| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Del Agua Villa, Mihai Atudorei, Hartwig Roman Siebner, Mattias Rickha. Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid-onset parkinsonian motor phenotype in mice. The European journal of neuroscience. 2024-12-03. PMID:39626697. |
we demonstrate a clear dose-dependent induction of parkinsonian motor behaviour by both a dopamine d1 receptor antagonist (sch23390) and a d2 receptor antagonist (haloperidol). |
2024-12-03 |
2024-12-06 |
mouse |
| Quincy Chopra, Vincent Peyko, Jessica Annie Lee, Leo Puhalla, David J Gemmel, Todd Boloti. Droperidol Plus Diphenhydramine for Symptom Improvement in Suspected Cannabinoid Hyperemesis Syndrome: A Prospective Cohort Study. Open access emergency medicine : OAEM. vol 16. 2024-12-02. PMID:39619486. |
retrospective data suggest the utility of droperidol, a dopamine antagonist like haloperidol, for treating acute chs. |
2024-12-02 |
2024-12-06 |
Not clear |
| B R Pradeepa, T M Vijayakumar, K Manikanda. Effects of piperine-haloperidol mixture on ketamine induced schizophrenia rats and metabolism-mediated inhibitory potency: in-vivo and in-vitro evaluation. 3 Biotech. vol 14. issue 12. 2024-12-02. PMID:39619819. |
pharmacodynamic assessments showed reductions in locomotor activity, immobility time, dopamine levels, and nitric oxide, with increased superoxide dismutase levels in the haloperidol-piperine group compared to haloperidol alone, reflecting enhanced therapeutic efficacy. |
2024-12-02 |
2024-12-06 |
human |
| Tatiana V Lipina, Huy Giang, Jonathan S Thacker, William C Wetsel, Marc G Caron, Jean Martin Beaulieu, Ali Salahpour, Amy J Ramse. Combination of haloperidol with UNC9994, β-arrestin-biased analog of aripiprazole, ameliorates schizophrenia-related phenotypes induced by NMDAR deficit in mice. The international journal of neuropsychopharmacology. 2024-11-29. PMID:39612588. |
aripiprazole, an atypical antipsychotic drug (apd), acts as a dopamine partial agonist and its combination with haloperidol (a typical apd) was suggested as a potential strategy to improve schizophrenia. |
2024-11-29 |
2024-12-02 |
mouse |
| Rihab Farooq, Huda Zahid, Ammara Shakil Sahibole, Syed Ali Bokhari, Mazin A Mukhta. Complex Pharmacodynamics of Aripiprazole and Haloperidol in Schizophrenia Management: A Case Report. Cureus. vol 16. issue 10. 2024-11-14. PMID:39525142. |
this case report discusses a 44-year-old male with chronic schizophrenia who experienced worsening psychotic symptoms following an interaction between aripiprazole, a partial dopamine agonist, and haloperidol, a first-generation antipsychotic (fga). |
2024-11-14 |
2024-11-17 |
Not clear |
| Manabu Takano, Tsuyoshi Okada, Katsutoshi Shioda, Chikara Yonekawa, Shiro Sud. Risperidone suppresses caffeine-induced hyperthermia and hyperactivity in rats. Neuroscience letters. 2024-09-02. PMID:39222834. |
haloperidol and dopamine d1 antagonist sch-23390 exacerbated hyperthermia without any effect on the hyperactivity. |
2024-09-02 |
2024-09-05 |
rat |
| Lydia J Hickman, Sophie L Sowden-Carvalho, Dagmar S Fraser, Bianca A Schuster, Alicia J Rybicki, Joseph M Galea, Jennifer L Coo. Dopaminergic manipulations affect the modulation and meta-modulation of movement speed: evidence from two pharmacological interventions. Behavioural brain research. 2024-08-25. PMID:39182625. |
the current paper reports effects on these kinematic features of movement following two forms of dopamine manipulation: study one highlights movement differences in individuals with pd both on and off their dopaminergic medication (n = 32); study two highlights movement differences in individuals from the general population on haloperidol (a dopamine receptor blocker, or "antagonist") and placebo (n = 43). |
2024-08-25 |
2024-08-28 |
Not clear |
| Mani Erfanian Abdoust, Monja Isabel Froböse, Alfons Schnitzler, Elisabeth Schreivogel, Gerhard Jocha. Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. PLoS biology. vol 22. issue 7. 2024-07-12. PMID:38995982. |
we found opposing effects of dopamine d2 (haloperidol) and acetylcholine m1 receptor (biperiden) antagonism on specific components of effort-based decision-making in healthy humans: haloperidol decreased, whereas biperiden increased the willingness to exert physical effort. |
2024-07-12 |
2024-07-15 |
Not clear |
| Chuyu Chen, Meghan Masotti, Nathaniel Shepard, Vanessa Promes, Giulia Tombesi, Daniel Arango, Claudia Manzoni, Elisa Greggio, Sabine Hilfiker, Yevgenia Kozorovitskiy, Loukia Parisiado. LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895420. |
haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine d2 receptors that are highly expressed in the striatum. |
2024-06-19 |
2024-06-21 |
mouse |
| Chuyu Chen, Meghan Masotti, Nathaniel Shepard, Vanessa Promes, Giulia Tombesi, Daniel Arango, Claudia Manzoni, Elisa Greggio, Sabine Hilfiker, Yevgenia Kozorovitskiy, Loukia Parisiado. LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895420. |
our study suggests that lrrk2 kinase plays a key role in striatal dopamine d2 receptor signaling underlying the undesirable motor side effects of haloperidol. |
2024-06-19 |
2024-06-21 |
mouse |
| Andreea O Diaconescu, Povilas Karvelis, Daniel J Hauk. Rethinking interpersonal judgments: dopamine antagonists impact attributional dynamics. Trends in cognitive sciences. 2024-05-26. PMID:38797602. |
investigated the effects of haloperidol, a d2/d3 dopamine antagonist, on social attributions. |
2024-05-26 |
2024-05-31 |
Not clear |
| Takumi Yamasaki, Yasushi Kiyokawa, Arisa Munetomo, Yukari Takeuch. Naloxone increases conditioned fear responses during social buffering in male rats. The European journal of neuroscience. 2024-04-22. PMID:38644789. |
given that opioids, dopamine, oxytocin and vasopressin play an important role in affiliative behaviour, here, we assessed the effects of the most well-known antagonists, naloxone (opioid receptor antagonist), haloperidol (dopamine d2 receptor antagonist), atosiban (oxytocin receptor antagonist) and sr49059 (vasopressin v1a receptor antagonist), on social buffering. |
2024-04-22 |
2024-04-24 |
human |
| Chang Hyeon Kong, Kyungnam Cho, Ji Won Min, Jae Youn Kim, Keontae Park, Do Yeon Kim, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jae Yeol Lee, Jong Hoon Ry. Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-09. PMID:37812895. |
also, oa normalised the levels of dopamine and acetylcholine in the striatum which were increased by haloperidol. |
2023-10-09 |
2023-10-15 |
mouse |
| Cátia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Graça Baltazar, Patrícia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. |
haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine d2 receptors, which are abundantly expressed in the striatum. |
2023-10-06 |
2023-10-15 |
mouse |
| Cátia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Graça Baltazar, Patrícia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. |
cell-type specific electrophysiological recordings further revealed that haloperidol not only reduces the excitability of striatal medium spiny neurons expressing dopamine d2 receptors (d2-msns) but also affects d1-msns by increasing the ratio of inhibitory/excitatory synaptic transmission (i/e ratio) specifically onto d1-msns but not d2-msns. |
2023-10-06 |
2023-10-15 |
mouse |
| Toshiro Niwa, Yuka Yamamot. Stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome P450 2D6. Drug metabolism and bioanalysis letters. 2023-09-15. PMID:37711131. |
the effects of antipsychotic agents, including dopamine d2 receptor blocking agents such as haloperidol, chlorpromazine, and sulpiride, and related compounds such as mirtazapine and sertraline, on dopamine formation from p-tyramine catalyzed by cytochrome p450 (cyp) 2d6.2 (arg296cys;ser486thr), cyp2d6.10 (pro34ser;ser486thr), and cyp2d6.39 (ser486thr) were compared with those of cyp2d6.1. |
2023-09-15 |
2023-10-07 |
Not clear |
| Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peter. Dopamine regulates decision thresholds in human reinforcement learning in males. Nature communications. vol 14. issue 1. 2023-09-04. PMID:37666865. |
here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection via a combined pharmacological neuroimaging approach in male human volunteers (n = 31, within-subjects; placebo, 150 mg of the dopamine precursor l-dopa, 2 mg of the d2 receptor antagonist haloperidol). |
2023-09-04 |
2023-09-07 |
human |
| Nannan Gao, Zhipeng Liu, Hongsheng Wang, Chen Shen, Zhaoqi Dong, Wanpeng Cui, Wen-Cheng Xiong, Lin Me. Deficiency of Cullin 3, a protein encoded by a schizophrenia and autism risk gene, impairs behaviors by enhancing the excitability of ventral tegmental area (VTA) DA neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-09. PMID:37558490. |
behavioral impairments were attenuated by dopamine d2 receptor antagonist haloperidol and chemogenetic inhibition of da neurons. |
2023-08-09 |
2023-08-16 |
mouse |
| Shobhit Kumar, Satish Kumar Gupta, Rakesh Pahw. Designing lisuride intranasal nanocarrier system for reduction of oxidative damage with enhanced dopamine level in brain for Parkinsonism. Journal of psychiatric research. vol 165. 2023-07-30. PMID:37517241. |
when lisuride ne was administered intranasally resulted in considerably higher dopamine concentrations (17.48 ± 0.05 ng/ml) in comparison to rats receiving haloperidol (7.28 ± 0.02 ng/ml). |
2023-07-30 |
2023-08-14 |
rat |
| Sanja Strbe, Ivan Maria Smoday, Ivan Krezic, Luka Kalogjera, Vlasta Vukovic, Helena Zizek, Slaven Gojkovic, Hrvoje Vranes, Ivan Barisic, Suncana Sikiric, Marijan Tepes, Katarina Oroz, Filip Brkic, Martin Drinkovic, Lidija Beketic Oreskovic, Jelena Popic, Alenka Boban Blagaic, Anita Skrtic, Mario Staresinic, Sven Seiwerth, Predrag Sikiri. Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy. Pharmaceuticals (Basel, Switzerland). vol 16. issue 6. 2023-06-28. PMID:37375736. |
in rats with complete calvariectomy, medication (bpc 157 10 µg/kg, 10 ng/kg ip or ig) was given 5 min after distinctive dopamine agents (mg/kg ip) (haloperidol (5), fluphenazine (5), clozapine (10), risperidone (5), olanzapine (10), quetiapine (10), or aripiprazole (10), domperidone (25), amphetamine (10), and combined amphetamine and haloperidol) and assessed at 15 min thereafter. |
2023-06-28 |
2023-08-14 |
rat |