| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L M Shantz, D J Feith, A E Peg. Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. The Biochemical journal. vol 358. issue Pt 1. 2001-09-20. PMID:11485548. |
when beta1-adrenergic stimulation was blocked by simultaneous treatment with isoproterenol and the beta1 antagonist atenolol, a significant, although reduced, hypertrophy was still present in the hearts of transgenic mice, suggesting that both beta1 and beta2 adrenergic receptors contribute to the hypertrophic phenotype. |
2001-09-20 |
2023-08-12 |
mouse |
| N Murad, M Fabiano de Franco, P J Tucc. [Functional characterization of myocardial hypertrophy induced by isoproterenol and its regression]. Arquivos brasileiros de cardiologia. vol 77. issue 1. 2001-09-13. PMID:11500747. |
[functional characterization of myocardial hypertrophy induced by isoproterenol and its regression]. |
2001-09-13 |
2023-08-12 |
Not clear |
| J Mészáros, D Khananshvili, G Har. Mechanisms underlying delayed afterdepolarizations in hypertrophied left ventricular myocytes of rats. American journal of physiology. Heart and circulatory physiology. vol 281. issue 2. 2001-08-16. PMID:11454597. |
cardiac hypertrophy was induced in rats by daily injection of isoproterenol (5 mg/kg ip) for 7 days. |
2001-08-16 |
2023-08-12 |
rat |
| C Morisco, D C Zebrowski, D E Vatner, S F Vatner, J Sadoshim. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. Journal of molecular and cellular cardiology. vol 33. issue 3. 2001-06-14. PMID:11181023. |
stimulation of cultured cardiac myocytes in vitro with isoproterenol (iso), an agonist for beta(1)- and beta(2)-ars, caused hypertrophy of myocytes along with increases in transcription of atrial natriuretic factor (anf) and actin reorganization. |
2001-06-14 |
2023-08-12 |
rat |
| C O Silva, W O Monteiro-Filho, G P Duarte, S Lahlo. Effects of long-term pretreatment with isoproterenol on inotropic responsiveness to alpha-adrenoceptor stimulation: study in isolated perfused rat hearts. The Journal of pharmacy and pharmacology. vol 53. issue 2. 2001-06-14. PMID:11273021. |
isoproterenol pretreatment caused cardiac hypertrophy (29%) as shown by a significant increase in the ratio of ventricular dry weight to body weight. |
2001-06-14 |
2023-08-12 |
rat |
| J E Melvin, H V Nguyen, K Nehrke, C M Schreiner, K G Ten Hagen, W Scot. Targeted disruption of the Nhe1 gene fails to inhibit beta(1)-adrenergic receptor-induced parotid gland hypertrophy. American journal of physiology. Gastrointestinal and liver physiology. vol 280. issue 4. 2001-04-19. PMID:11254496. |
nhe1 transcripts increased approximately 50% by 2 h, and a more than twofold increase was noted at 24 h. isoproterenol did not acutely increase na(+)/h(+) exchanger activity; however, exchanger activity was significantly elevated by 24 h. to test whether nhe1 activity is essential for inducing salivary gland hypertrophy in vivo, mice with targeted disruption of nhe1 were treated with isoproterenol. |
2001-04-19 |
2023-08-12 |
mouse |
| D E Dostal, G W Booz, K M Bake. Regulation of angiotensinogen gene expression and protein in neonatal rat cardiac fibroblasts by glucocorticoid and beta-adrenergic stimulation. Basic research in cardiology. vol 95. issue 6. 2001-03-08. PMID:11192370. |
since glucocorticoids and beta-adrenergic stimuli have been implicated in cardiac hypertrophy, and function as regulators of the circulating renin-angiotensin system, we examined the effects of dexamethasone and isoproterenol on angiotensinogen mrna levels and protein secretion in cultured neonatal rat cardiac fibroblasts. |
2001-03-08 |
2023-08-12 |
rat |
| P A Shaw, W A Y. Autonomic regulation of cystatin S gene expression in rat submandibular glands. Autonomic neuroscience : basic & clinical. vol 83. issue 1-2. 2001-01-18. PMID:11023628. |
the beta-adrenergic agonist isoproterenol (ipr) induces hypertrophic and hyperplastic enlargements of rat salivary glands and the expression of a number of genes including cystatin s. sympathectomy reduces, but does not completely block, ipr-induced expression of the cystatin s gene in submandibular glands of adult female rats, indicating the participation of sympathetic factor(s) in its regulation. |
2001-01-18 |
2023-08-12 |
human |
| P Bokník, M Fockenbrock, S Herzig, J Knapp, B Linck, H Lüss, F U Müller, T Müller, W Schmitz, F Schröder, J Neuman. Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 3. 2001-01-05. PMID:10997724. |
cardiac hypertrophy was induced in rats by chronic s.c. administration of isoproterenol (iso, 2.4 mg/kg/day) via osmotic minipumps. |
2001-01-05 |
2023-08-12 |
human |
| K Hayashi, K Saito, Y Kizawa, M Sano, T Kusama, K Iwamoto, H Murakam. Involvement of angiotensin II and endothelin-1 in the development of submandibular gland hypertrophy in response to isoproterenol in rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 126. issue 2. 2001-01-02. PMID:11050684. |
involvement of angiotensin ii and endothelin-1 in the development of submandibular gland hypertrophy in response to isoproterenol in rats. |
2001-01-02 |
2023-08-12 |
rat |
| K Hayashi, K Saito, Y Kizawa, M Sano, T Kusama, K Iwamoto, H Murakam. Involvement of angiotensin II and endothelin-1 in the development of submandibular gland hypertrophy in response to isoproterenol in rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 126. issue 2. 2001-01-02. PMID:11050684. |
we investigated whether angiotensin ii (ang ii) and endothelin-1(et-1) are involved in submandibular hypertrophy in response to repeated treatment with isoproterenol (iso) in rats. |
2001-01-02 |
2023-08-12 |
rat |
| C Moisin, N Balta, V Filcescu, I F Dumitriu, G Stoian, G Pete. Activity of Na+/K+-ATPase and of Ca++-ATPase under the action of adenosine triphosphate in experimental myocardial hypertrophy. Romanian journal of physiology : physiological sciences. vol 35. issue 3-4. 2000-11-30. PMID:11061329. |
this paper presents the results of our research on the mechanisms involved in the modifications occurring in the activity of ionic pumps (na+/k+-atpase and ca++-atpase) at the level of the sarcolemma, the sarcoplasmic reticulum and mitochondrial membrane of the myocardial cell in experimental myocardial hypertrophy induced by isoproterenol. |
2000-11-30 |
2023-08-12 |
rat |
| J A Silva, R C Araujo, O Baltatu, S M Oliveira, C Tschöpe, E Fink, S Hoffmann, R Plehm, K X Chai, L Chao, J Chao, D Ganten, J B Pesquero, M Bade. Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 13. 2000-11-08. PMID:11023967. |
induction of cardiac hypertrophy by isoproterenol treatment revealed a marked protective effect of the kallikrein transgene because the cardiac weight of tgr(hklk1) increased significantly less, and the expression of atrial natriuretic peptide and collagen iii as markers for hypertrophy and fibrosis, respectively, were less enhanced. |
2000-11-08 |
2023-08-12 |
human |
| F Di Fusco, S Hashim, M B Anand-Srivastav. Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart. American journal of physiology. Cell physiology. vol 279. issue 4. 2000-10-30. PMID:11003579. |
these results suggest that the decreased expression of g(s)alpha proteins may not be the cause but the effect of hypertrophy and that the diminished responsiveness of adenylyl cyclase to gtpgammas, isoproterenol, naf, and forskolin in hearts from av shunt rats may partly be due to the decreased expression of g(s)alpha. |
2000-10-30 |
2023-08-12 |
rat |
| N Murad, P J Tucc. Isoproterenol-induced hypertrophy may result in distinct left ventricular changes. Clinical and experimental pharmacology & physiology. vol 27. issue 5-6. 2000-09-20. PMID:10831235. |
the aim of the present study was to analyse the possible lack of uniformity in isoproterenol (iso)-induced myocardial hypertrophy. |
2000-09-20 |
2023-08-12 |
rat |
| A P Raval, H R Patel, P M Ambadka. Effect of acute administration of isoproterenol on submandibular salivary gland of female rat. Indian journal of experimental biology. vol 38. issue 3. 2000-09-06. PMID:10927867. |
further, it has also been demonstrated that chronic administration of a beta-adrenergic agonist isoproterenol (ipr) results in hypertrophy and hyperplasia of submandibular gland [schneyer c a, am j physiol, 203 (1962) 232]. |
2000-09-06 |
2023-08-12 |
rat |
| J Tse, M W Huang, R J Leone, H R Weiss, Y Q He, P M Schol. Down regulation of myocardial beta1-adrenoceptor signal transduction system in pacing-induced failure in dogs with aortic stenosis-induced left ventricular hypertrophy. Molecular and cellular biochemistry. vol 205. issue 1-2. 2000-08-01. PMID:10821423. |
we recently demonstrated that rapid ventricular pacing caused cardiac failure (failure) in dogs with aortic stenosis-induced left ventricular hypertrophy (hypertrophy) and isoproterenol caused no significant increases in function, o2 consumption and intracellular cyclic amp level in the failing hypertrophied hearts. |
2000-08-01 |
2023-08-12 |
Not clear |
| M W Huang, R J Leone, H R Weiss, J Tse, P M Schol. Effects of beta-adrenoceptor stimulation on pacing-induced failure of dog hypertrophic hearts. Clinical and experimental pharmacology & physiology. vol 27. issue 3. 2000-06-21. PMID:10744348. |
isoproterenol (iso; 0.1 microg/kg per min) was infused into a coronary artery in five anaesthetized open-chest control, five aortic stenosis-induced left ventricular hypertrophy (lvh) and five lvh pacing-induced failure dogs. |
2000-06-21 |
2023-08-12 |
dog |
| S Lahlou, G C Lima, C S Leão-Filho, G P Duart. Effects of long-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats. Canadian journal of physiology and pharmacology. vol 78. issue 3. 2000-05-11. PMID:10721819. |
isoproterenol pretreatment for 15 days caused cardiac hypertrophy without affecting baseline blood pressure and heart rate. |
2000-05-11 |
2023-08-12 |
rat |
| G Szymanska, H Strömer, M Silverman, Y Belu-John, J P Morga. Altered phosphorylation of sarcoplasmic reticulum contributes to the diminished contractile response to isoproterenol in hypertrophied rat hearts. Pflugers Archiv : European journal of physiology. vol 439. issue 1-2. 2000-03-02. PMID:10650994. |
we tested the hypothesis that changes in phosphorylation of the sarcoplasmic reticulum (sr) protein, phospholamban (pib) and myofibrillar proteins troponin i (tni) and c protein are responsible for the decreased relaxant response to isoproterenol in cardiac hypertrophy and failure induced by ascending aortic banding in rats. |
2000-03-02 |
2023-08-12 |
rat |