| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dorothy J Yamamoto, Nancy R Zahnise. Differences in rat dorsal striatal NMDA and AMPA receptors following acute and repeated cocaine-induced locomotor activation. PloS one. vol 7. issue 5. 2012-09-27. PMID:22655064. |
to determine if such changes contribute to the differential development of locomotor sensitization, we examined protein levels of total, phosphorylated, and cell surface glutamate n-methyl d-aspartate (nmda) and α-amino-3-hydroxy-5-methylisoxazole-4-propionate (ampa) receptors (rs) following acute or repeated cocaine (10 mg/kg, i.p.) |
2012-09-27 |
2023-08-12 |
rat |
| Kristin M Timmer, Jeffery D Stekete. Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats. Psychopharmacology. vol 221. issue 1. 2012-09-25. PMID:22147256. |
examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats. |
2012-09-25 |
2023-08-12 |
rat |
| Kristin M Timmer, Jeffery D Stekete. Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats. Psychopharmacology. vol 221. issue 1. 2012-09-25. PMID:22147256. |
evidence suggests that group i metabotropic glutamate receptor 5 (mglur5) is necessary for cocaine sensitization, and stimulation of this receptor in the mpfc potentially alters cell excitability directly through glutamate release or indirectly through downstream signaling cascades. |
2012-09-25 |
2023-08-12 |
rat |
| K D Fischer-Smith, A C W Houston, G V Rebe. Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell. Neuroscience. vol 210. 2012-09-21. PMID:22433294. |
differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell. |
2012-09-21 |
2023-08-12 |
human |
| K D Fischer-Smith, A C W Houston, G V Rebe. Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell. Neuroscience. vol 210. 2012-09-21. PMID:22433294. |
consistent with this view, glutamate type 1 transporter (glt1), the transporter responsible for >90% of glutamate uptake, is downregulated in nac after several days of withdrawal in rats previously trained to self-administer cocaine under limited access conditions (1-2 h/d). |
2012-09-21 |
2023-08-12 |
human |
| K D Fischer-Smith, A C W Houston, G V Rebe. Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell. Neuroscience. vol 210. 2012-09-21. PMID:22433294. |
thus, glutamate regulation in core appears to be a critical factor in the drug-seeking behavior that follows relatively long periods of cocaine withdrawal. |
2012-09-21 |
2023-08-12 |
human |
| Colin N Haile, James J Mahoney, Thomas F Newton, Richard De La Garz. Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. Pharmacology & therapeutics. vol 134. issue 2. 2012-09-12. PMID:22327234. |
pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. |
2012-09-12 |
2023-08-12 |
Not clear |
| Colin N Haile, James J Mahoney, Thomas F Newton, Richard De La Garz. Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. Pharmacology & therapeutics. vol 134. issue 2. 2012-09-12. PMID:22327234. |
in addition to dysregulated striatal dopamine, norepinephrine and glutamate are also altered in cocaine dependence. |
2012-09-12 |
2023-08-12 |
Not clear |
| Chris Tallarida, Kevin Song, Robert B Raffa, Scott M Rawl. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino acids. vol 42. issue 6. 2012-09-10. PMID:21850438. |
experiments revealed that 2-pmpa displayed no overt behavioral activity by itself but attenuated stereotypical counts (c-shape hyperkinesias) elicited by four compounds (2-pmpa rank order potency: glutamate>nmda>pilocarpine>cocaine). |
2012-09-10 |
2023-08-12 |
Not clear |
| Ashley P Kennedy, Robin E Gross, Natasha Whitfield, Karen P G Drexler, Clinton D Kilt. A controlled trial of the adjunct use of D-cycloserine to facilitate cognitive behavioral therapy outcomes in a cocaine-dependent population. Addictive behaviors. vol 37. issue 8. 2012-09-07. PMID:22578380. |
the goal of this study was to determine if the n-methyl-d-aspartate (nmda) glutamate receptor partial agonist and cognitive enhancer, d-cycloserine (dcs), could boost the cocaine abstinence and treatment retention goals of cognitive behavioral therapy (cbt). |
2012-09-07 |
2023-08-12 |
human |
| Astrid K Stoker, Berend Olivier, Athina Marko. Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. Psychopharmacology. vol 221. issue 2. 2012-08-15. PMID:22147259. |
involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. |
2012-08-15 |
2023-08-12 |
Not clear |
| Joachim D Uys, Lori Knackstedt, Phelipe Hurt, Kenneth D Tew, Yefim Manevich, Steven Hutchens, Danyelle M Townsend, Peter W Kaliva. Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 12. 2012-08-08. PMID:21796101. |
impaired glutamate homeostasis in the nucleus accumbens has been linked to cocaine relapse in animal models, and results in part from cocaine-induced downregulation of the cystine-glutamate exchanger. |
2012-08-08 |
2023-08-12 |
mouse |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Chad Giles, Anthony Purgianto, Chad Seubert, John R Mantsc. Glutamatergic plasticity in medial prefrontal cortex and ventral tegmental area following extended-access cocaine self-administration. Brain research. vol 1413. 2012-06-12. PMID:21855055. |
the current study investigated the expression and postsynaptic density redistribution of glutamate receptors and synaptic scaffolding proteins in dorsomedial and ventromedial prefrontal cortex and ventral tegmental area after cocaine self-administration. |
2012-06-12 |
2023-08-12 |
rat |
| Ryan T LaLumiere, Kyle C Smith, Peter W Kaliva. Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell. The European journal of neuroscience. vol 35. issue 4. 2012-06-12. PMID:22321070. |
the suppression of cue-induced cocaine seeking by pepa in the il was reversed by intra-shell microinjections of either dopamine or the ampa receptor antagonist cnqx, suggesting that the accumbens shell bidirectionally regulates cocaine-seeking depending on whether dopamine input is mimicked or glutamate input is inhibited. |
2012-06-12 |
2023-08-12 |
rat |
| Vladimir I Chefer, Ruizhong Wang, Toni S Shippenber. Basolateral amygdala-driven augmentation of medial prefrontal cortex GABAergic neurotransmission in response to environmental stimuli associated with cocaine administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 10. 2012-06-04. PMID:21633339. |
we used in vivo microdialysis and pharmacological inactivation techniques to identify alterations in mpfc glutamate (glu) and gamma-aminobutyric acid (gaba) transmission in response to cues previously associated with experimenter-administered cocaine (coc) and the bla contribution to these effects. |
2012-06-04 |
2023-08-12 |
rat |
| Monica S Guzman, Xavier De Jaeger, Sanda Raulic, Ivana A Souza, Alex X Li, Susanne Schmid, Ravi S Menon, Raul R Gainetdinov, Marc G Caron, Robert Bartha, Vania F Prado, Marco A M Prad. Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission. PLoS biology. vol 9. issue 11. 2012-05-17. PMID:22087075. |
these observations indicate that previous functions attributed to striatal cholinergic neurons in spontaneous locomotor activity and in the rewarding responses to cocaine are mediated by glutamate and not by acetylcholine release. |
2012-05-17 |
2023-08-12 |
mouse |
| J David Glass, Allison J Brager, Adam C Stowie, Rebecca A Prosse. Cocaine modulates pathways for photic and nonphotic entrainment of the mammalian SCN circadian clock. American journal of physiology. Regulatory, integrative and comparative physiology. vol 302. issue 6. 2012-05-15. PMID:22218419. |
in complementary in vitro experiments, photic-like phase-delay shifts of the scn circadian neuronal activity rhythm induced by glutamate application to the scn were completely blocked by cocaine. |
2012-05-15 |
2023-08-12 |
mouse |
| Kalindi Bakshi, Mary Kosciuk, Robert G Nagele, Eitan Friedman, Hoau-Yan Wan. Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP. PloS one. vol 6. issue 9. 2012-03-05. PMID:21980374. |
prenatal cocaine exposure causes sustained phosphorylation of the synaptic anchoring protein, glutamate receptor interacting protein (grip1/2), preventing synaptic targeting of the glur2/3-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (ampars; j. neurosci. |
2012-03-05 |
2023-08-12 |
rat |
| Xiaoxu Liu, J Eric Jensen, Timothy E Gillis, Chun S Zuo, Andrew P Prescot, Melanie Brimson, Kenroy Cayetano, Perry F Renshaw, Marc J Kaufma. Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys. Psychopharmacology. vol 217. issue 3. 2012-01-31. PMID:21494788. |
chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys. |
2012-01-31 |
2023-08-12 |
monkey |
| D A Lane, B Reed, M J Kreek, V M Picke. Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21215761. |
differential glutamate ampa-receptor plasticity in subpopulations of vta neurons in the presence or absence of residual cocaine: implications for the development of addiction. |
2012-01-27 |
2023-08-12 |
mouse |