| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Zharkovskiĭ, A V Beliako. [Effect of varying the dose of haloperidol during its prolonged administration on the development of tolerance and hypersensitivity in dopamine receptors]. Farmakologiia i toksikologiia. vol 46. issue 5. 1983-12-17. PMID:6628655. |
[effect of varying the dose of haloperidol during its prolonged administration on the development of tolerance and hypersensitivity in dopamine receptors]. |
1983-12-17 |
2023-08-12 |
mouse |
| A M Zharkovskiĭ, A V Beliako. [Effect of varying the dose of haloperidol during its prolonged administration on the development of tolerance and hypersensitivity in dopamine receptors]. Farmakologiia i toksikologiia. vol 46. issue 5. 1983-12-17. PMID:6628655. |
it has been shown in experiments on male mice that prolonged administration (for 20 days) of haloperidol in doses of 0.1, 1.0, 5.0 and 10.00 mg/kg produced an increase in the tolerance to thecataleptogenic effect at the end of administration and a rise in 3h-spiroperidole binding with striatum membranes on the 5th day after discontinuation of the neuroleptic, which attests to an increase in the sensitivity of dopamine receptors. |
1983-12-17 |
2023-08-12 |
mouse |
| A M Zharkovskiĭ, A V Beliako. [Effect of varying the dose of haloperidol during its prolonged administration on the development of tolerance and hypersensitivity in dopamine receptors]. Farmakologiia i toksikologiia. vol 46. issue 5. 1983-12-17. PMID:6628655. |
variation of haloperidol dose every other three days during 20 days of drug administration (1.0--0.1 ... 1.0 mg/kg and 1.0--10.00 ... 1.0 mg/kg) eliminated the manifestations of tolerance and hypersensitivity of dopamine receptors. |
1983-12-17 |
2023-08-12 |
mouse |
| L A Kamal, S Arbilla, A M Galzin, S Z Lange. Amphetamine inhibits the electrically evoked release of [3H]dopamine from slices of the rabbit caudate. The Journal of pharmacology and experimental therapeutics. vol 227. issue 2. 1983-12-17. PMID:6631724. |
the dopamine receptor antagonists, haloperidol and sulpiride, were not able to antagonize the inhibition by amphetamine of the electrically evoked release of [3h] dopamine at concentrations which effectively blocked apomorphine-induced inhibition of stimulation-evoked release of the labeled neurotransmitter. |
1983-12-17 |
2023-08-12 |
rabbit |
| J M Farah, K T Demarest, K E Moor. A comparison of domperidone and haloperidol effects on different dopaminergic neurons in the rat brain. Life sciences. vol 33. issue 16. 1983-12-17. PMID:6633157. |
domperidone, a dopamine (da) receptor antagonist with reportedly preferential actions outside of the blood-brain barrier, and haloperidol, a centrally active da antagonist, were compared with respect to their abilities to increase the activity of dopaminergic neurons in the rat brain. |
1983-12-17 |
2023-08-12 |
rat |
| C M Bradshaw, R Y Pun, N T Slater, M J Stoker, E Szabad. Differential antagonistic effects of haloperidol on excitatory responses of cortical neurones to phenylephrine, noradrenaline and dopamine. Neuropharmacology. vol 22. issue 8. 1983-11-23. PMID:6312360. |
differential antagonistic effects of haloperidol on excitatory responses of cortical neurones to phenylephrine, noradrenaline and dopamine. |
1983-11-23 |
2023-08-12 |
Not clear |
| N E Andén, M Grabowska-Andén, S Lindgren, U Thornströ. Synthesis rate of dopamine: difference between corpus striatum and limbic system as a possible explanation of variations in reactions to drugs. Naunyn-Schmiedeberg's archives of pharmacology. vol 323. issue 3. 1983-11-23. PMID:6621714. |
although the synthesis of dopamine was enhanced in all regions by haloperidol and gammabutyrolactone, it was increased to almost 400% of the control in the corpus striatum but to only somewhat more than 200% in the olfactory tubercle and some other limbic regions. |
1983-11-23 |
2023-08-12 |
rat |
| N E Andén, M Grabowska-Andén, S Lindgren, U Thornströ. Synthesis rate of dopamine: difference between corpus striatum and limbic system as a possible explanation of variations in reactions to drugs. Naunyn-Schmiedeberg's archives of pharmacology. vol 323. issue 3. 1983-11-23. PMID:6621714. |
the findings indicate that b-ht 920 is relatively more potent than haloperidol in inhibiting the dopamine neurotransmission in the limbic system than in the corpus striatum. |
1983-11-23 |
2023-08-12 |
rat |
| P M Iuvon. Short-term regulation of tyrosine hydroxylase in tonically-active and in tonically-inactive dopamine neurons: effects of haloperidol and protein phosphorylation. Life sciences. vol 33. issue 13. 1983-10-28. PMID:6136885. |
short-term regulation of tyrosine hydroxylase in tonically-active and in tonically-inactive dopamine neurons: effects of haloperidol and protein phosphorylation. |
1983-10-28 |
2023-08-12 |
rat |
| S K Rastogi, R B Rastogi, R L Singhal, Y D Lapierr. Behavioural and biochemical alterations following haloperidol treatment and withdrawal: the animal model of tardive dyskinesia reexamined. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 2-3. 1983-10-28. PMID:6137027. |
long-term administration of haloperidol resulted in supersensitivity of dopamine receptors. |
1983-10-28 |
2023-08-12 |
rat |
| S K Rastogi, R B Rastogi, R L Singhal, Y D Lapierr. Behavioural and biochemical alterations following haloperidol treatment and withdrawal: the animal model of tardive dyskinesia reexamined. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 2-3. 1983-10-28. PMID:6137027. |
chronic haloperidol treatment significantly decreased dopamine synthesis and release as evidenced by low activity of tyrosine hydroxylase and low level of homovanillic acid in striatum. |
1983-10-28 |
2023-08-12 |
rat |
| S K Rastogi, R B Rastogi, R L Singhal, Y D Lapierr. Behavioural and biochemical alterations following haloperidol treatment and withdrawal: the animal model of tardive dyskinesia reexamined. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 2-3. 1983-10-28. PMID:6137027. |
these data suggest that chronic haloperidol treatment and subsequent withdrawal results in the development of behavioural dopamine supersensitivity as well as biochemical alterations in dopaminergic and gabaergic system. |
1983-10-28 |
2023-08-12 |
rat |
| D G Pur. Cholinergic transmission by embryonic retinal neurons in culture: inhibition by dopamine. Brain research. vol 285. issue 1. 1983-10-28. PMID:6309334. |
this inhibitory effect is blocked reversibly by the dopamine antagonists, haloperidol and fluphenazine. |
1983-10-28 |
2023-08-12 |
chicken |
| K Negishi, T Teranishi, S Kat. A GABA antagonist, bicuculline, exerts its uncoupling action on external horizontal cells through dopamine cells in carp retina. Neuroscience letters. vol 37. issue 3. 1983-10-28. PMID:6310453. |
these uncoupling actions of bcc were similar to those of amphetamine (20 microm) or dopamine (10-20 microm) and were abolished by the presence of a dopaminergic blocker, haloperidol (20-40 microm). |
1983-10-28 |
2023-08-12 |
Not clear |
| b' V K Gurkalo, M A Zabezhinski\\xc4\\xa. [Effects of apomorphine and haloperidol on experimental hepatocarcinogenesis]. Voprosy onkologii. vol 29. issue 8. 1983-10-21. PMID:6310890.' |
the modifying effect of apomorphine and haloperidol - agonist and antagonist of dopamine receptors, respectively - on the development of n-nitrosodiethylamine (ndea) - induced hepatic tumors was studied in 60 noninbred albino male rats. |
1983-10-21 |
2023-08-12 |
rat |
| L X Cubeddu, I S Hoffmann, M K James, D M Niedzwieck. Changes in the sensitivity to apomorphine of dopamine receptors modulating dopamine and acetylcholine release after chronic treatment with bromocriptine or haloperidol. The Journal of pharmacology and experimental therapeutics. vol 226. issue 3. 1983-10-21. PMID:6887008. |
changes in the sensitivity to apomorphine of dopamine receptors modulating dopamine and acetylcholine release after chronic treatment with bromocriptine or haloperidol. |
1983-10-21 |
2023-08-12 |
rabbit |
| H Rosengarten, E Friedman, A J Friedhof. Sensitive periods for the effect of haloperidol on development of striatal dopamine receptors. Birth defects original article series. vol 19. issue 4. 1983-09-23. PMID:6871420. |
sensitive periods for the effect of haloperidol on development of striatal dopamine receptors. |
1983-09-23 |
2023-08-12 |
Not clear |
| P Jenner, R Kerwin, N M Rupniak, K Murugaiah, M D Hall, S Fleminger, C D Marsde. Long-term adaptive changes in striatal dopamine function in response to chronic neuroleptic intake in rats. Journal of neural transmission. Supplementum. vol 18. 1983-09-20. PMID:6135741. |
haloperidol and sulpiride differentially alter striatal 3h-acetylcholine and 3h-glutamate release in a manner suggesting selective changes in dopamine receptors lying on striatal cell bodies and on the terminals of corticostriate glutamate terminals. |
1983-09-20 |
2023-08-12 |
rat |
| N J Smatresk, M Pokorski, S Lahir. Opposing effects of dopamine receptor blockade on ventilation and carotid chemoreceptor activity. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 54. issue 6. 1983-09-20. PMID:6874478. |
we conclude that dopamine antagonism by haloperidol blocks the central integration of peripheral chemoreceptor activity, thus attenuating the ventilatory chemoreflex responses to hypoxia while augmenting the carotid chemoreceptor response. |
1983-09-20 |
2023-08-12 |
Not clear |
| J Z Nowak, S Arbilla, A M Galzin, S Z Lange. Changes in sensitivity of release modulating dopamine autoreceptors after chronic treatment with haloperidol. The Journal of pharmacology and experimental therapeutics. vol 226. issue 2. 1983-09-20. PMID:6875865. |
changes in sensitivity of release modulating dopamine autoreceptors after chronic treatment with haloperidol. |
1983-09-20 |
2023-08-12 |
rabbit |