| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lori A Knackstedt, Roberto I Melendez, Peter W Kaliva. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological psychiatry. vol 67. issue 1. 2010-02-25. PMID:19717140. |
ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. |
2010-02-25 |
2023-08-12 |
Not clear |
| Lori A Knackstedt, Roberto I Melendez, Peter W Kaliva. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological psychiatry. vol 67. issue 1. 2010-02-25. PMID:19717140. |
the cystine-glutamate exchanger is downregulated after chronic cocaine, resulting in reduced extracellular levels of nucleus accumbens glutamate. |
2010-02-25 |
2023-08-12 |
Not clear |
| Lori A Knackstedt, Roberto I Melendez, Peter W Kaliva. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological psychiatry. vol 67. issue 1. 2010-02-25. PMID:19717140. |
the importance of cocaine-induced loss of glutamate homeostasis is revealed by n-acetylcysteine restoring cystine-glutamate exchange and attenuating reinstatement to cocaine seeking. |
2010-02-25 |
2023-08-12 |
Not clear |
| b' B \\xc5\\xbdelezn\\xc3\\xa1, J Maixnerov\\xc3\\xa1, R Maty\\xc5\\xa1kov\\xc3\\xa1, R Haugvicov\\xc3\\xa1, D Bloke\\xc5\\xa1ov\\xc3\\xa1, L Malet\\xc3\\xadnsk\\xc3\\xa. Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice. Physiological research. vol 58. issue 5. 2010-02-24. PMID:19093718.' |
anorexigenic effect of cholecystokinin is lost but that of cart (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice. |
2010-02-24 |
2023-08-12 |
mouse |
| Dong Kun Lee, Wei Choon Alvin Koh, Yoon-Bo Shim, Insop Shim, Eun Sang Cho. Repeated cocaine administration increases nitric oxide efflux in the rat dorsal striatum. Psychopharmacology. vol 208. issue 2. 2010-02-23. PMID:19936712. |
repeated injections of cocaine alter extracellular nitric oxide (no) efflux via interactions between dopamine and glutamate receptor-coupled signaling cascades. |
2010-02-23 |
2023-08-12 |
rat |
| M Corominas, C Roncero, M Casa. Corticotropin releasing factor and neuroplasticity in cocaine addiction. Life sciences. vol 86. issue 1-2. 2010-02-19. PMID:19914260. |
the present review explores the effects of stress on the pattern of interaction between crf, dopamine and glutamate in distinct structures of the mesocorticolimbic circuitry, including the ventral tegmental area (vta), amygdala, bed nucleus of stria terminalis (bnst) and the prefrontal cortex (pfc), after acute and chronic cocaine consumption as well as in early withdrawal and protracted abstinence. |
2010-02-19 |
2023-08-12 |
Not clear |
| Zheng-Xiong Xi, Xia Li, Xiao-Qing Peng, Jie Li, Lauren Chun, Eliot L Gardner, Ajit G Thomas, Barbara S Slusher, Charles R Ashb. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895667. |
pharmacological activation of group ii metabotropic glutamate receptors (mglur2/3) inhibits cocaine self-administration and reinstatement of drug-seeking behavior, suggesting a possible use of mglur2/3 agonists in the treatment of cocaine dependence. |
2010-02-05 |
2023-08-12 |
rat |
| Shaolin Yang, Betty Jo Salmeron, Thomas J Ross, Zheng-Xiong Xi, Elliot A Stein, Yihong Yan. Lower glutamate levels in rostral anterior cingulate of chronic cocaine users - A (1)H-MRS study using TE-averaged PRESS at 3 T with an optimized quantification strategy. Psychiatry research. vol 174. issue 3. 2010-01-28. PMID:19906515. |
lower glutamate levels in rostral anterior cingulate of chronic cocaine users - a (1)h-mrs study using te-averaged press at 3 t with an optimized quantification strategy. |
2010-01-28 |
2023-08-12 |
human |
| Heath D Schmidt, Katie R Famous, R C Pierc. The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT. The European journal of neuroscience. vol 30. issue 7. 2010-01-18. PMID:19788581. |
furthermore, microinjection of the ionotropic glutamate receptor antagonist cnqx (0.3 microg) into the pptg/ldt attenuated the reinstatement of drug seeking induced by a priming injection of cocaine (10 mg/kg, i.p.). |
2010-01-18 |
2023-08-12 |
rat |
| Rayna M Bauzo, Heather L Kimmel, Leonard L Howel. Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys. Pharmacology, biochemistry, and behavior. vol 94. issue 1. 2009-12-17. PMID:19703487. |
recent evidence indicates that group ii metabotropic glutamate receptors (mglur2 and mglur3) may play a role in the pathology of cocaine addiction. |
2009-12-17 |
2023-08-12 |
human |
| Hui Lu, Byungkook Lim, Mu-ming Po. Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 40. 2009-11-10. PMID:19812341. |
biochemical assays of isolated mpfc tissue from postnatal rats further showed that cocaine exposure in utero caused a marked reduction in the surface expression of gaba(a) receptor subunits alpha1, beta2, and beta3, but had no effect on glutamate receptor subunit glur1. |
2009-11-10 |
2023-08-12 |
rat |
| Nora Siegal, Diana Dow-Edward. Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats. Neuroscience letters. vol 464. issue 1. 2009-11-03. PMID:19660521. |
since isoflurane acts primarily by increasing the effects of the inhibitory neurotransmitter gamma-amino butyric acid (gaba) and reducing the effects of the excitatory amino acid glutamate, these amino acids may play more prominent roles in sensitization to cocaine in females than previously understood. |
2009-11-03 |
2023-08-12 |
rat |
| Xiaohu Xie, Jeffery D Stekete. Effects of repeated exposure to cocaine on group II metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. Psychopharmacology. vol 203. issue 3. 2009-09-28. PMID:19005645. |
effects of repeated exposure to cocaine on group ii metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. |
2009-09-28 |
2023-08-12 |
rat |
| Xiaohu Xie, Jeffery D Stekete. Effects of repeated exposure to cocaine on group II metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. Psychopharmacology. vol 203. issue 3. 2009-09-28. PMID:19005645. |
enhanced excitatory output from the medial prefrontal cortex (mpfc), which can be modulated by group ii metabotropic glutamate receptors (mglur), is thought to play a key role in the development of sensitization to cocaine. |
2009-09-28 |
2023-08-12 |
rat |
| Johanna Schumann, Henry Matzner, Avner Michaeli, Rami Yak. NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization. Neuroscience letters. vol 461. issue 2. 2009-09-23. PMID:19524640. |
in particular, the activation of ionotropic glutamate n-methyl-d-aspartate receptor (nmdar) in the ventral tegmental area (vta) is critical for both cocaine-induced synaptic plasticity induced by a single cocaine injection and for the initiation of cocaine psychomotor sensitization. |
2009-09-23 |
2023-08-12 |
Not clear |
| Vidhya Kumaresan, Menglu Yuan, Judy Yee, Katie R Famous, Sharon M Anderson, Heath D Schmidt, R Christopher Pierc. Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behavioural brain research. vol 202. issue 2. 2009-08-19. PMID:19463707. |
metabotropic glutamate receptor 5 (mglur5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. |
2009-08-19 |
2023-08-12 |
rat |
| Vidhya Kumaresan, Menglu Yuan, Judy Yee, Katie R Famous, Sharon M Anderson, Heath D Schmidt, R Christopher Pierc. Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behavioural brain research. vol 202. issue 2. 2009-08-19. PMID:19463707. |
accumulating evidence suggests that metabotropic glutamate receptors (mglurs) are involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior. |
2009-08-19 |
2023-08-12 |
rat |
| Osnat Ben-Shahar, Ilona Obara, Alexis W Ary, Natalie Ma, Mario A Mangiardi, Robert L Medina, Karen K Szumlinsk. Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. Synapse (New York, N.Y.). vol 63. issue 7. 2009-08-13. PMID:19306440. |
human cocaine addicts show altered function within the basal ganglia and the medial prefrontal cortex (mpfc) and altered glutamate function within these areas is postulated to be critical for cocaine addiction. |
2009-08-13 |
2023-08-12 |
human |
| Osnat Ben-Shahar, Ilona Obara, Alexis W Ary, Natalie Ma, Mario A Mangiardi, Robert L Medina, Karen K Szumlinsk. Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. Synapse (New York, N.Y.). vol 63. issue 7. 2009-08-13. PMID:19306440. |
the present project utilized a highly valid animal model of cocaine addiction, to test whether excessive use of cocaine alters glutamate function within these brain areas. |
2009-08-13 |
2023-08-12 |
human |
| Youssef Sari, Kathryn D Smith, Pir K Ali, George V Rebe. Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625514. |
because glt1 is responsible for the uptake of >or=90% of extracellular glutamate, we tested the hypothesis that increased glt1 expression attenuates cocaine relapse. |
2009-08-10 |
2023-08-12 |
rat |