| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Wright, J Bempong, M L Kirby, R L Barlow, J R Bloomquis. Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia. Brain research. vol 788. issue 1-2. 1998-07-23. PMID:9555021. |
in synaptosome preparations from mouse striatum and cortex, the hp metabolites haloperidol pyridinium (hpp+), reduced haloperidol pyridinium (rhpp+), and haloperidol tetrahydropyridine (hptp) inhibited the presynaptic uptake of dopamine and serotonin, with greater affinity for the serotonin transporter. |
1998-07-23 |
2023-08-12 |
mouse |
| R Y Wang, X Lian. M100907 and clozapine, but not haloperidol or raclopride, prevent phencyclidine-induced blockade of NMDA responses in pyramidal neurons of the rat medial prefrontal cortical slice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 1. 1998-07-20. PMID:9608579. |
furthermore, the atypical apd clozapine, but not the typical apd haloperidol or raclopride (a selective dopamine d2,3 receptor antagonist), mimicked the action of m100907, preventing the pcp-induced effect. |
1998-07-20 |
2023-08-12 |
rat |
| L Ouedraogo, M Magnon, L Sawadogo, R Tricoch. Receptors involved in the positive inotropic action induced by dopamine on the ventricle of a 7-day-old chick embryo heart. Fundamental & clinical pharmacology. vol 12. issue 2. 1998-07-16. PMID:9565766. |
moreover, haloperidol (2 microm) antagonized the positive inotropic response to dopamine but had not any significant effect on the response to isoprenaline. |
1998-07-16 |
2023-08-12 |
chicken |
| L Ouedraogo, M Magnon, L Sawadogo, R Tricoch. Receptors involved in the positive inotropic action induced by dopamine on the ventricle of a 7-day-old chick embryo heart. Fundamental & clinical pharmacology. vol 12. issue 2. 1998-07-16. PMID:9565766. |
the combined application of both propranolol and haloperidol antagonized the positive inotropic response to dopamine to a greater extent than when these two antagonists were given alone. |
1998-07-16 |
2023-08-12 |
chicken |
| L Ouedraogo, M Magnon, L Sawadogo, R Tricoch. Receptors involved in the positive inotropic action induced by dopamine on the ventricle of a 7-day-old chick embryo heart. Fundamental & clinical pharmacology. vol 12. issue 2. 1998-07-16. PMID:9565766. |
furthermore, in preparations in which sodium channels were inactivated by high potassium physiological salt solution, high concentrations of dopamine (0.1 mm to 1 mm) induced a slow developing electrical and positive inotropic responses which were also inhibited by propranolol and haloperidol, but not by phentolamine. |
1998-07-16 |
2023-08-12 |
chicken |
| P Seeman, T Talleric. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Molecular psychiatry. vol 3. issue 2. 1998-07-16. PMID:9577836. |
as determined by the new dissociation constants, antipsychotic drugs which elicit parkinsonism (trifluperazine, chlorpromazine, raclopride, haloperidol, fluphenazine, risperidone) bind more tightly than dopamine to d2, while those antipsychotic drugs which elicit little or no parkinsonism (melperone, seroquel, perlapine, clozapine, remoxipride, molindone, sulpiride, olanzapine, sertindole) bind more loosely than dopamine to d2 receptors. |
1998-07-16 |
2023-08-12 |
human |
| B K Yamamoto, S Novotne. Regulation of extracellular dopamine by the norepinephrine transporter. Journal of neurochemistry. vol 71. issue 1. 1998-07-09. PMID:9648875. |
the combined systemic administration of haloperidol and the local infusion of dmi produced an augmented increase in extracellular dopamine in the cortex compared with the increase produced by either drug alone. |
1998-07-09 |
2023-08-12 |
rat |
| B K Yamamoto, S Novotne. Regulation of extracellular dopamine by the norepinephrine transporter. Journal of neurochemistry. vol 71. issue 1. 1998-07-09. PMID:9648875. |
this synergistic increase in dopamine overflow is likely due to the combination of impulse-mediated dopamine release produced by haloperidol and blockade of the norepinephrine transporter. |
1998-07-09 |
2023-08-12 |
rat |
| B K Yamamoto, S Novotne. Regulation of extracellular dopamine by the norepinephrine transporter. Journal of neurochemistry. vol 71. issue 1. 1998-07-09. PMID:9648875. |
although the stimulation of extracellular dopamine by idazoxan and dmi could be due to the increased extracellular concentrations of norepinephrine produced by these drugs, an increase in dopamine also was observed in lesioned rats that were depleted of norepinephrine and challenged with haloperidol. |
1998-07-09 |
2023-08-12 |
rat |
| B K Yamamoto, S Novotne. Regulation of extracellular dopamine by the norepinephrine transporter. Journal of neurochemistry. vol 71. issue 1. 1998-07-09. PMID:9648875. |
this contrasted with the lack of an effect of haloperidol on cortical dopamine in unlesioned controls. |
1998-07-09 |
2023-08-12 |
rat |
| G Davidkova, L W Zhou, M Morabito, S P Zhang, B Weis. D2 dopamine antisense RNA expression vector, unlike haloperidol, produces long-term inhibition of D2 dopamine-mediated behaviors without causing Up-regulation of D2 dopamine receptors. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618422. |
d2 dopamine antisense rna expression vector, unlike haloperidol, produces long-term inhibition of d2 dopamine-mediated behaviors without causing up-regulation of d2 dopamine receptors. |
1998-07-02 |
2023-08-12 |
mouse |
| G Davidkova, L W Zhou, M Morabito, S P Zhang, B Weis. D2 dopamine antisense RNA expression vector, unlike haloperidol, produces long-term inhibition of D2 dopamine-mediated behaviors without causing Up-regulation of D2 dopamine receptors. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618422. |
long-term inhibition of d2 dopamine receptors using classic d2 dopamine receptor antagonists such as haloperidol often causes a compensatory up-regulation of the d2 dopamine receptors. |
1998-07-02 |
2023-08-12 |
mouse |
| H Moore, C L Todd, A A Grac. Striatal extracellular dopamine levels in rats with haloperidol-induced depolarization block of substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634572. |
correlations between substantia nigra (sn) dopamine (da) cell activity and striatal extracellular da were examined using simultaneous extracellular single-unit recordings and in vivo microdialysis performed in drug-naive rats and in rats treated repeatedly with haloperidol (hal). |
1998-07-02 |
2023-08-12 |
rat |
| T Ozaki, E Katsumoto, K Mui, D Furutsuka, S Yamagam. Distribution of Fos- and Jun-related proteins and activator protein-1 composite factors in mouse brain induced by neuroleptics. Neuroscience. vol 84. issue 4. 1998-06-23. PMID:9578405. |
we immunocytochemically investigated the expression of fos- and jun-related proteins and examined activator protein-1 dna-binding activity in ddy mouse brain 120 min after the administration of haloperidol (1 mg/kg), (-)-sulpiride (20 mg/kg) and a selective dopamine d1 receptor antagonist, sch23390 (1 mg/kg). |
1998-06-23 |
2023-08-12 |
mouse |
| K E Vanove. Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice. Psychopharmacology. vol 136. issue 2. 1998-06-18. PMID:9551768. |
the noncompetitive ampa antagonists, gyki 52466 (5-40 mg/kg) and ly300164 (1-6 mg/kg), and the competitive ampa antagonists, ly326325 (5-80 mg/kg) and nbqx (10-80 mg/kg), were compared to the dopamine antagonist, haloperidol (0.03-1.0 mg/kg), for their ability to inhibit dopamine-mediated behaviors after i.p. |
1998-06-18 |
2023-08-12 |
mouse |
| M Gil, A Armari. Chronic immobilization stress appears to increase the role of dopamine in the control of active behaviour in the forced swimming test. Behavioural brain research. vol 91. issue 1-2. 1998-06-18. PMID:9578443. |
on the following day, half of the rats were administered saline and the others the dopamine antagonist haloperidol (0.5 mg/kg). |
1998-06-18 |
2023-08-12 |
rat |
| C W Tsao, Y S Lin, J T Chen. Inhibition of immune cell proliferation with haloperidol and relationship of tyrosine hydroxylase expression to immune cell growth. Life sciences. vol 62. issue 21. 1998-06-18. PMID:9619850. |
haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of t cell hybridoma (10i) and rat nervous pheochromocytoma cells (pc12). |
1998-06-18 |
2023-08-12 |
rat |
| T Sasaki, J L Kennedy, J N Nobreg. Regional brain changes in [3H]SCH 23390 binding to dopamine D1, receptors after long-term haloperidol treatment: lack of correspondence with the development of vacuous chewing movements. Behavioural brain research. vol 90. issue 2. 1998-05-27. PMID:9521545. |
regional brain changes in [3h]sch 23390 binding to dopamine d1, receptors after long-term haloperidol treatment: lack of correspondence with the development of vacuous chewing movements. |
1998-05-27 |
2023-08-12 |
rat |
| J Zhang, J A Engel, B Söderpalm, L Svensso. Repeated administration of amphetamine induces sensitisation to its disruptive effect on prepulse inhibition in the rat. Psychopharmacology. vol 135. issue 4. 1998-05-21. PMID:9539265. |
the development of sensitisation was blocked by pretreatment with haloperidol (hpd, 0.1 mg/kg, sc), which suggests that sensitisation to the disruptive effect of amp was dependent on dopamine (da) d2 receptor activation. |
1998-05-21 |
2023-08-12 |
rat |
| A Wirz-Justice, C Cajochen, P Nussbau. A schizophrenic patient with an arrhythmic circadian rest-activity cycle. Psychiatry research. vol 73. issue 1-2. 1998-05-11. PMID:9463841. |
high-dose haloperidol treatment may have lowered the circadian alertness threshold, whereas clozapine augmented circadian amplitude (perhaps through its high affinity to dopamine d4 and serotonin 5ht7 receptors in the suprachiasmatic nuclei). |
1998-05-11 |
2023-08-12 |
Not clear |