| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Avila G, Picazo O, Chuc-Meza E, Garc\\xc3\\xada-Ramirez . Reduction of dopaminergic transmission in the globus pallidus increases anxiety-like behavior without altering motor activity. Behavioural brain research. vol 386. 2021-08-24. PMID:32194191. |
additionally, the effect on da receptors in the gp was tested by local administration of the dopamine agonist pd168,077, antagonist haloperidol and psychostimulant amphetamine. |
2021-08-24 |
2023-08-13 |
rat |
| Darlene Mae Ortiz, Raly James Perez Custodio, Arvie Abiero, Chrislean Jun Botanas, Leandro Val Sayson, Mikyung Kim, Hyun Jun Lee, Hee Jin Kim, Youngdo Jeong, Sulmin Yoon, Yong Sup Lee, Jae Hoon Cheon. The dopaminergic alterations induced by 4-F-PCP and 4-Keto-PCP may enhance their drug-induced rewarding and reinforcing effects: Implications for abuse. Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33135332. |
dopamine (da) receptor antagonists (sch23390 and haloperidol) were administered during cpp to evaluate the involvement of the mesolimbic dopaminergic system. |
2021-08-16 |
2023-08-13 |
Not clear |
| Makoto Kimura, Yasunori Oda, Hiroshi Kimura, Masahito Nangaku, Yuki Hirose, Tomihisa Niitsu, Nobuhisa Kanahara, Yukihiko Shirayama, Kenji Hashimoto, Masaomi Iy. Reduction of dopamine and glycogen synthase kinase-3 signaling in rat striatum after continuous administration of haloperidol. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33485878. |
reduction of dopamine and glycogen synthase kinase-3 signaling in rat striatum after continuous administration of haloperidol. |
2021-08-10 |
2023-08-13 |
rat |
| B\\xc3\\xa1rbara Nunes Krum, Airton C Martins, Lib\\xc3\\xa2nia Queir\\xc3\\xb3s, Beatriz Ferrer, Ginger L Milne, F\\xc3\\xa9lix Alexandre Antunes Soares, Roselei Fachinetto, Michael Aschne. Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans. Molecular neurobiology. vol 58. issue 1. 2021-08-04. PMID:32935232. |
haloperidol is a typical antipsychotic drug commonly used to treat a broad range of psychiatric disorders related to dysregulations in the neurotransmitter dopamine (da). |
2021-08-04 |
2023-08-13 |
caenorhabditis_elegans |
| Nicole S Lee, Annaliese K Beer. The role of dopamine signaling in prairie vole peer relationships. Hormones and behavior. vol 127. 2021-06-25. PMID:33152338. |
haloperidol blockade of dopamine receptors at multiple doses did not alter selective preferences for familiar same-sex partners, suggesting that dopamine neurotransmission is not necessary for the formation of prairie vole peer relationships, unlike mate relationships. |
2021-06-25 |
2023-08-13 |
Not clear |
| Jochen Michely, Shivakumar Viswanathan, Tobias U Hauser, Laura Delker, Raymond J Dolan, Christian Grefke. The role of dopamine in dynamic effort-reward integration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32268344. |
in a placebo-controlled, within-subject, study, we probed the impact of increasing brain dopamine levels (150\xe2\x80\x89mg of levodopa) and blocking dopamine receptors (1.5\xe2\x80\x89mg of haloperidol) in the context of a novel dynamic effort task in healthy human subjects. |
2021-06-23 |
2023-08-13 |
human |
| Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibu. Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders. Nature communications. vol 12. issue 1. 2021-06-22. PMID:34108486. |
hyperdopaminergia and autistic-like behaviours are corrected by the dopamine d1-like receptor antagonist sch-23390, providing a potential alternative strategy to the d2-like antagonist haloperidol that has only minimal therapeutic effects in mps-iiia. |
2021-06-22 |
2023-08-13 |
mouse |
| Uri Nimrod Ram\\xc3\\xadrez-Jarqu\\xc3\\xadn, Neelam Shahani, William Pryor, Alessandro Usiello, Srinivasa Subramania. The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33009372. |
here, we have identified that the depletion of the mtor gene in the mice striatum completely prevented the extrapyramidal motor side effects (catalepsy) induced by the dopamine 2 receptor (d2r) antagonist haloperidol, which is the most widely used typical antipsychotic drug. |
2021-06-18 |
2023-08-13 |
mouse |
| Makoto Kimura, Yasunori Oda, Kengo Oishi, Kouhei Yoshino, Hiroshi Kimura, Tomihisa Niitsu, Nobuhisa Kanahara, Yukihiko Shirayama, Kenji Hashimoto, Masaomi Iy. Effects of repeated electroconvulsive shocks on dopamine supersensitivity psychosis model rats. Schizophrenia research. vol 228. 2021-06-18. PMID:33429150. |
the objective of this study was to examine whether repeated es can release rats from dopamine supersensitivity states such as striatal dopamine d2 receptor (drd2) up-regulation and voluntary hyperlocomotion following chronic administration of haloperidol (hal). |
2021-06-18 |
2023-08-13 |
rat |
| Jos\\xc3\\xa9 Britto-J\\xc3\\xbanior, David H A Pinheiro, Alberto F O Justo, Guilherme M Figueiredo Murari, Rafael Campos, Fernanda V Mariano, Val\\xc3\\xa9ria B de Souza, Andr\\xc3\\xa9 A Schenka, Fabiola Z M\\xc3\\xb3nica, Edson Antunes, Gilberto De Nucc. Endothelium-derived dopamine modulates EFS-induced contractions of human umbilical vessels. Pharmacology research & perspectives. vol 8. issue 4. 2021-06-03. PMID:32567793. |
efs studies were performed in the presence and absence of l-name, the \xce\xb1-adrenergic blockers prazosin and idazoxan, and the dopamine antagonists sch-23390 and haloperidol. |
2021-06-03 |
2023-08-13 |
human |
| K Schmack, M Bosc, T Ott, J F Sturgill, A Kepec. Striatal dopamine mediates hallucination-like perception in mice. Science (New York, N.Y.). vol 372. issue 6537. 2021-04-09. PMID:33795430. |
hallucination-like percepts were preceded by elevated striatal dopamine levels, could be induced by optogenetic stimulation of mesostriatal dopamine neurons, and could be reversed by the antipsychotic drug haloperidol. |
2021-04-09 |
2023-08-13 |
mouse |
| Graziela Vieira, Juliana Cavalli, Elaine C D Gon\\xc3\\xa7alves, Saulo F P Braga, Rafaela S Ferreira, Adair R S Santos, Ma\\xc3\\xadra Cola, N\\xc3\\xa1dia R B Raposo, Raffaele Capasso, Rafael C Dutr. Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443870. |
moreover, terpineol showed an antidepressant-like effect in the preventive treatment that was blocked by a nonselective dopaminergic receptor antagonist (haloperidol), a selective dopamine d2 receptor antagonist (sulpiride), a selective cb1 cannabinoid receptor antagonist/inverse agonist (am281), and a potent and selective cb2 cannabinoid receptor inverse agonist (am630), but it was not blocked by a nonselective adenosine receptor antagonist (caffeine) or a \xce\xb2-adrenoceptor antagonist (propranolol). |
2021-04-02 |
2023-08-13 |
Not clear |
| Karima Chakroun, David Mathar, Antonius Wiehler, Florian Ganzer, Jan Peter. Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making. eLife. vol 9. 2021-02-22. PMID:32484779. |
thirty-one healthy male participants performed a restless four-armed bandit task in a within-subjects design under three drug conditions: 150 mg of the dopamine precursor l-dopa, 2 mg of the d2 receptor antagonist haloperidol, and placebo. |
2021-02-22 |
2023-08-13 |
human |
| Ben Wagner, Mareike Clos, Tobias Sommer, Jan Peter. Dopaminergic Modulation of Human Intertemporal Choice: A Diffusion Model Analysis Using the D2-Receptor Antagonist Haloperidol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 41. 2021-01-19. PMID:32948675. |
we previously reported elevated caudate activation under haloperidol in this sample of participants, supporting the idea that haloperidol elevated dopamine neurotransmission (e.g., by blocking inhibitory feedback via presynaptic d2 auto-receptors). |
2021-01-19 |
2023-08-13 |
human |
| Michael Silkstone, Stefan M Brudzynsk. Dissimilar interaction between dopaminergic and cholinergic systems in the initiation of emission of 50-kHz and 22-kHz vocalizations. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31655084. |
the current study tests the hypothesis that initial antagonism of dopamine receptors by systemic haloperidol or intraacumbens raclopride should increase the subsequent emission of 22\xe2\x80\xafkhz usvs induced by carbachol from the lateral septum. |
2020-12-31 |
2023-08-13 |
rat |
| Tibor Stark, Martina Di Bartolomeo, Roberta Di Marco, Eva Drazanova, Chiara Bianca Maria Platania, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Claudio D'Addario, Lucie Kratka, Vladimir Pekarik, Fabiana Piscitelli, Zuzana Babinska, Julia Fedotova, Giovanni Giurdanella, Salvatore Salomone, Alexandra Sulcova, Claudio Bucolo, Carsten T Wotjak, Zenon Starcuk, Filippo Drago, Raphael Mechoulam, Vincenzo Di Marzo, Vincenzo Mical. Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. Biochemical pharmacology. vol 177. 2020-12-07. PMID:32360362. |
peripubertal treatment with the non-euphoric phytocannabinoid cannabidiol (30\xc2\xa0mg/kg) from postnatal day (pnd) 19 to pnd 39 was able to reverse in mam exposed rats: i) the up-regulation of the dopamine d3 receptor mrna (only partially prevented by haloperidol 0.6\xc2\xa0mg/kg/day); and ii) the regional blood flow changes in mam exposed rats. |
2020-12-07 |
2023-08-13 |
rat |
| Matthew R Bailey, Eileen Chun, Elke Schipani, Peter D Balsam, Eleanor H Simpso. Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach. Behavioral neuroscience. vol 134. issue 2. 2020-10-30. PMID:32175760. |
we tested the effect of the dopamine d2 receptor antagonist, haloperidol, on performance in the cec and cvc assays and found that d2r signaling is important for effort-based, but not value-based decision making. |
2020-10-30 |
2023-08-13 |
mouse |
| Elisa Guma, Jill Rocchetti, Gabriel A Devenyi, Arnaud Tanti, Axel P Mathieu, Jason P Lerch, Guillaume Elgbeili, Blandine Courcot, Naguib Mechawar, M Mallar Chakravarty, Bruno Giro. Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:31127135. |
following our previous work, we undertook a longitudinal study to examine the effects of chronic (9-week) typical (haloperidol (hal)) and atypical (clozapine (clz)) apds on the neuroanatomy of wild-type (wt) and dopamine d3-knockout (d3ko) mice using magnetic resonance imaging (mri) and histological assessments in a sub-region of the anterior cingulate cortex (the prelimbic [pl] area) and striatum. |
2020-10-20 |
2023-08-13 |
mouse |
| Rafaela R Silva, Lucas T Parreiras-E-Silva, Thais E T Pompeu, Diego A Duarte, Carlos A M Fraga, Eliezer J Barreiro, Ricardo Menegatti, Claudio M Costa-Neto, Fran\\xc3\\xa7ois No\\xc3\\xab. Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31214037. |
evaluation of functional selectivity of haloperidol, clozapine, and lassbio-579, an experimental compound with antipsychotic-like actions in rodents, at g protein and arrestin signaling downstream of the dopamine d lassbio-579, an |
2020-09-29 |
2023-08-13 |
Not clear |
| Jaime Lee, Shane Thwaites, Andrea Gogos, Maarten van den Buus. Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by (\\xc2\\xb1)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31941052. |
pretreatment of the animals with the dopamine d1 receptor antagonist, sch23390, the dopamine d2 receptor antagonist, haloperidol, the serotonin (5-ht)1a receptor antagonist, way100635, or the 5-ht2a receptor antagonist, ketanserin, all blocked the effect of mdma, although the drugs differentially affected the individual s1 and s2 amplitudes. |
2020-09-28 |
2023-08-13 |
rat |