| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Youssef Sari, Kathryn D Smith, Pir K Ali, George V Rebe. Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625514. |
our results suggest that glutamate plays a key role in cue-induced relapse to cocaine-seeking behavior, implicating glt1 as a potential therapeutic target for cocaine addiction. |
2009-08-10 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher Muelle. Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19135470. |
locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects. |
2009-08-05 |
2023-08-12 |
Not clear |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher Muelle. Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19135470. |
the trafficking of the glutamate receptors was investigated in the dorsal and ventral prefrontal cortex at 1 and 21 days after repeated cocaine administration which produced robust locomotor sensitization. |
2009-08-05 |
2023-08-12 |
Not clear |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher Muelle. Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19135470. |
thus, enhanced trafficking of glutamate receptors from cytosolic to synaptosomal compartment is associated with prolonged withdrawal from repeated exposure to cocaine and may have functional consequences for the synaptic and behavioral plasticity. |
2009-08-05 |
2023-08-12 |
Not clear |
| Xia Li, Jie Li, Xiao-Qing Peng, Krista Spiller, Eliot L Gardner, Zheng-Xiong X. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19158667. |
metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal gabaergic mechanism. |
2009-08-03 |
2023-08-12 |
rat |
| Lori A Knackstedt, Steven LaRowe, Pascale Mardikian, Robert Malcolm, Himanshu Upadhyaya, Sarra Hedden, Athina Markou, Peter W Kaliva. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biological psychiatry. vol 65. issue 10. 2009-07-30. PMID:19103434. |
the present study determined if, akin to cocaine, nicotine self-administration in rats induces adaptations in the expression of glutamate transporters and cystine-glutamate exchangers in brain nuclei implicated in reinforcement and if treating cigarette smokers with a drug that restores cystine-glutamate exchange affects the number of cigarettes smoked. |
2009-07-30 |
2023-08-12 |
rat |
| Lori A Knackstedt, Peter W Kaliva. Glutamate and reinstatement. Current opinion in pharmacology. vol 9. issue 1. 2009-07-14. PMID:19157986. |
new molecular and neurochemical adaptations in the glutamatergic system which drive cocaine relapse have been identified, such as the ability of cb1 receptor stimulation to reduce basal glutamate levels and the involvement of the glur1 receptor subunit in reinstatement. |
2009-07-14 |
2023-08-12 |
Not clear |
| Elena Yablonsky-Alter, Mervan S Agovic, Eleonora Gashi, Theodore I Lidsky, Eitan Friedman, Shailesh P Banerje. Cocaine challenge enhances release of neuroprotective amino acid taurine in the striatum of chronic cocaine treated rats: a microdialysis study. Brain research bulletin. vol 79. issue 3-4. 2009-07-07. PMID:19166917. |
we investigated effects of acute or chronic cocaine administration and cocaine challenge following chronic cocaine exposure on the release of excitotoxic glutamate and neuroprotective taurine in the rat striatum by microdialysis. |
2009-07-07 |
2023-08-12 |
rat |
| Elena Yablonsky-Alter, Mervan S Agovic, Eleonora Gashi, Theodore I Lidsky, Eitan Friedman, Shailesh P Banerje. Cocaine challenge enhances release of neuroprotective amino acid taurine in the striatum of chronic cocaine treated rats: a microdialysis study. Brain research bulletin. vol 79. issue 3-4. 2009-07-07. PMID:19166917. |
cocaine challenge, following withdrawal after repeated cocaine exposure markedly increased the release of glutamate, which may cause neurotoxicity. |
2009-07-07 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher Mueller, Chad Seubert, John R Mantsc. Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration. Neuroscience letters. vol 452. issue 2. 2009-06-29. PMID:19118598. |
neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mglur5 and homer proteins following extinction of cocaine self-administration. |
2009-06-29 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher Mueller, Chad Seubert, John R Mantsc. Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration. Neuroscience letters. vol 452. issue 2. 2009-06-29. PMID:19118598. |
this study examined the role of group1 metabotropic glutamate receptor mglur5 and associated postsynaptic scaffolding protein homer1b/c in behavioral plasticity after three withdrawal treatments from cocaine self-administration. |
2009-06-29 |
2023-08-12 |
rat |
| M B Ghasemzadeh, C Mueller, P Vasudeva. Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Neuroscience. vol 159. issue 1. 2009-06-25. PMID:19105975. |
behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. |
2009-06-25 |
2023-08-12 |
rat |
| M B Ghasemzadeh, C Mueller, P Vasudeva. Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Neuroscience. vol 159. issue 1. 2009-06-25. PMID:19105975. |
these observations suggest that significant redistribution of glutamate receptors and postsynaptic scaffolding proteins into synaptosomal membrane fraction is associated with withdrawal from behavioral sensitization to cocaine. |
2009-06-25 |
2023-08-12 |
rat |
| R Martin-Fardon, M A S Baptista, C V Dayas, F Weis. Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19258516. |
to advance understanding of the potential of metabotropic glutamate receptor (mglur) 5 as treatment targets for cocaine addiction, the effects of mtep [3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]piperidine] (a selective mglur5 antagonist) on conditioned reinstatement of cocaine seeking were examined. |
2009-06-23 |
2023-08-12 |
rat |
| R Martin-Fardon, M A S Baptista, C V Dayas, F Weis. Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19258516. |
the findings implicate mglur5-regulated glutamate transmission in appetitive behavior controlled by reward-related stimuli but without selectivity for cocaine seeking. |
2009-06-23 |
2023-08-12 |
rat |
| Johanna Schumann, Rami Yak. Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474322. |
activation of ionotropic glutamate receptor nmda receptor (nmdar) in the vta is critical for the development of cocaine psychomotor sensitization. |
2009-06-23 |
2023-08-12 |
Not clear |
| M Behnam Ghasemzadeh, Lindsay K Windham, Russell W Lake, Christopher J Acker, Peter W Kaliva. Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling. Synapse (New York, N.Y.). vol 63. issue 1. 2009-06-16. PMID:18932227. |
cocaine activates homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling. |
2009-06-16 |
2023-08-12 |
rat |
| S Pendyam, A Mohan, P W Kalivas, S S Nai. Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19084053. |
computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. |
2009-05-20 |
2023-08-12 |
rat |
| S Pendyam, A Mohan, P W Kalivas, S S Nai. Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19084053. |
chronic cocaine administration causes instability in extracellular glutamate in the nucleus accumbens that is thought to contribute to the vulnerability to relapse. |
2009-05-20 |
2023-08-12 |
rat |
| Guo-Chi Zhang, Khang Vu, Nikhil K Parelkar, Li-Min Mao, Ian M Stanford, Eugene E Fibuch, John Q Wan. Acute administration of cocaine reduces metabotropic glutamate receptor 8 protein expression in the rat striatum in vivo. Neuroscience letters. vol 449. issue 3. 2009-04-27. PMID:19010389. |
acute administration of cocaine reduces metabotropic glutamate receptor 8 protein expression in the rat striatum in vivo. |
2009-04-27 |
2023-08-12 |
human |