| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K M O'Boyle, K T Gavin, N Harriso. Chronic antagonist treatment does not alter the mode of interaction of dopamine with rat striatal dopamine receptors. Journal of receptor research. vol 13. issue 1-4. 1993-04-15. PMID:8450496. |
chronic treatment with the d1 and d2 dopamine receptor antagonists sch 23390 (0.5 mg/kg) and haloperidol decanoate (25 mg/kg) caused an up-regulation in d1 and d2 receptor densities, respectively, with no change in kd. |
1993-04-15 |
2023-08-12 |
rat |
| J Maj, Z Rogóz, G Skuza, H Sowińsk. The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test. Polish journal of pharmacology and pharmacy. vol 44. issue 4. 1993-03-17. PMID:1363131. |
reduction of the immobility time induced by cgp 37849 and cgp 39551 in the forced swimming test in rats was antagonized by haloperidol and (+/-)-sulpiride, but not by sch 23390 or prazosin. |
1993-03-17 |
2023-08-11 |
mouse |
| J W Kebabian, D R Britton, M P DeNinno, R Perner, L Smith, P Jenner, R Schoenleber, M William. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. European journal of pharmacology. vol 229. issue 2-3. 1993-03-02. PMID:1362704. |
in rats with unilateral 6-ohda (6-hydroxydopamine) lesions of the nigro-striatal dopaminergic pathway, a-77636 elicits prolonged (> 20 h) contralateral turning that is blocked by sch 23390, a d1 receptor antagonist, but not by haloperidol at doses selective for the dopamine d2 receptor. |
1993-03-02 |
2023-08-11 |
mouse |
| W Kropf, J Krieglstein, K Kuschinsk. Effects of stimulation of putative dopamine autoreceptors on electroencephalographic power spectrum in comparison with effects produced by blockade of postsynaptic dopamine receptors in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1490099. |
in contrast, antagonists at da receptors (haloperidol 0.1 mg/kg i.p., d2 blocker) or sch 23390 (0.2 mg/kg i.p., d1 blocker) led to little increases in the delta band, but more pronounced increases in the alpha-2 band. |
1993-03-01 |
2023-08-11 |
rat |
| I Mortensen, J E Kristiansen, A V Christensen, E F Hvidber. The antibacterial effect of some neuroleptics on strains isolated from patients with meningitis. Pharmacology & toxicology. vol 71. issue 6. 1993-02-05. PMID:1362269. |
eighty-two strains of bacteria (neisseria meningitidis, haemophilus influenzae, enterobacteriaceae, streptococcus pneumoniae, group b streptococci and listeria monocytogenes) were examined for their in vitro susceptibility to eight drugs, seven neuroleptics (perphenazine, fluphenazine, cis(z)-clopenthixol, haloperidol, clozapine, clebopride and sch 23390), and the neuroleptically inactive trans(e)-clopenthixol. |
1993-02-05 |
2023-08-11 |
Not clear |
| J Day, H C Fibige. Dopaminergic regulation of cortical acetylcholine release. Synapse (New York, N.Y.). vol 12. issue 4. 1993-01-19. PMID:1465741. |
both d1 (sch 23390) and d2 (haloperidol, raclopride) da receptor antagonists attenuated the amphetamine-induced increase in cortical ach release; however, only the d1 antagonist significantly reduced basal output of cortical ach. |
1993-01-19 |
2023-08-11 |
Not clear |
| b' R R Ga\\xc4\\xadnetdinov, E A Budygin, G I Kovalev, V S Kudrin, K S Raevski\\xc4\\xa. [Different effects of typical and atypical neuroleptics on K+-stimulated dopamine release from isolated rat striatum]. Biulleten\' eksperimental\'noi biologii i meditsiny. vol 114. issue 7. 1992-12-01. PMID:1358258.' |
effects of haloperidol (10(-7)-alpha 10(-5) m), trifluoperazine, metoclopramide, tiapride, sulpiride, thioridazine, clozapine remoxipride, raclopride, cis- and trans-isomers of carbidine, sch 23390 (all at the 10(-6) m) on the k(+)-stimulated (28 mm) dopamine (da) release from isolated rat striatum were studied. |
1992-12-01 |
2023-08-11 |
rat |
| I M Lang, S K Sarn. The role of adrenergic receptors in the initiation of vomiting and its gastrointestinal motor correlates. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1357160. |
the responses to uk-14304 or clonidine were also blocked by fentanyl, 1-(1-naphthyl) piperazine, methysergide, sch 22390 or scopolamine, but not by haloperidol, sulpiride, domperidone or naloxone. |
1992-11-20 |
2023-08-11 |
Not clear |
| G Schettini, C Ventra, T Florio, M Grimaldi, O Meucci, A Marin. Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D1 and D2 dopamine receptors: involvement of G proteins in the development of receptor supersensitivity. Journal of neurochemistry. vol 59. issue 5. 1992-11-20. PMID:1402912. |
rats receiving injections of specific antagonists of dopamine receptors (sch 23390 for d1, haloperidol for d2, and haloperidol+sch 23390) once daily for 21 days develop a selective supersensitivity of the blocked receptors. |
1992-11-20 |
2023-08-11 |
rat |
| K G Todd, C H Beck, M T Martin-Iverso. Effects of D1 and D2 dopamine antagonists on behavior of polydipsic rats. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409772. |
the behavioral and neurochemical effects of sch3390 (sch), a dopamine (da) d1 antagonist, and haloperidol (hal), a da d2 receptor antagonist, on schedule-induced polydipsia (sip) were examined. |
1992-11-18 |
2023-08-11 |
rat |
| J Mierau, G Schingnit. Biochemical and pharmacological studies on pramipexole, a potent and selective dopamine D2 receptor agonist. European journal of pharmacology. vol 215. issue 2-3. 1992-11-13. PMID:1356788. |
both effects were fully antagonized by haloperidol but not by the selective da d1 receptor antagonist sch 23390. |
1992-11-13 |
2023-08-11 |
mouse |
| G J LaHoste, J F Marshal. Dopamine supersensitivity and D1/D2 synergism are unrelated to changes in striatal receptor density. Synapse (New York, N.Y.). vol 12. issue 1. 1992-11-12. PMID:1357762. |
the state of d1/d2 synergism was found to be independent of striatal d1 or d2 receptor density in rats as: (1) increasing striatal d1 and/or d2 receptor density (as confirmed by quantitative receptor autoradiography) by chronic treatment with sch 23390 (0.5 mg/kg/day for 21 days) and/or haloperidol (0.5 mg/kg/day for 21 days) did not alter the normal pattern of d1/d2 synergism as determined by behavioral responsiveness to agonist stimulation of d1 or d2 receptors, and (2) 5 days of reserpine treatment (1 mg/kg/day), although not significantly changing striatal d1 or d2 receptor density, induced a breakdown in d1/d2 synergism (i.e., behavior was elicited by independent stimulation of d1 or d2 receptors). |
1992-11-12 |
2023-08-11 |
rat |
| J Maj, Z Rogóz, G Skuza, H Sowińsk. The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist. Neuropharmacology. vol 31. issue 7. 1992-11-06. PMID:1407405. |
that increase was completely antagonized by haloperidol and partly by sch 23390 and (+/-)-sulpiride; prazosin was inactive. |
1992-11-06 |
2023-08-11 |
rat |
| J Maj, Z Rogóz, G Skuza, H Sowińsk. The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist. Neuropharmacology. vol 31. issue 7. 1992-11-06. PMID:1407405. |
also, in that case haloperidol and sch 23390 produced the strongest antagonistic effect; (+/-)-sulpiride and prazosin had a distinctly less potent action. |
1992-11-06 |
2023-08-11 |
rat |
| B Levant, D E Grigoriadis, E B DeSouz. Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain. The Journal of pharmacology and experimental therapeutics. vol 262. issue 3. 1992-10-22. PMID:1356154. |
the pharmacological profile of [3h]quinpirole binding in striatum was: (-)-n-n-propylnorapomorphine (+/-)-2-amino-6,7-dihydroxyl-1,2,3,4-tetrahydronaphthalene greater than or equal to quinpirole greater than apomorphine greater than bromocriptine greater than dopamine greater than skf 38393 much greater than 5-hydroxytryptamine for putative dopamine agonists; spiperone greater than (+)-butaclamol greater than haloperidol greater than (-)-sulpiride greater than clozapine greater than sch 23390 much greater than cinanserin for antagonists. |
1992-10-22 |
2023-08-11 |
rat |
| P Bo, F Savold. Comparative study of the EEG profile of neuroleptics selective for D-1 or D-2 dopamine receptors in the rabbit. Pharmacological research. vol 26. issue 1. 1992-10-01. PMID:1387476. |
the data indicate that, although to a lesser degree, the d-1 receptor antagonist sch 23390 induced eeg effects similar to those of haloperidol, whereas blockade of d-2 receptors by raclopride resulted in different patterns of eeg activity. |
1992-10-01 |
2023-08-11 |
rabbit |
| S Kawagishi, K Yoshino, T E Jones, M Iwamoto, S Arai, N Aman. Dopamine receptor antagonists increase markedly the quantity of retrograde transport of HRP in the rat masseteric motoneuron. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1355002. |
horseradish peroxidase (hrp) was injected, bilaterally, into the rat masseter muscle, subsequent to an intramuscular or intraperitoneal injection of one of five dopamine antagonists (chlorpromazine and haloperidol as the d1 and d2 receptor antagonist, sch 23390 as the specific d1 receptor antagonist, sulpiride and domperidone as the specific d2 receptor antagonist). |
1992-09-29 |
2023-08-11 |
rat |
| S Kawagishi, K Yoshino, T E Jones, M Iwamoto, S Arai, N Aman. Dopamine receptor antagonists increase markedly the quantity of retrograde transport of HRP in the rat masseteric motoneuron. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1355002. |
chlorpromazine, haloperidol, sch 23390 and sulpiride significantly raised the quantity of retrograde transport of hrp. |
1992-09-29 |
2023-08-11 |
rat |
| C W Schindler, J W Zheng, S R Tella, S R Goldber. Pharmacological mechanisms in the cardiovascular effects of methamphetamine in conscious squirrel monkeys. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1325059. |
the dopaminergic antagonists sch 23390 and haloperidol antagonized some of the cardiovascular effects of methamphetamine. |
1992-09-25 |
2023-08-11 |
monkey |
| B Levant, C B Nemerof. Further studies on the modulation of regional brain neurotensin concentrations by antipsychotic drugs: focus on haloperidol and BMY 14802. The Journal of pharmacology and experimental therapeutics. vol 262. issue 1. 1992-08-11. PMID:1625208. |
increases in neurotensin concentrations produced by haloperidol and bmy 14802 were not antagonized by sch 23390. |
1992-08-11 |
2023-08-11 |
rat |