| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Levinson, S Garside, P I Rosebush, M F Mazure. Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat. Neuroscience. vol 84. issue 1. 1998-05-08. PMID:9522374. |
the dopamine antagonist haloperidol can cause tardive side-effects that may persist after the drug is withdrawn. |
1998-05-08 |
2023-08-12 |
rat |
| A J Levinson, S Garside, P I Rosebush, M F Mazure. Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat. Neuroscience. vol 84. issue 1. 1998-05-08. PMID:9522374. |
these results indicate that haloperidol can produce selective changes in midbrain dopamine neurons that persist long after discontinuation of the drug. |
1998-05-08 |
2023-08-12 |
rat |
| M Melis, G Mereu, V Lilliu, M Quartu, M Diana, G L Gess. Haloperidol does not produce dopamine cell depolarization-block in paralyzed, unanesthetized rats. Brain research. vol 783. issue 1. 1998-04-30. PMID:9479061. |
haloperidol does not produce dopamine cell depolarization-block in paralyzed, unanesthetized rats. |
1998-04-30 |
2023-08-12 |
rat |
| G N Bancroft, K A Morgan, R J Flietstra, B Levan. Binding of [3H]PD 128907, a putatively selective ligand for the D3 dopamine receptor, in rat brain: a receptor binding and quantitative autoradiographic study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 4. 1998-04-30. PMID:9509498. |
the pharmacological profile for [3h]pd 128907 was similar to that of [3h](+)-7-oh-dpat with the rank order of potency for dopamine agonists being pd 128907 approximately 7-oh-dpat approximately quinpirole > or = dopamine; for antagonists, spiperone > (+)-butaclamol approximately domperidone > or = haloperidol > sch 23390. |
1998-04-30 |
2023-08-12 |
rat |
| M J Mijnster, A Schotte, G J Docter, P Voor. Effects of risperidone and haloperidol on tachykinin and opioid precursor peptide mRNA levels in the caudate-putamen and nucleus accumbens of the rat. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517839. |
however, when doses of risperidone and haloperidol were modified to attain comparable dopamine d2 receptor occupancy, the drugs had comparable effects on preproenkephalin-a mrna levels. |
1998-04-30 |
2023-08-12 |
rat |
| B M Cohen, W Wan, M P Froimowitz, D J Ennulat, S Cherkerzian, H Konieczn. Activation of midline thalamic nuclei by antipsychotic drugs. Psychopharmacology. vol 135. issue 1. 1998-04-22. PMID:9489932. |
rats were given single doses of the typical high and low potency neuroleptics haloperidol (1 mg/kg) and chlorpromazine (20 mg/kg), the atypical neuroleptics thiroridazine (20 mg/kg) and clozapine (20 mg/kg), the specific dopamine antagonist raclopride (3 mg/kg), the mixed dopamine/serotonin antagonist risperidone (3 mg/kg) or drug-free vehicle. |
1998-04-22 |
2023-08-12 |
rat |
| S A Sands, A L de Blas, B M Chronwal. Dopamine D2 receptor effects on GABA(A) receptor expression may modify melanotrope peptide release. Peptides. vol 19. issue 2. 1998-04-13. PMID:9493875. |
following chronic treatment with haloperidol, a d2 receptor antagonist, gaba(a) receptor immunoreactivity increased, whereas it decreased after chronic treatment with bromocriptine, a dopamine d2 receptor agonist. |
1998-04-13 |
2023-08-12 |
Not clear |
| M A Vital, J C Flório, R Frussa-Filho, R De Lucia, S Tufik, J Palermo-Net. Effects of haloperidol and GM1 ganglioside treatment on striatal D2 receptor binding and dopamine turnover. Life sciences. vol 62. issue 13. 1998-04-06. PMID:9519797. |
effects of haloperidol and gm1 ganglioside treatment on striatal d2 receptor binding and dopamine turnover. |
1998-04-06 |
2023-08-12 |
rat |
| M A Vital, J C Flório, R Frussa-Filho, R De Lucia, S Tufik, J Palermo-Net. Effects of haloperidol and GM1 ganglioside treatment on striatal D2 receptor binding and dopamine turnover. Life sciences. vol 62. issue 13. 1998-04-06. PMID:9519797. |
and 1 mg/kg haloperidol i.p., twice daily, for 30 days) as well as the effects of a 3 day treatment with gm1 were investigated in rats withdrawn from haloperidol administration by measuring striatal d2 dopamine receptor binding and dopamine turnover. |
1998-04-06 |
2023-08-12 |
rat |
| M A Vital, J C Flório, R Frussa-Filho, R De Lucia, S Tufik, J Palermo-Net. Effects of haloperidol and GM1 ganglioside treatment on striatal D2 receptor binding and dopamine turnover. Life sciences. vol 62. issue 13. 1998-04-06. PMID:9519797. |
the results showed that under these two experimental conditions gm1 modified neither the haloperidol-induced striatal d2 dopamine receptor up regulation nor the decrease in dopamine turnover produced by haloperidol withdrawal. |
1998-04-06 |
2023-08-12 |
rat |
| T A Reader, A R Ase, N Huang, C Hébert, N M van Gelde. Neuroleptics and dopamine transporters. Neurochemical research. vol 23. issue 1. 1998-04-03. PMID:9482270. |
the effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. |
1998-04-03 |
2023-08-12 |
rat |
| T A Reader, A R Ase, N Huang, C Hébert, N M van Gelde. Neuroleptics and dopamine transporters. Neurochemical research. vol 23. issue 1. 1998-04-03. PMID:9482270. |
the dopamine d1 receptors, labeled with [3h]sch23390, increased in nucleus accumbens, latero-dorsal rostral neostriatum and substantia nigra, after clozapine but not haloperidol. |
1998-04-03 |
2023-08-12 |
rat |
| T A Reader, A R Ase, N Huang, C Hébert, N M van Gelde. Neuroleptics and dopamine transporters. Neurochemical research. vol 23. issue 1. 1998-04-03. PMID:9482270. |
the dopamine d2 receptors, studied with [3h]raclopride, increased in nucleus accumbens and in dorso-lateral, ventro-medial and dorso-medial quadrants of the rostral neostriatum after either haloperidol or clozapine treatments, and also in latero-ventral rostral neostriatum but only after haloperidol. |
1998-04-03 |
2023-08-12 |
rat |
| S J Choi, K J Yoon, K K Park, J M Ngong, K F Solima. The thymolytic effect of cocaine and monoaminergic drugs in the mouse. Life sciences. vol 62. issue 10. 1998-03-18. PMID:9496713. |
thymus glands were aseptically removed from mice and thymocytes were isolated and then incubated in microtiter plates with various concentrations (10[-8]-10[-4] m) of cc, apomorphine (am), haloperidol (hp), dopamine (da) and epinephrine (en) for 18 hrs. |
1998-03-18 |
2023-08-12 |
mouse |
| S J Choi, K J Yoon, K K Park, J M Ngong, K F Solima. The thymolytic effect of cocaine and monoaminergic drugs in the mouse. Life sciences. vol 62. issue 10. 1998-03-18. PMID:9496713. |
apomorphine, haloperidol and dopamine also exhibited a similar dose dependent inhibition of thymocyte proliferation. |
1998-03-18 |
2023-08-12 |
mouse |
| M Mukherjee, A Ghos. Influence of haloperidol on testicular functions in rat. Indian journal of experimental biology. vol 35. issue 9. 1998-03-12. PMID:9475081. |
the study involved exploration of the role of dopamine antagonist haloperidol on the testicular functions of rat. |
1998-03-12 |
2023-08-12 |
rat |
| M A Riva, F Tascedda, E Lovati, G Racagn. Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs. Brain research. Molecular brain research. vol 50. issue 1-2. 1998-02-19. PMID:9406928. |
haloperidol increased their mrna levels in striatum whereas clozapine, consistent with its relatively weaker influence on nigro-striatal dopamine function, did not change the expression of nr subunits in this region. |
1998-02-19 |
2023-08-12 |
rat |
| A Porras, B Sanz, F Mor. Dopamine-glutamate interactions in the prefrontal cortex of the conscious rat: studies on ageing. Mechanisms of ageing and development. vol 99. issue 1. 1998-02-19. PMID:9430101. |
this increase in glutamate concentration induced by apomorphine was significantly attenuated by blockade of d1-d2 dopamine receptors with haloperidol. |
1998-02-19 |
2023-08-12 |
rat |
| J Arnt, T Skarsfeld. Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 2. 1998-02-12. PMID:9430133. |
however, among the group of novel apds there are many individual differences in models reflecting limbic versus striatal inhibition of dopamine function: clozapine and sertindole show the largest limbic selectivity, followed by quetiapine, ziprasidone, olanzapine and remoxipride, whereas risperidone in many respects has a profile that resembles haloperidol. |
1998-02-12 |
2023-08-12 |
Not clear |
| W Blenau, J Erber, A Bauman. Characterization of a dopamine D1 receptor from Apis mellifera: cloning, functional expression, pharmacology, and mRNA localization in the brain. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422342. |
dopaminergic receptor ligands compete for this high-affinity binding, with the following order of potency: r(+)-lisuride > chlorpromazine = cis(z)-flupentixol > dopamine > s(+)-butaclamol > r(+)-sch 23390 > haloperidol. |
1998-02-02 |
2023-08-12 |
Not clear |