| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Lucas, P De Deurwaerdère, S Caccia, Umberto Spampinat. The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727716. |
the effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-ht(2a) and 5-ht(2c) receptor subtypes and significance of the haloperidol dose used. |
2000-05-25 |
2023-08-12 |
rat |
| G Lucas, P De Deurwaerdère, S Caccia, Umberto Spampinat. The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727716. |
this study investigated, using microdialysis in freely-moving rats, the role of serotonin (5-ht) and 5-ht(2) receptor subtypes in the enhancement of striatal dopamine (da) release induced by various doses of haloperidol. |
2000-05-25 |
2023-08-12 |
rat |
| G Lucas, P De Deurwaerdère, S Caccia, Umberto Spampinat. The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727716. |
dopamine released by 0.1 mg/kg haloperidol was enhanced (+100%) by citalopram, decreased (-61%) by sr 4634b, but unaltered by sb 206553. |
2000-05-25 |
2023-08-12 |
rat |
| G Lucas, P De Deurwaerdère, S Caccia, Umberto Spampinat. The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727716. |
finally, none of the compounds used were able to modify the enhancement of dopamine release induced by 1 mg/kg haloperidol. |
2000-05-25 |
2023-08-12 |
rat |
| T H Svensso. Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs. Brain research. Brain research reviews. vol 31. issue 2-3. 2000-05-17. PMID:10719159. |
clinical studies utilizing imaging techniques demonstrate that classical antipsychotic drugs, such as haloperidol, in clinically effective doses display around 75% dopamine (da)-d(2) receptor occupancy in the brain. |
2000-05-17 |
2023-08-12 |
rat |
| C K Meshul, C Alle. Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion. Synapse (New York, N.Y.). vol 36. issue 2. 2000-05-12. PMID:10767060. |
we also reported on blockade of dopamine d-2 receptors with haloperidol resulting in ultrastructural changes within the striatum consistent with increased functioning of the glutamatergic corticostriatal pathway (meshul and tan 1994). |
2000-05-12 |
2023-08-12 |
rat |
| J F Cryan, A Harkin, M Naughton, J P Kelly, B E Leonar. Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action. European journal of pharmacology. vol 390. issue 3. 2000-05-11. PMID:10708734. |
pre-treatment with the dopamine, d(2) antagonist, haloperidol (1 mg/kg) and sulpiride (30 mg/kg) had a similar effect in blocking the hypothermia as way 100635, suggesting a role for dopamine d(2) receptors in the response. |
2000-05-11 |
2023-08-12 |
rat |
| D Boulay, R Depoortere, A Oblin, D J Sanger, H Schoemaker, G Perraul. Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice. European journal of pharmacology. vol 391. issue 1-2. 2000-05-11. PMID:10720636. |
d(2)(-/-) mice were totally unresponsive to the cataleptogenic effects of the dopamine d(2)-like receptor antagonist haloperidol (0.125-2 mg/kg i.p. |
2000-05-11 |
2023-08-12 |
mouse |
| D Boulay, R Depoortere, A Oblin, D J Sanger, H Schoemaker, G Perraul. Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice. European journal of pharmacology. vol 391. issue 1-2. 2000-05-11. PMID:10720636. |
in agreement with the observation that dopamine d(2) and dopamine d(1) receptor expression was essentially identical in d(3)(+/+), d(3)(+/-) and d(3)(-/-) mice, dopamine d(3) receptor homozygous and heterozygous mutant mice, on the whole, did not differ from their controls in the time spent in a cataleptic position following administration of either haloperidol (0.5-2 mg/kg i.p.) |
2000-05-11 |
2023-08-12 |
mouse |
| D Boulay, R Depoortere, A Oblin, D J Sanger, H Schoemaker, G Perraul. Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice. European journal of pharmacology. vol 391. issue 1-2. 2000-05-11. PMID:10720636. |
also, dopamine d(3) receptor mutant mice were no more responsive than wild-type controls when co-administered subthreshold doses of haloperidol (0.125 mg/kg) and sch 23390 (0.03 mg/kg), suggesting that dopamine d(3) receptor knock-out mice are not more sensitive than wild-types to the synergistic effects of concurrent blockade of dopamine d(2) and dopamine d(1) receptors in this model. |
2000-05-11 |
2023-08-12 |
mouse |
| D Boulay, R Depoortere, A Oblin, D J Sanger, H Schoemaker, G Perraul. Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice. European journal of pharmacology. vol 391. issue 1-2. 2000-05-11. PMID:10720636. |
these results suggest that the dopamine d(2) receptor subtype is necessary for haloperidol to produce catalepsy, and that the dopamine d(3) receptor subtype appears to exert no observable control over the catalepsy produced by dopamine d(2)-like, d(1)-like and the combination of d(1)-like and d(2)-like receptor antagonists. |
2000-05-11 |
2023-08-12 |
mouse |
| R Petersen, B Finsen, O A Andreassen, J Zimmer, H A Jørgense. No changes in dopamine D(1) receptor mRNA expressing neurons in the dorsal striatum of rats with oral movements induced by long-term haloperidol administration. Brain research. vol 859. issue 2. 2000-05-09. PMID:10719094. |
no changes in dopamine d(1) receptor mrna expressing neurons in the dorsal striatum of rats with oral movements induced by long-term haloperidol administration. |
2000-05-09 |
2023-08-12 |
rat |
| R Petersen, B Finsen, O A Andreassen, J Zimmer, H A Jørgense. No changes in dopamine D(1) receptor mRNA expressing neurons in the dorsal striatum of rats with oral movements induced by long-term haloperidol administration. Brain research. vol 859. issue 2. 2000-05-09. PMID:10719094. |
in this study, we measured the expression of dopamine d(1) receptor mrna by dorsal striatal neurons in rats with high and low level of vcm after treatment with haloperidol for 38 weeks. |
2000-05-09 |
2023-08-12 |
rat |
| G A Siebert, S M Pond, L J Bryan-Lluk. Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 3. 2000-04-13. PMID:10731037. |
we recently showed that haloperidol and its metabolites are inhibitors of the human noradrenaline transporter (nat), dopamine transporter (dat) and serotonin transporter (sert), and determined their ki values for inhibition of the three transporters expressed in transfected cos-7 cells. |
2000-04-13 |
2023-08-12 |
human |
| E A Del Bel, F S Guimarãe. Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice. Psychopharmacology. vol 147. issue 4. 2000-03-28. PMID:10672628. |
neuroleptic drugs such as haloperidol, which block dopamine receptors, also cause catalepsy in rodents. |
2000-03-28 |
2023-08-12 |
mouse |
| J E Magnusson, K Fishe. The involvement of dopamine in nociception: the role of D(1) and D(2) receptors in the dorsolateral striatum. Brain research. vol 855. issue 2. 2000-03-21. PMID:10677598. |
it was found that micro-injection of the non-selective dopamine antagonist haloperidol into the dorsolateral striatum increases formalin-induced nociception whereas injection of the non-selective dopamine agonist apomorphine reduces formalin-induced nociception. |
2000-03-21 |
2023-08-12 |
rat |
| A S Bazian, V M Getsova, N V Orlov. [The neurochemical mechanisms of the formation and consolidation of haloperidol-induced catalepsy]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 49. issue 6. 2000-03-17. PMID:10693278. |
in rat brain cortex, haloperidol initiates the long-term potentiation of k(+)-induced ca(2+)-dependent noradrenaline (na) and dopamine (da) secretion in vitro and in vivo. |
2000-03-17 |
2023-08-12 |
rat |
| S K Kim, G Y Kwon, S W Shin, B K Cho. Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells. Neurochemistry international. vol 36. issue 1. 2000-03-08. PMID:10566955. |
we pretreated the cells with dopamine, haloperidol, pentylenetetrazol, and muscimol before each stimulation. |
2000-03-08 |
2023-08-12 |
rat |
| S K Kim, G Y Kwon, S W Shin, B K Cho. Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells. Neurochemistry international. vol 36. issue 1. 2000-03-08. PMID:10566955. |
on the other hand, the dopamine and haloperidol pretreatment significantly elevated the levels of npy expression that were induced by nmda and kainic acid. |
2000-03-08 |
2023-08-12 |
rat |
| H L Rowley, P L Needham, I C Kilpatrick, D J Hea. A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 2. 2000-03-08. PMID:10685875. |
the acute effects of systemic administration of the antipsychotic drug, zotepine, on extracellular dopamine (da) in the frontal cortex of freely-moving rats were studied using in vivo microdialysis and compared with the actions of clozapine, olanzapine and haloperidol. |
2000-03-08 |
2023-08-12 |
rat |