| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R D O'Neill, M Fillenz, W J Albery, N J Goddar. The monitoring of ascorbate and monoamine transmitter metabolites in the striatum of unanaesthetised rats using microprocessor-based voltammetry. Neuroscience. vol 9. issue 1. 1983-09-09. PMID:6192357. |
changes in dopamine release from the striatum have been monitored continuously over 48 h in unanaesthetised rats after the intraperitoneal administration of haloperidol. |
1983-09-09 |
2023-08-12 |
rat |
| R Scorza-Smeraldi, M G Sabbadini Villa, G Fabio, P Bonara, M Vanoli, L Resele, C Zanuss. HLA antigens and the reactivity of lymphocytes to some drugs and PHA. International journal of immunopharmacology. vol 5. issue 2. 1983-09-09. PMID:6603432. |
peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their hla types, were cultured in vitro in the presence of pha and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). |
1983-09-09 |
2023-08-12 |
human |
| E Melamed, R Durst, Y Frucht, M Globu. Differential effect of acute and chronic haloperidol administration on dopamine turnover in rat nigrostriatal and retinal dopaminergic neurons. European journal of pharmacology. vol 89. issue 3-4. 1983-09-09. PMID:6873163. |
differential effect of acute and chronic haloperidol administration on dopamine turnover in rat nigrostriatal and retinal dopaminergic neurons. |
1983-09-09 |
2023-08-12 |
rat |
| R L Singhal, R B Rastogi, Y D Lapierr. Diazepam potentiates the effect of neuroleptics on behavioural activity as well as dopamine and norepinephrine turnover: Do benzodiazepines have antipsychotic potency? Journal of neural transmission. vol 56. issue 2-3. 1983-08-26. PMID:6306165. |
acute haloperidol or chlorpromazine treatment increased striatal dopamine as well as cerebro-cortical norepinephrine turnover. |
1983-08-26 |
2023-08-12 |
rat |
| R L Singhal, R B Rastogi, Y D Lapierr. Diazepam potentiates the effect of neuroleptics on behavioural activity as well as dopamine and norepinephrine turnover: Do benzodiazepines have antipsychotic potency? Journal of neural transmission. vol 56. issue 2-3. 1983-08-26. PMID:6306165. |
when diazepam was administered together with haloperidol or chlorpromazine, a further decrease particularly in dopamine release was seen in striatum. |
1983-08-26 |
2023-08-12 |
rat |
| G R Van Loon, A Shum, S R George, S H Shi. Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons: prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats. Brain research bulletin. vol 10. issue 4. 1983-08-26. PMID:6860978. |
antiserum to prl generated in rabbits and not cross-reacting with other anterior pituitary hormones was administered iv to adult, male rats which received haloperidol 2.5 mg/kg or tartaric acid vehicle sc 22 hr and 12 hr before measurement of dopamine turnover. |
1983-08-26 |
2023-08-12 |
rat |
| G R Van Loon, A Shum, S R George, S H Shi. Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons: prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats. Brain research bulletin. vol 10. issue 4. 1983-08-26. PMID:6860978. |
haloperidol increased median eminence dopamine synthesis rate, and prl antiserum completely prevented this effect, supporting the thesis that the haloperidol-induced increase in tuberoinfundibular dopamine turnover is mediated by prl. |
1983-08-26 |
2023-08-12 |
rat |
| T Matsumoto, H Uchimura, M Hirano, J S Kim, H Yokoo, M Shimomura, T Nakahara, K Inoue, K Oomagar. Differential effects of acute and chronic administration of haloperidol on homovanillic acid levels in discrete dopaminergic areas of rat brain. European journal of pharmacology. vol 89. issue 1-2. 1983-08-17. PMID:6861888. |
after acute administration of haloperidol, homovanillic acid (hva) levels were increased in the prefrontal cortex, anterior cingulate cortex, discrete limbic areas and a14 dopamine (da) neurons. |
1983-08-17 |
2023-08-12 |
rat |
| P L Canonico, C A Valdenegro, R M MacLeo. The inhibition of phosphatidylinositol turnover: a possible postreceptor mechanism for the prolactin secretion-inhibiting effect of dopamine. Endocrinology. vol 113. issue 1. 1983-08-11. PMID:6861715. |
dopamine decreased the incorporation of 32p into pi, but not into pc or pe, by female rat pituitary glands; this effect was reversed by two dopamine receptor-blocking agents, haloperidol and pimozide. |
1983-08-11 |
2023-08-12 |
rat |
| R W Fuller, H D Snoddy, N R Mason, J A Clemens, K G Bemi. Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide. Neuroendocrinology. vol 36. issue 4. 1983-08-11. PMID:6866215. |
both haloperidol and domperidone increased serum prolactin concentration when given alone or in combination with ly141865, indicating they were both capable of blocking peripheral (pituitary) dopamine receptors. |
1983-08-11 |
2023-08-12 |
rat |
| R W Fuller, H D Snoddy, N R Mason, J A Clemens, K G Bemi. Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide. Neuroendocrinology. vol 36. issue 4. 1983-08-11. PMID:6866215. |
in contrast, haloperidol but not domperidone caused a marked elevation in brain levels of dopac and of homovanillic acid and prevented the lowering of these brain dopamine metabolites by ly141865. |
1983-08-11 |
2023-08-12 |
rat |
| A Akaike, M Sasa, S Takaor. Effects of haloperidol and sulpiride on dopamine-induced inhibition of nucleus accumbens neurons. Life sciences. vol 32. issue 23. 1983-07-15. PMID:6855460. |
these results indicate that dopamine produces an inhibition of the acc neuron and that, compared to haloperidol, sulpiride is a less potent blocker of the postsynaptic dopamine receptor involved in the dopamine-induced inhibition. |
1983-07-15 |
2023-08-12 |
rat |
| Y Yamasaki, O Shimamura, A Kizu, M Nakagawa, H Ijich. Interactions of morphine with PGE1, isoproterenol, dopamine and aminophylline in rat mast cells; their effect on IgE-mediated 14C-serotonin release. Agents and actions. vol 13. issue 1. 1983-07-08. PMID:6683067. |
pge1 (2 x 10(-8) -2 x 10(-5) m), isoproterenol (10(-10) -10(-8) m), dopamine (4 x 10(-8) -4 x 10(-6) m) and aminophylline (6 x 10(-6) -6 x 10(-4) m) caused dose-related inhibition of the mediator release 1 min after an antigen challenge, and propranolol (10(-7) m) blocked the inhibition by isoproterenol (10(-8) m) but not that by dopamine (4 x 10(-6) m), while haloperidol (4 x 10(-6) m) blocked that by dopamine (4 x 10(-6) m) but not that by isoproterenol (10(-8) m). |
1983-07-08 |
2023-08-12 |
rat |
| M L Barbaccia, N Brunello, D M Chuang, E Cost. Serotonin-elicited amplification of adenylate cyclase activity in hippocampal membranes from adult rat. Journal of neurochemistry. vol 40. issue 6. 1983-07-08. PMID:6854325. |
dopamine (da) also stimulates adenylate cyclase located in hippocampal membranes; its effect can be blocked by haloperidol (10(-6) m), which fails to inhibit 5-ht stimulation. |
1983-07-08 |
2023-08-12 |
rat |
| K S Kendler, R E Weitzman, R T Rubi. Lack of arginine vasopressin response to central dopamine blockade in normal adults. The Journal of clinical endocrinology and metabolism. vol 47. issue 1. 1983-06-17. PMID:263292. |
haloperidol, a central nervous system dopamine blocker, was given im to seven normal volunteers at a dose level (1.0 mg) known to have central nervous system effects. |
1983-06-17 |
2023-08-11 |
human |
| C B Nemeroff, D Luttinger, D E Hernandez, R B Mailman, G A Mason, S D Davis, E Widerlöv, G D Frye, C A Kilts, K Beaumont, G R Breese, A J Prang. Interactions of neurotensin with brain dopamine systems: biochemical and behavioral studies. The Journal of pharmacology and experimental therapeutics. vol 225. issue 2. 1983-06-17. PMID:6682440. |
peripheral injection of haloperidol produced qualitatively similar effects on dopamine metabolism, but the effects of haloperidol, unlike those of i.c. |
1983-06-17 |
2023-08-12 |
mouse |
| S M Leventer, K M Johnso. Effects of phencyclidine on the release of radioactivity from rat striatal slices labeled with [3H]choline. The Journal of pharmacology and experimental therapeutics. vol 225. issue 2. 1983-06-17. PMID:6842397. |
haloperidol blocked the inhibitory effects of pcp, amphetamine and pergolide on ach release, supporting the notion that the decrease in ach release produced by pcp is mediated indirectly via the release of dopamine onto cholinergic neurons. |
1983-06-17 |
2023-08-12 |
rat |
| S Algeri, A Carolei, P Ferretti, C Gallone, G Palladini, G Venturin. Effects of dopaminergic agents on monoamine levels and motor behaviour in planaria. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 74. issue 1. 1983-06-10. PMID:6132769. |
haloperidol reduced motor activity and dopamine and norepinephrine levels. |
1983-06-10 |
2023-08-12 |
Not clear |
| P B Zanzonico, R E Bigler, B Schmal. Neuroleptic binding sites: specific labeling in mice with [18F]haloperidol, a potential tracer for positron emission tomography. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 24. issue 5. 1983-06-10. PMID:6132964. |
haloperidol labeled with fluorine-18 (t 1/2 = 110 min, positron emission 97%), prepared yielding .04 ci/millimole by the balz-schiemann reaction, was evaluated in a murine model as a potential radiotracer for noninvasive determination, by positron-emission tomography, of regional concentrations of brain dopamine receptors in patients. |
1983-06-10 |
2023-08-12 |
mouse |
| P B Zanzonico, R E Bigler, B Schmal. Neuroleptic binding sites: specific labeling in mice with [18F]haloperidol, a potential tracer for positron emission tomography. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 24. issue 5. 1983-06-10. PMID:6132964. |
because the cerebellum is relatively deficient in dopamine receptors, the observed decrease in cerebellar radioactivity may reflect a saturable component of haloperidol transport into brain. |
1983-06-10 |
2023-08-12 |
mouse |