| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Silva, R C Araujo, O Baltatu, S M Oliveira, C Tsch\\xc3\\xb6pe, E Fink, S Hoffmann, R Plehm, K X Chai, L Chao, J Chao, D Ganten, J B Pesquero, M Bade. Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 13. 2000-11-08. PMID:11023967. |
induction of cardiac hypertrophy by isoproterenol treatment revealed a marked protective effect of the kallikrein transgene because the cardiac weight of tgr(hklk1) increased significantly less, and the expression of atrial natriuretic peptide and collagen iii as markers for hypertrophy and fibrosis, respectively, were less enhanced. |
2000-11-08 |
2023-08-12 |
human |
| F Di Fusco, S Hashim, M B Anand-Srivastav. Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart. American journal of physiology. Cell physiology. vol 279. issue 4. 2000-10-30. PMID:11003579. |
these results suggest that the decreased expression of g(s)alpha proteins may not be the cause but the effect of hypertrophy and that the diminished responsiveness of adenylyl cyclase to gtpgammas, isoproterenol, naf, and forskolin in hearts from av shunt rats may partly be due to the decreased expression of g(s)alpha. |
2000-10-30 |
2023-08-12 |
rat |
| N Murad, P J Tucc. Isoproterenol-induced hypertrophy may result in distinct left ventricular changes. Clinical and experimental pharmacology & physiology. vol 27. issue 5-6. 2000-09-20. PMID:10831235. |
the aim of the present study was to analyse the possible lack of uniformity in isoproterenol (iso)-induced myocardial hypertrophy. |
2000-09-20 |
2023-08-12 |
rat |
| A P Raval, H R Patel, P M Ambadka. Effect of acute administration of isoproterenol on submandibular salivary gland of female rat. Indian journal of experimental biology. vol 38. issue 3. 2000-09-06. PMID:10927867. |
further, it has also been demonstrated that chronic administration of a beta-adrenergic agonist isoproterenol (ipr) results in hypertrophy and hyperplasia of submandibular gland [schneyer c a, am j physiol, 203 (1962) 232]. |
2000-09-06 |
2023-08-12 |
rat |
| J Tse, M W Huang, R J Leone, H R Weiss, Y Q He, P M Schol. Down regulation of myocardial beta1-adrenoceptor signal transduction system in pacing-induced failure in dogs with aortic stenosis-induced left ventricular hypertrophy. Molecular and cellular biochemistry. vol 205. issue 1-2. 2000-08-01. PMID:10821423. |
we recently demonstrated that rapid ventricular pacing caused cardiac failure (failure) in dogs with aortic stenosis-induced left ventricular hypertrophy (hypertrophy) and isoproterenol caused no significant increases in function, o2 consumption and intracellular cyclic amp level in the failing hypertrophied hearts. |
2000-08-01 |
2023-08-12 |
Not clear |
| M W Huang, R J Leone, H R Weiss, J Tse, P M Schol. Effects of beta-adrenoceptor stimulation on pacing-induced failure of dog hypertrophic hearts. Clinical and experimental pharmacology & physiology. vol 27. issue 3. 2000-06-21. PMID:10744348. |
isoproterenol (iso; 0.1 microg/kg per min) was infused into a coronary artery in five anaesthetized open-chest control, five aortic stenosis-induced left ventricular hypertrophy (lvh) and five lvh pacing-induced failure dogs. |
2000-06-21 |
2023-08-12 |
dog |
| S Lahlou, G C Lima, C S Le\\xc3\\xa3o-Filho, G P Duart. Effects of long-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats. Canadian journal of physiology and pharmacology. vol 78. issue 3. 2000-05-11. PMID:10721819. |
isoproterenol pretreatment for 15 days caused cardiac hypertrophy without affecting baseline blood pressure and heart rate. |
2000-05-11 |
2023-08-12 |
rat |
| G Szymanska, H Str\\xc3\\xb6mer, M Silverman, Y Belu-John, J P Morga. Altered phosphorylation of sarcoplasmic reticulum contributes to the diminished contractile response to isoproterenol in hypertrophied rat hearts. Pflugers Archiv : European journal of physiology. vol 439. issue 1-2. 2000-03-02. PMID:10650994. |
we tested the hypothesis that changes in phosphorylation of the sarcoplasmic reticulum (sr) protein, phospholamban (pib) and myofibrillar proteins troponin i (tni) and c protein are responsible for the decreased relaxant response to isoproterenol in cardiac hypertrophy and failure induced by ascending aortic banding in rats. |
2000-03-02 |
2023-08-12 |
rat |
| G Szymanska, H Str\\xc3\\xb6mer, M Silverman, Y Belu-John, J P Morga. Altered phosphorylation of sarcoplasmic reticulum contributes to the diminished contractile response to isoproterenol in hypertrophied rat hearts. Pflugers Archiv : European journal of physiology. vol 439. issue 1-2. 2000-03-02. PMID:10650994. |
in isolated perfused heart preparations under maximal isoproterenol stimulation, the capacity for in vitro camp-dependent phosphorylation of pib was significantly increased at the compensatory stage of hypertrophy (126-130%, p<0.001), but decreased with failure (70-76%, p<0.001). |
2000-03-02 |
2023-08-12 |
rat |
| G Szymanska, H Str\\xc3\\xb6mer, M Silverman, Y Belu-John, J P Morga. Altered phosphorylation of sarcoplasmic reticulum contributes to the diminished contractile response to isoproterenol in hypertrophied rat hearts. Pflugers Archiv : European journal of physiology. vol 439. issue 1-2. 2000-03-02. PMID:10650994. |
as a consequence, linear correlation was observed between the maximal increase in ec50 and the maximal rate of relaxation [(-dp/dt)/devp] upon isoproterenol stimulation, declining with progressive hypertrophy to failure. |
2000-03-02 |
2023-08-12 |
rat |
| N Murad, P J Tucc. Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 32. issue 6. 1999-10-21. PMID:10412557. |
isovolumetric left ventricle preparations of rats with cardiac hypertrophy (h; n = 10) induced by isoproterenol administration showed higher dpmax (174 +/- 14 mmhg) than control (c; n = 8) animals (155 +/- 12 mmhg) or rats with regression (r; n = 8) of hypertrophy (144 +/- 11 mmhg). |
1999-10-21 |
2023-08-12 |
rat |
| Y Ishigai, T Mori, S Moriyama, T Shiban. Induction of cardiac beta-adrenergic receptor kinase 1 in rat heart failure caused by coronary ligation. Journal of molecular and cellular cardiology. vol 31. issue 6. 1999-09-08. PMID:10371700. |
four weeks after the ligation of rat coronary artery, lv dp/d t max was reduced, cardiac response to isoproterenol was impaired, and ratio of right ventricular weight to body weight, an index of cardiac hypertrophy, was increased. |
1999-09-08 |
2023-08-12 |
rat |
| L McMartin, R J Summer. Functional analysis of desensitization of the beta-adrenoceptor signalling pathway in rat cardiac tissues following chronic isoprenaline infusion. British journal of pharmacology. vol 127. issue 4. 1999-08-26. PMID:10433510. |
isoprenaline infusion caused marked hypertrophy of atria and ventricles and reduced the resting rate of spontaneously beating right atria and the basal force of left atrial contraction. |
1999-08-26 |
2023-08-12 |
rat |
| O Chaparro, W H Yu, P A Sha. Isoproterenol-induced expression of the cystatin S gene in submandibular glands of parasympathectomized rats. Brain research. Molecular brain research. vol 61. issue 1-2. 1999-06-10. PMID:9795188. |
isoproterenol (ipr), a beta-adrenergic agonist, induces hypertrophic and hyperplastic enlargement of rat salivary glands and expression of a number of genes including cystatin s. sympathectomy reduces, but does not completely block ipr-induced expression of the cystatin s gene in the submandibular glands of adult female rats, indicating the participation of sympathetic factor(s) in this regulation. |
1999-06-10 |
2023-08-12 |
rat |
| R D Piper, F Y Li, M L Myers, W J Sibbal. Effects of isoproterenol on myocardial structure and function in septic rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 86. issue 3. 1999-05-07. PMID:10066715. |
we found that 1) sepsis reduced contractile function, indicated by a rightward shift in the starling curve (anova with repeated measures, sepsis effect, p < 0.002); 2) sepsis-induced myocardial depression was reversed by isoproterenol treatment (isoproterenol effect, p < 0.0001); 3) sepsis reduced, but did not block, isoproterenol-induced myocardial hypertrophy (isoproterenol effect, p < 0.0001); 4) sepsis did not protect the heart from catecholamine-induced tissue injury; 5) the septic heart was protected against the effects of ischemiareperfusion (decreased postreperfusion resting tension, anova with repeated measures, p < 0.01), an effect attenuated by isoproterenol treatment (p < 0.005); and 6) sepsis reduced the incidence of sustained asystole or ventricular fibrillation after ischemia-reperfusion (p < 0.05), an effect also attenuated by isoproterenol treatment (p < 0.01). |
1999-05-07 |
2023-08-12 |
rat |
| Y Zou, I Komuro, T Yamazaki, S Kudoh, H Uozumi, T Kadowaki, Y Yazak. Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. The Journal of biological chemistry. vol 274. issue 14. 1999-04-27. PMID:10092665. |
these results suggest that isoproterenol induces erk activation and cardiomyocyte hypertrophy through two different g proteins, gs and gi. |
1999-04-27 |
2023-08-12 |
Not clear |
| C Burtea, R Gatina, G Stoian, M Mardare, I F Dumitru, C T Dragomi. Spin-spin relaxation times in myocardial hypertrophy induced by endocrine agents in rat. Magma (New York, N.Y.). vol 7. issue 3. 1999-04-21. PMID:10050945. |
male and female wistar rats were treated with different hormones (hydrocortisone acetate, testosterone, estradiol, thyroid hormones) in combination with isoproterenol (a synthetic catecholamine that induces myocardial ischemia and hypertrophy). |
1999-04-21 |
2023-08-12 |
rat |
| K L Naim, P Rabindranauth, H R Weiss, J Tse, R J Leone, P M Schol. Positive inotropy due to lowering cyclic GMP is also mediated by increases in cyclic AMP in control and hypertrophic hearts. Canadian journal of physiology and pharmacology. vol 76. issue 6. 1999-04-13. PMID:9923398. |
isoproterenol (iso) (0.1 mg x kg(-1) x min(-1)) was infused into a branch of the left anterior descending coronary artery of seven control and eight hypertrophy open-chest anesthetized dogs. |
1999-04-13 |
2023-08-12 |
Not clear |
| G Iaccarino, P C Dolber, R J Lefkowitz, W J Koc. Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Hypertension (Dallas, Tex. : 1979). vol 33. issue 1 Pt 2. 1999-02-26. PMID:9931136. |
both treatments resulted in cardiac hypertrophy, but only isoproterenol induced significant increases in beta-adrenergic receptor kinase-1 protein levels and activity. |
1999-02-26 |
2023-08-12 |
mouse |
| S S Meyrelles, H Mauad, S C Mathias, A M Cabral, E C Vasque. Effects of myocardial hypertrophy on neural reflexes controlling cardiovascular function. Journal of the autonomic nervous system. vol 73. issue 2-3. 1999-02-25. PMID:9862388. |
adult male wistar rats were subjected to myocardial hypertrophy (mhr) treating them with the beta-adrenoceptor agonist isoproterenol (0.3 mg/kg/day, s.c.) for 15 days and compared with vehicle injected control rats (cr). |
1999-02-25 |
2023-08-12 |
rat |