| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Christensen, J Arnt, O Svendse. Pharmacological differentiation of dopamine D-1 and D-2 antagonists after single and repeated administration. Psychopharmacology. Supplementum. vol 2. 1985-07-24. PMID:2860659. |
the compounds can be classified into three pharmacological subgroups: butyrophenones (e.g., haloperidol) with affinity for d-2 receptors; phenothiazines (e.g., fluphenazine and perphenazine) with affinity for both d-2 and d-1 receptors but with preference for the d-2 receptors; and thioxanthenes (e.g., cis(z)-flupentixol and cis(z)-clopenthixol) with equal affinity for d-1 and d-2 receptors, and the selective d-1 antagonist sch 23390. |
1985-07-24 |
2023-08-11 |
mouse |
| S Boyce, E Kelly, A Davis, S Fleminger, P Jenner, C D Marsde. SCH 23390 may alter dopamine-mediated motor behaviour via striatal D-1 receptors. Biochemical pharmacology. vol 34. issue 10. 1985-07-02. PMID:2988552. |
sch 23390 potently displaced the specific binding of 3h-piflutixol to d-1 sites in striatal membranes but haloperidol was only weakly effective. |
1985-07-02 |
2023-08-11 |
rat |
| S Boyce, E Kelly, A Davis, S Fleminger, P Jenner, C D Marsde. SCH 23390 may alter dopamine-mediated motor behaviour via striatal D-1 receptors. Biochemical pharmacology. vol 34. issue 10. 1985-07-02. PMID:2988552. |
sch 23390 weakly displaced specific 3h-spiperone binding to d-2 sites, but haloperidol was potent. |
1985-07-02 |
2023-08-11 |
rat |
| S Boyce, E Kelly, A Davis, S Fleminger, P Jenner, C D Marsde. SCH 23390 may alter dopamine-mediated motor behaviour via striatal D-1 receptors. Biochemical pharmacology. vol 34. issue 10. 1985-07-02. PMID:2988552. |
sch 23390 was more effective than haloperidol in inhibiting dopamine stimulated striatal adenylate cyclase activity. |
1985-07-02 |
2023-08-11 |
rat |
| S Boyce, E Kelly, A Davis, S Fleminger, P Jenner, C D Marsde. SCH 23390 may alter dopamine-mediated motor behaviour via striatal D-1 receptors. Biochemical pharmacology. vol 34. issue 10. 1985-07-02. PMID:2988552. |
however, sch 23390 inhibited apomorphine-induced stereotypy and climbing behaviour in rats with equal potency to haloperidol. |
1985-07-02 |
2023-08-11 |
rat |
| J Hytte. Functional evidence for selective dopamine D-1 receptor blockade by SCH 23390. Neuropharmacology. vol 23. issue 12A. 1985-04-17. PMID:6152023. |
in contrast to haloperidol, a specific dopamine d-2 antagonist, which inhibited the decline in release of both ligands from preloaded slices induced by apomorphine, sch 23390 was without effect on this release from slices loaded with [3h]dopamine but had effect on release from slices loaded with [3h]choline, in concentrations 350 times greater than those of haloperidol (ic50 = 0.63 microm). |
1985-04-17 |
2023-08-12 |
rat |