All Relations between Haloperidol and dopamine

Publication Sentence Publish Date Extraction Date Species
Chang Hyeon Kong, Kyungnam Cho, Ji Won Min, Jae Youn Kim, Keontae Park, Do Yeon Kim, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jae Yeol Lee, Jong Hoon Ry. Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-09. PMID:37812895. also, oa normalised the levels of dopamine and acetylcholine in the striatum which were increased by haloperidol. 2023-10-09 2023-10-15 mouse
C\\xc3\\xa1tia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Gra\\xc3\\xa7a Baltazar, Patr\\xc3\\xadcia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine d2 receptors, which are abundantly expressed in the striatum. 2023-10-06 2023-10-15 mouse
C\\xc3\\xa1tia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Gra\\xc3\\xa7a Baltazar, Patr\\xc3\\xadcia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. cell-type specific electrophysiological recordings further revealed that haloperidol not only reduces the excitability of striatal medium spiny neurons expressing dopamine d2 receptors (d2-msns) but also affects d1-msns by increasing the ratio of inhibitory/excitatory synaptic transmission (i/e ratio) specifically onto d1-msns but not d2-msns. 2023-10-06 2023-10-15 mouse
Toshiro Niwa, Yuka Yamamot. Stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome P450 2D6. Drug metabolism and bioanalysis letters. 2023-09-15. PMID:37711131. the effects of antipsychotic agents, including dopamine d2 receptor blocking agents such as haloperidol, chlorpromazine, and sulpiride, and related compounds such as mirtazapine and sertraline, on dopamine formation from p-tyramine catalyzed by cytochrome p450 (cyp) 2d6.2 (arg296cys;ser486thr), cyp2d6.10 (pro34ser;ser486thr), and cyp2d6.39 (ser486thr) were compared with those of cyp2d6.1. 2023-09-15 2023-10-07 Not clear
Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peter. Dopamine regulates decision thresholds in human reinforcement learning in males. Nature communications. vol 14. issue 1. 2023-09-04. PMID:37666865. here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection via a combined pharmacological neuroimaging approach in male human volunteers (n\xe2\x80\x89=\xe2\x80\x8931, within-subjects; placebo, 150\xe2\x80\x89mg of the dopamine precursor l-dopa, 2\xe2\x80\x89mg of the d2 receptor antagonist haloperidol). 2023-09-04 2023-09-07 human
Nannan Gao, Zhipeng Liu, Hongsheng Wang, Chen Shen, Zhaoqi Dong, Wanpeng Cui, Wen-Cheng Xiong, Lin Me. Deficiency of Cullin 3, a protein encoded by a schizophrenia and autism risk gene, impairs behaviors by enhancing the excitability of ventral tegmental area (VTA) DA neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-09. PMID:37558490. behavioral impairments were attenuated by dopamine d2 receptor antagonist haloperidol and chemogenetic inhibition of da neurons. 2023-08-09 2023-08-16 mouse
Shobhit Kumar, Satish Kumar Gupta, Rakesh Pahw. Designing lisuride intranasal nanocarrier system for reduction of oxidative damage with enhanced dopamine level in brain for Parkinsonism. Journal of psychiatric research. vol 165. 2023-07-30. PMID:37517241. when lisuride ne was administered intranasally resulted in considerably higher dopamine concentrations (17.48\xc2\xa0\xc2\xb1\xc2\xa00.05\xc2\xa0ng/ml) in comparison to rats receiving haloperidol (7.28\xc2\xa0\xc2\xb1\xc2\xa00.02\xc2\xa0ng/ml). 2023-07-30 2023-08-14 rat
Sanja Strbe, Ivan Maria Smoday, Ivan Krezic, Luka Kalogjera, Vlasta Vukovic, Helena Zizek, Slaven Gojkovic, Hrvoje Vranes, Ivan Barisic, Suncana Sikiric, Marijan Tepes, Katarina Oroz, Filip Brkic, Martin Drinkovic, Lidija Beketic Oreskovic, Jelena Popic, Alenka Boban Blagaic, Anita Skrtic, Mario Staresinic, Sven Seiwerth, Predrag Sikiri. Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy. Pharmaceuticals (Basel, Switzerland). vol 16. issue 6. 2023-06-28. PMID:37375736. in rats with complete calvariectomy, medication (bpc 157 10 \xc2\xb5g/kg, 10 ng/kg ip or ig) was given 5 min after distinctive dopamine agents (mg/kg ip) (haloperidol (5), fluphenazine (5), clozapine (10), risperidone (5), olanzapine (10), quetiapine (10), or aripiprazole (10), domperidone (25), amphetamine (10), and combined amphetamine and haloperidol) and assessed at 15 min thereafter. 2023-06-28 2023-08-14 rat
Luis Felipe Sarmiento, Jorge Alexander R\\xc3\\xados-Fl\\xc3\\xb3rez, Hector Andres Paez-Ardila, P\\xc3\\xaassi Socorro Lima de Sousa, Antonio Olivera-La Rosa, Anderson Manoel Herculano Oliveira da Silva, Amauri Gouvei. Pharmacological Modulation of Temporal Discounting: A Systematic Review. Healthcare (Basel, Switzerland). vol 11. issue 7. 2023-04-13. PMID:37046974. the most important findings were the involvement of dopamine modulation in a u-shape for choosing the delayed outcome (metoclopradime, haloperidol, and amisulpride). 2023-04-13 2023-08-14 Not clear
Maciej M Jankowski, Bogna M Ignatowska-Jankowska, Wojciech Glac, Marek Wiergowski, Paulina Kazmierska-Grebowska, Artur H Swiergie. Intravenous haloperidol and cocaine alter the distribution of T CD3 Clinical and experimental pharmacology & physiology. 2023-02-21. PMID:36802086. intravenous haloperidol and cocaine alter the distribution of t cd3 the modulation of dopamine transmission evokes strong behavioral effects that can be achieved by commonly used psychoactive drugs such as haloperidol or cocaine. 2023-02-21 2023-08-14 rat
Maciej M Jankowski, Bogna M Ignatowska-Jankowska, Wojciech Glac, Marek Wiergowski, Paulina Kazmierska-Grebowska, Artur H Swiergie. Intravenous haloperidol and cocaine alter the distribution of T CD3 Clinical and experimental pharmacology & physiology. 2023-02-21. PMID:36802086. cocaine non-specifically increases dopamine transmission by blocking dopamine active transporter (dat) and evokes behavioral arousal, while haloperidol is a non-specific d2-like dopamine receptor antagonist with sedative effects. 2023-02-21 2023-08-14 rat
Hamna Rafiq, Muhammad Farhan, Hira Rafi, Sadia Rehman, Maria Arshad, Sarah Shakee. Inhibition of drug induced Parkinsonism by chronic supplementation of quercetin in haloperidol-treated wistars. Pakistan journal of pharmaceutical sciences. vol 35. issue 6. 2023-02-15. PMID:36789825. haloperidol causes drug-induced parkinsonism (dip) by blocking central dopamine receptors and causing extrapyramidal symptoms during long-term treatment. 2023-02-15 2023-08-14 rat
Jingheng Zhou, Jicheng Li, Amy B Papaneri, Guohong Cu. AJ76 and UH232 as potential agents for diagnosing early-stage Parkinson's disease. Neuropharmacology. 2023-01-09. PMID:36623805. the use of haloperidol in the original dnc test to challenge dopamine neurons was less than ideal, as it may cause extrapyramidal motor symptoms. 2023-01-09 2023-08-14 mouse
Jingheng Zhou, Jicheng Li, Amy B Papaneri, Guohong Cu. AJ76 and UH232 as potential agents for diagnosing early-stage Parkinson's disease. Neuropharmacology. 2023-01-09. PMID:36623805. here we report an improved dnc test, in which the original challenging agents, haloperidol and methylphenidate, are replaced by a single challenging agent, a dopamine autoreceptor preferring antagonist aj76 or uh232. 2023-01-09 2023-08-14 mouse
Kota Yamada, Koji Tod. Pupillary dynamics of mice performing a Pavlovian delay conditioning task reflect reward-predictive signals. Frontiers in systems neuroscience. vol 16. 2022-12-26. PMID:36567756. furthermore, we clarified that pupil size is still modulated by reward prediction even after the disruption of body movements by intraperitoneal injection of haloperidol, a dopamine d2 receptor antagonist. 2022-12-26 2023-08-14 mouse
Nicolette A Moya, Seongsik Yun, Stefan W Fleps, Madison M Martin, Jacob A Nadel, Lisa R Beutler, Larry S Zweifel, Jones G Parke. The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-11-15. PMID:36380221. we combined this manipulation with antipsychotic treatment (haloperidol) and compared it to brain-wide dopamine release via amphetamine treatment. 2022-11-15 2023-08-14 mouse
Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. we here collected data on a standard gambling task in healthy volunteers given either placebo, 2.5\xc2\xa0mg of the dopamine antagonist haloperidol or 100/25\xc2\xa0mg of the dopamine precursor levodopa in a within-subject design. 2022-11-09 2023-08-14 human
Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. shortened deliberation times on haloperidol occurred in low sensation-seekers only, suggesting a correlation between sensation-seeking personality trait and baseline dopamine levels. 2022-11-09 2023-08-14 human
Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. we hypothesise that levodopa increases risk-taking behaviour via overstimulation at both d1 and d2 receptor level, while a single low dose of haloperidol, as previously reported (frank and o'reilly 2006), may block d2 receptors pre- and post-synaptically and may paradoxically lead to higher striatal dopamine acting on remaining striatal d1 receptors, causing speedier decision without influencing risk tolerance. 2022-11-09 2023-08-14 human
Roberto De Masi, Stefania Orlando, Maria Carmela Cost. Dementia-Associated Compulsive Singing (DACS): Presentation of Unpublished Clinical Cases Miniseries. International journal of environmental research and public health. vol 19. issue 17. 2022-09-09. PMID:36078557. previously described only as a "punding" aspect of the dopamine dysregulation syndrome (dds) in the parkinson's disease (pd), compulsive singing has now been described, for the first time, in four non-pd patients effectively treated with haloperidol or quetiapine. 2022-09-09 2023-08-14 Not clear