| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xia Li, Jie Li, Eliot L Gardner, Zheng-Xiong X. Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20534005. |
the metabotropic glutamate receptor 7 (mglur7) has been reported to be involved in cocaine and alcohol self-administration. |
2010-09-13 |
2023-08-12 |
rat |
| Xia Li, Jie Li, Eliot L Gardner, Zheng-Xiong X. Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20534005. |
in vivo microdialysis demonstrated that cocaine priming significantly increased extracellular dopamine in the nac, ventral pallidum and dorsal striatum, while increasing extracellular glutamate in the nac only. |
2010-09-13 |
2023-08-12 |
rat |
| Carrie R Ferrario, Xuan Li, Xiaoting Wang, Jeremy M Reimers, Jamie L Uejima, Marina E Wol. The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19924109. |
the role of glutamate receptor redistribution in locomotor sensitization to cocaine. |
2010-09-07 |
2023-08-12 |
rat |
| Cameron H Good, Carl R Lupic. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534838. |
in contrast, activation of glutamate afferents onto the same da neurons via stimulation within the vta evoked epscs mediated by glur2-lacking ampars that demonstrated ltd or epscs mediated by glur2-containing ampa receptors that did not express ltd. twenty-four hours after single cocaine injections to rats, glur2-lacking ampars were increased at both ppn and local vta projections, and this permitted ltd expression in both pathways. |
2010-08-24 |
2023-08-12 |
rat |
| Cameron H Good, Carl R Lupic. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534838. |
these results demonstrate that cocaine more globally increases glur2-lacking ampa receptors at all glutamate synapses on vta dopamine neurons, whereas delta(9)-thc selectively increased glur2-lacking ampa receptors at subcortical ppn synapses. |
2010-08-24 |
2023-08-12 |
rat |
| Brenda L McKee, Modjgan Keyghobadi, Adrienne P Tozier De La Poterie, Charles K Meshu. Lesion of the ventromedial nucleus of the thalamus blocks acute cocaine-induced changes in striatal glutamate. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169577. |
a single injection of cocaine increases extracellular glutamate in the rat dorsolateral striatum 1 day after the acute cocaine was administered (mckee and meshul, 2005). |
2010-07-19 |
2023-08-12 |
rat |
| Brenda L McKee, Modjgan Keyghobadi, Adrienne P Tozier De La Poterie, Charles K Meshu. Lesion of the ventromedial nucleus of the thalamus blocks acute cocaine-induced changes in striatal glutamate. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169577. |
one day after a single cocaine or vehicle injection, extracellular glutamate was measured in the dorsolateral striatum using in vivo microdialysis. |
2010-07-19 |
2023-08-12 |
rat |
| Brenda L McKee, Modjgan Keyghobadi, Adrienne P Tozier De La Poterie, Charles K Meshu. Lesion of the ventromedial nucleus of the thalamus blocks acute cocaine-induced changes in striatal glutamate. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169577. |
this study shows a critical role for the vm nucleus of the thalamus in mediating the effects of cocaine on extracellular glutamate levels in the rat dorsolateral striatum. |
2010-07-19 |
2023-08-12 |
rat |
| S Ramiro-Fuentes, O Ortiz, R Moratalla, E Fernandez-Espej. Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors. Neuroscience. vol 167. issue 2. 2010-06-17. PMID:20167255. |
intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid cb1 receptor silencing: critical role for glutamate receptors. |
2010-06-17 |
2023-08-12 |
rat |
| S Ramiro-Fuentes, O Ortiz, R Moratalla, E Fernandez-Espej. Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors. Neuroscience. vol 167. issue 2. 2010-06-17. PMID:20167255. |
accumbal glutamate and glutamate receptors have been proposed to be involved in cb(1)r-mediated effects on cocaine reward. |
2010-06-17 |
2023-08-12 |
rat |
| S Ramiro-Fuentes, O Ortiz, R Moratalla, E Fernandez-Espej. Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors. Neuroscience. vol 167. issue 2. 2010-06-17. PMID:20167255. |
the objectives of the present study were (i) to discern the cpp effects of in vivo gene silencing of accumbal cb(1) receptors by means of lentiviruses containing sirnas; (ii) to discern the cpp effects of intra-accumbens infusions of the cannabinoid cb(1)r ligand rimonabant, and to evaluate whether effects are due to receptor blockade or inverse agonism; (iii) to discern the role of cb(1)r located within the nucleus accumbens shell in the rewarding effects of cocaine, by means of local infusions of rimonabant, and (iv) to discern the role of glutamate receptors (ampar, nmdar, mglur2/3) in rimonabant-induced effects on cpp in cocaine-treated rats. |
2010-06-17 |
2023-08-12 |
rat |
| S Ramiro-Fuentes, O Ortiz, R Moratalla, E Fernandez-Espej. Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors. Neuroscience. vol 167. issue 2. 2010-06-17. PMID:20167255. |
finally, in cocaine-treated rats, local rimonabant induced place aversion to the drug (not place preference), and this effect was mediated by glutamate neurotransmission because it was abolished after blockade of ampa, nmda or mglu2/3 receptors, even though only the blockade of mglu2/3 autoreceptors restored the emergence of place preference to cocaine. |
2010-06-17 |
2023-08-12 |
rat |
| Jacqueline F McGinty, Timothy W Whitfield, William J Berglin. Brain-derived neurotrophic factor and cocaine addiction. Brain research. vol 1314. 2010-06-07. PMID:19732758. |
furthermore, 3 weeks after bdnf infusion in animals with a cocaine self-administration history, suppressed basal levels of glutamate are normalized and a cocaine prime-induced increase in extracellular glutamate levels in the nucleus accumbens is prevented. |
2010-06-07 |
2023-08-12 |
Not clear |
| Roy A Wise, Marisela Morale. A ventral tegmental CRF-glutamate-dopamine interaction in addiction. Brain research. vol 1314. 2010-06-07. PMID:19800323. |
thus, a complex and not yet fully understood interaction of crf, glutamate, and the mesocorticolimbic dopamine system is established by experience with cocaine, and this alteration appears to contribute importantly to the transition from casual to compulsive cocaine-seeking. |
2010-06-07 |
2023-08-12 |
Not clear |
| Xiao-Qing Peng, Jie Li, Eliot L Gardner, Charles R Ashby, Ajit Thomas, Krystyna Wozniak, Barbara S Slusher, Zheng-Xiong X. Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19887067. |
we have recently reported that the endogenous mglu2/3 agonist n-acetylaspartylglutamate (naag) and the n-acetylated-alpha-linked-acidic dipeptidase (naaladase, a naag degradation enzyme) inhibitor 2-pmpa significantly inhibit cocaine self-administration and cocaine-induced reinstatement of drug-seeking behavior by attenuating cocaine-enhanced extracellular dopamine and glutamate in the nucleus accumbens. |
2010-04-05 |
2023-08-12 |
rat |
| Ju Hwan Yang, Eun Sang Cho. Repeated cocaine administration increases cleaved poly(ADP-ribose) polymerase-1 expression in the rat dorsal striatum. Neuroscience letters. vol 471. issue 1. 2010-04-05. PMID:20079403. |
taken together, these findings suggest that parp-1 activation is upregulated by repeated cocaine administration, and that interactions between dopamine d1 and glutamate receptors may be involved in this upregulation. |
2010-04-05 |
2023-08-12 |
rat |
| Heath D Schmidt, R Christopher Pierc. Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Annals of the New York Academy of Sciences. vol 1187. 2010-04-02. PMID:20201846. |
a growing body of evidence indicates that repeated exposure to cocaine leads to profound changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. |
2010-04-02 |
2023-08-12 |
Not clear |
| Heath D Schmidt, R Christopher Pierc. Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Annals of the New York Academy of Sciences. vol 1187. 2010-04-02. PMID:20201846. |
therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction. |
2010-04-02 |
2023-08-12 |
Not clear |
| Emmanuel Valjent, Jesus Bertran-Gonzalez, Benjamin Aubier, Paul Greengard, Denis Hervé, Jean-Antoine Giraul. Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 2. 2010-03-01. PMID:19759531. |
the induction of sensitized responses to cocaine required dopamine d1 and glutamate nmda receptors. |
2010-03-01 |
2023-08-12 |
mouse |
| Zheng-Xiong Xi, Michael Kiyatkin, Xia Li, Xiao-Qing Peng, Armina Wiggins, Krista Spiller, Jie Li, Eliot L Gardne. N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. Neuropharmacology. vol 58. issue 1. 2010-02-25. PMID:19559037. |
pharmacological activation of group ii metabotropic glutamate (mglu2 and mglu3) receptors inhibits reward-seeking behavior and/or rewarding efficacy induced by drugs (cocaine, nicotine) or natural rewards (food, sucrose). |
2010-02-25 |
2023-08-12 |
rat |