| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuyoshi Suto, Greg I Elmer, Bin Wang, Zhi-Bing You, Roy A Wis. Bidirectional modulation of cocaine expectancy by phasic glutamate fluctuations in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 21. 2013-08-09. PMID:23699516. |
bidirectional modulation of cocaine expectancy by phasic glutamate fluctuations in the nucleus accumbens. |
2013-08-09 |
2023-08-12 |
rat |
| Nobuyoshi Suto, Greg I Elmer, Bin Wang, Zhi-Bing You, Roy A Wis. Bidirectional modulation of cocaine expectancy by phasic glutamate fluctuations in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 21. 2013-08-09. PMID:23699516. |
thus we measured extracellular fluctuations of nas glutamate in response to discriminative stimuli that signaled either cocaine availability or cocaine omission. |
2013-08-09 |
2023-08-12 |
rat |
| Chiung-Chun Huang, Che-Ming Yeh, Mei-Ying Wu, Kuei-Sen Hs. A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23452061. |
our results reveal a novel 5-ht1b receptor-mediated ltd in the nac and suggest that cocaine exposure may result in elevated phosphorylation of presynaptic proteins involved in regulating glutamate release, which counteracts the presynaptic depressant effects of 5-ht1b receptors and thereby impairs the induction of ltd by 5-ht. |
2013-08-06 |
2023-08-12 |
mouse |
| Alexis W Ary, Kevin D Lominac, Melissa G Wroten, Amy R Williams, Rianne R Campbell, Osnat Ben-Shahar, Georg von Jonquieres, Matthias Klugmann, Karen K Szumlinsk. Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 19. 2013-08-06. PMID:23658151. |
intriguingly, both these transgenic manipulations produced glutamate anomalies within the nucleus accumbens (nac) of cocaine-naive animals that are reminiscent of those observed in cocaine experienced animals, including reduced basal extracellular glutamate content, reduced homer1/2 and glutamate receptor expression, and augmented cocaine-elicited glutamate release. |
2013-08-06 |
2023-08-12 |
mouse |
| Alexis W Ary, Kevin D Lominac, Melissa G Wroten, Amy R Williams, Rianne R Campbell, Osnat Ben-Shahar, Georg von Jonquieres, Matthias Klugmann, Karen K Szumlinsk. Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 19. 2013-08-06. PMID:23658151. |
together, these data provide novel evidence in support of opposing roles for constitutively expressed homer1 and homer2 isoforms in regulating mpfc glutamate transmission in vivo and support the hypothesis that cocaine-elicited increases in the relative amount of mpfc homer2 versus homer1 signaling produces abnormalities in nac glutamate transmission that enhance vulnerability to cocaine reward. |
2013-08-06 |
2023-08-12 |
mouse |
| Kathryn D Fischer, Alexander C W Houston, George V Rebe. Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 22. 2013-07-26. PMID:23719800. |
decreased expression of glutamate type i transporter (glt1), which is responsible for >90% of glutamate clearance, occurs in the core of rats withdrawn from cocaine self-administration, while treatment with ceftriaxone, a β-lactam antibiotic previously shown to increase glt1 expression and function in rodents, upregulates glt1 and attenuates cue-induced cocaine reinstatement. |
2013-07-26 |
2023-08-12 |
rat |
| Pavel I Ortinski, Jill R Turner, R Christopher Pierc. Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 22. 2013-07-26. PMID:23719812. |
additionally, prior cocaine self-administration limits activation of the extrasynaptic nmdar pool by increasing glutamate reuptake. |
2013-07-26 |
2023-08-12 |
rat |
| Xia Li, Zheng-Xiong Xi, Athina Marko. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. vol 66. 2013-07-02. PMID:22546614. |
metabotropic glutamate 7 (mglu7) receptor: a target for medication development for the treatment of cocaine dependence. |
2013-07-02 |
2023-08-12 |
Not clear |
| Xia Li, Zheng-Xiong Xi, Athina Marko. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. vol 66. 2013-07-02. PMID:22546614. |
in vivo microdialysis studies indicated that systemic or intra-nac administration of amn082 significantly decreased extracellular γ-aminobutyric acid (gaba) and elevated extracellular glutamate, but had no effect on extracellular dopamine in the nac, suggesting that a non-dopaminergic mechanism underlies the effects of amn082 on the actions of cocaine. |
2013-07-02 |
2023-08-12 |
Not clear |
| Xia Li, Zheng-Xiong Xi, Athina Marko. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. vol 66. 2013-07-02. PMID:22546614. |
these increases in extracellular glutamate functionally antagonized cocaine-induced inhibition of nac-ventral pallidum gabaergic neurotransmission, and therefore, the rewarding effects of cocaine. |
2013-07-02 |
2023-08-12 |
Not clear |
| Xia Li, Zheng-Xiong Xi, Athina Marko. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. vol 66. 2013-07-02. PMID:22546614. |
in addition, elevated extracellular glutamate activated presynaptic mglu2/3 autoreceptors which in turn inhibited cocaine priming- or cue-induced enhancement of glutamate release and reinstatement of drug-seeking behavior. |
2013-07-02 |
2023-08-12 |
Not clear |
| Amanda Gabriele, Alejandra M Pacchioni, Ronald E Se. Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats. Pharmacology, biochemistry, and behavior. vol 103. issue 2. 2013-06-11. PMID:23026056. |
dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats. |
2013-06-11 |
2023-08-12 |
rat |
| Amanda Gabriele, Alejandra M Pacchioni, Ronald E Se. Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats. Pharmacology, biochemistry, and behavior. vol 103. issue 2. 2013-06-11. PMID:23026056. |
the current study measured dlcpu dopamine (da) and glutamate (glu) release during drug seeking following limited or extended abstinence, as well as in response to a cocaine priming injection alone. |
2013-06-11 |
2023-08-12 |
rat |
| P S S Rao, Y Sar. Glutamate transporter 1: target for the treatment of alcohol dependence. Current medicinal chemistry. vol 19. issue 30. 2013-05-21. PMID:22680643. |
a number of studies have reported that drugs of abuse, including alcohol and cocaine, alter glutamate transport. |
2013-05-21 |
2023-08-12 |
mouse |
| Alfred J Robison, Vincent Vialou, Michelle Mazei-Robison, Jian Feng, Saïd Kourrich, Miles Collins, Sunmee Wee, George Koob, Gustavo Turecki, Rachael Neve, Mark Thomas, Eric J Nestle. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467346. |
although Δfosb and camkiiα both regulate ampa glutamate receptor expression and function in nac, dendritic spine formation on nac medium spiny neurons (msns), and locomotor sensitization to cocaine, no direct link between these molecules has to date been explored. |
2013-04-26 |
2023-08-12 |
human |
| Osnat Ben-Shahar, Arianne D Sacramento, Bailey W Miller, Sierra M Webb, Melissa G Wroten, Hannah E Silva, Amanda L Caruana, Evan J Gordon, Kyle L Ploense, Jennifer Ditzhazy, Tod E Kippin, Karen K Szumlinsk. Deficits in ventromedial prefrontal cortex group 1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 2. 2013-03-04. PMID:23303930. |
deficits in ventromedial prefrontal cortex group 1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administration. |
2013-03-04 |
2023-08-12 |
rat |
| Osnat Ben-Shahar, Arianne D Sacramento, Bailey W Miller, Sierra M Webb, Melissa G Wroten, Hannah E Silva, Amanda L Caruana, Evan J Gordon, Kyle L Ploense, Jennifer Ditzhazy, Tod E Kippin, Karen K Szumlinsk. Deficits in ventromedial prefrontal cortex group 1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 2. 2013-03-04. PMID:23303930. |
because group 1 metabotropic glutamate receptors (mglurs) regulate drug-related learning, we assayed the consequences of extended access to intravenous cocaine (6 h/d; 0.25 mg/infusion for 10 d) on the pfc expression of group 1 mglurs and the relevance of observed changes for cocaine seeking. |
2013-03-04 |
2023-08-12 |
rat |
| Carrie R Ferrario, Ivan Goussakov, Grace E Stutzmann, Marina E Wol. Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870207. |
nmdar currents did not differ between groups, but a smaller percentage of spines in the cocaine group responded to glutamate uncaging with nmdar-mediated ca(2+) entry. |
2013-02-19 |
2023-08-12 |
rat |
| Jiann Wei Yeoh, Morgan H James, Phillip Jobling, Jaideep S Bains, Brett A Graham, Christopher V Daya. Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus. The Journal of physiology. vol 590. issue 16. 2013-01-08. PMID:22641785. |
dual-labelling for orexin and excitatory inputs using the vesicular glutamate transporter (vglut2), showed that passive cocaine exposure increased vglut2-positive appositions onto orexin neurones. |
2013-01-08 |
2023-08-12 |
Not clear |
| Suzan Owaisat, Robert B Raffa, Scott M Rawl. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neuroscience letters. vol 525. issue 1. 2012-11-27. PMID:22877698. |
the present data suggest that harmine displays preferential efficacy against different addictive substances (cocaine>amphetamines>nicotine) and, at least for cocaine, is dependent on the glutamate system. |
2012-11-27 |
2023-08-12 |
Not clear |