| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeyu Li, Ou Hu, Suowen Xu, Chenjia Lin, Wenjing Yu, Dinghu Ma, Jing Lu, Peiqing Li. The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy. International journal of biological sciences. vol 20. issue 3. 2024-01-22. PMID:38250153. |
atad3a prevents isoproterenol (iso)-induced mitochondrial calcium accumulation, improving mitochondrial dysfunction and er stress, which preserves cardiac function and attenuates cardiac hypertrophy. |
2024-01-22 |
2024-01-24 |
Not clear |
| Jiachen Xu, Shiqi Liang, Qinyan Wang, Qingsong Zheng, Mengyang Wang, Jinfu Qian, Tianxiang Yu, Shuaijie Lou, Wu Luo, Hao Zhou, Guang Lian. JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-10. PMID:38195959. |
in this study, we demonstrated that deficiency of a deubiquitinase, josephin domain-containing protein 2 (josd2), ameliorated isoprenaline (iso)- and myocardial infarction (mi)-induced cardiac hypertrophy, fibrosis, and dysfunction both in vitro and in vivo. |
2024-01-10 |
2024-01-13 |
Not clear |
| Li Xianchao, Yang Wu, Yunzhao Yang, Yaohua Wu, Xi Yu, Wenjuan H. Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice. Free radical research. 2023-12-25. PMID:38145457. |
in this study, an isoproterenol (iso)-induced pathological cardiac hypertrophy model was established to investigate the protective effect of omaveloxolone in vivo and in vitro. |
2023-12-25 |
2023-12-27 |
mouse |
| Chan-Ok Son, Mi-Hyeon Hong, Hye-Yoom Kim, Byung-Hyuk Han, Chang-Seob Seo, Ho-Sub Lee, Jung-Joo Yoon, Dae-Gill Kan. Sibjotang Protects against Cardiac Hypertrophy In Vitro and In Vivo. Life (Basel, Switzerland). vol 13. issue 12. 2023-12-23. PMID:38137908. |
in vitro, h9c2 cells were induced by dox (1 μm) in the presence or absence of sjt (1-5 μg/ml) and incubated for 24 h. in vivo, sjt was administrated to isoproterenol (iso)-induced cardiac hypertrophy mice ( |
2023-12-23 |
2023-12-25 |
mouse |
| Yu Sun, Jin Dong, Xiaohong Chai, Jingping Wang, Bao Li, Jinjing Yan. Semaphorin‑3A alleviates cardiac hypertrophy by regulating autophagy. Experimental and therapeutic medicine. vol 27. issue 1. 2023-12-21. PMID:38125367. |
the present study evaluated the role of semaphorin-3a (sema3a), a neurochemical inhibitor, in cardiac hypertrophy, utilizing an isoproterenol (iso) induced h9c2 cell model. |
2023-12-21 |
2023-12-23 |
Not clear |
| Huiling Luan, Zhenhui Wang, Zhenzhen Zhang, Baohua Hou, Zhenzhen Liu, Lanping Yang, Mengmeng Yang, Yile Ma, Baobao Zhan. Brassica oleracea L. extract ameliorates isoproterenol- induced myocardial injury by regulating HIF-1α-mediated glycolysis. Fitoterapia. 2023-10-31. PMID:37907131. |
the effects of boe on myocardial cells were evaluated using isoproterenol (iso)-treated h9c2 cells and wistar rats, and the results revealed that boe could inhibit cardiomyocyte hypertrophy and reduce the levels of b-type natriuretic peptide, nitric oxide, reactive oxygen species, lactic acid, and pyruvic acid. |
2023-10-31 |
2023-11-08 |
rat |
| Wenqi Li, Yuzhong Zhu, Wenjing Wang, Dan He, Lei Feng, Zijian L. Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation. Bioscience reports. 2023-08-31. PMID:37650260. |
our findings demonstrated that src mediates isoproterenol (iso)-induced cardiac hypertrophy, fibrosis, and inflammation in vivo. |
2023-08-31 |
2023-09-07 |
Not clear |
| Samantha Morón-Ros, Albert Blasco-Roset, Artur Navarro-Gascon, Celia Rupérez, Monica Zamora, Fatima Crispi, Iker Uriarte, Maite G Fernández-Barrena, Matias Avila, Gemma Ferrer-Curriu, Josep Lupón, Antoni Bayés-Genis, Francesc Villarroya, Aleix Gavaldà-Navarro, Anna Planavil. A new FGF15/19-mediated gut-to-heart axis controls cardiac hypertrophy. The Journal of pathology. 2023-08-31. PMID:37650293. |
we found that mice lacking fgf15 did not develop cardiac hypertrophy in response to three different pathophysiological stimuli (high-fat diet, isoproterenol, or cold exposure). |
2023-08-31 |
2023-09-07 |
mouse |
| Meifang Chen, Liming Peng, Chenglong Zhang, Qiong Liu, Tianyi Long, Qiying Xi. Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice. Journal of physiology and biochemistry. 2023-08-03. PMID:37537429. |
the mice model of isoproterenol (iso)-induced cardiac hypertrophy was constructed and verified for physiological, functional, and fibrotic alterations in this study. |
2023-08-03 |
2023-08-14 |
mouse |
| Dingyan Zhou, Weizhe Liu, Juanjuan Zhang, Yucui Dong, Jiangli Wu, Yu Zhang, Cheng Dai, Tingting Zhang, Gaoshan Yang, Yue Zhang, Aiying L. Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4. Cell death discovery. vol 9. issue 1. 2023-08-01. PMID:37528096. |
in this study, the mouse model of cardiac hypertrophy was established by isoprenaline (iso) induction with or without bel treatment. |
2023-08-01 |
2023-08-14 |
mouse |
| Zhao Fang, Shuang Li, Feierkaiti Yushanjiang, Gaoke Feng, Shengyu Cui, Shan Hu, Xuejun Jiang, Chengyin Li. Curcumol alleviates cardiac remodeling via the AKT/NF-κB pathway. International immunopharmacology. vol 122. 2023-07-01. PMID:37392572. |
curcumol significantly attenuated cardiac dysfunction, myocardial fibrosis, and hypertrophy in the animal model of isoproterenol (iso)-induced cardiac remodeling. |
2023-07-01 |
2023-08-14 |
mouse |
| Peilei Lu, Danyu Zhang, Fan Ding, Jialu Ma, Yang K Xiang, Meimi Zha. Silencing of circCacna1c Inhibits ISO-Induced Cardiac Hypertrophy through miR-29b-2-5p/NFATc1 Axis. Cells. vol 12. issue 12. 2023-06-28. PMID:37371137. |
adult male c57bl/6 mice and h9c2 cells were treated with isoprenaline hydrochloride (iso) to establish a hypertrophy model. |
2023-06-28 |
2023-08-14 |
mouse |
| Andrea Ruiz-Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser Hawimel O Alatawi, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Xiangjun Zhao, Oveena Fonseka, Xin Wang, Susanne S Hille, Norbert Frey, Tao Wang, Tamer M A Mohamed, Oliver J Müller, Elizabeth J Cartwright, Wei Li. Restored autophagy is protective against PAK3-induced cardiac dysfunction. iScience. vol 26. issue 6. 2023-06-16. PMID:37324527. |
myocardium with pak3 overexpression displayed hypertrophic growth, excessive fibrosis, and aggravated apoptosis following isoprenaline stimulation as early as two days. |
2023-06-16 |
2023-08-14 |
mouse |
| Lintong Men, Junyi Guo, Yu Cao, Bingyu Huang, Qian Wang, Shengqi Huo, Moran Wang, Dewei Peng, Lulu Peng, Wei Shi, Sheng Li, Li Lin, Jiagao L. IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. Free radical biology & medicine. 2023-06-12. PMID:37307935. |
bazedoxifene (5mg/kg/day by oral gavage once a day) exhibited similar effect as carvedilol (10mg/kg/day by oral gavage once a day) on attenuating chronic isoproterenol (30mg/kg by abdominal injection once a day, 7 days) induced cardiac systolic dysfunction, cardiac hypertrophy and fibrosis in c57bl/6 mice. |
2023-06-12 |
2023-08-14 |
mouse |
| Zhen Guo, Yue-Huai Hu, Guo-Shuai Feng, Carla Valenzuela Ripoll, Zhen-Zhen Li, Si-Dong Cai, Qian-Qian Wang, Wen-Wei Luo, Qian Li, Li-Ying Liang, Zhong-Kai Wu, Ji-Guo Zhang, Ali Javaheri, Lei Wang, Jing Lu, Pei-Qing Li. JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. Acta pharmacologica Sinica. 2023-05-15. PMID:37186122. |
cardiac hypertrophy was induced in rats by subcutaneous injection of isoproterenol (iso, 1.2 mg·kg |
2023-05-15 |
2023-08-14 |
rat |
| Zhuang Ma, Zuheng Liu, Xudong Li, Hao Zhang, Dunzheng Han, Wenjun Xiong, Haobin Zhou, Xi Yang, Qingchun Zeng, Hao Ren, Dingli X. Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function. Biology. vol 12. issue 4. 2023-04-28. PMID:37106782. |
we studied the function of pink1 in mitophagy in isoproterenol (iso)-induced cardiomyocyte injury and transverse aortic constriction (tac)-induced myocardial hypertrophy. |
2023-04-28 |
2023-08-14 |
mouse |
| HuiTing Liu, ZhiXiang Zhou, HuaNian Deng, Zhen Tian, ZeFan Wu, XiYan Liu, Zhong Ren, ZhiSheng Jian. Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway. European journal of pharmacology. 2023-04-20. PMID:37080331. |
in this study, the effects of trim65 on isoproterenol (iso)-induced cardiac hypertrophy and the underlying mechanisms were investigated. |
2023-04-20 |
2023-08-14 |
mouse |
| Sandra Tejedor, Marc Buigues, Hernán González-King, Andreia M Silva, Nahuel Aquiles García, Niek Dekker, Pilar Sepúlved. Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047440. |
when injected intraperitoneally into mice treated with isoproterenol, osm-loaded sevs reduced fibrosis, prevented cardiac hypertrophy, and increased angiogenesis. |
2023-04-13 |
2023-08-14 |
mouse |
| Jing Liu, Xiaoli Li, Lu Ding, Wei Li, Xiaolin Niu, Dengfeng Ga. GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 117. 2023-04-04. PMID:37012864. |
grk2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of nrf2 signaling and the promotion of nlrp3 inflammasome and oxidative stress. |
2023-04-04 |
2023-08-14 |
Not clear |
| Jing Liu, Xiaoli Li, Lu Ding, Wei Li, Xiaolin Niu, Dengfeng Ga. GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 117. 2023-04-04. PMID:37012864. |
in this study, we clarified the effect of grk2 on cardiac hypertrophy in h9c2 cells induced by isoproterenol (iso) and examined the underlying mechanisms. |
2023-04-04 |
2023-08-14 |
Not clear |