| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrzej M Janczewski, Toshiaki Kadokami, Bonnie Lemster, Carole S Frye, Charles F McTiernan, Arthur M Feldma. Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-alpha. American journal of physiology. Heart and circulatory physiology. vol 284. issue 3. 2003-03-11. PMID:12578819. |
tg-f mice showed lv hypertrophy without dilatation and only a small reduction of basal fractional shortening (fs) and response to isoproterenol (iso). |
2003-03-11 |
2023-08-12 |
mouse |
| María Paz Ocaranza, Guillermo Díaz-Araya, Mario Chiong, David Muñoz, Juan Pablo Riveros, Roberto Ebensperger, Sebastián Sabat, Pablo Irarrázaval, Jorge E Jalil, Sergio Lavander. Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis. Journal of cardiovascular pharmacology. vol 40. issue 2. 2002-12-24. PMID:12131554. |
isoproterenol and angiotensin i-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis. |
2002-12-24 |
2023-08-12 |
rat |
| María Paz Ocaranza, Guillermo Díaz-Araya, Mario Chiong, David Muñoz, Juan Pablo Riveros, Roberto Ebensperger, Sebastián Sabat, Pablo Irarrázaval, Jorge E Jalil, Sergio Lavander. Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis. Journal of cardiovascular pharmacology. vol 40. issue 2. 2002-12-24. PMID:12131554. |
this study investigated whether long-term administration of isoproterenol (iso) induces differential expression of angiotensin-converting enzyme (ace) in lung, plasma, and left ventricle (lv) during development of left ventricular hypertrophy (lvh) and myocardial fibrosis. |
2002-12-24 |
2023-08-12 |
rat |
| Cristina O Silva, Gloria P Duarte, Saad Lahlo. Alpha-adrenergic responsiveness in rat isolated perfused heart after abdominal aortic coarctation. The Journal of pharmacy and pharmacology. vol 54. issue 1. 2002-07-17. PMID:11829125. |
chronic isoproterenol pre-treatment, a well-known model of compensatory hypertrophy associated with cardiac beta-adrenoceptor desensitization, enhances the inotropic response to phenylephrine in rat isolated perfused hearts, supporting the hypothesis that myocardial alpha-adrenoceptor stimulation contributes to the maintenance of myocardial performance in situations in which cardiac beta-adrenoceptor function is compromised. |
2002-07-17 |
2023-08-12 |
rat |
| Kelly G Ten Hagen, Marlene M Balys, Lawrence A Tabak, James E Melvi. Analysis of isoproterenol-induced changes in parotid gland gene expression. Physiological genomics. vol 8. issue 2. 2002-05-06. PMID:11875188. |
parotid gland acinar cells undergo marked hypertrophy and hyperplasia upon systemic exposure to the beta-adrenergic agonist, isoproterenol. |
2002-05-06 |
2023-08-12 |
mouse |
| Orlando F Bueno, Benjamin J Wilkins, Kevin M Tymitz, Betty J Glascock, Thomas F Kimball, John N Lorenz, Jeffery D Molkenti. Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 7. 2002-04-25. PMID:11904392. |
cnabeta-deficient mice were dramatically impaired in their ability to mount a productive hypertrophic response induced by pressure overload, angiotensin ii infusion, or isoproterenol infusion. |
2002-04-25 |
2023-08-12 |
mouse |
| Birgit Andrée, Anne Fleige, Hans-Henning Arnold, Thomas Bran. Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Molecular and cellular biology. vol 22. issue 5. 2002-04-02. PMID:11839816. |
no difference, however, was observed between homozygous and heterozygous mice in the ability to develop cardiac hypertrophy in response to isoproterenol. |
2002-04-02 |
2023-08-12 |
mouse |
| W Wallis, M Cooklin, D J Sheridan, C H Fr. The action of isoprenaline on the electrophysiological properties of hypertrophied left ventricular myocytes. Archives of physiology and biochemistry. vol 109. issue 2. 2002-03-07. PMID:11780772. |
the augmentation of i(ca) and i(cl) by isoprenaline was also reduced in hypertrophy, but no other characteristics of the two currents, or the dose-dependency of the action of isoprenaline were a function of cardiac growth. |
2002-03-07 |
2023-08-12 |
Not clear |
| N Balta, I Stoian, C Petec, G Pete. Decreased SOD activity and increased nitrates level in rat heart with left ventricular hypertrophy induced by isoproterenol. Romanian journal of physiology : physiological sciences. vol 36. issue 3-4. 2002-01-31. PMID:11797933. |
decreased sod activity and increased nitrates level in rat heart with left ventricular hypertrophy induced by isoproterenol. |
2002-01-31 |
2023-08-12 |
rat |
| N Balta, I Stoian, C Petec, G Pete. Decreased SOD activity and increased nitrates level in rat heart with left ventricular hypertrophy induced by isoproterenol. Romanian journal of physiology : physiological sciences. vol 36. issue 3-4. 2002-01-31. PMID:11797933. |
in an attempt to understand the molecular basis of antioxidant changes during ventricular hypertrophy, we have used isoproterenol treated rats. |
2002-01-31 |
2023-08-12 |
rat |
| F H Leenen, R White, B Yua. Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system. American journal of physiology. Heart and circulatory physiology. vol 281. issue 6. 2002-01-07. PMID:11709406. |
to assess the possible contribution of the circulatory and cardiac renin-angiotensin system (ras) to the cardiac hypertrophy induced by a beta-agonist, the present study evaluated the effects of isoproterenol, alone or combined with an angiotensin i-converting enzyme inhibitor or at(1) receptor blocker, on plasma and lv renin activity, ang i, and ang ii, as well as left ventricular (lv) and right ventricular (rv) weight. |
2002-01-07 |
2023-08-12 |
rat |
| L M Shantz, D J Feith, A E Peg. Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. The Biochemical journal. vol 358. issue Pt 1. 2001-09-20. PMID:11485548. |
however, stimulation of beta-adrenergic signalling by isoproterenol resulted in severe hypertrophy and even death in odc-overexpressing mice without further altering polyamine levels, compared with only a mild hypertrophy in littermates. |
2001-09-20 |
2023-08-12 |
mouse |
| L M Shantz, D J Feith, A E Peg. Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. The Biochemical journal. vol 358. issue Pt 1. 2001-09-20. PMID:11485548. |
when beta1-adrenergic stimulation was blocked by simultaneous treatment with isoproterenol and the beta1 antagonist atenolol, a significant, although reduced, hypertrophy was still present in the hearts of transgenic mice, suggesting that both beta1 and beta2 adrenergic receptors contribute to the hypertrophic phenotype. |
2001-09-20 |
2023-08-12 |
mouse |
| N Murad, M Fabiano de Franco, P J Tucc. [Functional characterization of myocardial hypertrophy induced by isoproterenol and its regression]. Arquivos brasileiros de cardiologia. vol 77. issue 1. 2001-09-13. PMID:11500747. |
[functional characterization of myocardial hypertrophy induced by isoproterenol and its regression]. |
2001-09-13 |
2023-08-12 |
Not clear |
| J Mészáros, D Khananshvili, G Har. Mechanisms underlying delayed afterdepolarizations in hypertrophied left ventricular myocytes of rats. American journal of physiology. Heart and circulatory physiology. vol 281. issue 2. 2001-08-16. PMID:11454597. |
cardiac hypertrophy was induced in rats by daily injection of isoproterenol (5 mg/kg ip) for 7 days. |
2001-08-16 |
2023-08-12 |
rat |
| C Morisco, D C Zebrowski, D E Vatner, S F Vatner, J Sadoshim. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. Journal of molecular and cellular cardiology. vol 33. issue 3. 2001-06-14. PMID:11181023. |
stimulation of cultured cardiac myocytes in vitro with isoproterenol (iso), an agonist for beta(1)- and beta(2)-ars, caused hypertrophy of myocytes along with increases in transcription of atrial natriuretic factor (anf) and actin reorganization. |
2001-06-14 |
2023-08-12 |
rat |
| C O Silva, W O Monteiro-Filho, G P Duarte, S Lahlo. Effects of long-term pretreatment with isoproterenol on inotropic responsiveness to alpha-adrenoceptor stimulation: study in isolated perfused rat hearts. The Journal of pharmacy and pharmacology. vol 53. issue 2. 2001-06-14. PMID:11273021. |
isoproterenol pretreatment caused cardiac hypertrophy (29%) as shown by a significant increase in the ratio of ventricular dry weight to body weight. |
2001-06-14 |
2023-08-12 |
rat |
| J E Melvin, H V Nguyen, K Nehrke, C M Schreiner, K G Ten Hagen, W Scot. Targeted disruption of the Nhe1 gene fails to inhibit beta(1)-adrenergic receptor-induced parotid gland hypertrophy. American journal of physiology. Gastrointestinal and liver physiology. vol 280. issue 4. 2001-04-19. PMID:11254496. |
nhe1 transcripts increased approximately 50% by 2 h, and a more than twofold increase was noted at 24 h. isoproterenol did not acutely increase na(+)/h(+) exchanger activity; however, exchanger activity was significantly elevated by 24 h. to test whether nhe1 activity is essential for inducing salivary gland hypertrophy in vivo, mice with targeted disruption of nhe1 were treated with isoproterenol. |
2001-04-19 |
2023-08-12 |
mouse |
| D E Dostal, G W Booz, K M Bake. Regulation of angiotensinogen gene expression and protein in neonatal rat cardiac fibroblasts by glucocorticoid and beta-adrenergic stimulation. Basic research in cardiology. vol 95. issue 6. 2001-03-08. PMID:11192370. |
since glucocorticoids and beta-adrenergic stimuli have been implicated in cardiac hypertrophy, and function as regulators of the circulating renin-angiotensin system, we examined the effects of dexamethasone and isoproterenol on angiotensinogen mrna levels and protein secretion in cultured neonatal rat cardiac fibroblasts. |
2001-03-08 |
2023-08-12 |
rat |
| P A Shaw, W A Y. Autonomic regulation of cystatin S gene expression in rat submandibular glands. Autonomic neuroscience : basic & clinical. vol 83. issue 1-2. 2001-01-18. PMID:11023628. |
the beta-adrenergic agonist isoproterenol (ipr) induces hypertrophic and hyperplastic enlargements of rat salivary glands and the expression of a number of genes including cystatin s. sympathectomy reduces, but does not completely block, ipr-induced expression of the cystatin s gene in submandibular glands of adult female rats, indicating the participation of sympathetic factor(s) in its regulation. |
2001-01-18 |
2023-08-12 |
human |