| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Kusayama, S Watanab. Reinforcing effects of methamphetamine in planarians. Neuroreport. vol 11. issue 11. 2001-01-04. PMID:10943713. |
this reinforcing effect was antagonized by pretreatment with non-selective dopamine antagonist, haloperidol. |
2001-01-04 |
2023-08-12 |
Not clear |
| M J Milla. Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082417. |
although antagonism of mesolimbic dopamine d(2) receptors by neuroleptics such as haloperidol attenuates positive symptoms of schizophrenia, a significant population of "resistant" patients fails to respond while negative and cognitive symptoms are little modified. |
2000-12-20 |
2023-08-12 |
Not clear |
| S Kapur, S C Barsoum, P Seema. Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027926. |
dopamine d(2) receptor blockade by haloperidol. |
2000-11-21 |
2023-08-12 |
Not clear |
| S Kapur, S C Barsoum, P Seema. Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027926. |
in the first direct comparison of these two methods we find that the dose of haloperidol required for blocking 50% of the dopamine d(2) receptors was 0.02 mg/kg/sc (95% ci 0.018-0.022 mg/kg) as measured using 3h-raclopride method; but was significantly higher with the eedq method 0.14 mg/kg/s.c. |
2000-11-21 |
2023-08-12 |
Not clear |
| M Hillefors, G von Eule. Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen. Neurochemistry international. vol 38. issue 1. 2000-11-20. PMID:10913686. |
competition curves were performed with agonists such as r(-)-propylnorapomorphine, dopamine, pd 128907, quinpirole, and bromocriptine, and antagonists such as haloperidol, raclopride, clozapine, gr 218231x, remoxipride, and u99194a. |
2000-11-20 |
2023-08-12 |
rat |
| R Carey, E Damianopoulos, G De Palm. 8-OH DPAT can restore the locomotor stimulant effects of cocaine blocked by haloperidol. Pharmacology, biochemistry, and behavior. vol 66. issue 4. 2000-11-07. PMID:10973527. |
ex vivo measurements of dopamine and 5-hydroxytryptamine metabolism in limbic tissue were consistent with the established effects of cocaine, haloperidol, and 8-oh dpat upon dopamine and 5-hydroxytryptamine neurotransmission. |
2000-11-07 |
2023-08-12 |
rat |
| N Nakao, K Nakai, T Itakur. Fetal striatal transplants reinstate the electrophysiological response of pallidal neurons to systemic apomorphine challenge in rats with excitotoxic striatal lesions. The European journal of neuroscience. vol 12. issue 9. 2000-11-07. PMID:10998125. |
the blockade of dopamine receptors with haloperidol reversed the increased rate to baseline levels. |
2000-11-07 |
2023-08-12 |
rat |
| J F Vanhauwe, K Josson, W H Luyten, A J Driessen, J E Leyse. G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991990. |
binding affinities of agonists (dopamine, 7-oh-dpat, pd128907, lisuride) and antagonists/inverse agonists (haloperidol, risperidone, domperidone, spiperone, raclopride, nemonapride), measured using [(125)i]iodosulpride and [(3)h]7-oh-dpat, were similar for hd(3) receptors in e. coli and cho cell membranes. |
2000-11-03 |
2023-08-12 |
human |
| J B Zawilska, J Rosiak, J Z Nowa. Near-ultraviolet radiation suppresses melatonin synthesis in the chicken retina: a role of dopamine. Life sciences. vol 67. issue 18. 2000-11-03. PMID:11045604. |
haloperidol, sulpiride (blockers of d2-family of dopamine (da) receptors) and 2-chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin (an antagonist of d4-da receptors), given intraocularly (1-100 nmol/eye) prevented the uv-a light-evoked decrease in aa-nat activity in the chicken retina in a dose-dependent manner, while raclopride (300 nmol/eye), an antagonist of d2/d3-da receptors, was ineffective. |
2000-11-03 |
2023-08-12 |
chicken |
| N M de Bruin, E L van Luijtelaar, S J Jansen, A R Cools, B A Ellenbroe. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000443. |
assuming that haloperidol decreases dopaminergic transmission in the nigrostriatal system via inhibition of the dopamine receptors and enhances dopaminergic transmission in the mesolimbic system via inhibition of the noradrenergic receptors, it was postulated that haloperidol would enhance the difference in dopaminergic reactivity between both systems in favor of the accumbens. |
2000-11-01 |
2023-08-12 |
rat |
| J Ahveninen, S Kähkönen, H Tiitinen, E Pekkonen, J Huttunen, S Kaakkola, R J Ilmoniemi, I P Jääskeläine. Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors. Neuroscience letters. vol 292. issue 1. 2000-10-25. PMID:10996442. |
suppression of transient 40-hz auditory response by haloperidol suggests modulation of human selective attention by dopamine d2 receptors. |
2000-10-25 |
2023-08-12 |
human |
| J Ahveninen, S Kähkönen, H Tiitinen, E Pekkonen, J Huttunen, S Kaakkola, R J Ilmoniemi, I P Jääskeläine. Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors. Neuroscience letters. vol 292. issue 1. 2000-10-25. PMID:10996442. |
either 2mg of dopamine d(2)-receptor antagonist haloperidol or a placebo was administered orally to 11healthy subjects in a double-blind randomized crossover design in two separate sessions. |
2000-10-25 |
2023-08-12 |
human |
| A S Bazyan, V M Getsova, N V Orlov. Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration. Neuroscience. vol 99. issue 2. 2000-10-19. PMID:10938433. |
haloperidol, a non-selective d(2) dopamine antagonist, both in vitro (1 microm) and in vivo (2.5 mg/kg i.p. |
2000-10-19 |
2023-08-12 |
rat |
| T Nakamura, K Uramura, T Nambu, T Yada, K Goto, M Yanagisawa, T Sakura. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain research. vol 873. issue 1. 2000-10-12. PMID:10915829. |
in behavioral studies, we found that orexin-a induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine d(2) (haloperidol and sulpiride) or d(1) (sch23390) antagonists. |
2000-10-12 |
2023-08-12 |
rat |
| T Ozak. Comparative effects of dopamine D(1) and D(2) receptor antagonists on nerve growth factor protein induction. European journal of pharmacology. vol 402. issue 1-2. 2000-10-11. PMID:10940355. |
we previously reported that following acute administration of haloperidol or (-)-sulpiride, both dopamine d(2)-receptor antagonists, to mice induced nerve growth factor (ngf) gene expression, mediated by the interaction of c-fos with the ap-1 binding site present in the first intron on the ngf gene. |
2000-10-11 |
2023-08-12 |
mouse |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
the ligands n-methylspiperone and haloperidol both bind to d(2)-like dopamine receptors. |
2000-09-28 |
2023-08-12 |
Not clear |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
the competitive nature of the binding over a wide range of haloperidol concentrations and the effect on dopamine release have never been tested in vivo. |
2000-09-28 |
2023-08-12 |
Not clear |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
we determined the competitive interaction between 3-n-[(11)c]methylspiperone ([(11)c]nmsp) and haloperidol binding to striatal dopamine d(2)-like receptors with positron emission tomography (pet) of pig brain. |
2000-09-28 |
2023-08-12 |
Not clear |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
we contend that this reveals the release of dopamine by high concentrations of haloperidol. |
2000-09-28 |
2023-08-12 |
Not clear |
| W R Wu, Z T Zhu, X Z Zh. Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens. Life sciences. vol 67. issue 3. 2000-09-19. PMID:10983868. |
perfusion with l-deprenyl or l-amphetamine, but not pargyline, into nucleus accumbens increased the dopamine efflux in a dose-dependent fashion, which could be antagonized by haloperidol pretreatment. |
2000-09-19 |
2023-08-12 |
rat |