| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Takita, E Herlenius, Y Yamamoto, S G Lindah. Effects of neuroactive substances on the morphine-induced respiratory depression; an in vitro study. Brain research. vol 884. issue 1--2. 2001-02-01. PMID:11082503. |
the adenosine receptor antagonist, theophylline (100 microm), the dopamine receptors antagonist, haloperidol (10 microm), the cyclooxygenase inhibitor, indomethacin (10 microm) and the phospholipase a(2) inhibitor, quinacrine (10 microm) had no effect on morphine-induced respiratory depression. |
2001-02-01 |
2023-08-12 |
rat |
| H H López, A Ettenber. Haloperidol challenge during copulation prevents subsequent increase in male sexual motivation. Pharmacology, biochemistry, and behavior. vol 67. issue 2. 2001-02-01. PMID:11124405. |
the current experiment was devised to investigate the role of dopamine in this process by assessing whether sexual behavior occurring in the presence of the dopamine receptor antagonist, haloperidol, would continue to alter the subjects' subsequent sexual motivation. |
2001-02-01 |
2023-08-12 |
human |
| L Besret, M A Caldwell, E M Torres, S B Dunnet. Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats. European journal of pharmacology. vol 408. issue 1. 2001-01-26. PMID:11070181. |
the effects of long-term administration of the dopamine d(2) receptor antagonist haloperidol on parkinsonian symptoms have been shown to persist after cessation of the drug treatment. |
2001-01-26 |
2023-08-12 |
rat |
| J W Grimm, R E Se. Chronic haloperidol-induced alterations in pallidal GABA and striatal D(1)-mediated dopamine turnover as measured by dual probe microdialysis in rats. Neuroscience. vol 100. issue 3. 2001-01-11. PMID:11098113. |
these results indicate a tonic increase in pallidal gaba levels and a hypersensitivity of d(1)-mediated striatal dopamine and dopamine metabolite decreases following chronic haloperidol treatment. |
2001-01-11 |
2023-08-12 |
rat |
| E Richelson, T Soude. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life sciences. vol 68. issue 1. 2001-01-11. PMID:11132243. |
using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (k(d)s) for nine new antipsychotic drugs (iloperidone, melperone, olanzapine, org 5222, quetiapine, risperidone, sertindole, ziprasidone, and zotepine), one metabolite of a new drug (9-oh-risperidone), and three older antipsychotics (clozapine, haloperidol, and pimozide) at nine different receptors (alpha1-adrenergic, alpha2-adrenergic, dopamine d2, histamine h1, muscarinic, and serotonin 5-ht1a, 5-ht1d, 5-ht2a, and 5-ht2c receptors). |
2001-01-11 |
2023-08-12 |
human |
| T Kusayama, S Watanab. Reinforcing effects of methamphetamine in planarians. Neuroreport. vol 11. issue 11. 2001-01-04. PMID:10943713. |
this reinforcing effect was antagonized by pretreatment with non-selective dopamine antagonist, haloperidol. |
2001-01-04 |
2023-08-12 |
Not clear |
| M J Milla. Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082417. |
although antagonism of mesolimbic dopamine d(2) receptors by neuroleptics such as haloperidol attenuates positive symptoms of schizophrenia, a significant population of "resistant" patients fails to respond while negative and cognitive symptoms are little modified. |
2000-12-20 |
2023-08-12 |
Not clear |
| S Kapur, S C Barsoum, P Seema. Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027926. |
dopamine d(2) receptor blockade by haloperidol. |
2000-11-21 |
2023-08-12 |
Not clear |
| S Kapur, S C Barsoum, P Seema. Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027926. |
in the first direct comparison of these two methods we find that the dose of haloperidol required for blocking 50% of the dopamine d(2) receptors was 0.02 mg/kg/sc (95% ci 0.018-0.022 mg/kg) as measured using 3h-raclopride method; but was significantly higher with the eedq method 0.14 mg/kg/s.c. |
2000-11-21 |
2023-08-12 |
Not clear |
| M Hillefors, G von Eule. Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen. Neurochemistry international. vol 38. issue 1. 2000-11-20. PMID:10913686. |
competition curves were performed with agonists such as r(-)-propylnorapomorphine, dopamine, pd 128907, quinpirole, and bromocriptine, and antagonists such as haloperidol, raclopride, clozapine, gr 218231x, remoxipride, and u99194a. |
2000-11-20 |
2023-08-12 |
rat |
| R Carey, E Damianopoulos, G De Palm. 8-OH DPAT can restore the locomotor stimulant effects of cocaine blocked by haloperidol. Pharmacology, biochemistry, and behavior. vol 66. issue 4. 2000-11-07. PMID:10973527. |
ex vivo measurements of dopamine and 5-hydroxytryptamine metabolism in limbic tissue were consistent with the established effects of cocaine, haloperidol, and 8-oh dpat upon dopamine and 5-hydroxytryptamine neurotransmission. |
2000-11-07 |
2023-08-12 |
rat |
| N Nakao, K Nakai, T Itakur. Fetal striatal transplants reinstate the electrophysiological response of pallidal neurons to systemic apomorphine challenge in rats with excitotoxic striatal lesions. The European journal of neuroscience. vol 12. issue 9. 2000-11-07. PMID:10998125. |
the blockade of dopamine receptors with haloperidol reversed the increased rate to baseline levels. |
2000-11-07 |
2023-08-12 |
rat |
| J F Vanhauwe, K Josson, W H Luyten, A J Driessen, J E Leyse. G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991990. |
binding affinities of agonists (dopamine, 7-oh-dpat, pd128907, lisuride) and antagonists/inverse agonists (haloperidol, risperidone, domperidone, spiperone, raclopride, nemonapride), measured using [(125)i]iodosulpride and [(3)h]7-oh-dpat, were similar for hd(3) receptors in e. coli and cho cell membranes. |
2000-11-03 |
2023-08-12 |
human |
| J B Zawilska, J Rosiak, J Z Nowa. Near-ultraviolet radiation suppresses melatonin synthesis in the chicken retina: a role of dopamine. Life sciences. vol 67. issue 18. 2000-11-03. PMID:11045604. |
haloperidol, sulpiride (blockers of d2-family of dopamine (da) receptors) and 2-chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin (an antagonist of d4-da receptors), given intraocularly (1-100 nmol/eye) prevented the uv-a light-evoked decrease in aa-nat activity in the chicken retina in a dose-dependent manner, while raclopride (300 nmol/eye), an antagonist of d2/d3-da receptors, was ineffective. |
2000-11-03 |
2023-08-12 |
chicken |
| N M de Bruin, E L van Luijtelaar, S J Jansen, A R Cools, B A Ellenbroe. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000443. |
assuming that haloperidol decreases dopaminergic transmission in the nigrostriatal system via inhibition of the dopamine receptors and enhances dopaminergic transmission in the mesolimbic system via inhibition of the noradrenergic receptors, it was postulated that haloperidol would enhance the difference in dopaminergic reactivity between both systems in favor of the accumbens. |
2000-11-01 |
2023-08-12 |
rat |
| J Ahveninen, S Kähkönen, H Tiitinen, E Pekkonen, J Huttunen, S Kaakkola, R J Ilmoniemi, I P Jääskeläine. Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors. Neuroscience letters. vol 292. issue 1. 2000-10-25. PMID:10996442. |
suppression of transient 40-hz auditory response by haloperidol suggests modulation of human selective attention by dopamine d2 receptors. |
2000-10-25 |
2023-08-12 |
human |
| J Ahveninen, S Kähkönen, H Tiitinen, E Pekkonen, J Huttunen, S Kaakkola, R J Ilmoniemi, I P Jääskeläine. Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors. Neuroscience letters. vol 292. issue 1. 2000-10-25. PMID:10996442. |
either 2mg of dopamine d(2)-receptor antagonist haloperidol or a placebo was administered orally to 11healthy subjects in a double-blind randomized crossover design in two separate sessions. |
2000-10-25 |
2023-08-12 |
human |
| A S Bazyan, V M Getsova, N V Orlov. Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration. Neuroscience. vol 99. issue 2. 2000-10-19. PMID:10938433. |
haloperidol, a non-selective d(2) dopamine antagonist, both in vitro (1 microm) and in vivo (2.5 mg/kg i.p. |
2000-10-19 |
2023-08-12 |
rat |
| T Nakamura, K Uramura, T Nambu, T Yada, K Goto, M Yanagisawa, T Sakura. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain research. vol 873. issue 1. 2000-10-12. PMID:10915829. |
in behavioral studies, we found that orexin-a induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine d(2) (haloperidol and sulpiride) or d(1) (sch23390) antagonists. |
2000-10-12 |
2023-08-12 |
rat |
| T Ozak. Comparative effects of dopamine D(1) and D(2) receptor antagonists on nerve growth factor protein induction. European journal of pharmacology. vol 402. issue 1-2. 2000-10-11. PMID:10940355. |
we previously reported that following acute administration of haloperidol or (-)-sulpiride, both dopamine d(2)-receptor antagonists, to mice induced nerve growth factor (ngf) gene expression, mediated by the interaction of c-fos with the ap-1 binding site present in the first intron on the ngf gene. |
2000-10-11 |
2023-08-12 |
mouse |