| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
the ligands n-methylspiperone and haloperidol both bind to d(2)-like dopamine receptors. |
2000-09-28 |
2023-08-12 |
Not clear |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
the competitive nature of the binding over a wide range of haloperidol concentrations and the effect on dopamine release have never been tested in vivo. |
2000-09-28 |
2023-08-12 |
Not clear |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
we determined the competitive interaction between 3-n-[(11)c]methylspiperone ([(11)c]nmsp) and haloperidol binding to striatal dopamine d(2)-like receptors with positron emission tomography (pet) of pig brain. |
2000-09-28 |
2023-08-12 |
Not clear |
| K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedd. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941144. |
we contend that this reveals the release of dopamine by high concentrations of haloperidol. |
2000-09-28 |
2023-08-12 |
Not clear |
| W R Wu, Z T Zhu, X Z Zh. Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens. Life sciences. vol 67. issue 3. 2000-09-19. PMID:10983868. |
perfusion with l-deprenyl or l-amphetamine, but not pargyline, into nucleus accumbens increased the dopamine efflux in a dose-dependent fashion, which could be antagonized by haloperidol pretreatment. |
2000-09-19 |
2023-08-12 |
rat |
| M E Liechti, F X Vollenweide. Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 4. 2000-09-14. PMID:10871712. |
we investigated the effect of pretreatment with the dopamine d(2) antagonist haloperidol (1.4 mg i.v.) |
2000-09-14 |
2023-08-12 |
human |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
the shortening of rts by stimuli predictive of high reward to be obtained was dose-dependently impaired by bilateral intra-nac infusion of the competitive nmda antagonist dl-2-amino-5-phosphonovaleric acid (apv) (1, 2, or 10 microg in 0.5 microl/side), but not by infusion of the preferential dopamine d(2) antagonist haloperidol (5 and 12.5 microg in 0.5 microl/side) or by infusion of vehicle (0.5 microl/side). |
2000-08-31 |
2023-08-12 |
rat |
| C F Wu, H L Zhang, W Li. Potentiation of ethanol-induced loss of the righting reflex by ascorbic acid in mice: interaction with dopamine antagonists. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880698. |
dopamine d(2) antagonists haloperidol (0.5, 1.0 mg/kg sc), and l-sulpiride (80 mg/kg sc) also significantly prolonged the duration of lorr induced by ethanol. |
2000-08-28 |
2023-08-12 |
mouse |
| C F Wu, H L Zhang, W Li. Potentiation of ethanol-induced loss of the righting reflex by ascorbic acid in mice: interaction with dopamine antagonists. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880698. |
in the interaction study, the synergistic effect of ascorbic acid (1000 mg/kg ip) on ethanol-induced lorr was significantly enhanced by dopamine d(2) antagonists haloperidol, l-sulpiride, and clozapine, and the highest dose of dopamine d(1) antagonist sch 23390. |
2000-08-28 |
2023-08-12 |
mouse |
| M Fendt, I Schwienbacher, M Koc. Amygdaloid N-methyl-D-aspartate and gamma-aminobutyric acid(A) receptors regulate sensorimotor gating in a dopamine-dependent way in rats. Neuroscience. vol 98. issue 1. 2000-08-24. PMID:10858611. |
the prepulse inhibition-disrupting effect of 6.25 microg dizocilpine or 10.0 ng picrotoxin was reversed by systemic co-administration of the dopamine antagonist haloperidol (0.1mg/kg i.p.). |
2000-08-24 |
2023-08-12 |
rat |
| H L Kimmel, W Gong, S D Vechia, R G Hunter, M J Kuha. Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900261. |
the locomotor effects of cart 55-102 were dose dependently blocked by the dopamine d(2) receptor antagonist haloperidol (0.03-1.0 mg/kg i.p.). |
2000-08-24 |
2023-08-12 |
rat |
| L Gazi, P Schoeffter, C Nunn, K Croskery, D Hoyer, D Feuerbac. Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 5. 2000-08-16. PMID:10832611. |
antagonist pkb-values obtained against dopamine in this system were: 8.55+/-0.19 (n=3) for the partial agonist l-745,870, 8.38+/-0.23 (n=5) for spiperone, 7.18+/-0.17 (n=4) for haloperidol, 7.04+/-0.13 (n=4) for clozapine and <6 for raclopride. |
2000-08-16 |
2023-08-12 |
human |
| J C O'Connor, L G Davis, S R Frame, J C Coo. Detection of dopaminergic modulators in a tier I screening battery for identifying endocrine-active compounds (EACs). Reproductive toxicology (Elmsford, N.Y.). vol 14. issue 3. 2000-08-01. PMID:10838120. |
apomorphine (apo; d(2) receptor agonist), haloperidol (hal; d(2) receptor antagonist), and reserpine (res; a dopamine depletor that acts to lower brain dopamine levels by depleting central nervous system monoamines via disrupting storage vesicle function) have been examined in a tier i screening battery, which has been designed to detect endocrine-active compounds (eacs). |
2000-08-01 |
2023-08-12 |
rat |
| P B Fitzgerald, S Kapur, G Remington, P Roy, R B Zipursk. Predicting haloperidol occupancy of central dopamine D2 receptors from plasma levels. Psychopharmacology. vol 149. issue 1. 2000-07-26. PMID:10789875. |
predicting haloperidol occupancy of central dopamine d2 receptors from plasma levels. |
2000-07-26 |
2023-08-12 |
Not clear |
| P Sikiric, J Separovic, G Buljat, T Anic, D Stancic-Rokotov, D Mikus, B Duplancic, A Marovic, I Zoricic, I Prkacin, M Lovric-Bencic, G Aralica, T Ziger, D Perovic, N Jelovac, G Dodig, I Rotkvic, S Mise, S Seiwerth, B Turkovic, Z Grabarevic, M Petek, R Rucma. Gastric mucosal lesions induced by complete dopamine system failure in rats. The effects of dopamine agents, ranitidine, atropine, omeprazole and pentadecapeptide BPC 157. Journal of physiology, Paris. vol 94. issue 2. 2000-07-24. PMID:10791690. |
for this purpose, a co-administration of reserpine and haloperidol, a dopamine granule depletor combined with a dopamine antagonist with pronounced ulcerogenic effect, was tested, and the rats were sacrificed 24 h after injurious agent(s) administration. |
2000-07-24 |
2023-08-12 |
rat |
| P Teismann, B Ferge. In vivo effects of the putative cognitive enhancer KA-672.HCl in comparison with 8-hydroxy-2-(di-N-propylamino) tetralin and haloperidol on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical brain regions. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 2. 2000-07-19. PMID:10800755. |
in vivo effects of the putative cognitive enhancer ka-672.hcl in comparison with 8-hydroxy-2-(di-n-propylamino) tetralin and haloperidol on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical brain regions. |
2000-07-19 |
2023-08-12 |
rat |
| P Teismann, B Ferge. In vivo effects of the putative cognitive enhancer KA-672.HCl in comparison with 8-hydroxy-2-(di-N-propylamino) tetralin and haloperidol on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical brain regions. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 2. 2000-07-19. PMID:10800755. |
in the present study the authors investigated the effects of ka-672.hcl (0.1 mg/kg and 1 mg/kg), 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (1 mg/kg), haloperidol (0.1 mg/kg) and a mixture of haloperidol and 8-oh-dpat on dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), serotonin (5-ht) and 5-hydroxyindolacetic acid (5-hiaa) levels, in striatum and cerebral cortex of rats. |
2000-07-19 |
2023-08-12 |
rat |
| R Bauer, A Mayr, W Lederer, P L Needham, I C Kilpatrick, W W Fleischhacker, J Marksteine. Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 1. 2000-07-17. PMID:10869885. |
first, the dopamine d(2) receptor antagonist, haloperidol, did not significantly alter synaptic protein levels or their encoding mrnas. |
2000-07-17 |
2023-08-12 |
Not clear |
| H E Shannon, K Rasmussen, F P Bymaster, J C Hart, S C Peters, M D Swedberg, L Jeppesen, M J Sheardown, P Sauerberg, A Fink-Jense. Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice. Schizophrenia research. vol 42. issue 3. 2000-07-11. PMID:10785583. |
behaviorally, xanomeline, like haloperidol, clozapine and olanzapine, blocked dopamine agonist-induced turning in unilateral 6-hydroxydopamine-lesioned rats, as well as apomorphine-induced climbing in mice. |
2000-07-11 |
2023-08-12 |
mouse |
| H E Shannon, K Rasmussen, F P Bymaster, J C Hart, S C Peters, M D Swedberg, L Jeppesen, M J Sheardown, P Sauerberg, A Fink-Jense. Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice. Schizophrenia research. vol 42. issue 3. 2000-07-11. PMID:10785583. |
however, unlike the dopamine antagonist antipsychotic haloperidol, xanomeline did not produce catalepsy in rats. |
2000-07-11 |
2023-08-12 |
mouse |