| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Tatsumi, K Jansen, R D Blakely, E Richelso. Pharmacological profile of neuroleptics at human monoamine transporters. European journal of pharmacology. vol 368. issue 2-3. 1999-06-01. PMID:10193665. |
using radioligand binding techniques, we determined the equilibrium dissociation constants (k(d)) for 37 neuroleptics and one metabolite of a neuroleptic (haloperidol metabolite) for the human serotonin, norepinephrine, and dopamine transporters with [3h]imipramine, [3h]nisoxetine, and [3h]win35428, respectively. |
1999-06-01 |
2023-08-12 |
human |
| P Stanzione, I Bodis-Wollner, M Pierantozzi, R Semprini, M Tagliati, A Peppe, G Bernard. A mixed D1 and D2 antagonist does not replay pattern electroretinogram alterations observed with a selective D2 antagonist in normal humans: relationship with Parkinson's disease pattern electroretinogram alterations. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 110. issue 1. 1999-06-01. PMID:10348324. |
it could argued that the increased dopamine release produced by the presynaptic d2 antagonistic action of haloperidol is subsequently counteracted at postsynaptic level by its d1 antagonistic effect, producing a net counterbalance at medium sfs. |
1999-06-01 |
2023-08-12 |
human |
| S M Grauer, K L Marqui. Intracerebral administration of metabotropic glutamate receptor agonists disrupts prepulse inhibition of acoustic startle in Sprague-Dawley rats. Psychopharmacology. vol 141. issue 4. 1999-05-28. PMID:10090648. |
in addition, pretreatment (30 min) with haloperidol (0.3 mg/kg ip) attenuated the ppi disruption induced by 1 micromol 1s,3r-acpd, suggesting dopamine may play a role in mglur agonist induced loss of ppi. |
1999-05-28 |
2023-08-12 |
rat |
| I Ninan, S K Kulkarn. Differential effects of olanzapine at dopamine D1 and D2 receptors in dopamine depleted animals. Psychopharmacology. vol 142. issue 2. 1999-05-27. PMID:10102770. |
unlike olanzapine, the selective dopamine d2 receptor antagonists such as haloperidol (0.25 and 0.5 mg/kg) and pimozide (0.5 and 1 mg/kg), the selective 5-ht2a receptor antagonist, ritanserin (0.5 and 1 mg/kg) or the antimuscarinic agent scopolamine (0.5 and 1 mg/kg) failed to produce any locomotor stimulant effect. |
1999-05-27 |
2023-08-12 |
mouse |
| R Depoortere, G Perrault, D J Sange. Intracranial self-stimulation under a progressive-ratio schedule in rats: effects of strength of stimulation, d-amphetamine, 7-OH-DPAT and haloperidol. Psychopharmacology. vol 142. issue 3. 1999-05-26. PMID:10208313. |
the effects of ip pretreatments with d-amphetamine, the dopamine d3/d2 receptor agonist 7-oh-dpat and haloperidol were then assessed. |
1999-05-26 |
2023-08-12 |
rat |
| K Huda, T L Salunga, S A Chowdhury, T Kawashima, K Matsunam. Dopaminergic modulation of transcallosal activity of cat motor cortical neurons. Neuroscience research. vol 33. issue 1. 1999-05-17. PMID:10096469. |
the effects of dopamine (da) and its antagonists on the transcallosal activity of pyramidal tract neurons (ptns) and non-ptns in the anesthetized cat motor cortex were studied with iontophoretic applications; dopamine, sch 23390 (d1 antagonist), sulpiride (d2 antagonist) and haloperidol. |
1999-05-17 |
2023-08-12 |
cat |
| K Huda, T L Salunga, S A Chowdhury, T Kawashima, K Matsunam. Dopaminergic modulation of transcallosal activity of cat motor cortical neurons. Neuroscience research. vol 33. issue 1. 1999-05-17. PMID:10096469. |
the number of spikes thus activated was counted for the control and test conditions after application of each drug: (1) dopamine application decreased the number of spikes evoked by transcallosal stimulation; (2) application of sch 23390, sulpiride and haloperidol restored these decreased spike numbers to the control level; (3) latency of neuronal response to transcallosal stimulation was not affected by the application of either da, sch 23390, sulpiride or haloperidol; and (4) there was no significant difference between ptns and non-ptns in the manner of response to da and its antagonist applications. |
1999-05-17 |
2023-08-12 |
cat |
| A Inoue, Y Nakat. [How do antipsychotics exert their effects on dopamine receptor subtypes?]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112. issue 6. 1999-05-17. PMID:10202760. |
aripiprazole, a candidate for a novel antipsychotic, has an antagonistic activity against dopamine d2 receptors with a high affinity, but has a weaker potency to up-regulate d2 receptors than haloperidol in the striatum and inhibitory effects on d2-receptor binding activities and mrna in the pituitary, when it is chronically administrated to rats. |
1999-05-17 |
2023-08-12 |
rat |
| E C Wolter. Dopaminomimetic psychosis in Parkinson's disease patients: diagnosis and treatment. Neurology. vol 52. issue 7 Suppl 3. 1999-05-10. PMID:10227604. |
unfortunately, typical antipsychotic agents such as haloperidol, which selectively antagonizes dopamine d-2 receptors, can induce extrapyramidal syndromes such as tardive parkinsonism. |
1999-05-10 |
2023-08-12 |
Not clear |
| N H Caskey, M E Jarvik, W C Wirshin. The effects of dopaminergic D2 stimulation and blockade on smoking behavior. Experimental and clinical psychopharmacology. vol 7. issue 1. 1999-05-07. PMID:10036612. |
in experiment 1, 4 participants were given haloperidol (a dopamine antagonist; placebo, 0.5, and 1.0 mg) on 3 occasions. |
1999-05-07 |
2023-08-12 |
human |
| S J Gladwell, J H Coot. Inhibitory and indirect excitatory effects of dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord in vitro. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082825. |
the dopamine induced slow depolarisation occurring in a sub-population of sympathetic preganglionic neurones was mimicked by quinpirole, a d2 agonist, and blocked by haloperidol, a d2 antagonist. |
1999-05-06 |
2023-08-12 |
rat |
| S J Gladwell, J H Coot. Inhibitory and indirect excitatory effects of dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord in vitro. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082825. |
haloperidol did not block the dopamine induced hyperpolarisations. |
1999-05-06 |
2023-08-12 |
rat |
| S J Gladwell, J H Coot. Inhibitory and indirect excitatory effects of dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord in vitro. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082825. |
dopamine also induced fast synaptic activity which was mimicked by a d2 agonist and blocked by haloperidol. |
1999-05-06 |
2023-08-12 |
rat |
| T Hayashi, T P Su, A Kagaya, A Nishida, M Shimizu, S Yamawak. Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025680. |
on the contrary, haloperidol, which is as potent a sigma receptor ligand as a dopamine d2 receptor ligand, did not affect the nmda-elicited increase in [ca2+]i. sulpiride increased the maximum effect afforded by different concentrations of nmda and shifted the dose-response curve of nmda to the left (ec50 value from 12.5 microm to 1.39 microm). |
1999-05-04 |
2023-08-12 |
rat |
| T Hayashi, T P Su, A Kagaya, A Nishida, M Shimizu, S Yamawak. Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025680. |
treatment of cells with dopamine (3 microm) tends to decrease the nmda-induced increase in [ca2+]i. sulpiride at 1 microm totally abolished this action of dopamine and restored its potentiating action on the nmda-induced increase in [ca2+]i. haloperidol, a potent dopamine d2 and sigma receptor ligand, did not affect the sulpiride's potentiating action on the nmda-induced responses. |
1999-05-04 |
2023-08-12 |
rat |
| S S Powlin, J C Cook, S Novak, J C O'Conno. Ex vivo and in vitro testis and ovary explants: utility for identifying steroid biosynthesis inhibitors and comparison to a Tier I screening battery. Toxicological sciences : an official journal of the Society of Toxicology. vol 46. issue 1. 1999-05-03. PMID:9928669. |
the testis explants were evaluated using the following compounds: ketoconazole (keto), a testosterone biosynthesis inhibitor; aminoglutethimide (ag) (only in vitro) and anastrozole (ana), aromatase inhibitors; finasteride (fin), a 5alpha-reductase inhibitor; 17beta-estradiol (17beta-e2), an estrogen receptor agonist; flutamide (flut), an androgen receptor antagonist; ici-182,780 (ici), an estrogen receptor antagonist; haloperidol (halo), a d2 receptor antagonist; and reserpine (res), a dopamine depletor. |
1999-05-03 |
2023-08-12 |
rat |
| E Eriksson, G Engberg, O Bing, H Nissbrand. Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 3. 1999-05-03. PMID:10063489. |
in anesthetized sd rats, mcpp induced a moderate reduction of nigral dopamine cell firing rate; supporting the assumption that this effect is secondary to the observed increase in dopamine release, it was blocked by pretreatment either with the dopamine synthesis inhibitor alpha-methyl-para-tyrosine or with the dopamine d2 receptor antagonist haloperidol. |
1999-05-03 |
2023-08-12 |
rat |
| E A Pehe. Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10086982. |
comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. |
1999-04-21 |
2023-08-12 |
rat |
| E A Pehe. Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10086982. |
the responses to d2 antagonist (haloperidol) administration, which has been shown to increase impulse-dependent dopamine release, were compared. |
1999-04-21 |
2023-08-12 |
rat |
| E A Pehe. Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10086982. |
results demonstrated a diminished effect of systemic haloperidol administration on dopamine efflux in the prefrontal cortex. |
1999-04-21 |
2023-08-12 |
rat |