| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana L Simmons, Bruce H Mandt, Christopher M C Ng, Toni L Richards, Dorothy J Yamamoto, Nancy R Zahniser, Richard M Alle. Low- and high-cocaine locomotor responding rats differ in reinstatement of cocaine seeking and striatal mGluR5 protein expression. Neuropharmacology. vol 75. 2014-08-19. PMID:23973314. |
here, we used the extinction/reinstatement model to address whether or not lcrs and hcrs differ in (i) extinction/reinstatement of cocaine self-administration behavior and (ii) levels of metabotropic glutamate receptors (mglurs) following these behaviors. |
2014-08-19 |
2023-08-12 |
rat |
| Stephen V Mahler, Megan Hensley-Simon, Pouya Tahsili-Fahadan, Ryan T LaLumiere, Charles Thomas, Rebecca V Fallon, Peter W Kalivas, Gary Aston-Jone. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addiction biology. vol 19. issue 1. 2014-08-18. PMID:23017017. |
modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. |
2014-08-18 |
2023-08-12 |
rat |
| Stephen V Mahler, Megan Hensley-Simon, Pouya Tahsili-Fahadan, Ryan T LaLumiere, Charles Thomas, Rebecca V Fallon, Peter W Kalivas, Gary Aston-Jone. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addiction biology. vol 19. issue 1. 2014-08-18. PMID:23017017. |
next, we sought to explore effects of modafinil on extracellular glutamate levels in accumbens after chronic cocaine. |
2014-08-18 |
2023-08-12 |
rat |
| Stephen V Mahler, Megan Hensley-Simon, Pouya Tahsili-Fahadan, Ryan T LaLumiere, Charles Thomas, Rebecca V Fallon, Peter W Kalivas, Gary Aston-Jone. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addiction biology. vol 19. issue 1. 2014-08-18. PMID:23017017. |
modafinil increased extracellular accumbens glutamate in chronic cocaine, but not chronic saline-pre-treated animals. |
2014-08-18 |
2023-08-12 |
rat |
| Ainhoa Plaza-Zabala, Xuan Li, Mike Milovanovic, Jessica A Loweth, Rafael Maldonado, Fernando Berrendero, Marina E Wol. An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure. Neuroscience letters. vol 557 Pt B. 2014-08-18. PMID:24262606. |
an investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure. |
2014-08-18 |
2023-08-12 |
rat |
| Ainhoa Plaza-Zabala, Xuan Li, Mike Milovanovic, Jessica A Loweth, Rafael Maldonado, Fernando Berrendero, Marina E Wol. An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure. Neuroscience letters. vol 557 Pt B. 2014-08-18. PMID:24262606. |
first, we tested whether hypocretin-1 by itself could acutely modulate glutamate receptor surface expression in the nac, given that hypocretin-1 in the vta reproduces cocaine's effects on glutamate transmission. |
2014-08-18 |
2023-08-12 |
rat |
| Ainhoa Plaza-Zabala, Xuan Li, Mike Milovanovic, Jessica A Loweth, Rafael Maldonado, Fernando Berrendero, Marina E Wol. An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure. Neuroscience letters. vol 557 Pt B. 2014-08-18. PMID:24262606. |
overall, our results fail to support a role for hypocretins in acute modulation of glutamate receptor levels in the nac or a role for altered hcrtr-2 expression in withdrawal-dependent synaptic adaptations in the nac following cocaine self-administration. |
2014-08-18 |
2023-08-12 |
rat |
| Raveendra-Panickar Dhanya, Douglas J Sheffler, Russell Dahl, Melinda Davis, Pooi San Lee, Li Yang, Hilary Highfield Nickols, Hyekyung P Cho, Layton H Smith, Manoranjan S D'Souza, P Jeffrey Conn, Andre Der-Avakian, Athina Markou, Nicholas D P Cosfor. Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence. Journal of medicinal chemistry. vol 57. issue 10. 2014-08-08. PMID:24735492. |
design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mglu2/3) receptor positive allosteric modulators (pams): pharmacological characterization and assessment in a rat model of cocaine dependence. |
2014-08-08 |
2023-08-13 |
rat |
| Cheryl F Lichti, Xiuzhen Fan, Robert D English, Yafang Zhang, Dingge Li, Fanping Kong, Mala Sinha, Clark R Andersen, Heidi Spratt, Bruce A Luxon, Thomas A Gree. Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens. Frontiers in behavioral neuroscience. vol 8. 2014-08-07. PMID:25100957. |
results of complementary ingenuity pathways analyses (ipa) and gene set enrichment analyses (gsea), both performed using protein quantitative data, demonstrate that cocaine increases vesicular transporters for dopamine and glutamate as well as increasing proteins in the rhoa pathway. |
2014-08-07 |
2023-08-13 |
rat |
| Arlene Martínez-Rivera, Enrique Rodríguez-Borrero, María Matías-Alemán, Alexandra Montalvo-Acevedo, Kathleen Guerrero-Figuereo, Liz J Febo-Rodríguez, Amarilys Morales-Rivera, Carmen S Maldonado-Vlaa. Metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited cocaine conditioning expression. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23850523. |
metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited cocaine conditioning expression. |
2014-07-15 |
2023-08-12 |
rat |
| Gabriel C Quinter. Role of nucleus accumbens glutamatergic plasticity in drug addiction. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24109187. |
on the other hand, cocaine self-administration and withdrawal increases the surface expression of subunit glutamate receptor 1 (glua1) of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors at the level of the nac. |
2014-06-24 |
2023-08-12 |
human |
| Gabriel C Quinter. Role of nucleus accumbens glutamatergic plasticity in drug addiction. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24109187. |
also, cocaine self-administration and withdrawal induce the formation of subunit glutamate receptor 2 (glua2), lacking the ca(2+)-permeable ampa receptors (cp-ampars) at the level of the nac. |
2014-06-24 |
2023-08-12 |
human |
| Ken T Wakabayashi, Eugene A Kiyatki. Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. Journal of neurochemistry. vol 128. issue 5. 2014-04-29. PMID:24111505. |
critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. |
2014-04-29 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Eugene A Kiyatki. Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. Journal of neurochemistry. vol 128. issue 5. 2014-04-29. PMID:24111505. |
recent studies reveal that cocaine experience results in persistent neuroadaptive changes within glutamate (glu) synapses in brain areas associated with drug reward. |
2014-04-29 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Eugene A Kiyatki. Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. Journal of neurochemistry. vol 128. issue 5. 2014-04-29. PMID:24111505. |
using high-speed amperometry with enzyme-based biosensors in freely moving rats, we show that initial intravenous cocaine induces rapid, transient glutamate (glu) release in the nac (nucleus accumbens), rapidly becoming a stronger, two-component increase with subsequent injections. |
2014-04-29 |
2023-08-12 |
rat |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. |
2014-04-22 |
2023-08-12 |
mouse |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
little is known about the properties and modulation of glutamate release from da midbrain terminals and the effect of cocaine. |
2014-04-22 |
2023-08-12 |
mouse |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
these findings demonstrate that acute cocaine inhibits da and glutamate release from midbrain da neurons via presynaptic d2r but has differential overall effects on their transmissions in the nac. |
2014-04-22 |
2023-08-12 |
mouse |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
we postulate that cocaine, by blocking da reuptake, prolongs da transients and facilitates the feedback inhibition of da and glutamate release from these terminals. |
2014-04-22 |
2023-08-12 |
mouse |
| Anthony Purgianto, Andrew F Scheyer, Jessica A Loweth, Kerstin A Ford, Kuei Y Tseng, Marina E Wol. Different adaptations in AMPA receptor transmission in the nucleus accumbens after short vs long access cocaine self-administration regimens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 9. 2014-04-04. PMID:23546386. |
together with data on cocaine infusions in each group, our results show that cp-ampar accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions. |
2014-04-04 |
2023-08-12 |
rat |