| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Chaki, T Funakoshi, R Yoshikawa, S Okuyama, T Kumagai, A Nakazato, M Nagamine, K Tomisaw. In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic, in rats. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462131. |
intraperitoneal administration of haloperidol highly occupied the dopamine d2 receptor in the striatum and nucleus accumbens, and alpha1 adrenoceptors in the frontal cortex. |
1999-10-12 |
2023-08-12 |
rat |
| A Ceci, A Brambilla, P Duranti, M Grauert, N Grippa, F Borsin. Effect of antipsychotic drugs and selective dopaminergic antagonists on dopamine-induced facilitatory activity in prelimbic cortical pyramidal neurons. An in vitro study. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430475. |
the facilitatory effect of dopamine in prelimbic cortex was concentration dependently antagonized by haloperidol, risperidone, quetiapine, clozapine and by the selective d4 dopaminergic receptor antagonist l-745,870, but not by the selective d2/d3 dopaminergic receptor antagonist (-)-sulpiride. |
1999-10-08 |
2023-08-12 |
Not clear |
| D Wirtshafter, K E Asi. Haloperidol induces Fos expression in the globus pallidus and substantia nigra of cynomolgus monkeys. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415370. |
systemic injections of the dopamine antagonist haloperidol (0.1-2.5 mg/kg) induced a dose dependent increase in fos-like immunoreactivity (fli) in the internal segment of the globus pallidus (gpi) and in the substantia nigra (sn) of cynomolgus monkeys. |
1999-09-28 |
2023-08-12 |
monkey |
| M S Gevaerd, R N Takahash. Involvement of dopamine receptors on locomotor stimulation and sensitization elicited by the interaction of ethanol and mazindol in mice. Pharmacology, biochemistry, and behavior. vol 63. issue 3. 1999-09-14. PMID:10418779. |
male swiss albino mice were treated daily for 7 days with combined etoh+mz (1.2 g/kg, 5.0 mg/kg ip), etoh (1.2 g/kg ip), mz (5.0 mg/kg ip), or control solution coadministered with the d1 dopamine antagonist sch-23390 (0.025 or 0.05 mg/kg ip), the mixed dopamine antagonist haloperidol (0.05 or 0.075 mg/kg ip), or vehicle. |
1999-09-14 |
2023-08-12 |
mouse |
| M Mavridis, M J Besso. Dopamine-opiate interaction in the regulation of neostriatal and pallidal neuronal activity as assessed by opioid precursor peptides and glutamate decarboxylase messenger RNA expression. Neuroscience. vol 92. issue 3. 1999-09-09. PMID:10426535. |
the expression of the messenger rnas encoding glutamate decarboxylase-the biosynthetic enzyme of gaba-and the precursor peptides of enkephalin (preproenkephalin) and dynorphin (preprodynorphin) were measured in rats after a sustained blockade of opioid receptors by naloxone (s.c. implanted osmotic minipump, eight days, 3 mg/kg per h), and/or a subchronic blockade of d2 dopamine receptors by haloperidol (one week, 1.25 mg/kg s.c. twice a day). |
1999-09-09 |
2023-08-12 |
rat |
| E Tupala, A Haapalinna, T Viitamaa, P T Männistö, V Saan. Effects of repeated low dose administration and withdrawal of haloperidol on sexual behaviour of male rats. Pharmacology & toxicology. vol 84. issue 6. 1999-09-01. PMID:10401732. |
it has been observed that a mixed dopamine d1/d2 antagonist, haloperidol, may cause a reduction in the number of intromissions required to achieve ejaculation. |
1999-09-01 |
2023-08-12 |
rat |
| J M Vaugeois, A T Corera, A Deslandes, J Costenti. Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacology, biochemistry, and behavior. vol 63. issue 2. 1999-08-20. PMID:10371658. |
15, 30 microg/kg sc), but also by the d2 dopamine receptor antagonist haloperidol (50, 100, 200 microg/kg ip), in contrast to that elicited by dopamine uptake inhibitors. |
1999-08-20 |
2023-08-12 |
mouse |
| S Cho, A M Duchemin, N H Neff, M Hadjiconstantino. Tyrosine hydroxylase, aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs. Brain research. vol 830. issue 2. 1999-08-11. PMID:10366680. |
mice were treated with dopamine (da) receptor agonist and antagonist drugs: agonists: (+/-)-skf 38393 ((+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1h)-3-benzazepine-7,8-diol) [da d1-like]; bromocriptine, [da d2 selective]; quinpirole, [da d2/d3 preferring]; (+/-)-7-hydroxy-dipropylamino-tetralin (7-oh-dpat), [da d3/d2 preferring], antagonists: r(+)-sch 23390 (r(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1h-3-benzazepine), [da d1-like]; and haloperidol, [da d2-like]. |
1999-08-11 |
2023-08-12 |
mouse |
| R A Wilke, P J Lupardus, D K Grandy, M Rubinstein, M J Low, M B Jackso. K+ channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors. The Journal of physiology. vol 517 ( Pt 2). 1999-08-02. PMID:10332090. |
in rat neurohypophysis the sigma receptor ligands skf10047, pentazocine, and ditolylguanidine all reversibly inhibited k+ current in a concentration-dependent fashion, as did haloperidol and apomorphine (ligands that bind to both dopamine and sigma receptors). |
1999-08-02 |
2023-08-12 |
mouse |
| H Araki, N Hino, Y Karasawa, H Kawasaki, Y Gomit. Effect of dopamine blockers on cerebral ischemia-induced hyperactivity in gerbils. Physiology & behavior. vol 66. issue 2. 1999-08-02. PMID:10336152. |
haloperidol, sulpiride, and eticlopride, all dopamine d2 receptor antagonists, decreased the ischemia-induced hyperactivity at doses that had no effects on locomotor activity in sham-operated animals. |
1999-08-02 |
2023-08-12 |
Not clear |
| J M Gulley, G V Rebe. Modulatory effects of ascorbate, alone or with haloperidol, on a lever-release conditioned avoidance response task. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340532. |
pretreatment with ascorbate, a modulator of dopamine transmission in the striatum, enhances the ability of haloperidol, a dopamine antagonist, to induce catalepsy and block the motor-activating effects of amphetamine. |
1999-07-28 |
2023-08-12 |
rat |
| J M Gulley, G V Rebe. Modulatory effects of ascorbate, alone or with haloperidol, on a lever-release conditioned avoidance response task. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340532. |
in contrast, 100 mg/kg ascorbate alone or in combination with haloperidol had no consistent effects on car performance, even at a haloperidol dose (0.005 mg/kg, sc) known to potentiate dopamine transmission by preferentially blocking autoreceptors. |
1999-07-28 |
2023-08-12 |
rat |
| G D Tollefson, T M Sange. Anxious-depressive symptoms in schizophrenia: a new treatment target for pharmacotherapy? Schizophrenia research. vol 35 Suppl. 1999-07-21. PMID:10190222. |
this study concluded that the novel pharmacology of olanzapine delivered greater therapeutic activity in anxious and depressive symptoms accompanying schizophrenia than did the conventional dopamine d2 antagonist haloperidol. |
1999-07-21 |
2023-08-12 |
human |
| X Shi, R Yin, D Dow-Edward. Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. European journal of pharmacology. vol 370. issue 3. 1999-07-16. PMID:10334498. |
chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. |
1999-07-16 |
2023-08-12 |
rat |
| X Shi, R Yin, D Dow-Edward. Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period. European journal of pharmacology. vol 370. issue 3. 1999-07-16. PMID:10334498. |
these data suggest that inhibition of the dopamine transporter during ontogeny produces long-term alterations in dopamine receptor regulation but that selective inhibitors of the dopamine transporter produced greater effects than cocaine on both raclopride and sch 23390 binding following chronic haloperidol injection. |
1999-07-16 |
2023-08-12 |
rat |
| M C Arenas, C Vinader-Caerols, S Monleón, A Parra, V M Simó. Dose dependency of sex differences in the effects of repeated haloperidol administration in avoidance conditioning in mice. Pharmacology, biochemistry, and behavior. vol 62. issue 4. 1999-07-09. PMID:10208376. |
the results did not show sex differences in the deteriorating effects of this dopamine antagonist in the escape-avoidance response, but a tendency in the number of nonresponses was observed in the same direction as former results: male animals were more sensitive than females to the inhibitory effect of the low dose of haloperidol. |
1999-07-09 |
2023-08-12 |
mouse |
| C L Todd, A A Grac. Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo. Brain research bulletin. vol 48. issue 2. 1999-07-02. PMID:10230713. |
interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo. |
1999-07-02 |
2023-08-12 |
rat |
| C L Todd, A A Grac. Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo. Brain research bulletin. vol 48. issue 2. 1999-07-02. PMID:10230713. |
in rats pre-treated with haloperidol, which prevents the effects of dopamine transporter inhibitors on dopamine cell activity, benztropine either increased or decreased firing rate; however, it consistently increased burst firing. |
1999-07-02 |
2023-08-12 |
rat |
| K D Youngren, F M Inglis, P J Pivirotto, H P Jedema, C W Bradberry, P S Goldman-Rakic, R H Roth, B Moghadda. Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 5. 1999-06-09. PMID:10192821. |
alterations in dopamine release in these discrete brain regions were measured in response to administration of clozapine or haloperidol. |
1999-06-09 |
2023-08-12 |
monkey |
| K D Youngren, F M Inglis, P J Pivirotto, H P Jedema, C W Bradberry, P S Goldman-Rakic, R H Roth, B Moghadda. Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 5. 1999-06-09. PMID:10192821. |
haloperidol did not produce a consistent effect on dopamine release in the principal sulcus, although it increased dopamine release in the caudate. |
1999-06-09 |
2023-08-12 |
monkey |