Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Wen Yin, Peng Zhang, Jing Hui Huang, Quan Yu Zhang, Rong Fan, Juan Li, Jing Jun Zhou, Yu Zhen Hu, Hai Tao Guo, Shu Miao Zhang, Yue Min Wang, Alan David Kaye, Chun Hu Gu, Jin Cheng Liu, Liang Cheng, Qin Cui, Ding Hua Yi, Jian Ming Pe. Stimulation of kappa-opioid receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19233160. |
cardiac hypertrophy and fibrosis were developed by intraperitoneal administration of isoprenaline (ip. |
2009-07-07 |
2023-08-12 |
rat |
Wen Yin, Peng Zhang, Jing Hui Huang, Quan Yu Zhang, Rong Fan, Juan Li, Jing Jun Zhou, Yu Zhen Hu, Hai Tao Guo, Shu Miao Zhang, Yue Min Wang, Alan David Kaye, Chun Hu Gu, Jin Cheng Liu, Liang Cheng, Qin Cui, Ding Hua Yi, Jian Ming Pe. Stimulation of kappa-opioid receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19233160. |
increases in heart weight, heart-to-body ratio, diameter of cardiomyocytes, and morphological hypertrophic alterations induced by isoprenaline were significantly attenuated by u50,488h(i.p. |
2009-07-07 |
2023-08-12 |
rat |
Bernard Abrenica, Mohamed AlShaaban, Michael P Czubry. The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy. Journal of molecular and cellular cardiology. vol 46. issue 5. 2009-06-17. PMID:19358331. |
we also demonstrate that over-expression of akap121 in cardiac myocytes reduces basal cell size, and blocks hypertrophy induced by isoproterenol, indicating that akap121 negatively regulates the hypertrophic process. |
2009-06-17 |
2023-08-12 |
rat |
Kyuho Jeong, Hayeong Kwon, Chanhee Min, Yunbae Pa. Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts. Experimental & molecular medicine. vol 41. issue 4. 2009-06-02. PMID:19299911. |
we investigated the effect of phenylephrine (pe)- and isoproterenol (iso)-induced cardiac hypertrophy on subcellular localization and expression of caveolin-3 and stat3 in h9c2 cardiomyoblast cells. |
2009-06-02 |
2023-08-12 |
Not clear |
M Anderson, D Moore, Df Larso. Comparison of isoproterenol and dobutamine in the induction of cardiac hypertrophy and fibrosis. Perfusion. vol 23. issue 4. 2009-05-19. PMID:19181756. |
comparison of isoproterenol and dobutamine in the induction of cardiac hypertrophy and fibrosis. |
2009-05-19 |
2023-08-12 |
mouse |
M Anderson, D Moore, Df Larso. Comparison of isoproterenol and dobutamine in the induction of cardiac hypertrophy and fibrosis. Perfusion. vol 23. issue 4. 2009-05-19. PMID:19181756. |
isoproterenol (iso) was a clinical therapeutic that is now used as a research means for the induction of cardiac hypertrophy. |
2009-05-19 |
2023-08-12 |
mouse |
A C Issy, C A da Silva, F S Guimarães, E A Del Be. Different role of isoproterenol and NOS inhibitors on salivary ducts of rats. Micron (Oxford, England : 1993). vol 40. issue 3. 2009-04-30. PMID:19167231. |
chronic treatment with isoproterenol, a beta receptor agonist, stimulates the release of no from acinar cells and induces salivary gland hypertrophy. |
2009-04-30 |
2023-08-12 |
rat |
Daniel R Higazi, Claire J Fearnley, Faye M Drawnel, Amarnath Talasila, Elaine M Corps, Oliver Ritter, Fraser McDonald, Katsuhiko Mikoshiba, Martin D Bootman, H Llewelyn Roderic. Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Molecular cell. vol 33. issue 4. 2009-04-06. PMID:19250908. |
moreover, we found that activation of the cna/nfat pathway and hypertrophy by isoproterenol and bayk8644, which enhance global ca(2+) fluxes, was also dependent on iicr and nuclear ca(2+) elevations. |
2009-04-06 |
2023-08-12 |
Not clear |
Yun-He Liu, Martin D'Ambrosio, Tang-dong Liao, Hongmei Peng, Nour-Eddine Rhaleb, Umesh Sharma, Sabine André, Hans-J Gabius, Oscar A Carreter. N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. American journal of physiology. Heart and circulatory physiology. vol 296. issue 2. 2009-03-12. PMID:19098114. |
we found that, in the left ventricle, gal-3 1) enhanced macrophage and mast cell infiltration, increased cardiac interstitial and perivascular fibrosis, and causes cardiac hypertrophy; 2) increased tgf-beta expression and smad3 phosphorylation; and 3) decreased negative change in pressure over time response to isoproterenol challenge, ratio of early left ventricular filling phase to atrial contraction phase, and left ventricular ejection fraction. |
2009-03-12 |
2023-08-12 |
rat |
Jun Cai, Fang-Fang Yi, Long Yang, Di-Fei Shen, Qinling Yang, Ankang Li, Asish K Ghosh, Zhou-Yan Bian, Ling Yan, Qi-Zhu Tang, Hongliang Li, Xin-Chun Yan. Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling. Hypertension (Dallas, Tex. : 1979). vol 53. issue 3. 2009-03-09. PMID:19204184. |
we investigated the effect of cardiac overexpression of rat ralt on cardiac hypertrophy induced by angiotensin ii and isoproterenol in ralt transgenic mice and wild-type littermates. |
2009-03-09 |
2023-08-12 |
mouse |
T Yar, M El-Hariri, M N El-Bahai, A O Bamos. Effects of Nigella sativa supplementation for one month on cardiac reserve in rats. Indian journal of physiology and pharmacology. vol 52. issue 2. 2009-01-22. PMID:19130857. |
the observed nigella-induced cardiac hypertrophy was associated with an increase in the baseline cardiac inotropic properties as well as the maximal peak tension generation upon progressive cardiac stress by isoproterenol infusion. |
2009-01-22 |
2023-08-12 |
rat |
Hae Jin Kee, Gwang Hyeon Eom, Hosouk Joung, Sera Shin, Ju-Ryoung Kim, Young Kuk Cho, Nakwon Choe, Bo-Woong Sim, Daewoong Jo, Myung Ho Jeong, Kyung Keun Kim, Jeong-Sun Seo, Hyun Koo. Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy. Circulation research. vol 103. issue 11. 2008-12-31. PMID:18849323. |
cardiac hypertrophy was introduced by aortic banding, by infusion of isoproterenol or angiotensin ii, or by swimming. |
2008-12-31 |
2023-08-12 |
mouse |
Evelyn T Flanagan, Maria M Buckley, Claire M Aherne, Fredolin Lainis, Munavvar Sattar, Edward J John. Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats. Experimental physiology. vol 93. issue 9. 2008-12-12. PMID:18487313. |
this study aimed to quantify the effect of cardiac hypertrophy induced with isoprenaline and caffeine on reflex regulation of renal sympathetic nerve activity by the arterial and cardiopulmonary baroreceptors. |
2008-12-12 |
2023-08-12 |
rat |
Guoqiang Wu, Hongxin Wang, Jing Yang, Yuhong Yang, Chunna Liu, Li Jing, Tak Ming Won. kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B). European journal of pharmacology. vol 595. issue 1-3. 2008-11-18. PMID:18721804. |
kappa-opioid receptor stimulation inhibits augmentation of ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - role of camkiidelta(b). |
2008-11-18 |
2023-08-12 |
rat |
Guoqiang Wu, Hongxin Wang, Jing Yang, Yuhong Yang, Chunna Liu, Li Jing, Tak Ming Won. kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B). European journal of pharmacology. vol 595. issue 1-3. 2008-11-18. PMID:18721804. |
we determined the effects of trans-(+/-)-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamid methanesulfonate salt (u50,488h), a selective kappa-opioid receptor agonist, on the enhancement of spontaneous ca(2+) transients and the induction of hypertrophy by isoprenaline, a beta-adrenoceptor agonist, in cultured neonatal ventricular myocytes. |
2008-11-18 |
2023-08-12 |
rat |
Guoqiang Wu, Hongxin Wang, Jing Yang, Yuhong Yang, Chunna Liu, Li Jing, Tak Ming Won. kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B). European journal of pharmacology. vol 595. issue 1-3. 2008-11-18. PMID:18721804. |
kappa-opioid receptor stimulation suppressed the stimulatory effect of isoprenaline on ca(2+) transients and cardiac hypertrophy, as did kn93, propranalol and verapamil. |
2008-11-18 |
2023-08-12 |
rat |
Elham Zarrinpashneh, Christophe Beauloye, Audrey Ginion, Anne-Catherine Pouleur, Xavier Havaux, Louis Hue, Benoit Viollet, Jean-Louis Vanoverschelde, Luc Bertran. AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol. Biochemical and biophysical research communications. vol 376. issue 4. 2008-11-13. PMID:18812163. |
ampkalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol. |
2008-11-13 |
2023-08-12 |
mouse |
Elham Zarrinpashneh, Christophe Beauloye, Audrey Ginion, Anne-Catherine Pouleur, Xavier Havaux, Louis Hue, Benoit Viollet, Jean-Louis Vanoverschelde, Luc Bertran. AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol. Biochemical and biophysical research communications. vol 376. issue 4. 2008-11-13. PMID:18812163. |
we investigated the contribution of ampkalpha2 in the control of cardiac hypertrophy by using ampkalpha2-/- mice submitted to isoproterenol. |
2008-11-13 |
2023-08-12 |
mouse |
Stevan P Tofovic, Xinchen Zhang, Hong Zhu, Edwin K Jackson, Olga Rafikova, Gordana Petrusevsk. 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling. Vascular pharmacology. vol 48. issue 4-6. 2008-10-27. PMID:18373958. |
the goals of this study were: 1) to compare the effects of e2, 2-me and 2-ee on proliferation of human pulmonary artery endothelial (hpaec) and smooth muscle cells (hpasmc) and lung fibroblasts (hlf); 2) to examine the effects of 2-me, its metabolic precursor 2-hydroxyestradiol (2-he) and 2-ee on isoproterenol (iso)-induced cardiac hypertrophy in male rats; and 3) to investigate in male rats the effects of 2-ee (10 mug/kg/h via osmotic pump) on the development of monocrotaline (mct; 60 mg/kg i.p. |
2008-10-27 |
2023-08-12 |
human |
Kazuhiko Hanada, Kazuhiko Asari, Masako Saito, Jun-Ichi Kawana, Mitsuo Mita, Hiroyasu Ogat. Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18534575. |
continuous administration of isoproterenol for 2 weeks produced heart failure, which is characterized by an increased heart rate, cardiac hypertrophy and downregulation of beta-adrenoceptors. |
2008-10-24 |
2023-08-12 |
rat |