| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Geurts, E Hermans, J M Maloteau. Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment. European journal of pharmacology. vol 382. issue 2. 1999-12-17. PMID:10528146. |
when measured in the presence of a saturating concentration of a dopamine d(2) receptor antagonist, the response to dopamine was not significantly affected by haloperidol treatment. |
1999-12-17 |
2023-08-12 |
rat |
| M Geurts, E Hermans, J M Maloteau. Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment. European journal of pharmacology. vol 382. issue 2. 1999-12-17. PMID:10528146. |
taken together, these results indicate that a functional pool of dopamine d(2) receptors is increased after prolonged haloperidol administration. |
1999-12-17 |
2023-08-12 |
rat |
| I E De Souza, G J McBean, G E Meredit. Chronic haloperidol treatment impairs glutamate transport in the rat striatum. European journal of pharmacology. vol 382. issue 2. 1999-12-17. PMID:10528149. |
chronic blockade of dopamine d(2) receptors with haloperidol elevates extracellular glutamate levels in the striatum. |
1999-12-17 |
2023-08-12 |
rat |
| J Yu, L Källström, F A Wiesel, A E Johnso. Neurochemical changes in the entopeduncular nucleus and increased oral behavior in rats treated subchronically with clozapine or haloperidol. Synapse (New York, N.Y.). vol 34. issue 3. 1999-12-10. PMID:10523757. |
in addition, vacuous chewing movements (vcm) were measured throughout the drug administration period as a functional indicator of drug action and changes in striatal dopamine d(2)-receptor binding were measured as a positive control for d(2)-receptor antagonist properties of haloperidol and clozapine. |
1999-12-10 |
2023-08-12 |
rat |
| J M Gulley, M Kuwajima, E Mayhill, G V Rebe. Behavior-related changes in the activity of substantia nigra pars reticulata neurons in freely moving rats. Brain research. vol 845. issue 1. 1999-12-10. PMID:10529445. |
subsequent injection with the dopamine antagonist haloperidol (1.0 mg/kg, s.c.) reversed amphetamine-induced inhibitions in all tested cells, which supports a role for dopamine in this effect. |
1999-12-10 |
2023-08-12 |
rat |
| B Caronti, F Passarelli, C Calderaro, G Palladini, F E Pontier. Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAs in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 5. 1999-12-02. PMID:10509379. |
these results indicate short-lasting dynamic changes of expression of lymphocyte d1b dopamine receptor mrna by haloperidol and suggest that the effects of dopamine and dopaminergic drugs on the immune system might be mediated, at least in part, by direct interaction of these substances with dopamine receptors on lymphocyte membrane. |
1999-12-02 |
2023-08-12 |
rat |
| I S Midzianovskai. [Two types of "spike-wave" discharges in the electrocorticogram of WAG/Rij rats, the genetic model of absence epilepsy]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 49. issue 5. 1999-12-01. PMID:10570541. |
since it has been shown earlier that haloperidol, which acts on dopamine receptors oppositely to apomorphine, enhance the generalized spike-wave activity and suppress the local discharges. |
1999-12-01 |
2023-08-12 |
rat |
| E Jakubowska-Doğr. Modification of avoidance responding by amphetamine and dopamine receptor antagonists. Polish journal of pharmacology. vol 51. issue 4. 1999-11-30. PMID:10540961. |
this study was designed to investigate the effects of preferential d1 (sch 23390) and d2 (haloperidol) dopamine (da) receptor antagonists and their interaction with low-dose (1 mg kg) d-amphetamine during the acquisition of two-way shuttle avoidance in rats. |
1999-11-30 |
2023-08-12 |
rat |
| E H Chartoff, R P Ward, D M Dors. Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. The Journal of pharmacology and experimental therapeutics. vol 291. issue 2. 1999-11-24. PMID:10525068. |
acute blockade of dopamine d(2) receptors by the typical antipsychotic drug haloperidol leads to alterations in neuronal gene expression and behavior. |
1999-11-24 |
2023-08-12 |
Not clear |
| S J Gladwell, J H Coot. Fast excitatory post synaptic potentials and their response to catecholaminergic antagonists in rat sympathetic preganglionic neurones in vitro. Neuroscience letters. vol 268. issue 2. 1999-11-22. PMID:10400085. |
the latter potential was blocked with the dopamine d2 antagonist haloperidol but not with the dopamine d1 antagonist sch 23390. |
1999-11-22 |
2023-08-12 |
rat |
| A Nakazato, Y Sekiguchi, K Ohta, S Chaki, S Okuyam. Chemical modification of apomorphine to discover sigma ligands: 6H-dibenzo[b,d]pyran and carbazole analogues. Bioorganic & medicinal chemistry. vol 7. issue 9. 1999-11-18. PMID:10530952. |
we focused on a difference in structural flexibility between haloperidol and apomorphine, and studied chemical modification of apomorphine, a compound with high affinity for dopamine d2 receptors but not for sigma receptors, for discovery of sigma ligands. |
1999-11-18 |
2023-08-12 |
Not clear |
| N Jelovac, P Sikiric, R Rucman, M Petek, A Marovic, D Perovic, S Seiwerth, S Mise, B Turkovic, G Dodig, P Miklic, G Buljat, I Prkaci. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. European journal of pharmacology. vol 379. issue 1. 1999-11-15. PMID:10499368. |
in other experiments, considering the gastric origin of this pentadecapeptide, the focus was shifted to the evidence that a dose of haloperidol, cataleptogenic due to dopamine receptors blockade, induces gastric ulcers in rats. |
1999-11-15 |
2023-08-12 |
mouse |
| C C Chinen, R Frussa-Filh. Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 5. 1999-11-15. PMID:10516963. |
this "injection-conditioned catalepsy" was also observed after repeated treatment with the dopamine d2 antagonists, haloperidol and metoclopramide. |
1999-11-15 |
2023-08-12 |
mouse |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected cos-7 cells. |
1999-11-08 |
2023-08-12 |
human |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
in this study, the hypothesis was partially investigated by determining the potencies of haloperidol and reduced haloperidol and the corresponding pyridinium and tetrahydropyridine metabolites, compared with mpp+ and mptp, as inhibitors of the noradrenaline transporter (nat), dopamine transporter (dat) and 5-ht transporter (sert). |
1999-11-08 |
2023-08-12 |
human |
| J M Stern, S E Kee. Maternal motivation of lactating rats is disrupted by low dosages of haloperidol. Behavioural brain research. vol 99. issue 2. 1999-10-27. PMID:10512589. |
motorically-active maternal behaviors of rats, such as retrieval and licking of pups, are known to be reduced or suspended following systemic injection of > or = 0.2 mg/kg haloperidol (hal), a dopamine (da) receptor blocker. |
1999-10-27 |
2023-08-12 |
rat |
| B A Morrow, S J Rosenberg, R H Rot. Chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats. Synapse (New York, N.Y.). vol 34. issue 1. 1999-10-20. PMID:10459169. |
chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats. |
1999-10-20 |
2023-08-12 |
rat |
| B A Morrow, S J Rosenberg, R H Rot. Chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats. Synapse (New York, N.Y.). vol 34. issue 1. 1999-10-20. PMID:10459169. |
rats treated for 21 days with clozapine or haloperidol, a typical antipsychotic without significant binding affinity for serotonergic receptors, showed lowered basal dopamine metabolism in the medial prefrontal cortex, the nucleus accumbens, and the striatum, as expected. |
1999-10-20 |
2023-08-12 |
rat |
| B A Morrow, S J Rosenberg, R H Rot. Chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats. Synapse (New York, N.Y.). vol 34. issue 1. 1999-10-20. PMID:10459169. |
when corrected for baseline differences, both challenges significantly elevated dopamine metabolism in the prefrontal cortex of the clozapine group more than the saline or haloperidol groups. |
1999-10-20 |
2023-08-12 |
rat |
| S Chaki, T Funakoshi, R Yoshikawa, S Okuyama, T Kumagai, A Nakazato, M Nagamine, K Tomisaw. In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic, in rats. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462131. |
in the present study, in vivo receptor occupancy of 5-ht2a, alpha1, dopamine d2 and d3 receptors by nra0045 was assessed, based on in vivo and ex vivo receptor binding, and findings were compared to reference antipsychotic drugs (haloperidol, risperidone, clozapine). |
1999-10-12 |
2023-08-12 |
rat |