| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Cruz, R M Beckstea. Quantitative radioimmunocytochemical evidence that haloperidol and SCH 23390 induce opposite changes in substance P levels of rat substantia nigra. Brain research. vol 457. issue 1. 1988-11-23. PMID:2458801. |
quantitative radioimmunocytochemical evidence that haloperidol and sch 23390 induce opposite changes in substance p levels of rat substantia nigra. |
1988-11-23 |
2023-08-11 |
rat |
| P K Sonsalla, L Manzino, R E Heikkil. Interactions of D1 and D2 dopamine receptors on the ipsilateral vs. contralateral side in rats with unilateral lesions of the dopaminergic nigrostriatal pathway. The Journal of pharmacology and experimental therapeutics. vol 247. issue 1. 1988-11-18. PMID:2971797. |
in rats with a unilateral lesion of the nigrostriatal dopaminergic pathway, the ipsilateral rotation produced by the enhanced actions of endogenous dopamine (da) on the nonlesioned side, induced by either the da-releasing drug amphetamine or the da uptake inhibitor gbr 13069, was blocked effectively by pretreatment with either the selective d1 da receptor antagonist, sch 23390, or the d2 selective antagonist, haloperidol. |
1988-11-18 |
2023-08-11 |
rat |
| C M Thonoor, M W Couch, D M Greer, K D Thomas, C M William. Biodistribution and radiation dosimetry of radioiodinated-SCH 23982, a potential dopamine D-1 receptor imaging agent. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 29. issue 10. 1988-11-10. PMID:3262726. |
administration of the antagonists propranolol (beta-1), prazosin (alpha-1), haloperidol (d-2) and ketanserin (5ht-2) did not significantly alter the striatum/cerebellum ratio; however, sch 23390, a d-1 antagonist, totally blocked ligand uptake by striatum and frontal cortex. |
1988-11-10 |
2023-08-11 |
human |
| S A Signs, M D Schechte. The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue. Pharmacology, biochemistry, and behavior. vol 30. issue 1. 1988-10-31. PMID:3174755. |
furthermore, the dopamine receptor antagonists sch 23390 (da1) and haloperidol (da2) did not affect ethanol-appropriate responding when administered in combination with the training dose of ethanol. |
1988-10-31 |
2023-08-11 |
rat |
| M K Menon, L I Gordon, C K Kodama, J Fitte. Influence of D-1 receptor system on the D-2 receptor-mediated hypothermic response in mice. Life sciences. vol 43. issue 10. 1988-10-07. PMID:2901020. |
the hypothermia induced by apomorphine, a mixed dopamine (da) agonist in male swiss-webster mice, was not blocked by the selective d-1 antagonist sch 23390 but was completely blocked by the selective d-2 antagonists haloperidol, sulpiride and ym-09151-2. |
1988-10-07 |
2023-08-11 |
mouse |
| W Dimpfel, M Spüler, R Koch, W Schatto. Radioelectroencephalographic comparison of memantine with receptor-specific drugs acting on dopaminergic transmission in freely moving rats. Neuropsychobiology. vol 18. issue 4. 1988-09-19. PMID:2841622. |
with regard to receptor specificity the research compounds sk & f 38393 (d-1 agonist), sch 23390 (d-1 antagonist), quinpirole (d-2 agonist) as well as haloperidol (d-2 antagonist, less specific) are tested under identical conditions. |
1988-09-19 |
2023-08-11 |
rat |
| J B Appel, R T Weathersby, K A Cunningham, P M Callahan, R L Barret. Stimulus properties of dopaminergic drugs: comparisons involving selective agonists and antagonists. Psychopharmacology series. vol 4. 1988-08-19. PMID:3293045. |
during substitution tests, no dose of any compound [apomorphine, ly 171555, lisuride, lsd, amphetamine, cocaine, (-) 3-ppp, or skf 82526] mimicked skf 38393, the effects of which were blocked by the d1 antagonist sch 23390 but not by haloperidol. |
1988-08-19 |
2023-08-11 |
rat |
| J B Appel, R T Weathersby, K A Cunningham, P M Callahan, R L Barret. Stimulus properties of dopaminergic drugs: comparisons involving selective agonists and antagonists. Psychopharmacology series. vol 4. 1988-08-19. PMID:3293045. |
postsynaptic and da "autoreceptor" agonists [apomorphine, (-) 3-ppp], as well as dopaminergic ergot derivatives (bromocriptine, lergotrile, lisuride) and sch 23390, substituted for ly 171555, a partial ergoline which has behavioral effects that are blocked by haloperidol and molindone, but not by either sch 23390 or serotonin (5-ht) antagonists (ketanserin, pizotifen). |
1988-08-19 |
2023-08-11 |
rat |
| E Nisoli, M Grilli, M Memo, C Missale, P F Span. Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. I. Frontal cortex. Neuroscience letters. vol 87. issue 3. 1988-07-22. PMID:2898117. |
we found that different selective agonists for d1 receptors were able to increase adenylate cyclase activity, and these effects were antagonized by haloperidol and sch 23390. |
1988-07-22 |
2023-08-11 |
rat |
| M Grilli, E Nisoli, M Memo, C Missale, P F Span. Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus. Neuroscience letters. vol 87. issue 3. 1988-07-22. PMID:2898118. |
the results show that different agonists for d1 da receptors, such as da itself, skf82526 and (-)-apomorphine, were able to increase adenylate cyclase activity, and these effects were antagonized by haloperidol and sch 23390. |
1988-07-22 |
2023-08-11 |
rat |
| P Butkerait, E Friedma. Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390. European journal of pharmacology. vol 148. issue 2. 1988-07-15. PMID:2897925. |
scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or sch 23390. |
1988-07-15 |
2023-08-11 |
rat |
| P Butkerait, E Friedma. Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390. European journal of pharmacology. vol 148. issue 2. 1988-07-15. PMID:2897925. |
in acute experiments, scopolamine (1.0 mg/kg) potentiated apomorphine stereotypy and inhibited the antistereotypic effect of both haloperidol (0.5 mg/kg) and sch 23390 (0.2 mg/kg). |
1988-07-15 |
2023-08-11 |
rat |
| P Butkerait, E Friedma. Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390. European journal of pharmacology. vol 148. issue 2. 1988-07-15. PMID:2897925. |
daily administration of either haloperidol (0.5 mg/kg) or sch 23390 (0.2 mg/kg) for 3 weeks produced enhanced stereotypic responses to apomorphine. |
1988-07-15 |
2023-08-11 |
rat |
| P Butkerait, E Friedma. Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390. European journal of pharmacology. vol 148. issue 2. 1988-07-15. PMID:2897925. |
co-administration of scopolamine (1.0 mg/kg) with haloperidol or sch 23390 significantly reduced the behavioral supersensitivity produced by haloperidol or sch 23390 alone. |
1988-07-15 |
2023-08-11 |
rat |
| H C Neijt, I J te Duits, H P Vijverber. Pharmacological characterization of serotonin 5-HT3 receptor-mediated electrical response in cultured mouse neuroblastoma cells. Neuropharmacology. vol 27. issue 3. 1988-07-12. PMID:3374770. |
observed antagonistic effects of sch 23390 [(r)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1h-3-benzazepi n-7-ol hemimaleate] and haloperidol are discussed. |
1988-07-12 |
2023-08-11 |
mouse |
| M Savasta, A Dubois, J Benavidès, B Scatto. Different plasticity changes in D1 and D2 receptors in rat striatal subregions following impairment of dopaminergic transmission. Neuroscience letters. vol 85. issue 1. 1988-05-27. PMID:2834672. |
the precise topographical changes in striatal d1 and d2 dopamine receptor density that occurred after chronic treatment with haloperidol or sch 23390 or after 6-hydroxydopamine-induced lesion of the mesostriatal dopaminergic pathway have been studied autoradiographically in the rat. |
1988-05-27 |
2023-08-11 |
rat |
| T Skarsfeld. Effect of chronic treatment with SCH 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in rats. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:3280330. |
effect of chronic treatment with sch 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (snc) and ventral tegmental area (vta) in rats. |
1988-05-06 |
2023-08-11 |
rat |
| T Skarsfeld. Effect of chronic treatment with SCH 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in rats. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:3280330. |
the effect of chronic treatment (21 days s.c.) with sch 23390 and haloperidol on spontaneously active da neurones in substantia nigra pars compacta (snc) and ventral tegmental area (vta) was studied in rats by means of single unit recording techniques. |
1988-05-06 |
2023-08-11 |
rat |
| T Skarsfeld. Effect of chronic treatment with SCH 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in rats. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:3280330. |
these results suggest that sch 23390 has a profile similar to that of haloperidol and that sch 23390 has clinical antipsychotic activity but also induces extrapyramidal side-effects. |
1988-05-06 |
2023-08-11 |
rat |
| R Lew, R J Summer. Characterization and localization of (-)[125I]-cyanopindolol binding to non-beta-adrenoceptor sites in dog kidney. Clinical and experimental pharmacology & physiology. vol 14. issue 9. 1988-05-05. PMID:2894910. |
compounds selective for dopamine d1-receptors (fluphenazine, sch 23390 and sk & f 82526) and d2-receptors (pimozide, domperidone, spiperone, haloperidol, sulpiride, cis- and trans-flupenthixol) competed with similar affinities (5-25 mumol/l) for (-)[125i]-cyp binding. |
1988-05-05 |
2023-08-11 |
dog |