| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomohiko Sakatani, Takeshi Shirayama, Taku Yamamoto, Hiroki Mani, Hirokazu Shiraishi, Hiroaki Matsubar. Cardiac hypertrophy diminished the effects of isoproterenol on delayed rectifier potassium current in rat heart. The journal of physiological sciences : JPS. vol 56. issue 2. 2006-10-19. PMID:16839443. |
on the other hand, isoproterenol increased i(ca) in both sham-operated (77.7% +/- 7.6%) and hypertrophic rats (69.6% +/- 9.7%). |
2006-10-19 |
2023-08-12 |
rat |
| Tomohiko Sakatani, Takeshi Shirayama, Taku Yamamoto, Hiroki Mani, Hirokazu Shiraishi, Hiroaki Matsubar. Cardiac hypertrophy diminished the effects of isoproterenol on delayed rectifier potassium current in rat heart. The journal of physiological sciences : JPS. vol 56. issue 2. 2006-10-19. PMID:16839443. |
consequently, isoproterenol prolonged further apd in hypertrophic rats (98 +/- 11 vs. 145 +/- 8.6 ms, p < 0.01), but not in sham-operated rats (55 +/- 3.9 vs. 61 +/- 5.6 ms, n.s.). |
2006-10-19 |
2023-08-12 |
rat |
| Tomohiko Sakatani, Takeshi Shirayama, Taku Yamamoto, Hiroki Mani, Hirokazu Shiraishi, Hiroaki Matsubar. Cardiac hypertrophy diminished the effects of isoproterenol on delayed rectifier potassium current in rat heart. The journal of physiological sciences : JPS. vol 56. issue 2. 2006-10-19. PMID:16839443. |
we concluded that in hypertrophic hearts, i(k) was not increased by isoproterenol because of the enhanced activity of phosphodiesterase, which leads to excessive apd prolongation. |
2006-10-19 |
2023-08-12 |
rat |
| Chitrang J Trivedi, R Balaraman, Jayesh B Majithiya, Sunil B Bothar. Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats. Pharmacology. vol 77. issue 1. 2006-09-26. PMID:16567950. |
however, it could not reduce oxidative stress and hypertrophy induced by isoproterenol. |
2006-09-26 |
2023-08-12 |
rat |
| Surender S Katoch, Asha Garg, Sushma Sharm. Histological evidences of reparative and regenerative effects of beta-adrenoceptor agonists, clenbuterol and isoproterenol, in denervated rat skeletal muscle. Indian journal of experimental biology. vol 44. issue 6. 2006-08-14. PMID:16784115. |
beta-agonists, clenbuterol (1.2 mg/kg body weight) and isoproterenol (2 mg/kg body weight), administration (daily oral administration; maximum 7 days) to normal innervated rats as well as denervated animals caused muscle hypertrophy. |
2006-08-14 |
2023-08-12 |
rat |
| Rakesh Kumar, Surender S Katoch, Sushma Sharm. Beta-adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle. Indian journal of experimental biology. vol 44. issue 5. 2006-07-05. PMID:16708889. |
daily oral administration of isoproterenol hydrochloride (60 mg/kg body weight; for 30 days) a beta-receptor agonist to normal innervated and denervated adult male swiss albino mice confirmed its ability to induce skeletal muscle hypertrophy and reverse denervation atrophy respectively. |
2006-07-05 |
2023-08-12 |
mouse |
| Catalin M Filipeanu, Fuguo Zhou, Erin K Fugetta, Guangyu W. Differential regulation of the cell-surface targeting and function of beta- and alpha1-adrenergic receptors by Rab1 GTPase in cardiac myocytes. Molecular pharmacology. vol 69. issue 5. 2006-06-26. PMID:16461589. |
consistent with the effects on receptor cell-surface targeting, rab1 selectively enhanced erk1/2 activation and hypertrophic growth in response to the alpha1-ar agonist phenylephrine but not to the beta-ar agonist isoproterenol. |
2006-06-26 |
2023-08-12 |
rat |
| Oleg Nisenberg, Anthony E Pegg, Patricia A Welsh, Kerry Keefer, Lisa M Shant. Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. The Biochemical journal. vol 393. issue Pt 1. 2006-03-16. PMID:16153183. |
the alphamhc/adometdc mice did not display an overt cardiac phenotype, but there was an increased cardiac hypertrophy after beta-adrenergic stimulation with isoprenaline ('isoproterenol'), as well as a small increase in spermine content. |
2006-03-16 |
2023-08-12 |
mouse |
| Keiichiro Kizaki, Muneyoshi Okada, Ryoichi Ito, Kazuki Yoshioka, Kazuyoshi Hashizume, Ken-ichiro Mutoh, Yukio Har. Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. Biological & pharmaceutical bulletin. vol 28. issue 12. 2006-03-09. PMID:16327176. |
gene expression of heparanase, matrix metalloproteinases (mmp)-2 and mmp-9 were examined in ventricles after chronic treatment with isoproterenol (iso) induced cardiac hypertrophy in rats. |
2006-03-09 |
2023-08-12 |
rat |
| Edilamar M Oliveira, Jos\\xc3\\xa9 E Kriege. Chronic beta-adrenoceptor stimulation and cardiac hypertrophy with no induction of circulating renin. European journal of pharmacology. vol 520. issue 1-3. 2006-02-10. PMID:16129426. |
altogether, these data provide evidence that isoproterenol induced hypertrophy is associated with cardiac induction of angiotensin-converting enzyme and daily transient hemodynamic overload even in the absence of systemic activation of renin-angiotensin system. |
2006-02-10 |
2023-08-12 |
rat |
| Madiha A H Hassan, Amal F Keta. Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T. BMC pharmacology. vol 5. 2006-02-01. PMID:15813973. |
sildenafil citrate increases myocardial cgmp content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin t. cardiac hypertrophy is a major risk factor for morbidity and mortality in a number of cardiovascular diseases. |
2006-02-01 |
2023-08-12 |
rat |
| Madiha A H Hassan, Amal F Keta. Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T. BMC pharmacology. vol 5. 2006-02-01. PMID:15813973. |
the present study investigated the in-vivo effect of sildenafil as a phosphodiestrase-5a (pde-5a) inhibitor on the hypertrophic response of rat heart to isoproterenol and the relation of this effect to the level of myocardial cgmp and integrity of the constitutive nitric oxide synthase (cnos) activity. |
2006-02-01 |
2023-08-12 |
rat |
| Huan Wang, Emily A Oestreich, Naoya Maekawa, Tara A Bullard, Karen L Vikstrom, Robert T Dirksen, Grant G Kelley, Burns C Blaxall, Alan V Smrck. Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circulation research. vol 97. issue 12. 2005-12-28. PMID:16293787. |
to address the significance of these functional deficits to cardiac pathology, plcepsilon(-/-) mice were subjected to a chronic isoproterenol model of hypertrophic stress. |
2005-12-28 |
2023-08-12 |
mouse |
| Michael D Faulx, Paul Ernsberger, Dorothy Vatner, Robert D Hoffman, William Lewis, Ryan Strachan, Brian D Hoi. Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice. American journal of physiology. Heart and circulatory physiology. vol 289. issue 1. 2005-08-11. PMID:15749746. |
we postulated that strain differences would result in greater left ventricular (lv) hypertrophy in response to isoproterenol in b6 than a/j mice and tested the hypothesis that a differential response could be explained partly by differences in beta-adrenergic receptor (beta-ar) density and/or coupling. |
2005-08-11 |
2023-08-12 |
mouse |
| Michael D Faulx, Paul Ernsberger, Dorothy Vatner, Robert D Hoffman, William Lewis, Ryan Strachan, Brian D Hoi. Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice. American journal of physiology. Heart and circulatory physiology. vol 289. issue 1. 2005-08-11. PMID:15749746. |
high-dose, short-term isoproterenol produces greater macro- and microscopic cardiac hypertrophy and injury in a/j than b6 mice. |
2005-08-11 |
2023-08-12 |
mouse |
| Romain Bos, Nathalie Mougenot, Laurent Findji, Odile M\\xc3\\xa9diani, Paul M Vanhoutte, Philippe Lecha. Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist. Journal of cardiovascular pharmacology. vol 45. issue 1. 2005-06-15. PMID:15613973. |
isoproterenol induced cardiac hypertrophy, which was completely inhibited by potassium canrenoate alone in atria and by potassium canrenoate plus losartan in infarcted ventricles. |
2005-06-15 |
2023-08-12 |
rat |
| Susanne Lutz, Roman A Mura, Hans Joerg Hippe, Christiane Tiefenbacher, Feraydoon Nirooman. Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. British journal of pharmacology. vol 140. issue 6. 2004-08-17. PMID:14559858. |
rats treated with isoproterenol developed myocardial hypertrophy, and ndpk in the sarcolemma rose by 60% during 14 days of treatment. |
2004-08-17 |
2023-08-12 |
rat |
| Remigio O L\\xc3\\xb3pez Sol\\xc3\\xads, Ulrike Kemmerling Weis, Alicia Ramos Ceballos, Gustavo Hoecker Sala. Differential expression of isoproterenol-induced salivary polypeptides in two mouse strains that are congenic for the H-2 histocompatibility gene complex. Journal of cellular biochemistry. vol 90. issue 5. 2004-07-20. PMID:14624454. |
these polypeptides, which have been considered as markers of the hypertrophic growth of the parotid acinar cells, are members of the complex family of salivary proline-rich proteins (prp) on the basis of both their massive accumulation in the parotid acinar cells in response to chronic isoproterenol, secretory character, high solubility in trichloroacetic acid and metachromatic staining by coomassie blue. |
2004-07-20 |
2023-08-12 |
mouse |
| Robson A S Santos, Anderson J Ferreira, Ana Paula Nadu, Aline N G Braga, Alvair Pinto de Almeida, Maria Jos\\xc3\\xa9 Campagnole-Santos, Ovidiu Baltatu, Radu Iliescu, Timothy L Reudelhuber, Michael Bade. Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats. Physiological genomics. vol 17. issue 3. 2004-07-16. PMID:15039487. |
strikingly, tgr(a1-7)3292 rats were significantly more resistant than control animals to induction of cardiac hypertrophy by isoproterenol. |
2004-07-16 |
2023-08-12 |
rat |
| Tatyana V Dudnakova, Vladimir L Lakomkin, Valerie G Tsyplenkova, Boris V Shekhonin, Vladimir P Shirinsky, Valeri I Kapelk. Alterations in myocardial ultrastructure and protein expression after a single injection of isoproterenol. Molecular and cellular biochemistry. vol 252. issue 1-2. 2004-06-03. PMID:14577591. |
obtained results indicate that even a single injection of isoproterenol creates long lasting structural alterations in cardiac muscle accompanied by the increased expression of extracellular matrix proteins and several sarcoplasmic proteins apparently involved in hypertrophic response of cardiomyocytes. |
2004-06-03 |
2023-08-12 |
rat |