| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Callahan, J B Appel, K A Cunningha. Dopamine D1 and D2 mediation of the discriminative stimulus properties of d-amphetamine and cocaine. Psychopharmacology. vol 103. issue 1. 1991-04-25. PMID:2006243. |
combination tests with da antagonists indicated that both the d1 antagonist sch 23390 (0.0063-0.25 mg/kg) and the d2 antagonist haloperidol (0.125-0.5 mg/kg) attenuated the effects of both stimulants; in addition, the substitution of cocaine (20 mg/kg) for d-amphetamine was blocked by both da antagonists. |
1991-04-25 |
2023-08-11 |
rat |
| G Volterra, F Borsini, A Lecci, A Mel. Desipramine and nortriptyline antagonize apomorphine and reserpine hypothermia by a different mechanism. The Journal of pharmacy and pharmacology. vol 42. issue 8. 1991-04-15. PMID:1981590. |
in apomorphine-treated animals the effect of both drugs was reversed by the mixed dopaminergic d1- d2-antagonist haloperidol (1 mg kg-1 i.p., 90 min), the d1-receptor blocking drug sch 23390 (0.05 mg kg-1 s.c., 30 min), the alpha 1-adrenoceptor blocking drugs prazosin (3 mg kg-1 s.c., 90 min) and phenoxybenzamine (20 mg kg-1 i.p., 65 min), the beta-adrenoceptor blocking drug (+/-)-propranolol (10 mg kg-1 i.p., 120 min), and the opioid antagonist naloxone (2 mg kg-1 i.p., 15 min). |
1991-04-15 |
2023-08-11 |
mouse |
| M A Parada, L Hernandez, M Puig de Parada, X Paez, B G Hoebe. Dopamine in the lateral hypothalamus may be involved in the inhibition of locomotion related to food and water seeking. Brain research bulletin. vol 25. issue 6. 1991-04-01. PMID:2289177. |
sch 23390 (15 micrograms), haloperidol (2.5 micrograms) and atropine (18 micrograms) did not modify the locomotion level of animals acclimated to the actimeters. |
1991-04-01 |
2023-08-11 |
rat |
| P dos S Rodrigues, J E Dowlin. Dopamine induces neurite retraction in retinal horizontal cells via diacylglycerol and protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 24. 1991-02-07. PMID:2263620. |
the effects of dopamine are blocked by haloperidol and sch 23390, a d1 antagonist, but not by sulpiride, a d2 antagonist. |
1991-02-07 |
2023-08-11 |
Not clear |
| S A Parashos, C Marin, P Barone, V Kapitzoglou-Logothetis, T N Chas. Effect of chronic D-1 and/or D-2 dopamine antagonist treatment on SKF 38393-induced non-stereotyped grooming. Psychopharmacology. vol 102. issue 3. 1991-01-17. PMID:2251338. |
the effects of chronic d-1 and/or d-2 dopamine (da) receptor blockade on a putative d-1 da receptor-mediated behavioral function was studied in rats treated for 21 days with the selective d-1 antagonist sch 23390, the predominantly d-2 antagonist haloperidol, or the combination of both drugs at the same daily doses. |
1991-01-17 |
2023-08-11 |
rat |
| T Ljungberg, M Enquis. Effects of dopamine D-1 and D-2 antagonists on decision making by rats: no reversal of neuroleptic-induced attenuation by scopolamine. Journal of neural transmission. General section. vol 82. issue 3. 1991-01-15. PMID:1979001. |
the effects of the dopamine (da) d-1 antagonist sch 23390 and the d-2 antagonists haloperidol and sulpiride on decision making in thirsty rats were investigated. |
1991-01-15 |
2023-08-11 |
rat |
| H E Shannon, S C Peter. A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2243341. |
the mixed d1/d2 dopaminergic antagonist haloperidol (0.003-3.0 mg/kg) and the selective d1 antagonist sch 23390 (0.01-0.3 mg/kg) produced dose-related decreases in locomotor activity when administered alone, and also produced dose-related reversals of the hyperactivity produced by scopolamine. |
1990-12-31 |
2023-08-11 |
mouse |
| A Lucchelli, C Boselli, E Gran. Dopamine-induced relaxation of the guinea-pig isolated jejunum is not mediated through dopamine receptors. Pharmacological research. vol 22. issue 4. 1990-10-23. PMID:1976247. |
the effects of the dopamine receptor blockers, haloperidol and cis-alpha-flupenthixol and the da1 selective blocker sch 23390 on the relaxing effect of dopamine were also studied. |
1990-10-23 |
2023-08-11 |
Not clear |
| A Lucchelli, C Boselli, E Gran. Dopamine-induced relaxation of the guinea-pig isolated jejunum is not mediated through dopamine receptors. Pharmacological research. vol 22. issue 4. 1990-10-23. PMID:1976247. |
the relaxing effect of dopamine was not reduced by haloperidol, cis-alpha-flupenthixol and sch 23390. |
1990-10-23 |
2023-08-11 |
Not clear |
| K Ossowska, M Karcz, J Wardas, S Wolfart. Striatal and nucleus accumbens D1/D2 dopamine receptors in neuroleptic catalepsy. European journal of pharmacology. vol 182. issue 2. 1990-10-17. PMID:1975782. |
however, similar doses of haloperidol and sch 23390, injected into the ventro-rostral striatum and nucleus accumbens, evoked a similar catalepsy. |
1990-10-17 |
2023-08-11 |
Not clear |
| A D Baine. Functional effects of proximal tubular dopamine production. American journal of hypertension. vol 3. issue 6 Pt 2. 1990-09-20. PMID:2200436. |
haloperidol and sch 23390 block dopamine excretion, therefore dopamine antagonists may inhibit tubular dopamine responses by lowering intracellular dopamine concentration as well as by receptor blockade. |
1990-09-20 |
2023-08-11 |
Not clear |
| R Maldonado, A Baamonde, V Daugé, J Fége. Effects induced by chronic treatment with selective D1 or D2 antagonists on open-field behavior and colonic temperature. Fundamental & clinical pharmacology. vol 4. issue 3. 1990-09-06. PMID:2142927. |
we have studied the behavioral responses in open-field and the changes in body temperature induced after chronic treatment with a selective d1 antagonist, sch 23390, a selective d2+ antagonist, sulpiride, or a non specific but preferential d2 antagonist, haloperidol. |
1990-09-06 |
2023-08-11 |
rat |
| R Maldonado, A Baamonde, V Daugé, J Fége. Effects induced by chronic treatment with selective D1 or D2 antagonists on open-field behavior and colonic temperature. Fundamental & clinical pharmacology. vol 4. issue 3. 1990-09-06. PMID:2142927. |
after chronic sch 23390, an increase of the locomotion and of the number of rears were observed whereas, no changes were induced by chronic sulpiride or haloperidol. |
1990-09-06 |
2023-08-11 |
rat |
| S Sweidan, H Edinger, A Siege. The role of D1 and D2 receptors in dopamine agonist-induced modulation of affective defense behavior in the cat. Pharmacology, biochemistry, and behavior. vol 36. issue 3. 1990-09-05. PMID:1974065. |
in addition, the injection of haloperidol (1.0 mg/kg), spiperone (0.2 mg/kg) or sch 23390 (0.1 mg/kg) alone inhibited the behavior. |
1990-09-05 |
2023-08-11 |
cat |
| T J Hudzik, B L Slife. The role of dopamine in the effects of pentazocine and tripelennamine. Pharmacology, biochemistry, and behavior. vol 36. issue 3. 1990-09-05. PMID:1974066. |
haloperidol and quinpirole pretreatment produced leftward shifts in the pentazocine dose-effect curve while raclopride and sch 23390 shifted the opioid curve to the right. |
1990-09-05 |
2023-08-11 |
rat |
| F B Weihmuller, M Hadjiconstantinou, J P Brun. Dopamine receptors and sensorimotor behavior in MPTP-treated mice. Behavioural brain research. vol 38. issue 3. 1990-08-16. PMID:1973042. |
the rank order of potency was haloperidol greater than sch 23390 much greater than l-sulpiride. |
1990-08-16 |
2023-08-11 |
mouse |
| F B Weihmuller, M Hadjiconstantinou, J P Brun. Dopamine receptors and sensorimotor behavior in MPTP-treated mice. Behavioural brain research. vol 38. issue 3. 1990-08-16. PMID:1973042. |
haloperidol and sch 23390 also produced somatosensory neglect in both control and mptp-treated mice, with haloperidol greater than sch 23390. |
1990-08-16 |
2023-08-11 |
mouse |
| R J Care. Dopamine receptors mediate drug-induced but not Pavlovian conditioned contralateral rotation in the unilateral 6-OHDA animal model. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2113414. |
subsequent tests with the d1 antagonist (sch 23390), or the d2 antagonist (haloperidol) partially suppressed and the combined d1-d2 antagonists completely suppressed the apomorphine-induced response of contralateral rotation. |
1990-08-01 |
2023-08-11 |
Not clear |
| F Amenta, A Ricci, J A Veg. Pharmacological characterization of rat renal medulla dopamine-sensitive cyclic adenosine monophosphate generating system. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2158544. |
this effect was blocked by the da-1 receptors antagonist sch 23390 and by the other da-2 receptor antagonists fluphenazine and haloperidol. |
1990-05-30 |
2023-08-11 |
rat |
| R Maldonado, V Daugé, J Feger, B P Roque. Chronic blockade of D2 but not D1 dopamine receptors facilitates behavioural responses to endogenous enkephalins, protected by kelatorphan, administered in the accumbens in rats. Neuropharmacology. vol 29. issue 3. 1990-05-24. PMID:2157999. |
in this study, the consequence of chronic treatment with sulpiride, a selective d2 dopamine receptor antagonist, sch 23390, a selective d1 dopamine receptor antagonist, or haloperidol, a nonspecific but preferential d2 receptor antagonist, on the behavioural response induced by acute administration of kelatorphan into the accumbens, has been investigated in rats. |
1990-05-24 |
2023-08-11 |
rat |