| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B S Starr, M S Star. Grooming in the mouse is stimulated by the dopamine D1 agonist SKF 38393 and by low doses of the D1 antagonist SCH 23390, but is inhibited by dopamine D2 agonists, D2 antagonists and high doses of SCH 23390. Pharmacology, biochemistry, and behavior. vol 24. issue 4. 1986-07-07. PMID:2940604. |
sch 23390 in neuroleptic doses, ru 24213 (d2 agonist), apomorphine and amphetamine (mixed d1/d2 agonists) and haloperidol (d2 antagonist) all suppressed the tendency of normal mice to groom, though probably by different mechanisms. |
1986-07-07 |
2023-08-11 |
mouse |
| J H Carlson, D A Bergstrom, J R Walter. Neurophysiological evidence that D-1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor-mediated effects of dopamine agonists. European journal of pharmacology. vol 123. issue 2. 1986-06-27. PMID:2940101. |
sch 23390 was more potent than haloperidol in its ability to attenuate the effects of apomorphine on pallidal activity, but unlike haloperidol, was unable to totally inhibit these effects, suggesting that the two antagonists block the excitatory effects of apomorphine on pallidal cell firing rates by different mechanisms. |
1986-06-27 |
2023-08-11 |
Not clear |
| Y Ohno, M Sasa, S Takaor. Excitation by dopamine D-2 receptor agonists, bromocriptine and LY 171555, in caudate nucleus neurons activated by nigral stimulation. Life sciences. vol 38. issue 20. 1986-06-25. PMID:2939313. |
the increase in firing rate by the d-2 agonists was apparently antagonized during simultaneous application of domperidone and haloperidol, but not affected during application of sch 23390 (d-1 antagonist). |
1986-06-25 |
2023-08-11 |
Not clear |
| M J Twery, B Kirkpatrick, E C Critcher, M H Lewis, R B Mailman, C W Coope. Motor effects of calcitonin administered intracerebroventricularly in the rat. European journal of pharmacology. vol 121. issue 2. 1986-05-28. PMID:3699092. |
the ct failed to displace either [3h]dopamine or [3h]spiperone from striatal membranes, and the behavioral effects were not blocked by haloperidol or sch 23390, suggesting that the peptide did not directly affect dopamine receptors. |
1986-05-28 |
2023-08-11 |
rat |
| A D Baines, R Drangov. Neural not tubular dopamine increases glomerular filtration rate in perfused rat kidneys. The American journal of physiology. vol 250. issue 4 Pt 2. 1986-05-13. PMID:2421588. |
haloperidol, sch 23390, and (+)butaclamol, but not (-)butaclamol, added during perfusion increased renovascular resistance 4-5% (p less than 0.001) and decreased inulin clearance 20% (p less than 0.001). |
1986-05-13 |
2023-08-11 |
rat |
| A D Baines, R Drangov. Neural not tubular dopamine increases glomerular filtration rate in perfused rat kidneys. The American journal of physiology. vol 250. issue 4 Pt 2. 1986-05-13. PMID:2421588. |
sch 23390 reduced fractional sodium excretion (p less than 0.01), but haloperidol and butaclamol did not. |
1986-05-13 |
2023-08-11 |
rat |
| C F Saller, A I Salam. D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 236. issue 3. 1986-04-18. PMID:3005552. |
both of these effects of haloperidol were blocked by nanomolar concentrations of sch 23390, a d-1 receptor antagonist. |
1986-04-18 |
2023-08-11 |
Not clear |
| C F Saller, A I Salam. D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 236. issue 3. 1986-04-18. PMID:3005552. |
in addition, sch 23390 reduced the ability of haloperidol to antagonize the inhibition of [3h]acetylcholine release produced by the da agonist apomorphine. |
1986-04-18 |
2023-08-11 |
Not clear |
| C F Saller, A I Salam. D-1 and D-2 dopamine receptor blockade: interactive effects in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 236. issue 3. 1986-04-18. PMID:3005552. |
likewise, in vivo, very low doses (less than 1 microgram/kg) of sch 23390 reduced the ability of haloperidol to elevate striatal da metabolite concentrations and plasma prolactin concentrations. |
1986-04-18 |
2023-08-11 |
Not clear |
| K A Cunningham, P M Callahan, J B Appe. Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393. European journal of pharmacology. vol 119. issue 1-2. 1986-03-07. PMID:2935415. |
the d2 agonists apomorphine and ly 171555 (levo-isomer of ly 141865) produced predominantly saline-lever responding; the d1 antagonist sch 23390, but not the d2 antagonist haloperidol, dose dependently antagonized the skf 38393 cue. |
1986-03-07 |
2023-08-11 |
rat |
| M L Porceddu, E Ongini, G Biggi. [3H]SCH 23390 binding sites increase after chronic blockade of D-1 dopamine receptors. European journal of pharmacology. vol 118. issue 3. 1986-03-05. PMID:2935413. |
haloperidol, which preferentially blocks d-2 receptors, induced only a slight, not significant increase in the total number of [3h]sch 23390 binding sites. |
1986-03-05 |
2023-08-11 |
Not clear |
| C Missale, M Pizzi, M Memo, G B Picotti, M O Carruba, P F Span. Postsynaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries. Neuroscience letters. vol 61. issue 1-2. 1986-02-18. PMID:2867503. |
measuring adenylate cyclase activity as a biochemical index of dopamine (da) receptors, it was found that the selective d1 da receptor agonist, skf 82526, was able to stimulate the camp formation in rabbit renal and mesenteric arteries, an effect blocked by haloperidol and by sch 23390. |
1986-02-18 |
2023-08-11 |
rabbit |
| G H Fletcher, M S Star. SKF 38393 and apomorphine modify locomotion and exploration in rats placed on a holeboard by separate actions at dopamine D-1 and D-2 receptors. European journal of pharmacology. vol 117. issue 3. 1986-02-17. PMID:3878300. |
these actions were blocked by sch 23390 (0.05 mg/kg, d-1 antagonist) but not by haloperidol (0.05 mg/kg, d-2 antagonist). |
1986-02-17 |
2023-08-11 |
rat |
| M Morelli, G Di Chiar. Catalepsy induced by SCH 23390 in rats. European journal of pharmacology. vol 117. issue 2. 1986-02-12. PMID:2866970. |
the ability of sch 23390 as compared to haloperidol to produce catalepsy in rats was evaluated in three tests for catalepsy. |
1986-02-12 |
2023-08-11 |
rat |
| M Morelli, G Di Chiar. Catalepsy induced by SCH 23390 in rats. European journal of pharmacology. vol 117. issue 2. 1986-02-12. PMID:2866970. |
catalepsy by sch 23390 and by haloperidol was prevented by scopolamine and potentiated by alpha-methyl-p-tyrosine pretreatment. |
1986-02-12 |
2023-08-11 |
rat |
| P Onali, G Mereu, M C Olianas, B Bunse, Z Rossetti, G L Gess. SCH 23390, a selective D1 dopamine receptor blocker, enhances the firing rate of nigral dopaminergic neurons but fails to activate striatal tyrosine hydroxylase. Brain research. vol 340. issue 1. 1985-10-03. PMID:2862956. |
maximal increase (110%) was of the same magnitude as that produced by a supramaximal dose of haloperidol, which produced no additional activation over that produced by sch 23390. |
1985-10-03 |
2023-08-11 |
Not clear |
| P Onali, G Mereu, M C Olianas, B Bunse, Z Rossetti, G L Gess. SCH 23390, a selective D1 dopamine receptor blocker, enhances the firing rate of nigral dopaminergic neurons but fails to activate striatal tyrosine hydroxylase. Brain research. vol 340. issue 1. 1985-10-03. PMID:2862956. |
contrary to haloperidol, sch 23390 failed to increase the affinity of tyrosine hydroxylase (th) for the pteridine cofactor and produced only a modest increase (30%) in da synthesis. |
1985-10-03 |
2023-08-11 |
Not clear |
| E B Nielsen, S A Jepse. Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs. European journal of pharmacology. vol 111. issue 2. 1985-09-23. PMID:2862045. |
haloperidol, spiroperidol and sch 23390) blocked the amph cue completely without any effect on the response rate. |
1985-09-23 |
2023-08-11 |
rat |
| G Mereu, M Collu, E Ongini, G Biggio, G L Gess. SCH 23390, a selective dopamine D1 antagonist, activates dopamine neurons but fails to prevent their inhibition by apomorphine. European journal of pharmacology. vol 111. issue 3. 1985-09-16. PMID:3894035. |
sch 23390, a rather selective d1 receptor blocker, activates the firing rate of dopamine (da) neurons in the substantia nigra (sn-da neurons) in rats, similarly to haloperidol (a d1-d2 receptor antagonist) and sulpiride (a selective d2 receptor blocker). |
1985-09-16 |
2023-08-11 |
rat |
| G Mereu, M Collu, E Ongini, G Biggio, G L Gess. SCH 23390, a selective dopamine D1 antagonist, activates dopamine neurons but fails to prevent their inhibition by apomorphine. European journal of pharmacology. vol 111. issue 3. 1985-09-16. PMID:3894035. |
unlike haloperidol or sulpiride, sch 23390 fails to prevent the inhibition by apomorphine of sn-da neurons, a da autoreceptor-mediated effect. |
1985-09-16 |
2023-08-11 |
rat |