| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Tommaso Angelone, Carmine Rocc. The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure. Journal of translational medicine. vol 22. issue 1. 2024-04-20. PMID:38643121. |
here, we investigated the role of selenot in the pathophysiology of hf: (i) by designing a small peptide (pselt), recapitulating selenot activity via the redox site, and assessed its beneficial action in a preclinical model of hf [aged spontaneously hypertensive heart failure (shhf) rats] and against isoproterenol (iso)-induced hypertrophy in rat ventricular h9c2 and adult human ac16 cardiomyocytes; (ii) by evaluating the selenot intra-cardiomyocyte production and secretion under hypertrophied stimulation. |
2024-04-20 |
2024-04-23 |
human |
| Xiao-Yun Ding, Hao Zhang, Yu-Mei Qiu, Meng-Die Xie, Hu Wang, Zheng-Yu Xiong, Ting-Ting Li, Chun-Ni He, Wei Dong, Xi-Lan Tan. Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits. Current medical science. 2024-04-19. PMID:38639827. |
in this study, we investigated the cardioprotective effects and mechanisms of the essential oil, the main active ingredient of cymbopogon citratus, on isoproterenol (iso)-induced cardiomyocyte hypertrophy. |
2024-04-19 |
2024-04-21 |
Not clear |
| Hui Fu, Bin Kong, Wei Shuai, Jun Zhu, Xi Wang, Yanhong Tang, He Huang, Congxin Huan. Leukocyte Ig-like receptor B4 (Lilrb4a) alleviates cardiac dysfunction and isoproterenol-induced arrhythmogenic remodeling associated with cardiac fibrosis and inflammation. Heart rhythm. 2024-04-18. PMID:38636927. |
in the isoproterenol (iso) induced animal model, it is often accompanied by myocardial hypertrophy, fibrosis, and inflammation. |
2024-04-18 |
2024-04-21 |
mouse |
| Kai He, Xiaoying Wang, Tingting Li, Yanfei Li, Linlin M. Chlorogenic Acid Attenuates Isoproterenol Hydrochloride-Induced Cardiac Hypertrophy in AC16 Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398512. |
chlorogenic acid attenuates isoproterenol hydrochloride-induced cardiac hypertrophy in ac16 cells by inhibiting the wnt/β-catenin signaling pathway. |
2024-02-24 |
2024-02-26 |
Not clear |
| Zhuo-Jing Yang, Chun-Ling Guo, Yu-Xin Gong, Long Li, Li-Li Wang, Hui-Min Liu, Ji-Min Cao, Zhao-Yang L. Dapagliflozin Suppresses Isoprenaline-Induced Cardiac Hypertrophy via Inhibition of Mitochondrial Fission. Journal of cardiovascular pharmacology. 2024-02-06. PMID:38030139. |
by continuously infusing isoprenaline (iso) for two weeks using a subcutaneous osmotic pump, a cardiac hypertrophic model was established in male c57bl/6 mice. |
2024-02-06 |
2024-02-09 |
mouse |
| Jacob J Russell, Srinivas Mummidi, Vincent G Demarco, Laurel A Grisanti, Chastidy A Bailey, Shawn B Bender, Bysani Chandraseka. Integrated miRNA-mRNA networks underlie attenuation of chronic β-adrenergic stimulation-induced cardiac remodeling by minocycline. Physiological genomics. 2024-02-05. PMID:38314697. |
isoproterenol infusion induced cardiac hypertrophy, with no change in cardiac function, that was prevented by minocycline. |
2024-02-05 |
2024-02-09 |
mouse |
| Zeyu Li, Ou Hu, Suowen Xu, Chenjia Lin, Wenjing Yu, Dinghu Ma, Jing Lu, Peiqing Li. The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy. International journal of biological sciences. vol 20. issue 3. 2024-01-22. PMID:38250153. |
atad3a prevents isoproterenol (iso)-induced mitochondrial calcium accumulation, improving mitochondrial dysfunction and er stress, which preserves cardiac function and attenuates cardiac hypertrophy. |
2024-01-22 |
2024-01-24 |
Not clear |
| Jiachen Xu, Shiqi Liang, Qinyan Wang, Qingsong Zheng, Mengyang Wang, Jinfu Qian, Tianxiang Yu, Shuaijie Lou, Wu Luo, Hao Zhou, Guang Lian. JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-10. PMID:38195959. |
in this study, we demonstrated that deficiency of a deubiquitinase, josephin domain-containing protein 2 (josd2), ameliorated isoprenaline (iso)- and myocardial infarction (mi)-induced cardiac hypertrophy, fibrosis, and dysfunction both in vitro and in vivo. |
2024-01-10 |
2024-01-13 |
Not clear |
| Li Xianchao, Yang Wu, Yunzhao Yang, Yaohua Wu, Xi Yu, Wenjuan H. Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice. Free radical research. 2023-12-25. PMID:38145457. |
in this study, an isoproterenol (iso)-induced pathological cardiac hypertrophy model was established to investigate the protective effect of omaveloxolone in vivo and in vitro. |
2023-12-25 |
2023-12-27 |
mouse |
| Chan-Ok Son, Mi-Hyeon Hong, Hye-Yoom Kim, Byung-Hyuk Han, Chang-Seob Seo, Ho-Sub Lee, Jung-Joo Yoon, Dae-Gill Kan. Sibjotang Protects against Cardiac Hypertrophy In Vitro and In Vivo. Life (Basel, Switzerland). vol 13. issue 12. 2023-12-23. PMID:38137908. |
in vitro, h9c2 cells were induced by dox (1 μm) in the presence or absence of sjt (1-5 μg/ml) and incubated for 24 h. in vivo, sjt was administrated to isoproterenol (iso)-induced cardiac hypertrophy mice ( |
2023-12-23 |
2023-12-25 |
mouse |
| Yu Sun, Jin Dong, Xiaohong Chai, Jingping Wang, Bao Li, Jinjing Yan. Semaphorin‑3A alleviates cardiac hypertrophy by regulating autophagy. Experimental and therapeutic medicine. vol 27. issue 1. 2023-12-21. PMID:38125367. |
the present study evaluated the role of semaphorin-3a (sema3a), a neurochemical inhibitor, in cardiac hypertrophy, utilizing an isoproterenol (iso) induced h9c2 cell model. |
2023-12-21 |
2023-12-23 |
Not clear |
| Huiling Luan, Zhenhui Wang, Zhenzhen Zhang, Baohua Hou, Zhenzhen Liu, Lanping Yang, Mengmeng Yang, Yile Ma, Baobao Zhan. Brassica oleracea L. extract ameliorates isoproterenol- induced myocardial injury by regulating HIF-1α-mediated glycolysis. Fitoterapia. 2023-10-31. PMID:37907131. |
the effects of boe on myocardial cells were evaluated using isoproterenol (iso)-treated h9c2 cells and wistar rats, and the results revealed that boe could inhibit cardiomyocyte hypertrophy and reduce the levels of b-type natriuretic peptide, nitric oxide, reactive oxygen species, lactic acid, and pyruvic acid. |
2023-10-31 |
2023-11-08 |
rat |
| Wenqi Li, Yuzhong Zhu, Wenjing Wang, Dan He, Lei Feng, Zijian L. Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation. Bioscience reports. 2023-08-31. PMID:37650260. |
our findings demonstrated that src mediates isoproterenol (iso)-induced cardiac hypertrophy, fibrosis, and inflammation in vivo. |
2023-08-31 |
2023-09-07 |
Not clear |
| Samantha Morón-Ros, Albert Blasco-Roset, Artur Navarro-Gascon, Celia Rupérez, Monica Zamora, Fatima Crispi, Iker Uriarte, Maite G Fernández-Barrena, Matias Avila, Gemma Ferrer-Curriu, Josep Lupón, Antoni Bayés-Genis, Francesc Villarroya, Aleix Gavaldà-Navarro, Anna Planavil. A new FGF15/19-mediated gut-to-heart axis controls cardiac hypertrophy. The Journal of pathology. 2023-08-31. PMID:37650293. |
we found that mice lacking fgf15 did not develop cardiac hypertrophy in response to three different pathophysiological stimuli (high-fat diet, isoproterenol, or cold exposure). |
2023-08-31 |
2023-09-07 |
mouse |
| Meifang Chen, Liming Peng, Chenglong Zhang, Qiong Liu, Tianyi Long, Qiying Xi. Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice. Journal of physiology and biochemistry. 2023-08-03. PMID:37537429. |
the mice model of isoproterenol (iso)-induced cardiac hypertrophy was constructed and verified for physiological, functional, and fibrotic alterations in this study. |
2023-08-03 |
2023-08-14 |
mouse |
| Dingyan Zhou, Weizhe Liu, Juanjuan Zhang, Yucui Dong, Jiangli Wu, Yu Zhang, Cheng Dai, Tingting Zhang, Gaoshan Yang, Yue Zhang, Aiying L. Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4. Cell death discovery. vol 9. issue 1. 2023-08-01. PMID:37528096. |
in this study, the mouse model of cardiac hypertrophy was established by isoprenaline (iso) induction with or without bel treatment. |
2023-08-01 |
2023-08-14 |
mouse |
| Zhao Fang, Shuang Li, Feierkaiti Yushanjiang, Gaoke Feng, Shengyu Cui, Shan Hu, Xuejun Jiang, Chengyin Li. Curcumol alleviates cardiac remodeling via the AKT/NF-κB pathway. International immunopharmacology. vol 122. 2023-07-01. PMID:37392572. |
curcumol significantly attenuated cardiac dysfunction, myocardial fibrosis, and hypertrophy in the animal model of isoproterenol (iso)-induced cardiac remodeling. |
2023-07-01 |
2023-08-14 |
mouse |
| Peilei Lu, Danyu Zhang, Fan Ding, Jialu Ma, Yang K Xiang, Meimi Zha. Silencing of circCacna1c Inhibits ISO-Induced Cardiac Hypertrophy through miR-29b-2-5p/NFATc1 Axis. Cells. vol 12. issue 12. 2023-06-28. PMID:37371137. |
adult male c57bl/6 mice and h9c2 cells were treated with isoprenaline hydrochloride (iso) to establish a hypertrophy model. |
2023-06-28 |
2023-08-14 |
mouse |
| Andrea Ruiz-Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser Hawimel O Alatawi, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Xiangjun Zhao, Oveena Fonseka, Xin Wang, Susanne S Hille, Norbert Frey, Tao Wang, Tamer M A Mohamed, Oliver J Müller, Elizabeth J Cartwright, Wei Li. Restored autophagy is protective against PAK3-induced cardiac dysfunction. iScience. vol 26. issue 6. 2023-06-16. PMID:37324527. |
myocardium with pak3 overexpression displayed hypertrophic growth, excessive fibrosis, and aggravated apoptosis following isoprenaline stimulation as early as two days. |
2023-06-16 |
2023-08-14 |
mouse |
| Lintong Men, Junyi Guo, Yu Cao, Bingyu Huang, Qian Wang, Shengqi Huo, Moran Wang, Dewei Peng, Lulu Peng, Wei Shi, Sheng Li, Li Lin, Jiagao L. IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. Free radical biology & medicine. 2023-06-12. PMID:37307935. |
bazedoxifene (5mg/kg/day by oral gavage once a day) exhibited similar effect as carvedilol (10mg/kg/day by oral gavage once a day) on attenuating chronic isoproterenol (30mg/kg by abdominal injection once a day, 7 days) induced cardiac systolic dysfunction, cardiac hypertrophy and fibrosis in c57bl/6 mice. |
2023-06-12 |
2023-08-14 |
mouse |