| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beatriz Martín-Fernández, Natalia de las Heras, María Miana, Sandra Ballesteros, María Valero-Muñoz, Dalton Vassallo, Ana Paula Davel, Luciana Venturini Rossoni, Victoria Cachofeiro, Vicente Laher. Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1. Experimental physiology. vol 97. issue 6. 2013-01-18. PMID:22327331. |
persistent β-adrenergic receptor stimulation with isoproterenol is associated with cardiac hypertrophy as well as cardiac synthesis of angiotensin ii. |
2013-01-18 |
2023-08-12 |
rat |
| Beatriz Martín-Fernández, Natalia de las Heras, María Miana, Sandra Ballesteros, María Valero-Muñoz, Dalton Vassallo, Ana Paula Davel, Luciana Venturini Rossoni, Victoria Cachofeiro, Vicente Laher. Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1. Experimental physiology. vol 97. issue 6. 2013-01-18. PMID:22327331. |
isoproterenol treatment induced cardiac hypertrophy and increased collagen content, both of which were normalized by spironolactone treatment. |
2013-01-18 |
2023-08-12 |
rat |
| Beatriz Martín-Fernández, Natalia de las Heras, María Miana, Sandra Ballesteros, María Valero-Muñoz, Dalton Vassallo, Ana Paula Davel, Luciana Venturini Rossoni, Victoria Cachofeiro, Vicente Laher. Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1. Experimental physiology. vol 97. issue 6. 2013-01-18. PMID:22327331. |
the observed reduction of the principal mediator of aldosterone cellular actions, sgk-1, by spironolactone in hearts from isoproterenol-treated rats suggests a role of mineralocorticoids in the cardiac hypertrophy, fibrosis, inflammation, oxidation and diastolic dysfunction induced by isoproterenol treatment in rats. |
2013-01-18 |
2023-08-12 |
rat |
| Subir Kumar Maulik, Pankaj Prabhakar, Amit Kumar Dinda, Sandeep Set. Genistein prevents isoproterenol-induced cardiac hypertrophy in rats. Canadian journal of physiology and pharmacology. vol 90. issue 8. 2013-01-11. PMID:22808991. |
isoproterenol (5 mg·(kg body weight)(-1)) was injected subcutaneously once daily for 14 days to induced cardiac hypertrophy. |
2013-01-11 |
2023-08-12 |
rat |
| Marco Fabricio Dias-Peixoto, Anderson J Ferreira, Pedro W M Almeida, Vinícius B A Braga, Danielle C O Coutinho, Dirceu S Melo, Ary Gomes Filho, Marcos B Melo, Leonardo Greco, Maria José Campagnole-Santos, Ricardo F Lima, Robson A S Santos, Silvia Guatimosi. The cardiac expression of Mas receptor is responsive to different physiological and pathological stimuli. Peptides. vol 35. issue 2. 2012-11-19. PMID:22504011. |
on the other hand, cardiac hypertrophy and damage elicited by isoproterenol treatment led to a reduction in mas expression. |
2012-11-19 |
2023-08-12 |
rat |
| Catherine L Passariello, Davide Gottardi, Silvia Cetrullo, Maddalena Zini, Gabriele Campana, Benedetta Tantini, Carla Pignatti, Flavio Flamigni, Carlo Guarnieri, Claudio M Caldarera, Claudio Stefanell. Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts. Biochimica et biophysica acta. vol 1823. issue 4. 2012-11-09. PMID:22230191. |
the responses of amp-activated protein kinase (ampk) and ornithine decarboxylase (odc) to isoproterenol have been examined in h9c2 cardiomyoblasts, ampk represents the link between cell growth and energy availability whereas odc, the key enzyme in polyamine biosynthesis, is essential for all growth processes and it is thought to have a role in the development of cardiac hypertrophy. |
2012-11-09 |
2023-08-12 |
Not clear |
| Daisuke Takeshita, Chikako Nakajima-Takenaka, Juichiro Shimizu, Hiroshi Hattori, Tamiji Nakashima, Akio Kikuta, Hiroko Matsuyoshi, Miyako Takak. Effects of formaldehyde on cardiovascular system in in situ rat hearts. Basic & clinical pharmacology & toxicology. vol 105. issue 4. 2012-11-01. PMID:19558560. |
the aim of the present study was to examine the effects of formaldehyde solution on rat left ventricular function and compare it with those in hypertrophic hearts treated with isoproterenol by pressure-volume measurements with the catheter method. |
2012-11-01 |
2023-08-12 |
rat |
| Julie A Wolfram, Anna Liner, Sandy L Richardson, Xiongwei Zhu, Mark A Smith, Brian D Hoit, Hyoung-Gon Le. The role of E2F1 in the development of hypertrophic cardiomyopathy. International journal of clinical and experimental pathology. vol 4. issue 5. 2012-10-31. PMID:21738823. |
accordingly, we tested the hypothesis that blocking the e2f1-mediated signal transduction pathway prevents cardiac hypertrophy by treating e2f1 knockout mice (e2f1-/-) with either isoproterenol (iso) or angiotensin ii (ang). |
2012-10-31 |
2023-08-12 |
mouse |
| Thomas J Larocca, Dongtak Jeong, Erik Kohlbrenner, Ahyoung Lee, Jiqiu Chen, Roger J Hajjar, Sima T Tarzam. CXCR4 gene transfer prevents pressure overload induced heart failure. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22668785. |
in isolated adult rat cardiac myocytes, cxcl12 treatment prevented isoproterenol induced hypertrophy and interrupted the calcineurin/nfat pathway. |
2012-10-31 |
2023-08-12 |
mouse |
| Rashmi Choudhary, K P Mishra, C Subramanya. Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant. Indian journal of clinical biochemistry : IJCB. vol 21. issue 2. 2012-10-30. PMID:23105625. |
intraperitoneal administration of isoproterenol (1 mg/kg body wt/day for 10 days) induced cardiac hypertrophy with increased heart weight and enhanced apoptosis of myocytes concomitant with accumulation of reactive oxygen species, decreased glutathione contents, increased activities of calcineurin and protein kinase c in ventricular tissue. |
2012-10-30 |
2023-08-12 |
rat |
| Rashmi Choudhary, K P Mishra, C Subramanya. Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant. Indian journal of clinical biochemistry : IJCB. vol 21. issue 2. 2012-10-30. PMID:23105625. |
administering eugenol for 3 days (1 mg/kg body wt/twice a day), followed by combined administration of isoproterenol and eugenol resulted in significant reversal of cardiac hypertrophy and restoration of above changes. |
2012-10-30 |
2023-08-12 |
rat |
| Christopher D Haines, Pamela A Harvey, Leslie A Leinwan. Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22759381. |
when challenged with the pathological stimulus, isoproterenol, arko females developed 2-fold more hypertrophy than wild-type females. |
2012-10-29 |
2023-08-12 |
mouse |
| Adila Parveen, Rashmi Babbar, Sarita Agarwal, Anita Kotwani, Mohammad Fahi. Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenol-induced chronic heart failure rats. Journal of cardiovascular pharmacology and therapeutics. vol 17. issue 2. 2012-10-09. PMID:21828283. |
fifteen days after isoproterenol administration, rats exhibited cardiac dysfunction, hypertrophy, and lv remodeling along with reduced baroreflex sensitivity. |
2012-10-09 |
2023-08-12 |
rat |
| Miyako Takak. Cardiac mechanoenergetics for understanding isoproterenol-induced rat heart failure. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 19. issue 3. 2012-10-02. PMID:22687629. |
the left ventricle (lv) function in rat cardiac hypertrophy models treated with isoproterenol (iso) up to 16 weeks was followed up with a non-invasive echocardiography. |
2012-10-02 |
2023-08-12 |
rat |
| You-mei Zuo, Xing-hui Wang, Shan Gao, Ye Zhan. Oligomerized grape seed proanthocyanidins ameliorates isoproterenol-induced cardiac remodeling in rats: role of oxidative stress. Phytotherapy research : PTR. vol 25. issue 5. 2012-09-12. PMID:21077263. |
the effects of oligomerized grape seed proanthocyanidins (gsp) on haemodynamics, cardiac hypertrophy and fibrosis as well as apoptosis signal-regulating kinase 1 (ask1) and nuclear factor-κb (nf-κb) cascades in isoproterenol (iso)-induced cardiac remodelling (cr) rat model were investigated, in addition, the serum sod activities and mda content were assayed. |
2012-09-12 |
2023-08-12 |
rat |
| Thomas G von Lueder, Jørgen Gravning, Ole-Jakob How, Leif E Vinge, Mohammed Shakil Ahmed, Kurt A Krobert, Finn Olav Levy, Terje S Larsen, Otto A Smiseth, Ellen Aasum, Håvard Attramada. Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American journal of physiology. Heart and circulatory physiology. vol 303. issue 1. 2012-09-04. PMID:22542621. |
increased cardiac mass and myocardial mrna expression of β-myosin heavy chain confirmed the similar induction of cardiac hypertrophy in both ab groups, but only nlc-ab hearts displayed significantly elevated mrna levels of brain natriuretic peptide and myocardial collagen contents as well as reduced β(1)-adrenergic receptor responsiveness to isoproterenol, indicating increased lv wall stress and the transition to hf. |
2012-09-04 |
2023-08-12 |
mouse |
| Feng Yin, Yun Zhu, Ping Li, Qi-De Han, You-Yi Zhan. [Isoproterenol-induced activation of MAPK, NFkappaB and JAK/STAT pathway in mouse myocardium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 4. 2012-08-16. PMID:12937826. |
this study was aimed to determine the in vivo signal transduction pathway responsible for isoproterenol (iso)-induced cardiac hypertrophy or remodeling. |
2012-08-16 |
2023-08-12 |
mouse |
| Melissa F Jackson, Dung Luong, Dor Dor Vang, Dilip K Garikipati, James B Stanton, O Lynne Nelson, Buel D Rodger. The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphism. The Journal of endocrinology. vol 213. issue 3. 2012-08-09. PMID:22431133. |
however, mstn-/- mice responded better to isoproterenol stress tests with greater increases in fractional shortening and ejection fraction-differences that were again more apparent in females and which are consistent with physiological cardiac hypertrophy. |
2012-08-09 |
2023-08-12 |
mouse |
| b' Bo Lu, Hongjuan Yu, Maarten Zwartbol, Willem P Ruifrok, Wiek H van Gilst, Rudolf A de Boer, Herman H W Sillj\\xc3\\xa. Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models. Physiological genomics. vol 44. issue 8. 2012-08-02. PMID:22353257.' |
hypertensive ren2 rats and animals with postmyocardial infarction (post-mi) hf were used as in vivo hf models, and neonatal rat cardiomyocytes treated with hypertrophy inducing hormones phenylephrine, endothelin-1, and isoproterenol were used as in vitro models. |
2012-08-02 |
2023-08-12 |
rat |
| Emanuele Giordano, Rebecca A Hillary, Thomas C Vary, Anthony E Pegg, Andrew D Sumner, Claudio M Caldarera, Xue-Qian Zhang, Jianliang Song, JuFang Wang, Joseph Y Cheung, Lisa M Shant. Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21814794. |
transgenic mice overexpressing odc in the heart (mhc-odc mice) experience a much more dramatic left ventricular hypertrophy in response to β-adrenergic stimulation with isoproterenol (iso) compared to wild-type (wt) controls. |
2012-05-31 |
2023-08-12 |
mouse |