| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P H Anderse. Comparison of the pharmacological characteristics of [3H]raclopride and [3H]SCH 23390 binding to dopamine receptors in vivo in mouse brain. European journal of pharmacology. vol 146. issue 1. 1988-05-03. PMID:2895008. |
thus, spiroperidol, haloperidol, 1-sulpiride, clebopride, ly 171555 and (-)-npa ((-)-n-propyl-norapomorphine) were d2 selective while sch 23390, skf 38393 and skf 75670 were d1 selective. |
1988-05-03 |
2023-08-11 |
mouse |
| P Angchanpen, M Marin-Grez, J Schnerman. Effect of dopamine antagonists on the urine flow of rats infused with hypotonic saline. British journal of pharmacology. vol 93. issue 1. 1988-04-28. PMID:2894873. |
blood pressure (bp) decreased after haloperidol and sch 23390 injection from control values of 121.7 +/- 1.7 and 116.5 +/- 7.4 to 113.3 +/- 3.3 and 106.0 +/- 8.8 mmhg respectively (p less than 0.05). |
1988-04-28 |
2023-08-11 |
rat |
| E Kouassi, J P Revillar. Contribution of beta-adrenoceptors to the dopamine-induced elevation of cyclic 3',5'-adenosine monophosphate levels in mouse lymphocytes. European journal of pharmacology. vol 144. issue 1. 1988-03-25. PMID:2893737. |
sch 23390 (selective da1 antagonist) and haloperidol (mixed da1/da2 antagonist) inhibited the da action only at high concentrations (10(-5)-10(-4) m) which did not affect the response to isoproterenol. |
1988-03-25 |
2023-08-11 |
mouse |
| F Ponzio, S Algeri, S Garattini, V Cioce, L Rusconi, G Sacchetti, C Manuel, C Notelle, L Duvert, J Legea. Behavioural and biochemical studies on 6-methylamino-4,5,6,7-tetrahydrobenzothiazole (14.839JL), a new potent dopaminergic agonist. Pharmacological research communications. vol 19. issue 8. 1988-03-23. PMID:3432322. |
conversely, the ability of 14.839jl to displace 3h spiperone from its binding sites was 100 and 10 times lower than that of haloperidol and sulpiride, and similar to that of sch 23390. |
1988-03-23 |
2023-08-11 |
Not clear |
| R E Chipkin, R D McQuade, L C Iori. D1 and D2 dopamine binding site up-regulation and apomorphine-induced stereotypy. Pharmacology, biochemistry, and behavior. vol 28. issue 4. 1988-03-10. PMID:2893388. |
in the first experiment, 19 days of pre-treatment with sch 23390 or haloperidol selectively increased by 35 and 40% the numbers of striatal d1 and d2 binding sites, respectively, without affecting their affinities. |
1988-03-10 |
2023-08-11 |
rat |
| R E Chipkin, R D McQuade, L C Iori. D1 and D2 dopamine binding site up-regulation and apomorphine-induced stereotypy. Pharmacology, biochemistry, and behavior. vol 28. issue 4. 1988-03-10. PMID:2893388. |
behaviorally, these rats were supersensitive to apomorphine's stereotypy-inducing effects; however, they also showed an increased sensitivity to the ability of either haloperidol or sch 23390 to block ais. |
1988-03-10 |
2023-08-11 |
rat |
| B A Ellenbroek, B W Peeters, W M Honig, A R Cool. The paw test: a behavioural paradigm for differentiating between classical and atypical neuroleptic drugs. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893411. |
the results show that: 1) the classical neuroleptic drugs haloperidol and chlorpromazine, the atypical neuroleptic drugs clozapine and thioridazine, the potential atypical neuroleptic drugs molindone and sch 23390, and the potential classical neuroleptic drug metoclopramide are potent in increasing the hindlimb retraction time; 2) the paw test discriminates between classical neuroleptics which are equipotent in prolonging both the forelimb (frt) and hindlimb retraction time (hrt) an atypical neuroleptics which are much more potent in prolonging hrt than in prolonging frt; 3) the non-neuroleptic drugs desipramine, diazepam and morphine do not influence the variables measured in the paw test, although morphine does produce catalepsy; 4) molindone as well as sch 23390 behave like atypical neuroleptic drugs in the paw test. |
1988-03-03 |
2023-08-11 |
rat |
| G L Orr, J W Gole, H J Notman, R G Downe. Pharmacological characterisation of the dopamine-sensitive adenylate cyclase in cockroach brain: evidence for a distinct dopamine receptor. Life sciences. vol 41. issue 25. 1988-02-18. PMID:2892104. |
the dopamine-sensitive ac is inhibited by the same compounds with the following order of potency: piflutixol greater than cis-flupentixol greater than (+)-butaclamol greater than spiperone greater than or equal to sch-23390 greater than cyproheptadine greater than skf-83566 greater than sch 23388 greater than mianserin greater than phentolamine greater than sulpiride greater than haloperidol. |
1988-02-18 |
2023-08-11 |
Not clear |
| S A Parashos, P Barone, I Tucci, T N Chas. Attenuation of D-1 antagonist-induced D-1 receptor upregulation by concomitant D-2 receptor blockade. Life sciences. vol 41. issue 20. 1987-12-23. PMID:3316889. |
the effect of chronic selective d-1 and/or d-2 dopamine receptor blockade on regional d-1 receptor binding was studied in rat brain following chronic treatment with the specific d-1 antagonist sch 23390 and/or the predominantly d-2 antagonist haloperidol. |
1987-12-23 |
2023-08-11 |
rat |
| S A Parashos, P Barone, I Tucci, T N Chas. Attenuation of D-1 antagonist-induced D-1 receptor upregulation by concomitant D-2 receptor blockade. Life sciences. vol 41. issue 20. 1987-12-23. PMID:3316889. |
haloperidol had no effect on d-1 receptor bmax or kd values, although, when administered with sch 23390, reduced the d-1 receptor upregulation induced by the d-1 antagonist in striatum and tuberculum olfactorium, but not in nucleus accumbens. |
1987-12-23 |
2023-08-11 |
rat |
| M Star. Opposing roles of dopamine D1 and D2 receptors in nigral gamma-[3H]aminobutyric acid release? Journal of neurochemistry. vol 49. issue 4. 1987-10-19. PMID:2957468. |
higher amounts (10 microm) of sch 23390, metoclopramide, or other d2 antagonists (loxapine, haloperidol) reduced evoked gaba release by themselves, probably by nonspecific mechanisms. |
1987-10-19 |
2023-08-11 |
rat |
| M R Melis, A Argiolas, G L Gess. Apomorphine-induced penile erection and yawning: site of action in brain. Brain research. vol 415. issue 1. 1987-10-15. PMID:3497688. |
apomorphine-induced penile erection and yawning were antagonized by pretreatment with neuroleptic drugs, such as haloperidol, (-)-sulpiride, a specific d2 da antagonist, and sch 23390, a specific d1 da antagonist. |
1987-10-15 |
2023-08-11 |
rat |
| A G Dupont, R A Lefebvre, M G Bogaer. Identification and characterization of peripheral neuronal dopamine receptors in the rat. Clinical and experimental hypertension. Part A, Theory and practice. vol 9. issue 5-6. 1987-10-13. PMID:2887314. |
like haloperidol, the da2-receptor antagonist domperidone antagonized the inhibition of neurogenic vasoconstriction by apomorphine in the three vascular beds; the da1-receptor antagonist sch 23390 had no influence. |
1987-10-13 |
2023-08-11 |
rat |
| B S Starr, M S Star. Behavioural interactions involving D1 and D2 dopamine receptors in non-habituated mice. Neuropharmacology. vol 26. issue 6. 1987-07-29. PMID:2955244. |
the effects of skf 38393 (d1-agonist) and sch 23390 (d1-antagonist) were compared with those of haloperidol (d2 greater than d1-antagonist) and metoclopramide (d2-antagonist) in the absence or presence of apomorphine (d1/d2-agonist) and ru 24213 (d2 agonist) in non-habituated mice. |
1987-07-29 |
2023-08-11 |
mouse |
| B S Starr, M S Star. Behavioural interactions involving D1 and D2 dopamine receptors in non-habituated mice. Neuropharmacology. vol 26. issue 6. 1987-07-29. PMID:2955244. |
apart from increased grooming with sch 23390 in small doses, both this drug and haloperidol dose-dependently decreased all motor activity. |
1987-07-29 |
2023-08-11 |
mouse |
| B S Starr, M S Star. Behavioural interactions involving D1 and D2 dopamine receptors in non-habituated mice. Neuropharmacology. vol 26. issue 6. 1987-07-29. PMID:2955244. |
in this model, sch 23390 modified behaviour mediated by d2-receptors in a different manner to the d2-receptor antagonists, haloperidol and metoclopramide, suggesting it may interact with a different population of d2-receptors, or with d1-receptors. |
1987-07-29 |
2023-08-11 |
mouse |
| E Ongini, M G Caporal. Differential effects of dopamine D-1 and D-2 receptor agonists on EEG activity and behaviour in the rabbit. Neuropharmacology. vol 26. issue 4. 1987-07-08. PMID:2953987. |
similarly, effects of apomorphine on both eeg and behaviour were prevented by sch 23390 and to a lesser extent by haloperidol, but not influenced by (-)-sulpiride. |
1987-07-08 |
2023-08-11 |
rabbit |
| Y Ohno, M Sasa, S Takaor. Coexistence of inhibitory dopamine D-1 and excitatory D-2 receptors on the same caudate nucleus neurons. Life sciences. vol 40. issue 19. 1987-06-18. PMID:3553819. |
the inhibitory effects of dopamine and skf 38393 were antagonized by haloperidol and sch 23390 (d-1 antagonist) without being affected by domperidone. |
1987-06-18 |
2023-08-11 |
Not clear |
| D J Sange. The actions of SCH 23390, a D1 receptor antagonist, on operant and avoidance behavior in rats. Pharmacology, biochemistry, and behavior. vol 26. issue 3. 1987-06-17. PMID:3554270. |
again, there was no within-session decline in responding after administration of sch 23390 although injection of a dose of 0.4 mg/kg of haloperidol produced a greater response deficit during the second half of the session. |
1987-06-17 |
2023-08-11 |
rat |
| D J Sange. The actions of SCH 23390, a D1 receptor antagonist, on operant and avoidance behavior in rats. Pharmacology, biochemistry, and behavior. vol 26. issue 3. 1987-06-17. PMID:3554270. |
sch 23390 disrupts operant bar pressing and one-way avoidance responding but its actions in these behavioral tests are not identical to the effects of typical neuroleptics such as haloperidol. |
1987-06-17 |
2023-08-11 |
rat |