardiomyocytes to investigate the role of irf3 in cardiac hypertrophy induced by aortic banding (ab) or isoproterenol (iso). |
2013-07-18 |
2023-08-12 |
mouse |
| Andrei Molojavyi, Antje Lindecke, Annika Raupach, Sarah Moellendorf, Karl Köhrer, Axel Gödeck. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiological genomics. vol 41. issue 2. 2013-07-15. PMID:20145201. |
to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild-type (wt) controls. |
2013-07-15 |
2023-08-12 |
mouse |
| Andrei Molojavyi, Antje Lindecke, Annika Raupach, Sarah Moellendorf, Karl Köhrer, Axel Gödeck. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiological genomics. vol 41. issue 2. 2013-07-15. PMID:20145201. |
after 14 days of isoproterenol infusion cardiac hypertrophy in wt and myo-/- mice reached a similar level. |
2013-07-15 |
2023-08-12 |
mouse |
| Ana Paula Nadu, Anderson J Ferreira, Timothy L Reudelhuber, Michael Bader, Robson A S Santo. Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats. Journal of the American Society of Hypertension : JASH. vol 2. issue 5. 2013-07-04. PMID:20409916. |
we investigated the expression of specific extracellular matrix (ecm) proteins in cardiac hypertrophy induced by isoproterenol in tgr(a1-7)3292 rats. |
2013-07-04 |
2023-08-12 |
rat |
| Rogerio Faustino Ribeiro, Felipe F Potratz, Brunella M M Pavan, Ludimila Forechi, Filipe Lugon Moulin Lima, Jonaina Fiorim, Aurelia Araujo Fernandes, Dalton Valentim Vassallo, Ivanita Stefano. Carvedilol prevents ovariectomy-induced myocardial contractile dysfunction in female rat. PloS one. vol 8. issue 1. 2013-07-01. PMID:23308166. |
carvedilol treatment in the ovx animals: prevented weight gain and slight hypertrophy, restored the reduced positive inotropic responses to ca(2+) and isoproterenol, prevented the reduction in serca2a expression, abolished the increase in superoxide anion production, normalized the increase in p22(phox) expression, and decreased serum angiotensin converting enzyme (ace) activity. |
2013-07-01 |
2023-08-12 |
rat |
| Isil Ozakca, Ebru Arioglu-Inan, Hrag Esfahani, V Melih Altan, Jean-Luc Balligand, Gizem Kayki-Mutlu, A Tanju Ozcelika. Nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage. American journal of physiology. Heart and circulatory physiology. vol 304. issue 9. 2013-06-28. PMID:23457011. |
nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage. |
2013-06-28 |
2023-08-12 |
rat |
| Vandana Sankar, Balasubramaniam Pangayarselvi, Ayyappan Prathapan, Kozhiparambil Gopalan Ragh. Desmodium gangeticum (Linn.) DC. exhibits antihypertrophic effect in isoproterenol-induced cardiomyoblasts via amelioration of oxidative stress and mitochondrial alterations. Journal of cardiovascular pharmacology. vol 61. issue 1. 2013-06-12. PMID:23052030. |
hypertrophy was induced by exposing h9c2 cell line to β-adrenergic receptor agonist, isoproterenol (iso), for 96 hours. |
2013-06-12 |
2023-08-12 |
Not clear |
| Qunhui Yang, Jiancheng Yang, Gaofeng Wu, Ying Feng, Qiufeng Lv, Shumei Lin, Jianmin H. Effects of taurine on myocardial cGMP/cAMP ratio, antioxidant ability, and ultrastructure in cardiac hypertrophy rats induced by isoproterenol. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392885. |
effects of taurine on myocardial cgmp/camp ratio, antioxidant ability, and ultrastructure in cardiac hypertrophy rats induced by isoproterenol. |
2013-06-12 |
2023-08-12 |
human |
| Qunhui Yang, Jiancheng Yang, Gaofeng Wu, Ying Feng, Qiufeng Lv, Shumei Lin, Jianmin H. Effects of taurine on myocardial cGMP/cAMP ratio, antioxidant ability, and ultrastructure in cardiac hypertrophy rats induced by isoproterenol. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392885. |
to investigate the preventive effects of taurine on cardiac hypertrophy in rats, myocardial injury was established by hypodermic injection of isoprenaline (iso) (10 mg/kg d) for 7 days. |
2013-06-12 |
2023-08-12 |
human |
| Qunhui Yang, Jiancheng Yang, Gaofeng Wu, Ying Feng, Qiufeng Lv, Shumei Lin, Jianmin H. Effects of taurine on myocardial cGMP/cAMP ratio, antioxidant ability, and ultrastructure in cardiac hypertrophy rats induced by isoproterenol. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392885. |
in conclusion, the present study demonstrated that taurine could inhibit the injury induced by iso by increasing myocardial negative inotropic effect and antioxidant ability, decreasing the hypertrophic response to isoproterenol and protecting the integrity of -myocardial ultrastructure, decreasing myocardial leak of ck-mb. |
2013-06-12 |
2023-08-12 |
human |
| Ming-Zi Chen, Qing-Ting Bu, Shu-Chao Pang, Feng-Lan Li, Mei-Na Sun, Er-Fu Chu, Hui L. Tetrodotoxin attenuates isoproterenol-induced hypertrophy in H9c2 rat cardiac myocytes. Molecular and cellular biochemistry. vol 371. issue 1-2. 2013-05-17. PMID:22941212. |
the present study was carried out to determine whether the reversible sodium channel blocker tetrodotoxin (ttx) exerts a direct anti-hypertrophic effect on isoproterenol (iso)-induced cell hypertrophy and find the underlying mechanism that regulate [na(+)]( i ). |
2013-05-17 |
2023-08-12 |
rat |
| B M Patel, S S Agarwal, S V Bhadad. Perindopril protects against streptozotocin-induced hyperglycemic myocardial damage/alterations. Human & experimental toxicology. vol 31. issue 11. 2013-04-30. PMID:22653691. |
we studied the effect of perindopril (1 mg/kg/d orally [po]) on cardiovascular complications in neonatal model of rats, which was induced by administering stz (90 mg/kg, intraperitoneally [ip]), in 5-d-old wistar rats and cardiac hypertrophy induced by isoprenaline (iso; 5 mg/kg, ip) for 10 d. various biochemical, cardiac, and hemodynamic parameters were measured at the end of 8 weeks of treatment in diabetes model and 10 d in hypertrophy model. |
2013-04-30 |
2023-08-12 |
rat |
| Vinodkumar B Pillai, Nagalingam R Sundaresan, Gene Kim, Sadhana Samant, Liliana Moreno-Vinasco, Joe G N Garcia, Mahesh P Gupt. Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling. American journal of physiology. Heart and circulatory physiology. vol 304. issue 3. 2013-03-22. PMID:23203961. |
whereas nampt(+/-) mice were protected against agonist (isoproterenol and angiotensin ii)-induced hypertrophy, nampt transgenic mice spontaneously developed cardiac hypertrophy at 6 mo of age. |
2013-03-22 |
2023-08-12 |
mouse |