| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lili Wu, Bo Yang, Yingze Sun, Guanwei Fan, Lina Ma, Ying Ma, Xianjia Xiong, Hui Zhou, Huiping Wang, Ling Zhang, Bing Yan. Isoprenaline Inhibits Histone Demethylase LSD1 to Induce Cardiac Hypertrophy. Cardiovascular toxicology. 2024-11-09. PMID:39521734. |
isoprenaline inhibits histone demethylase lsd1 to induce cardiac hypertrophy. |
2024-11-09 |
2024-11-17 |
rat |
| Lili Wu, Bo Yang, Yingze Sun, Guanwei Fan, Lina Ma, Ying Ma, Xianjia Xiong, Hui Zhou, Huiping Wang, Ling Zhang, Bing Yan. Isoprenaline Inhibits Histone Demethylase LSD1 to Induce Cardiac Hypertrophy. Cardiovascular toxicology. 2024-11-09. PMID:39521734. |
both isoprenaline (iso)-treated and transverse aortic constriction (tac)-treated rats developed hypertrophic hearts. |
2024-11-09 |
2024-11-17 |
rat |
| Yaxin Zhi, Yanru Duan, Ying Zhang, Haijuan Hu, Fengli Hu, Pengfei Wang, Bin Liu, Chuan Wang, Demin Liu, Guoqiang G. miR-421-Mediated Suppression of FGF13 as a Novel Mechanism Ameliorating Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress. European journal of pharmacology. 2024-11-01. PMID:39486770. |
firstly, we observed an increase in fgf13 expression levels in human hypertrophic myocardium tissues, as well as in mouse models of tac-induced hypertrophy and in neonatal rat cardiomyocyte (nrcm) models induced by isoproterenol (iso). |
2024-11-01 |
2024-11-05 |
mouse |
| Fatmah R Alsereidi, Zenith Khashim, Hezlin Marzook, Ahmed M Al-Rawi, Tiana Salomon, Mahra K Almansoori, Moustafa M Madkour, Ahmed Mohamed Hamam, Mahmoud M Ramadan, Quinn P Peterson, Mohamed A Sale. Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells. Cardiovascular diabetology. vol 23. issue 1. 2024-10-30. PMID:39472869. |
our results demonstrate that dapa effectively attenuates isoproterenol (iso)-induced hypertrophy in cardiomyocytes, reducing cell size and improving cellular structure. |
2024-10-30 |
2024-11-02 |
Not clear |
| Jung-Joo Yoon, Ai-Lin Tai, Hye-Yoom Kim, Byung-Hyuk Han, Sarah Shin, Ho-Sub Lee, Dae-Gill Kan. TongGuanWan Alleviates Doxorubicin- and Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis by Modulating Apoptotic and Fibrotic Pathways. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408900. |
doxorubicin (dox), a common chemotherapy drug, and isoproterenol (iso), a β-adrenergic agonist, both induce cardiac hypertrophy through different mechanisms. |
2024-10-16 |
2024-10-18 |
mouse |
| Xiaohua Guo, Pengfei Wang, Huiqing Wei, Jie Yan, Donglei Zhang, Yuxing Qian, Bingyan Gu. Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress. International immunopharmacology. vol 142. issue Pt B. 2024-09-18. PMID:39293311. |
interleukin(il)-37 attenuates isoproterenol (iso)-induced cardiac hypertrophy by suppressing jak2/stat3-signaling associated inflammation and oxidative stress. |
2024-09-18 |
2024-09-21 |
Not clear |
| Steeve Akumwami, Asadur Rahman, Masafumi Funamoto, Akram Hossain, Asahiro Morishita, Yasumasa Ikeda, Hiroaki Kitamura, Kento Kitada, Takahisa Noma, Yuichi Ogino, Akira Nishiyam. Effects of D-Allose on experimental cardiac hypertrophy. Journal of pharmacological sciences. vol 156. issue 2. 2024-08-23. PMID:39179333. |
furthermore, in mice subjected to a 14-day continuous infusion of isoproterenol (iso) to induce cardiac hypertrophy, d-allose treatment via drinking water notably reduced iso-induced cardiac hypertrophy and remodelling markers, with minimal effects on ventricular wall thickness observed in echocardiographic analyses. |
2024-08-23 |
2024-08-27 |
mouse |
| Shaolin Gong, Yuan Sui, Mengxuan Xiao, Daoyao Fu, Zhiping Xiong, Liuping Zhang, Qingshan Tian, Yongnan Fu, Wenjun Xion. Canagliflozin mediates mitophagy through the AMPK/PINK1/PARKIN pathway to alleviate isoprenaline-induced cardiac remodelling. Journal of cardiovascular pharmacology. 2024-08-16. PMID:39150485. |
our results indicate that the administration of canagliflozin significantly attenuates myocardial hypertrophy and fibrosis and enhances cardiac ejection function in mice with isoprenaline (iso)-induced cardiac remodeling. |
2024-08-16 |
2024-08-18 |
mouse |
| Cong-Ting Guo, Blake D Jardin, Jun-Sen Lin, Rachelle L Ambroise, Ze Wang, Lu-Zi Yang, Neil Mazumdar, Fu-Jian Lu, Qing Ma, Yang-Po Cao, Can-Zhao Liu, Kai-Long Li, Xu-Jie Liu, Feng Lan, Ming-Ming Zhao, Han Xiao, Er-Dan Dong, William T Pu, Yu-Xuan Gu. In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury. Acta pharmacologica Sinica. 2024-07-23. PMID:39043970. |
germline and cardiomyocyte-specific palmd knockout mice were grossly normal at baseline but exhibited compromised cardiac hypertrophy and aggravated cardiac injury upon long-term isoproterenol treatment. |
2024-07-23 |
2024-07-26 |
mouse |
| Patricia Perez-Bonilla, Brianna LaViolette, Bidur Bhandary, Soumya Ullas, Xian Chen, Dinesh Hirenallur-Shanthapp. Isoproterenol induced cardiac hypertrophy: A comparison of three doses and two delivery methods in C57BL/6J mice. PloS one. vol 19. issue 7. 2024-07-22. PMID:39038017. |
isoproterenol induced cardiac hypertrophy: a comparison of three doses and two delivery methods in c57bl/6j mice. |
2024-07-22 |
2024-07-25 |
mouse |
| Jerome Ndudi Asiwe, Abayomi M Ajayi, Benneth Ben-Azu, Adesoji Adedipe Fasanmad. Vincristine attenuates isoprenaline-induced cardiac hypertrophy in male Wistar rats via suppression of ROS/NO/NF-қB signalling pathways. Microvascular research. 2024-06-16. PMID:38880384. |
this study investigated the effects of vcr on isoprenaline (iso), a beta-adrenergic receptor agonist, induced cardiac hypertrophy in male wistar rats. |
2024-06-16 |
2024-06-19 |
rat |
| Zhong-Yan Zhou, Jie Ma, Wai-Rong Zhao, Wen-Ting Shi, Jing Zhang, Yan-Yan Hu, Mei-Yan Yue, Wen-Long Zhou, Hua Yan, Jing-Yi Tang, Yu Wan. Qiangxinyin formula protects against isoproterenol-induced cardiac hypertrophy. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 130. 2024-06-14. PMID:38810550. |
we found that qxy significantly protected against isoproterenol (iso)-induced cardiac hypertrophy and dysfunction in zebrafish. |
2024-06-14 |
2024-06-17 |
zebrafish |
| Yumei Qiu, Mengdie Xie, Xiaoyun Ding, Hao Zhang, Hongming Li, Hu Wang, Tingting Li, Wei Dong, Fangqin Jiang, Xilan Tan. Inhibition of Cholesteryl Ester Transfer Protein Contributes to the Protection of Ginsenoside Re Against Isoproterenol-Induced Cardiac Hypertrophy. Cureus. vol 16. issue 5. 2024-06-10. PMID:38854305. |
this study aimed to investigate the therapeutic effects and underlying mechanism of re on isoproterenol (iso)-induced cardiac hypertrophy |
2024-06-10 |
2024-06-14 |
Not clear |
| Steeve Akumwami, Kento Kitada, Yoshihide Fujisawa, Netish Kumar Kundo, Md Moshiur Rahman, Asahiro Morishita, Hiroaki Kitamura, Asadur Rahman, Yuichi Ogino, Akira Nishiyam. The Journal of pharmacology and experimental therapeutics. 2024-06-07. PMID:38849140. |
continuous isoproterenol administration for 14 days induced cardiac hypertrophy, associated with sodium-driven water retention in the heart, increased the total body sodium, potassium and water contents at the tissue level, and increased the water intake and blood pressure of the mice. |
2024-06-07 |
2024-06-10 |
mouse |
| Vaishnavi Golatkar, Lokesh Kumar Bhat. Artesunate attenuates isoprenaline induced cardiac hypertrophy in rats via SIRT1 inhibiting NF-κB activation. European journal of pharmacology. 2024-06-06. PMID:38843948. |
artesunate attenuates isoprenaline induced cardiac hypertrophy in rats via sirt1 inhibiting nf-κb activation. |
2024-06-06 |
2024-06-10 |
rat |
| Vaishnavi Golatkar, Lokesh Kumar Bhat. Artesunate attenuates isoprenaline induced cardiac hypertrophy in rats via SIRT1 inhibiting NF-κB activation. European journal of pharmacology. 2024-06-06. PMID:38843948. |
the present study aimed to investigate the effect of artesunate against isoprenaline induced cardiac hypertrophy in rats via sirt1 inhibiting nf-κb activation. |
2024-06-06 |
2024-06-10 |
rat |
| Vaishnavi Golatkar, Lokesh Kumar Bhat. Artesunate attenuates isoprenaline induced cardiac hypertrophy in rats via SIRT1 inhibiting NF-κB activation. European journal of pharmacology. 2024-06-06. PMID:38843948. |
experimental cardiac hypertrophy was induced in rats by subcutaneous administration of isoprenaline (5 mg/kg) for 14 days. |
2024-06-06 |
2024-06-10 |
rat |
| Ramison Santos, Patrick Turck, Victor de Mello Palma, Fernanda Visioli, Vanessa Duarte Ortiz, Isabel Cristina Teixeira Proença, Tânia Regina G Fernandes, Elissa Fernandes, Silvio Tasca, Cristina Campos Carraro, Adriane Belló-Klein, Alex Sander da Rosa Araujo, Neelam Khaper, Alexandre Luz de Castr. MELATONIN IMPROVES NITRIC OXIDE BIOAVAILABILITY IN ISOPROTERENOL INDUCED MYOCARDIAL INJURY. Molecular and cellular endocrinology. 2024-05-26. PMID:38797355. |
animals that received isoproterenol demonstrated a reduction in left ventricle systolic and diastolic diameter, indicating the presence of concentric hypertrophy. |
2024-05-26 |
2024-05-31 |
rat |
| Ubaid Tariq, Soumalya Sarkar, Navya Malladi, Roshan Kumar, Paramesha Bugga, Praloy Chakraborty, Sanjay K Banerje. Knockdown of SCN5A alters metabolic-associated genes and aggravates hypertrophy in the cardiomyoblast. Molecular biology reports. vol 51. issue 1. 2024-05-17. PMID:38758505. |
therefore, to understand the loss of scn5a function in cardiomyocytes, we have knocked down the scn5a gene (scn5a-kd) in h9c2 cells and explored the cell phenotype and molecular behaviors in the presence and absence of isoproterenol (iso), an adrenergic receptor agonist that induces cardiac hypertrophy. |
2024-05-17 |
2024-05-27 |
Not clear |
| Siling Liu, Linjie Su, Jie Li, Yuexin Zhang, Xiaopei Hu, Pengcheng Wang, Peiqing Liu, Jiantao Y. Inhibition of miR-146b-5p alleviates isoprenaline-induced cardiac hypertrophy via regulating DFCP1. Molecular and cellular endocrinology. 2024-04-22. PMID:38649132. |
isoprenaline (iso) treatment induced significant hypertrophy and markedly enhanced the expression of mir-146b-5p in cultured neonatal rat cardiomyocytes and hearts of c57bl/6 mice. |
2024-04-22 |
2024-04-26 |
mouse |