| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Li Liu, Ben Liu, Yang-Yang Qu, Hui-Juan Chai, Rui Li, Ling Zhan. [Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained β adrenergic receptor-stimulated cardiac hypertrophy in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 1. 2015-05-16. PMID:23426507. |
in this study, we observe how n-acetylcysteine (nac) affects the oxidative stress and calcium/calmodulin-dependent protein kinase ii (camkii) expression in heart of isoproterenol (iso)-stimulated rats, and investigate whether oxidative stress and camkii contribute to the development of sustained βar-stimulated cardiac hypertrophy. |
2015-05-16 |
2023-08-12 |
rat |
| Hongliang Dai, Guizhi Jia, Xin Liu, Zhining Liu, Hongxin Wan. Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca²⁺-mediated calcineurin/NFATc3 and CaMKII signaling cascades. Environmental toxicology and pharmacology. vol 38. issue 1. 2015-04-13. PMID:24975447. |
in vitro cardiac hypertrophic model induced by isoprenaline (iso) was employed to explore the anti-hypertrophic action of aps. |
2015-04-13 |
2023-08-13 |
Not clear |
| Jiaojiao Wang, Zhiping Liu, Xiaojun Feng, Si Gao, Suowen Xu, Peiqing Li. Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling. Archives of biochemistry and biophysics. vol 562. 2015-02-27. PMID:25151306. |
ing3 expression was present in relatively high abundance in the heart, and was prominently upregulated in hypertrophic agonists angiotensin ii (ang ii), phenylephrine (pe), or isoproterenol (iso)-stimulated cardiomyocytes and in hearts of rat undergoing abdominal aortic constriction (aac) surgery. |
2015-02-27 |
2023-08-13 |
rat |
| Bernardo A Petriz, Octavio L Franc. Effects of hypertension and exercise on cardiac proteome remodelling. BioMed research international. vol 2014. 2015-02-12. PMID:24877123. |
proteomic research has revealed that several molecular targets are associated with pathologic cardiac hypertrophy, including angiotensin ii, endothelin-1 and isoproterenol. |
2015-02-12 |
2023-08-13 |
Not clear |
| Xi Chen, Siyu Zeng, Jian Zou, Yanfang Chen, Zhongbao Yue, Ying Gao, Luankun Zhang, Weiwei Cao, Peiqing Li. Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25045214. |
rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting nf-κb activation. |
2015-02-12 |
2023-08-13 |
rat |
| Xi Chen, Siyu Zeng, Jian Zou, Yanfang Chen, Zhongbao Yue, Ying Gao, Luankun Zhang, Weiwei Cao, Peiqing Li. Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25045214. |
however, little is known about the role of rapa in cardiac hypertrophy induced by isoproterenol and its underlying mechanism. |
2015-02-12 |
2023-08-13 |
rat |
| Xi Chen, Siyu Zeng, Jian Zou, Yanfang Chen, Zhongbao Yue, Ying Gao, Luankun Zhang, Weiwei Cao, Peiqing Li. Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25045214. |
in this study, rapa was administrated intraperitoneally for one week after the rat model of cardiac hypertrophy induced by isoproterenol established. |
2015-02-12 |
2023-08-13 |
rat |
| Xi Chen, Siyu Zeng, Jian Zou, Yanfang Chen, Zhongbao Yue, Ying Gao, Luankun Zhang, Weiwei Cao, Peiqing Li. Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25045214. |
our results shed new light on mechanisms underlying the protective role of rapa against cardiac hypertrophy induced by isoproterenol, suggesting that blocking proinflammatory response by rapa might contribute to the maintenance of energy homeostasis during the progression of cardiac hypertrophy. |
2015-02-12 |
2023-08-13 |
rat |
| Tadashi Yoshida, Maho Yamashita, Chihiro Horimai, Matsuhiko Hayash. Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. The Journal of biological chemistry. vol 289. issue 38. 2015-02-02. PMID:25100730. |
cardiac hypertrophy was induced by chronic infusion of the β-adrenoreceptor agonist isoproterenol (iso). |
2015-02-02 |
2023-08-13 |
mouse |
| Cui Li, Xuelian Li, Xu Gao, Ruixue Zhang, Ying Zhang, Haihai Liang, Chaoqian Xu, Weijie Du, Yong Zhang, Xue Liu, Ning Ma, Zhidan Xu, Leimin Wang, Xu Chen, Yanjie Lu, Jiaming Ju, Baofeng Yang, Hongli Sha. MicroRNA-328 as a regulator of cardiac hypertrophy. International journal of cardiology. vol 173. issue 2. 2014-12-18. PMID:24631114. |
mir-328 expression was upregulated in cardiomyocyte treated with isoproterenol (iso) to induce hypertrophy; while knockdown of mir-328 attenuated the hypertrophic responses. |
2014-12-18 |
2023-08-12 |
mouse |
| Martine Desrois, Frank Kober, Carole Lan, Christiane Dalmasso, Mark Cole, Kieran Clarke, Patrick J Cozzone, Monique Bernar. Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart - a longitudinal MR study. NMR in biomedicine. vol 27. issue 5. 2014-11-24. PMID:24677605. |
the chronic administration of the β-adrenoreceptor agonist isoproterenol (isop) is used in animals to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines. |
2014-11-24 |
2023-08-12 |
rat |
| Han-Jun Wang, Wei Wang, Kurtis G Cornish, George J Rozanski, Irving H Zucke. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension (Dallas, Tex. : 1979). vol 64. issue 4. 2014-11-21. PMID:24980663. |
most importantly, we found that epicardial application of resiniferatoxin largely prevented the elevated left ventricle end-diastolic pressure, lung edema, and cardiac hypertrophy, partially reduced left ventricular dimensions in the failing heart, and increased cardiac contractile reserve in response to β-adrenergic receptor stimulation with isoproterenol in chf rats. |
2014-11-21 |
2023-08-13 |
rat |
| Enrico Patrucco, Katrin Domes, Mauro Sbroggió, Anne Blaich, Jens Schlossmann, Matthias Desch, Sergei D Rybalkin, Joseph A Beavo, Robert Lukowski, Franz Hofman. Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 35. 2014-11-12. PMID:25139994. |
in particular, βrm mice developed the same hypertrophy as wt controls when subjected to thoracic aortic constriction or isoproterenol infusion. |
2014-11-12 |
2023-08-13 |
mouse |
| Hassan N Althurwi, Osama H Elshenawy, Ayman O S El-Kad. Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. Journal of cardiovascular pharmacology. vol 63. issue 2. 2014-10-06. PMID:24157956. |
furthermore, fenofibrate significantly decreased the hypertrophic markers and the increase in heart-to-body weight ratio induced by isoproterenol. |
2014-10-06 |
2023-08-12 |
rat |
| Jason H Yang, Renata K Polanowska-Grabowska, Jeffrey S Smith, Charles W Shields, Jeffrey J Saucerma. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. Journal of molecular and cellular cardiology. vol 66. 2014-08-18. PMID:24225179. |
ca(2+) and cell hypertrophy measurements validated these predictions and identified higher isoproterenol sensitivity for contractile enhancements (ec50=1.84 nmol/l) over cell hypertrophy (ec50=85.9 nmol/l). |
2014-08-18 |
2023-08-12 |
Not clear |
| Yang Wu, Yu-qin Wang, Bao-xia Wan. [MicroRNA-133a attenuates isoproterenol-induced neonatal rat cardiomyocyte hypertrophy by downregulating L-type calcium channel α1C subunit gene expression]. Zhonghua xin xue guan bing za zhi. vol 41. issue 6. 2014-08-14. PMID:24113045. |
to investigate the effects of microrna-133a on isoproterenol (iso)-induced neonatal rat cardiomyocyte hypertrophy and related molecular mechanism focusing on the changes of l-type calcium channel α1c subunit. |
2014-08-14 |
2023-08-12 |
rat |
| Hae Jin Kee, Sangha Park, Wanseok Kang, Kyung Seob Lim, Jung Ha Kim, Youngkeun Ahn, Myung Ho Jeon. Piceatannol attenuates cardiac hypertrophy in an animal model through regulation of the expression and binding of the transcription factor GATA binding factor 6. FEBS letters. vol 588. issue 9. 2014-06-27. PMID:24662306. |
piceatannol pretreatment suppresses cardiac hypertrophy induced by isoproterenol as assessed by heart weight/body weight ratio, cross-sectional area, and expression of hypertrophic markers. |
2014-06-27 |
2023-08-12 |
rat |
| Jia-Xi Xu, Man Si, Hui-Ran Zhang, Xing-Juan Chen, Xi-Dong Zhang, Chuan Wang, Xiao-Na Du, Hai-Lin Zhan. Phosphoinositide kinases play key roles in norepinephrine- and angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac function. The Journal of biological chemistry. vol 289. issue 10. 2014-06-24. PMID:24448808. |
in two animal models of cardiac hypertrophy, pip2 levels were significantly reduced in hypertrophic hearts induced by isoprenaline but not in those induced by swimming exercise. |
2014-06-24 |
2023-08-12 |
rat |
| Inbal Rachmin, Sagi Tshori, Yoav Smith, Amit Oppenheim, Sylvie Marchetto, Gillian Kay, Roger S-Y Foo, Noa Dagan, Eliahu Golomb, Dan Gilon, Jean-Paul Borg, Ehud Razi. Erbin is a negative modulator of cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 16. 2014-06-17. PMID:24711380. |
cardiac hypertrophy was induced in mice either by isoproterenol administration or by aortic constriction. |
2014-06-17 |
2023-08-13 |
mouse |
| Carmen C Sucharov, Jamie G Hijmans, Rebecca D Sobus, William F A Melhado, Shelley D Miyamoto, Brian L Stauffe. β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. Journal of applied physiology (Bethesda, Md. : 1985). vol 115. issue 7. 2014-06-03. PMID:23887897. |
we found that isoproterenol treatment (through osmotic minipump implantation) of young and adult mice produced similar degrees of cardiac hypertrophy and recapitulated several age-related molecular abnormalities in human heart failure, including phospholamban phosphorylation and β-ar expression. |
2014-06-03 |
2023-08-12 |
mouse |